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Photosynthetic co-culture system of algae and human umbilical vein endothelial cells:The effect on alleviating hypoxia and hypoxia/reoxygenation injury

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Biosurface and Biotribology 2024年第2期10卷 76-88页

作者： Donghu Lin Yuanyuan Chen Xinyu Tao Xin Che shiyu Li shiyu cheng Shuxin Qu Institute of Biomedical Engineering College of MedicineSouthwest Jiaotong UniversityChengduSichuanChina Key Laboratory of Advanced Technologies of Materials Ministry of Education School of Materials Science and EngineeringSouthwest Jiaotong UniversityChengduSichuanChina School of Life Science and Engineering Southwest Jiaotong UniversityChengduSichuanChina

It is a developed photosynthetic co-culture system to alleviate the hypoxia and hypoxia/reoxygenation(H/R)-injured human umbilical vein endothelial cells(HUVECs).The algae,Chlorella vulgaris,were encapsulated to slow their growth while not affecting the photosynthetic oxygen-producing capacity by Layer-by-layer(LbL)using gelatin and sodium alginate as the positive and negative charges materials,***,the photosynthetic co-culture system of HUVECs and self-oxygenating alginate hydrogel(Algae-gel)was constructed in which the optimal ratios between algae and HUVECs were 5:1 and 20:1 for a 2D or 3D co-cultured manner,*** indicated that the 3D cocultured manner of HUVECs needed more O_(2) by the production of algae than it did in a 2D co-cultured *** co-cultured Algae-gel could alleviate hypoxia and the oxidative stress injury of hypoxia and hypoxia/reoxygenation(H/R)-treated HUVECs in the proliferation,intracellular ROS and cellular migratory *** addition,the Algaegel could downregulate the expression of hypoxia-inducible factors 1α(HIF-1α)and vascular endothelial growth factor(VEGF)of hypoxia and H/R-injured HUVECs due to the improvement of hypoxia and H/R *** photosynthetic co-culture system could offer a promising approach for repairing hypoxia and H/R-injured cells or tissue by providing safe and stable O_(2).

关键词： biomaterials biomedical application bionic design regenerative medicine self-assembly tissue engineering

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非贵金属催化电极Ni/C@CF的制备及绿色类Fenton性能

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高等学校化学学报 2024年第2期45卷 125-132页

作者：成施雨杨灵包芮于陈宸崔萌萌张谷令李华中央民族大学民族地区生态环境国家民委重点实验室北京100081 中央民族大学生命与环境科学学院北京100081 中央民族大学理学院北京100081

传统芬顿(Fenton)法利用Fe2+催化H_(2)O_(2)产生具有强氧化性的羟基自由基(•OH),可以高效氧化降解水中有机污染物,但其操作pH范围窄(pH≈3)和易产生铁絮凝沉淀的缺点限制了其应用发展.原子氢H*作为一种单电子供体,可以将电子快速转移到H... 详细信息

传统芬顿(Fenton)法利用Fe2+催化H_(2)O_(2)产生具有强氧化性的羟基自由基(•OH),可以高效氧化降解水中有机污染物,但其操作pH范围窄(pH≈3)和易产生铁絮凝沉淀的缺点限制了其应用发展.原子氢H*作为一种单电子供体,可以将电子快速转移到H_(2)O_(2)中,生成•OH,适用于广泛的pH值,没有铁污泥产生,是一种新型高效绿色芬顿法.然而,原子H*更易相互结合形成H_(2),极不稳定,因此,探索合适的电催化剂对H*绿色Fenton的应用起着至关重要的作用.本文以炭黑作为载体,通过液相还原法制备了具有催化活性高、性能稳定的Ni/C@碳毡(Ni/C@CF)非贵金属电催化材料,制备的Ni纳米粒子均匀分散在炭黑上.以此电极材料为阴极,构建绿色Fenton催化体系,能够催化H_(2)O和H+生成H*,进而催化H_(2)O_(2)产生•OH,高效降解去除水中抗生素污染物.通过调节制备方法、电压、溶液pH值及外加氧化剂量,确定了该体系下的最佳反应条件.

