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Abnormal adipose tissue-derived microbes drive metabolic disorder and exacerbate postnatal growth retardation in piglet

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Life Metabolism 2024年第2期3卷 55-69页

作者： Tongxing Song Ming Qi Yucheng Zhu Nan Wang Zhibo Liu Na Li Jiacheng Yang Yanxu Han Jing Wang shiyu tao Zhuqing Ren Yulong Yin Jinshui Zheng Bie Tan College of Animal Science and Technology Huazhong Agricultural UniversityWuhanHubei 430070China College of Animal Science and Technology Hunan Agricultural UniversityChangshaHunan 410000China Laboratory of Animal Nutritional Physiology and Metabolic Process CAS Key Laboratory of Agro-ecological Processes in Subtropical RegionNational Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry ProductionInstitute of Subtropical AgricultureChinese Academy of SciencesChangshaHunan 410125China State Key Laboratory of Agricultural Microbiology Huazhong Agricultural UniversityWuhanHubei 430070China Hubei Key Laboratory of Agricultural Bioinformatics Huazhong Agricultural UniversityWuhanHubei 430070China

Postnatal growth retardation(PGR)frequently occurs during early postnatal development of piglets and induces high *** date,the mechanism of PGR remains poorly *** tissue-derived microbes have been documented to be associated with several disorders of metabolism and body ***,the connection between microbial disturbance of adipose tissue and pig PGR remains ***,we investigated piglets with PGR and found that the adipose tissue of PGR piglets was charac-terized by metabolism impairment,adipose abnormality,and specific enrichment of culturable bacteria from *** of Sphingomonas paucimobilis,a species of Sphingomonas genus from the alphaproteobacteria,induced PGR in ***,this bacterium could also lead to metabolic disorders and susceptibility to acute stress,resulting in weight loss in ***,multi-omics analysis indicated the changes in lipid metabolism as a response of adipose tissue to abnormal microbial *** experimental tests proved that one of the altered lipids phosphatidylethanolamines could rescue the metabolism disorder and growth retardation,thereby suppressing the amount of Sphingomonas in the adipose ***,these results highlight that the microbe–host crosstalk may regulate the metabolic function of adipose tissue in response to PGR.

关键词： adipose tissue microbe metabolic disorder postnatal growth retardation piglet

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益生菌及其代谢物对仔猪肠道稳态调控作用的研究进展

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浙江大学学报（农业与生命科学版） 2024年第4期50卷 495-505页

作者：宋梦真李靖靖李家旋陶诗煜华中农业大学动物科学技术学院湖北武汉430070

益生菌及其代谢物通过增强肠道屏障功能和调节宿主免疫反应等方式发挥有益作用,对仔猪生长发育具有重要意义。本文从益生菌调控仔猪肠道屏障功能和益生菌代谢物对仔猪肠道稳态的影响方面进行了概述,全面探讨了益生菌及其代谢物调控仔猪... 详细信息

益生菌及其代谢物通过增强肠道屏障功能和调节宿主免疫反应等方式发挥有益作用,对仔猪生长发育具有重要意义。本文从益生菌调控仔猪肠道屏障功能和益生菌代谢物对仔猪肠道稳态的影响方面进行了概述,全面探讨了益生菌及其代谢物调控仔猪肠道稳态的作用效果与机制,旨在为利用益生菌调控仔猪肠道健康提供理论参考。

关键词：益生菌代谢物肠道屏障肠道稳态仔猪

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胜利油田水驱开发技术进展及发展方向

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油气地质与采收率 2024年第5期31卷 99-112页

作者：王建刘丽杰吴义志刘海成贾元元宋志超陶仕玉中国石化胜利油田分公司勘探开发研究院山东东营257015 中国地质大学(北京)能源学院北京100083

水驱油藏是中国东部老油田开发的主体,经过长期注水开发已整体进入特高含水期,室内研究及矿场实践表明,仍有大幅度提高采收率的潜力,但受储层非均质性和开发动态非均质性影响,科学开发和效益开发难度加大,亟需攻关进一步提高采收率技术... 详细信息

