检索结果-南通市图书馆

Shape Memory Polymer Composites:4D Printing,Smart Structures,and Applications

在线全文

学校读者我要写书评

暂无评论

Research 2024年第3期2023卷 319-343页

作者： shiyu yan Fenghua Zhang Lan Luo Linlin Wang yanju Liu Jinsong Leng Centre for Composite Materials and Structures Harbin Institute of Technology(HIT)No.2 Yikuang StreetHarbin 150000People's Republic of China Department of Astronautic Science and Mechanics Harbin Institute of Technology(HIT)No.92 West Dazhi StreetHarbin 150000People's Republic of China.

Shape memory polymers (SMPs) and their composites (SMPCs) are smart materials that can be stably deformed and then return to their original shape under external stimulation, thus having a memory of their shape. Three-dimensional (3D) printing is an advanced technology for fabricating products using a digital software tool. Four-dimensional (4D) printing is a new generation of additive manufacturing technology that combines shape memory materials and 3D printing technology. Currently, 4D-printed SMPs and SMPCs are gaining considerable research attention and are finding use in various fields, including biomedical science. This review introduces SMPs, SMPCs, and 4D printing technologies, highlighting several special 4D-printed structures. It summarizes the recent research progress of 4D-printed SMPs and SMPCs in various fields, with particular emphasis on biomedical applications. Additionally, it presents an overview of the challenges and development prospects of 4D-printed SMPs and SMPCs and provides a preliminary discussion and useful reference for the research and application of 4D-printed SMPs and SMPCs.

关键词： composites printing Smart

Amine-functionalized SiO2 nanodot-coated layered double hydroxide nanocomposites for enhanced gene delivery

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2015年第2期8卷 682-694页

作者： Li Li Wenyi Gu Jian Liu shiyu yan Zhi Ping Xu Australian Institute for Bioengineering and Nanotechnology The University of Queensland Brisbane QLD 4072 Australia Department of Chemical Engineering Curtin University Perth WA 6845 Australia

In this work a novel strategy has been developed to prepare well-dispersed amine-functionalized SiO2 nanodot-coated layered double hydroxide nano- composite （NH2-SiO2@LDH） via electrostatic interactions and condensation of （3-aminopropyl）triethoxysilane （APTES）. This nanocomposite system is well dispersed in culture media and phosphate buffered saline, and exhibits low cytotoxicity and good biocompatibility. The fluorescence microscopy images and flow cytometry data indicate that such an NH2-SiO2@LDH nanocomposite is able to efficiently deliver small interfering RNA （siRNA） into the U2OS cell line to inhibit cell proliferation. Thus, NH2-SiOR@LDH nanocomposite has a great potential as a nanocarrier for efficient gene delivery.

关键词： layered double hydroxide(LDH) functionalization self-assembl3~gene delivery

Auranofin mitigates systemic iron overload and induces ferroptosis via distinct mechanisms

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2020年第1期5卷 1239-1247页

作者： Lei yang Hao Wang Xiang yang Qian Wu Peng An Xi Jin Weiwei Liu Xin Huang Yuzhu Li shiyu yan Shuying Shen Tingbo Liang Junxia Min Fudi Wang Department of Nutrition Precision Nutrition Innovation CenterSchool of Public HealthZhengzhou University450001 ZhengzhouChina The First Affiliated Hospital School of Public HealthInstitute of Translational MedicineZhejiang University School of Medicine310058 HangzhouChina Department of Nutrition and Health Beijing Advanced Innovation Center for Food Nutrition and Human HealthChina Agricultural University100193 BeijingChina School of Nursing Xinxiang Medical University453003 XinxiangChina

Iron homeostasis is essential for health;moreover,hepcidin-deficiency results in iron overload in both hereditary hemochromatosis and iron-loading ***,we identified iron modulators by functionally screening hepcidin agonists using a library of 640 FDA-approved drugs in human hepatic Huh7 *** validated the results in C57BL/6J mice and a mouse model of hemochromatosis(Hfe^(−/−)mice).Our screen revealed that the anti-rheumatoid arthritis drug auranofin(AUR)potently upregulates hepcidin ***,we found that canonical signaling pathways that regulate iron,including the Bmp/Smad and IL-6/Jak2/Stat3 pathways,play indispensable roles in mediating AUR’s *** addition,AUR induces IL-6 via the NF-κB *** C57BL/6J mice,acute treatment with 5 mg/kg AUR activated hepatic IL-6/hepcidin signaling and decreased serum iron and transferrin *** chronically treating male Hfe^(−/−)mice with 5 mg/kg AUR activated hepatic IL-6/hepcidin signaling,decreasing systemic iron overload,but less effective in *** analyses revealed that estrogen reduced the ability of AUR to induce IL-6/hepcidin signaling in Huh7 cells,providing a mechanistic explanation for ineffectiveness of AUR in female Hfe^(−/−)***,high-dose AUR(25 mg/kg)induces ferroptosis and causes lipid peroxidation through inhibition of thioredoxin reductase(TXNRD)*** demonstrate the ferroptosis inhibitor ferrostatin significantly protects liver toxicity induced by highdose AUR without comprising its beneficial effect on iron *** conclusion,our findings provide compelling evidence that TXNRD is a key regulator of ferroptosis,and AUR is a novel activator of hepcidin and ferroptosis via distinct mechanisms,suggesting a promising approach for treating hemochromatosis and hepcidin-deficiency related disorders.