关键词：芬顿反应原子氢 Ni/C@CF材料电催化有机污染物

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大型综合医院应急救援空间设计初探——以深圳宝安空海救援医院项目为例

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中国医院建筑与装备 2024年第9期25卷 23-30页

作者：郑洁程世毓李睿斌同圆设计集团股份有限公司济南250000 西安建筑科技大学西安710000

城市的快速发展往往带来许多潜在的安全隐患,突发事件的时有发生给人类的生活带来了巨大的灾难。为提高突发事件的应急处置能力,该文以深圳Ⅰ级综合应急保障医院——深圳宝安空海救援医院为研究对象,从厘清应急救援空间建设内涵及其发... 详细信息

城市的快速发展往往带来许多潜在的安全隐患,突发事件的时有发生给人类的生活带来了巨大的灾难。为提高突发事件的应急处置能力,该文以深圳Ⅰ级综合应急保障医院——深圳宝安空海救援医院为研究对象,从厘清应急救援空间建设内涵及其发展现状入手,研讨应急救援的工作流程及功能要素,总结应急救援空间设计策略,用于指导深圳宝安空海救援医院的设计实践。

关键词：综合医院深圳地区应急救援空间应急救援策略设计实践

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高温环境对防弹插板抗弹性能影响分析

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兵器装备工程学报 2024年第2期45卷 94-99页

作者：聂嘉兴程时雨李忠盛黄安畏郭峰林禹李鹏吴永鹏中国兵器工业第五九研究所重庆400039

采用M80弹(7.62 mm×51 mm NATO)分别对常温和高温(55℃)下的防弹插板进行实弹射击试验,以研究高温环境对防弹插板抗弹性能的影响。通过分析试验时防弹插板弹击瞬间凹陷值,同时结合聚氨酯树脂的剥离强度、超高分子量聚乙烯纤维层压板剥... 详细信息

采用M80弹(7.62 mm×51 mm NATO)分别对常温和高温(55℃)下的防弹插板进行实弹射击试验,以研究高温环境对防弹插板抗弹性能的影响。通过分析试验时防弹插板弹击瞬间凹陷值,同时结合聚氨酯树脂的剥离强度、超高分子量聚乙烯纤维层压板剥离强度和弯曲强度的测试结果对高温下抗弹性能变化原因进行了研究。结果表明:高温下防弹插板抗弹性能明显下降,相对于常温下每发弹的弹击瞬间凹陷值增加了2~5 mm。其主要原因是超高分子量聚乙烯纤维层压板在高温下抵抗变形的能力发生明显下降,从而导致防弹插板的弹击瞬间凹陷值增大。

关键词：防弹插板弹击瞬间凹陷值高温环境超高分子量聚乙烯纤维层压板

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城市社区养老设施空间设计初探

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城市建筑 2024年第20期21卷 37-40,62页

作者：郑洁程世毓韩延栋王宪峰同圆设计集团股份有限公司

随着全球人口老龄化的加速发展,城市社区养老问题日益凸显,成为社会各界关注的焦点。社区养老设施作为老年人日常生活的重要载体,其空间设计的合理性与人性化直接关系到老年人的生活质量与幸福感。文章以老年人的行为特征和根本需求为... 详细信息

随着全球人口老龄化的加速发展,城市社区养老问题日益凸显,成为社会各界关注的焦点。社区养老设施作为老年人日常生活的重要载体,其空间设计的合理性与人性化直接关系到老年人的生活质量与幸福感。文章以老年人的行为特征和根本需求为出发点,将养老设施空间需求类型分为活动型养老设施、日托型养老设施、照料型养老设施、托护型养老设施,并总结其不同的设计要点。

关键词：养老设施社区适老化空间行为需求

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Experimental investigation on weak shock wave mitigation characteristics of flexible polyurethane foam and polyurea

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Defence Technology（防务技术） 2024年第1期31卷 179-191页

作者： shiyu Jia cheng Wang Wenlong Xu Dong Ma Fangfang Qi State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing100081China Institute for Advanced Technology Shandong UniversityJinan250061China