水驱油藏是中国东部老油田开发的主体,经过长期注水开发已整体进入特高含水期,室内研究及矿场实践表明,仍有大幅度提高采收率的潜力,但受储层非均质性和开发动态非均质性影响,科学开发和效益开发难度加大,亟需攻关进一步提高采收率技术。整装油藏针对特高含水后期极端耗水严重、效益稳产及水驱提高采收率难等问题,深化了极端耗水层带理论,创新形成了层系近阻重组开发技术、特高含水油藏矢量开发技术和特高含水后期流场调整开发技术,实现了控耗水、降递减,平均采收率为43.7%;断块油藏针对断层多、断块小的特点及特高含水期剩余油规模小、动用难的问题,深化剩余油富集规律及水动力调控机制认识,创新形成了人工边水驱、立体开发等主导开发技术系列,提高了储量控制和水驱动用程度,平均采收率为29.4%,支撑了断块油藏效益稳产;低渗透油藏针对储层物性差、有效建驱难等问题,持续开展非线性渗流机理和压驱开发机理研究,攻关配套开发技术,不断拓宽开发界限,创新形成特低渗透油藏仿水平井注水、一般低渗透油藏井网适配提高采收率、低渗透-致密油藏压驱注水等差异开发技术系列,平均采收率为15.7%,实现了低渗透油藏提速提效开发。通过以上技术进步,实现了特高含水期水驱油藏的效益开发。结合不同类型油藏开发特点及面临形势,对水驱油藏进一步提高采收率提出了下步发展方向。

关键词：水驱剩余油开发理论开发技术提高采收率发展方向

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Maternal imprinting of the neonatal microbiota colonization in intrauterine growth restricted piglets:a review

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Journal of Animal Science and Biotechnology 2020年第1期11卷 1-8页

作者： Lili Jiang Cuiping Feng shiyu tao Na Li Bin Zuo Dandan Han Junjun Wang State Key Laboratory of Animal Nutrition College of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China Department of Obstetrics and Gynecology China-Japan Friendship HospitalBeijing 100029China.

Early colonization of intestinal microbiota during the neonatal stage plays an important role on the development of intestinal immune system and nutrients absorption of the *** to the normal birth weight(NBW)piglets,intrauterine growth restricted(IUGR)piglets have a different intestinal microbiota during their early life,which is related to maternal imprinting on intestinal microbial succession during gestation,at birth and via *** allocation of limited nutrients among fetuses during gestation could be one of the main causes for impaired intestinal development and microbiota colonization in neonatal IUGR *** this review,we summarized the potential impact of maternal imprinting on the colonization of the intestinal microbiota in IUGR piglets,including maternal undernutrition,imbalanced allocation of nutrients among fetuses,as well as vertical microbial transmission from mother to offspring during gestation and *** the same time,we give information about the current maternal nutritional strategies(mainly breastfeeding,probiotics and prebiotics)to help colonization of the advantageous intestinal microbiota for IUGR piglets.

关键词： IUGR piglet Microbial colonization Maternal imprinting Nutritional intervention

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Comparative proteomic analysis of the effects of high-concentrate diet on the hepatic metabolism and inflammatory response in lactating dairy goats

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Journal of Animal Science and Biotechnology 2016年第2期7卷 217-227页

作者： Yongqian Duanmu Rihua Cong shiyu tao Jing Tian Haibo Dong Yuanshu Zhang Yingdong Ni Ruqian Zhao Key Laboratory of Animal Physiology & Biochemistry Ministry of AgricultureNanjing Agricultural University College of Veterinary Medicine Northwest A & F University