关键词： peroxidation overload mechanisms

Integrated Use of Alternative Methods for Evaluating the Skin Sensitization Potencies of Five Frequently Used Preservatives in Cosmetics

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

China Detergent & Cosmetics 2023年第2期8卷 38-47页

作者： Wang Rui Wang Huan Han Yu-qing Zhao Jinfeng yan shiyu Pan Yao Department of Cosmetics College of Chemistry and Materials EngineeringBeijing Technology and Business UniversityChina Beijing Key Laboratory of Plant Research and Development China Institute of Cosmetic Regulatory Science Beijing Technology and Business UniversityChina

In vitro skin sensitization testing methods based on the adverse outcome pathway(AOP)were used to evaluate the skin sensitization potencies of 5 commonly used *** to the“2 out of 3”principle of the integrated approaches to testing and assessment(IATA)the direct peptide reactivity assay(DPRA)and the human cell line activation test(h-CLAT)were used to detect the preservatives commonly used in cosmetics,including *** paraben,propyl paraben,imidazolidinyl urea and DMDM *** DPRA and the h-CLA were carried out according to the OEC442C and 442E guidelines,*** results show *** and methyl paraben are both negative in DPRA and h-CLAT while imidazolidinyl urea and DMDM hydantoin are both positive in these two *** paraben has negative result in DPRA but positive result in ***,imidazolidiny urea and DMDM hydantoin are sensitizers,while phenoxyethanol and methylparaben are *** animal and human data into consideration,it is predicted that propyl paraben should be a *** combination of DPRA and h-CLAT can make up for the limitations of using a single method,and it is suitable for the preliminary screening of cosmetic raw materials according to skin sensitization.

关键词： Skin sensitization preservative alternative method DPRA h-CLAT AOP

在线全文

学校读者我要写书评

暂无评论

多类运动想象任务脑电信号的KNN分类研究

仪器仪表学报 2012年第8期33卷 1714-1720页

作者：刘冲颜世玉赵海滨王宏东北大学机械工程与自动化学院沈阳110819

针对基于多类任务的运动想象脑电信号的特点,使用共空间模式特征提取方法分别在"一对一"和"一对多"2种特征提取方法下提取了4类任务(想象左右手、双足以及舌头)运动想象脑电信号的特征。设计了基于多类任务模式的k最近邻分类器,针对多... 详细信息

针对基于多类任务的运动想象脑电信号的特点,使用共空间模式特征提取方法分别在"一对一"和"一对多"2种特征提取方法下提取了4类任务(想象左右手、双足以及舌头)运动想象脑电信号的特征。设计了基于多类任务模式的k最近邻分类器,针对多类任务分类过程中会出现不同类别的样本点数相等的情况,通过判断距离的方法改进了分类器,对2种特征提取方法下的共空间模式特征进行分类,分类结果的平均最大Kappa系数分别达到了0.55和0.59,说明了该特征提取及分类方法对该数据集的有效性。

关键词：运动想象多类任务共空间模式 k最近邻

基于稀疏度自适应压缩感知的电容层析成像图像重建算法

在线全文

学校读者我要写书评

暂无评论

电子与信息学报 2018年第5期40卷 1250-1257页

作者：吴新杰闫诗雨徐攀峰颜华辽宁大学物理学院沈阳110036 沈阳工业大学信息科学与工程学院沈阳110870

为提高电容层析成像(ECT)系统重建图像的质量,该文提出一种基于改进稀疏度自适应的压缩感知电容层析成像算法。利用压缩感知与电容层析成像算法的契合点,以随机改造后的电容层析成像灵敏度矩阵为观测矩阵,离散余弦基为稀疏基,测量电容... 详细信息