In recent years,explosion shock wave has been considered as a signature injury of the current military *** strong shock wave is lethal to the human body,weak shock wave can cause many more lasting *** investigate the protection ability and characteristics of flexible materials and structures under weak shock wave loading,the blast wave produced by TNT explosive is loaded on the polyurethane foam with the density of 200.0 kg/m3(F-200)and 400.0 kg/m3(F-400),polyurea with the density of 1100.0 kg/m^(3)(P-1100)and structures composed of the two materials,which are intended for individual *** results indicate that the shock wave is attenuated to weak pressure disturbance after interacting with the flexible materials which are not *** shock wave protective capability of single-layer materials is dependent on their thickness,density and microscopic *** overpressure,maximum pressure rise rate and impulse of transmitted wave decrease exponentially with increase in sample *** the same thickness,F-400 provides better protective capability than F-200 while P-1100 shows the best protective capability among the three *** this study,as the materials are not destroyed,F-200 with a thickness more than10.0 mm,F-400 with a thickness more than 4.0 mm,and P-1100 with a thickness more than 1.0 mm can attenuate the overpressure amplitude more than 90.0%.Further,multi-layer flexible composites are *** layer layouts of designed structures and layer thickness of the single-layer materials can affect the protective *** the research range,the structure in which polyurea is placed on the impact side shows the optimal shock wave protective performance,and the thicknesses of polyurea and polyurethane foam are 1.0 mm and 4.0 mm *** overpressure attenuation rate reached maximum value of 93.3%and impulse attenuation capacity of this structure are better than those of s

关键词： Free-field explosion Weak shock wave mitigation Polyurea Polyurethane foam Multi-layered composites

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Propagation Properties of Shock Waves in Polyurethane Foam based on Atomistic Simulations

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Defence Technology（防务技术） 2024年第1期31卷 117-129页

作者： Zhiqiang Hu Jianli Shao shiyu Jia Weidong Song cheng Wang State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing 100081China

Porous materials are widely used in the field of protection because of their excellent energy absorption *** this work,a series of polyurethane microscopic models are established and the effect of porosity on the shock waves is studied with classical molecular dynamics ***,shock Hugoniot relations for different porosities are obtained,which compare well with the experimental *** pores collapse and form local stress wave,which results in the complex multi-wave structure of the shock *** microstructure analysis shows that the local stress increases and the local velocity decreases gradually during the process of pore collapse to complete ***,it leads to stress relaxation and velocity *** shock stress peaks can be fitted with two exponential functions,and the amplitude of attenuation coefficient decreases with the increase of ***,the pore collapse under shock or non-shock are discussed by the entropy increase rate of the *** energy is dissipated mainly through the multiple interactions of the waves under *** energy is dissipated mainly by the friction between atoms under non-shock.

关键词： Polyurethane foam Shock wave Attenuation Atomistic simulation

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FPSblo:A Blockchain Network Transmission Model Utilizing Farthest Point Sampling

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Computers, Materials & Continua 2024年第2期78卷 2491-2509页

作者： Longle cheng Xiru Li shiyu Fang Wansu Pan He Zhao Haibo Tan Xiaofeng Li Hefei Institutes of Physical Science Chinese Academy of SciencesHefei230031China University of Science and Technology of China Hefei230026China

Peer-to-peer(P2P)overlay networks provide message transmission capabilities for blockchain *** data transmission efficiency in P2P networks can greatly enhance the performance of blockchain ***,traditional blockchain P2P networks face a common challenge where there is often a mismatch between the upper-layer traffic requirements and the underlying physical network *** mismatch results in redundant data transmission and inefficient routing,severely constraining the scalability of blockchain *** address these pressing issues,we propose FPSblo,an efficient transmission method for blockchain *** inspiration for FPSblo stems from the Farthest Point Sampling(FPS)algorithm,a well-established technique widely utilized in point cloud image *** this work,we analogize blockchain nodes to points in a point cloud image and select a representative set of nodes to prioritize message forwarding so that messages reach the network edge quickly and are evenly ***,we compare our model with the Kadcast transmission model,which is a classic improvement model for blockchain P2P transmission networks,the experimental findings show that the FPSblo model reduces 34.8%of transmission redundancy and reduces the overload rate by 37.6%.By conducting experimental analysis,the FPS-BT model enhances the transmission capabilities of the P2P network in blockchain.