Background： To understand the impact of feeding a high-concentrate diet to mid-lactating goats for a long time on liver metabolism and inflammatory response, two dimensional polyacrylamide gel electrophoresis（2-DE） and real-time PCR method were employed to detect proteins differentially expressed in liver and their m RNAs expression in goats fed high concentrate diet（HC） or low concentrate diet（LC）. Twelve lactating dairy goats were randomly assigned to either a HC diet group（65 % concentrate of dry matter; n = 6） or a LC diet group（35 % concentrate of dry matter; n = 6） for 10 ***： Twenty differentially expressed spots（≥2.0-fold changes） in the hepatic tissues were excised and successfully identified using MALDI TOF/TOF. Of these, 8 proteins were up-regulated, while the rest 12 proteins were down-regulated in HC goats compared to LC. Differential expressed proteins including alpha enolase 1（ENO1）, glutamate dehydrogenase 1（GLUD1）, glutathione S-transferase A1（GSTA1）, ATP synthase subunit 5β（ATP5β）, superoxide dismutase [Cu-Zn]（SOD1）, cytochrom c oxidase subunit Via（COX6A1） and heat shock protein 60（HSP60） were further verified by real-time PCR and/or western blot at m RNA or protein expression level. Consistent with the 2-DE results, a significant decrease of β-actin protein expression and SOD enzyme activity was observed in liver of HC goats（P 〈 0.05）, while ENO1 protein expression was significantly up-regulated in HC compared to LC goats（P 〈 0.05）. However, western blot analysis did not show a significant difference of hepatic HSP60 protein between HC and LC group, which did not match the decrease of HSP60 content detected by 2-DE analysis. Real-time PCR showed that glutathione S-transferase P1（GSTP1） and SOD1 m RNA expression was significantly decreased in liver of HC goats, while cytochrom c oxidase（COX3） and ATPase 8（ATP8） m RNAs expression were markedly increased compared to LC（P 〈 0.05）. Gene Ontology（GO） analysis revealed that HC diet resulted in alt

关键词： High concentrate diet Lactating goats Liver Mitochondria Proteomics

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Effects of chronic dexamethasone administration on hyperglycemia and insulin release in goats

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Journal of Animal Science and Biotechnology 2018年第3期9卷 585-594页

作者： Liqiong Niu Qu Chen Canfeng Hua Yali Geng Liuping Cai shiyu tao Yingdong Ni Ruqian Zhao Key Laboratory of Animal Physiology & Biochemistry Nanjing Agricultural University

Background: Dexamethasone(Dex), a synthetic glucocorticoid, is among the most commonly used drugs worldwide in animals and humans as an anti-inflammatory and immunosuppressive agent. GC has profound effects on plasma glucose level and other metabolic conditions. However, the effect of prolonged use of Dex on glucose metabolism in ruminants is still ***: Ten goats were randomly assigned to two groups: the control goats were injected with saline, and the Dex-treated goats were intramuscularly injected daily for 21 d with 0.2 mg/kg Dex. The results showed that plasma glucose and insulin concentrations were significantly increased after Dex administration(P 0.05). The expression of several key genes, involved in blood glucose regulation, was detected by real-time PCR in the small intestine, skeletal muscle and liver. The expression of glucose transporter type 2(GLUT2), sodium-glucose transporter 1(SGLT1) and sodium-potassium ATPase(Na-K/ATPase) in the small intestine were generally increased by Dex, and GLUT2 m RNA expression was significantly up-regulated(P < 0.05). In liver, the expression of genes involved in gluconeogenesis including glucose-6-phosphatase catalytic subunit(G6 PC), cytosolic form of phosphoenolpyruvate carboxykinase(PCK1) and pyruvate carboxylase(PC), were significantly down-regulated by Dex. However, the protein expression levels of PCK1 & PCK2 were significantly increased by Dex, suggesting a post-transcriptional regulation. In dorsal longissimus, the m RNA expression of genes associated with gluconeogenesis and the insulin signaling pathway were generally upregulated by Dex, but the m RNA expression of two markers of muscle atrophy, namely F-box protein 32(FBXO32/Atrogin1) and muscle RING-finger protein 1(Mu RF1), was not altered by ***

关键词： Blood glucose Dexamethasone Gluconeogenesis Goat Liver

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基于LSTM算法的FY-3B卫星春玉米叶面积指数反演

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吉林大学学报（地球科学版） 2022年第6期52卷 2071-2080页

作者：张霞陶诗语张茂中国科学院空天信息创新研究院北京100101 中国科学院大学北京100049

FY-3B卫星具有观测频次高、成像范围广等特点,可为玉米叶面积指数(leaf area index,LAI)反演研究提供长时序观测数据。LSTM((long short term memory)算法具有在多时相数据中提取时间特征的能力,能解决光谱数据与LAI之间复杂的非线性问... 详细信息