为提高电容层析成像(ECT)系统重建图像的质量,该文提出一种基于改进稀疏度自适应的压缩感知电容层析成像算法。利用压缩感知与电容层析成像算法的契合点,以随机改造后的电容层析成像灵敏度矩阵为观测矩阵,离散余弦基为稀疏基,测量电容值为观测值,建立模型。利用线性反投影算法(LBP算法)所得图像预估原始图像稀疏度,以预估稀疏度值作为索引原子初始值进行稀疏度自适应迭代。改进后的稀疏度自适应匹配追踪重构算法实现ECT图像重建,解决了稀疏度预估不准确导致重建图像精度差的问题。仿真实验结果表明,该算法可以有效重建ECT图像,其成像质量优于LBP算法、Landweber算法、Tikhonov算法等传统算法,是研究电容层析成像图像重建的一种新的方法和手段。

关键词：图像重建电容层析成像稀疏度自适应压缩感知

在线全文

学校读者我要写书评

暂无评论

基于小波包分解的意识脑电特征提取

仪器仪表学报 2012年第8期33卷 1748-1752页

作者：颜世玉刘冲赵海滨王宏东北大学机械工程与自动化学院沈阳110004

针对2种不同意识任务(想象左手运动和想象右手运动)的脑-机接口(brain-computer interface,BCI)设计,提出了基于小波包分解的特征提取方法。首先深入研究了小波包变换,结合事件相关去同步化(event-related desynchronization,ERD)/事件... 详细信息

针对2种不同意识任务(想象左手运动和想象右手运动)的脑-机接口(brain-computer interface,BCI)设计,提出了基于小波包分解的特征提取方法。首先深入研究了小波包变换,结合事件相关去同步化(event-related desynchronization,ERD)/事件相关同步化(event-related synchronization,ERS)现象,提出以小波包分解系数来考虑特征,然后对C3、C4导联脑电信号进行小波包分解系数方差和相对能量2种特征的提取,最后采用最简线性分类器进行分类。结果表明,2种特征对应的最大分类正确率均达到了85%,对应时间分别为4.34 s和4.39 s。因此,在保证分类正确率的前提下,所提方法更加简单和有效,为大脑意识任务分类提供了新思路。

关键词：脑电脑-机接口小波包变换方差相对能量

在线全文

学校读者我要写书评

暂无评论

堆芯稳态核设计程序验证基准题衍生技术研究

哈尔滨工业大学学报 2019年第11期51卷 160-166页

作者：闫仕宇阳小华刘志明王瑶南华大学计算机学院

软件验证是保证核电软件质量的必经步骤之一,基准题验证是核电软件验证的一种重要手段.基准题的数据来源主要是通过自主实验、收集核电厂运行数据、加入国际实验研究计划和购买国际基准题的数据等传统方法获取,但是存在成本高,周期长的... 详细信息

软件验证是保证核电软件质量的必经步骤之一,基准题验证是核电软件验证的一种重要手段.基准题的数据来源主要是通过自主实验、收集核电厂运行数据、加入国际实验研究计划和购买国际基准题的数据等传统方法获取,但是存在成本高,周期长的问题.为了给堆芯稳态核设计程序验证测试提供更多的验证基准题,本文基于蜕变测试原理提出一种基准题衍生技术,该技术首先建立基准题衍生框架,主要思想是根据蜕变关系的参变量及关系式,直接对原始基准题的相关输入和输出参变量进行计算求解,得到衍生基准题(新的测试用例).再者,针对基准题以固定格式输入卡的形式实现待测程序数据输入的特点,为了提高衍生效率,设计基准题自动衍生算法,开发基准题自动衍生工具系统.最后,以堆芯稳态中子扩散程序的二维、三维基准题的衍生为实例展示.结果表明,该技术可自动地实现单个或者批量生成二维,三维衍生基准题.不但生成数据准确、效率高,而且比传统的方法成本低.

关键词：堆芯稳态核设计基准题衍生技术核电软件验证

在线全文

学校读者我要写书评

暂无评论

儿童青少年肥胖干预研究需开展依从性评价

中国学校卫生 2023年第4期44卷 481-484,493页

作者：王海俊严诗钰北京大学公共卫生学院妇幼卫生学系北京100191

为遏制儿童青少年超重肥胖的流行,国内外学者开展各类干预研究,但是相似的干预措施效果并不一致,可能与干预研究的依从性有关。依从性评价能更好地解释干预措施和效果的关联,通过加强研究依从性能促进干预效果。然而,目前依从性评价存... 详细信息

为遏制儿童青少年超重肥胖的流行,国内外学者开展各类干预研究,但是相似的干预措施效果并不一致,可能与干预研究的依从性有关。依从性评价能更好地解释干预措施和效果的关联,通过加强研究依从性能促进干预效果。然而,目前依从性评价存在研究数量少、评价指标不全面、评价方法质量低、具体实施困难等问题,需要进一步解决。未来研究中需要在干预开始前考虑能够促进依从性的措施,在实施过程中尽可能详细地进行依从性评价数据的收集,从而更好地评价干预效果。

关键词：肥胖症干预病人依从儿童青少年

同方期刊数据库