关键词： Blockchain P2P networks scalability farthest point sampling

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Computational fluid dynamics simulation and experimental study on mixing performance of a three-dimensional circular cyclone-type microreactor

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Chinese Chemical Letters 2024年第4期35卷 382-388页

作者： shiyu Hou Maolin Sun Liming Cao Chaoming Liang Jiaxin Yang Xinggui Zhou Jinxing Ye Ruihua cheng School of Chemical Engineering East China University of Science and TechnologyShanghai 200237China School of Biomedical and Pharmaceutical Sciences Guangdong University of TechnologyGuangzhou 510006China School of Pharmacy East China University of Science and TechnologyShanghai 200237China

Microchannels enable the fast and efficient mixing of multiphase *** this study, a millimeter-scale three-dimensional(3D) circular cyclone-type microreactor was designed for the *** flow characteristics and mixing intensity were simulated by computational fluid dynamics simulations at a flow rate range of 12–96 m L/min using a water/ethyl acetate *** the 3D variable-diameter structure,the microreactor induced paired opposite vortices and abruptly changed the local pressure to achieve a stable turbulent effect within the theoretical range of laminar *** injection simulations indicated that sufficient mixing units successfully promote fluid ***-coupling experiments showed a segregation index of X_S= 0.00,039 within a residence time of 9 *** experiments on the nbutanol/succinic acid/water system showed that the 3D circular cyclone-type microreactor achieved 100%extraction efficiency(E) in 4.25 s, and the overall volume mass transfer coefficient(K_La) reached 0.05–1.5s^(-1) in 12–96 m L/*** isolated yield of the phase transfer alkylation and oxidation reactions in the 3D circular cyclone-type microreactor achieved 99% within 36 s, which was superior to the coil microreactor and batch reactor.

关键词： Microfluidics Passive microreactor CFD simulation Extraction Liquid-liquid biphase reaction

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Design of artificial biomimetic channels with Na^(+)permeation rate and selectivity potentially outperforming the natural sodium channel

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Nano Research 2024年第9期17卷 8638-8646页

作者： Zhi Zhu Yan Zhao Chao Chang Shaojian Yan Tingyu Sun shiyu Gu Yangmei Li Dengsong Zhang Chunlei Wang Xiao cheng Zeng School of Optical-Electrical and Computer Engineering University of Shanghai for Science and TechnologyShanghai 200093China Innovation Laboratory of Terahertz Biophysics National Innovation Institute of Defense TechnologyBeijing 100071China School of Physics Peking UniversityBeijing 100871China International Joint Laboratory of Catalytic Chemistry College of SciencesShanghai UniversityShanghai 200444China Department of Materials Science and Engineering City University of Hong KongHong Kong 999077China

Artificial ion channels that enable high-efficiency ion transport have important implications in nanofluidics and biomedical applications such as drug ***,we show a simulation-based chemical design of a biomimetic sodium channel that possesses permeation rate and selectivity potentially higher than those of the state-of-the-art natural vertebrate voltage-gated sodium ***,our theoretical findings have undergone empirical testing,aligning well with the Arrhenius law as derived from a diverse range of experimental *** high-efficiency ion transport is achieved by anchoring the carboxylate functional groups within the channel filter.A key chemical guiding principle underlying the ion channel design is that the free-energy barrier for the Na^(+)passage across the channel should be comparable to typical thermal energy at room *** the implementation of the chemical design,we found that the relatively low free-energy barrier can be attributed to the compensation effect of the carboxylate groups to the partially lost oxygen shell of the ion within the ion channel,as well as to the consonant vibration of the ions inside and outside the *** mechanistic understanding brings new insight,at the molecular level,into the high-efficiency ion transport across the designed membrane *** proof of principle achieved from the simulations will stimulate future experimental confirmation and potential applications of the high-performance artificial channels in nanofluidics and in bioinspired iontronics.

关键词： sodium channels anchoring carboxylate functional groups molecular dynamics simulations low free-energy barrier for ion passage thermal kinetic energy

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