FY-3B卫星具有观测频次高、成像范围广等特点,可为玉米叶面积指数(leaf area index,LAI)反演研究提供长时序观测数据。LSTM((long short term memory)算法具有在多时相数据中提取时间特征的能力,能解决光谱数据与LAI之间复杂的非线性问题。本文基于辽宁省锦州市近地实测春玉米LAI和反射率光谱数据,利用光谱响应函数模拟FY-3B多光谱波段,结合与春玉米LAI相关性较高的28种植被指数,应用LSTM算法建立不同隐藏层的预测模型,并与偏最小二乘法(partial least-squares regression,PLSR)建立的模型进行预测精度对比。结果表明:隐藏层的层数对LSTM模型的拟合效果有较大影响,三层LSTM模型将LAI估算精度的决定系数由0.8183(单层LSTM)、0.7800(PLSR)提升至0.8692;对应地,将均方根误差由0.5091、0.4906降低至0.3726,模型精度提升明显。

关键词：春玉米叶面积指数 FY-3B LSTM

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Negative effects of long-term feeding of high-grain diets to lactating goats on milk fat production and composition by regulating gene expression and DNA methylation in the mammary gland

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Journal of Animal Science and Biotechnology 2018年第1期9卷 217-227页

作者： Ping Tian Yanwen Luo Xian Li Jing Tian shiyu tao Canfeng Hua Yali Geng Yingdong Ni Ruqian Zhao Key Laboratory of Animal Physiology&Biochemistry Nanjing Agricultural University College of Veterinary Medicine Northwest A and F University

Background： It is well known that feeding a high concentrate（HC） diet to lactating ruminants likely induces subacute ruminal acidosis（SARA） and leads to a decrease in milk fat production. However, the effects of feeding a HC diet for long periods on milk fatty acids composition and the mechanism behind the decline of milk fat still remains poorly understood. The aim of this study was to investigate the impact of feeding a HC diet to lactating dairy goats on milk fat yield and fatty acids composition with an emphasis on the mechanisms underlying the milk fat depression. Seventeen mid-lactating dairy goats were randomly allocated to three groups. The control treatment was fed a low-concentrate diet（35% concentrate, n = 5, LC） and there were two high-concentrate treatments（65% concentrate, HC）, one fed a high concentrate diet for a long period（19 wks, n = 7, HL）; one fed a high concentrate diet for a short period of time（4 wk, n = 5, HS）. Milk fat production and fatty acids profiles were measured. In order to investigate the mechanisms underlying the changes in milk fat production and composition,the gene expression involved in lipid metabolism and DNA methylation in the mammary gland were also ***： Milk production was increased by feeding the HC diet in the HS and HL groups compared with the LC diet（P 〈 0.01）, while the percentage of milk fat was lower in the HL（P 〈 0.05） but not in the HS group. The total amount of saturated fatty acids（SFA） in the milk was not changed by feeding the HC diet, whereas the levels of unsaturated fatty acids（UFA） and monounsaturated fatty acids（MUFA） were markedly decreased in the HL group compared with the LC group（P 〈 0.05）. Among these fatty acids, the concentrations of C15：0（P 〈 0.01）, C17：0（P 〈 0.01）, C17：1（P 〈 0.01）, C18：1 n-9 c（P 〈 0.05）, C18：3 n-3 r（P 〈 0.01） and C20：0（P 〈 0.01） were markedly lower in the HL group, and the concentrations of C20：0（P 〈 0.05） and C18：3 n-3 r（P 〈 0.01） were lower in the HS group compared

关键词： DNA methylation Gene expression Goat High concentrate diet Milk fat

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Early life administration of milk fat globule membrane promoted SCFA-producing bacteria colonization,intestinal barriers and growth performance of neonatal piglets

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Animal Nutrition 2021年第2期7卷 346-355页

作者： Yujun Wu Xiangyu Zhang Dandan Han Yu Pi shiyu tao Shiyi Zhang Shilan Wang Junying Zhao Lijun Chen Junjun Wang State Key Laboratory of Animal Nutrition College of Animal Science and TechnologyChina Agricultural UniversityBeijing100193China National Engineering Center of Dairy for Early Life Health Beijing Sanyuan Foods Co.LtdBeijing100163China

Milk fat globule membrane(MFGM)possesses various nutritional and biological benefits for mammals,whereas its effects on neonatal gut microbiota and barrier integrity remained *** study investigated the effects of MFGM administration on microbial compositions and intestinal barrier functions of neonatal *** newborn piglets were randomly allocated into a CON group or MFGM group,orally administered with saline or MFGM solution(1 g/kg body weight)respectively during the first postnatal week,and all piglets were breastfed during the whole neonatal *** present study found that the MFGM oral administration during the first postnatal week increased the plasma immunoglobulin(lg)G level,body weight and average daily gain of piglets(P<0.05)on 21 ***-tionally,MFGM administration enriched fecal SCFA-producing bacteria(Ruminococaceae_UCG-002,Ruminococaceae_UCG-010,Ruminococaceae_UCG-004,Ruminococaceae_UCG-014 and[Ruminococcus]_gauvrearuii_group),SCFA concentrations(acetate,propionate and butyrate;P<0.05)and their receptor(G-protein coupled receptor 41,GPR41).Furthermore,MFGM administration promoted intestinal villus morphology(P<0.05)and barrier functions by upregulating genes of tight junctions(E-cadherin,claudin-1,occludin and zonula occludin 1[ZO-1]),mucins(mucin-13 and mucin-20)and interleukin(IL)-22(P<0.05).Positive correlation was found between the beneficial microbes and SCFA levels pairwise with the intestinal barrier genes(P<0.05).In conclusion,orally administrating MFGM during the first postnatal week stimulated SCFA-producing bacteria colonization and SCFA generation,enhanced intes-tinal barrier functions and consequently improved growth performance of neonatal piglets on 21 *** findings will provide new insights about MFGM intervention for microbial colonization and intestinal development of neonates during their early life.

关键词： Milk fat globule membrane Gut microbiota SCFA Intestinal barrier Piglet

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Evaluation of the Mechanisms Underlying Amino Acid and Microbiota Interactions in Intestinal Infections Using Germ-Free Animals

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Infectious Microbes & Diseases 2021年第2期3卷 79-86页

作者： Yapeng Yang Peng Bin shiyu tao Guoqiang Zhu Zhifeng Wu Wei Cheng Wenkai Ren Hong Wei State Key Laboratory of Agricultural Microbiology College of Animal Sciences and TechnologyHuazhong Agricultural UniversityWuhanHubeiChina Jiangsu Co-Innovation Center for Important Animal Infectious Diseases and Zoonoses Joint International Research Laboratory of Agriculture and AgriProduct Safety of Ministry of Education of ChinaCollege of Veterinary MedicineYangzhou UniversityYangzhouJiangsuChina State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources Guangdong Laboratory of Lingnan Modern AgricultureNational Engineering Research Center for Breeding Swine IndustryGuangdong Provincial Key Laboratory of Animal Nutrition ControlCollege of Animal ScienceSouth China Agricultural UniversityGuangzhouGuangdongChina

Intestinal infectious diseases refer to the inflammatory changes in the intestinal tract caused by pathogens(including bacteria,viruses,fungi,protozoa,or parasites)or their toxic products.A large number of microorganisms colonize the intestinal tract of healthy people,which together with the intestinal epithelium constitute the biological barrier of the intestinal tract to resist infectious *** an“invisible organ,”the intestinal flora is closely related to human nutrition metabolism and intestinal infections.A variety of intestinal flora participates in the nutritional metabolism of amino acids,and the small molecular substances produced by the amino acid metabolism through the intestinal flora can enhance intestinal immunity and resist bacterial *** turn,amino acids can also regulate the composition of the intestinal flora,maintain the steady-state of the intestinal flora,protect the intestinal barrier,and inhibit colonization by pathogenic *** a model animal with a clear microbial background,germ-free(GF)animals can clarify the mechanisms of interactions between intestinal microbes and amino acid metabolism in intestinal infections by combining genetic engineering technology and multi-omics *** article reviews related researches on the involvement of intestinal microbes in host amino acid metabolism and resistance to intestinal infections and discusses the advantages of GF animal models for studying the underlying *** GF animal model is helpful to further study the intervention effects of amino acid metabolism of targeted intestinal flora on intestinal infections.

关键词： germ-free animal intestinal barrier intestinal flora intestinal immunity intestinal infection metabolism of amino acids

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