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Alpl prevents bone ageing sensitivity by specifically regulating senescence and differentiation in mesenchymal stem cells

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Bone Research 2018年第4期6卷 393-407页

作者： Wenjia Liu Liqiang Zhang Kun Xuan Chenghu Hu shiyu Liu Li Liao Bei Li fang Jin Songtao Shi Yan Jin MS-State Key Laboratory & National Clinical Research Center for Oral Diseases & Shaanxi International Joint Research Center for Oral Diseases Center for Tissue EngineeringSchool of StomatologyFourth Military Medical UniversityXi’anChina Xi’an Institute of Tissue Engineering and Regenerative Medicine Xi’anChina Department of Anatomy and Cell Biology School of Dental MedicineUniversity of PennsylvaniaPhiladelphiaPAUSA

Mutations in the liver/bone/kidney alkaline phosphatase(Alpl) gene cause hypophosphatasia(HPP) and early-onset bone dysplasia,suggesting that this gene is a key factor in human bone development. However, how and where Alpl acts in bone ageing is largely unknown. Here, we determined that ablation of Alpl induces prototypical premature bone ageing characteristics, including bone mass loss and marrow fat gain coupled with elevated expression of p16INK4A(p16) and p53 due to senescence and impaired differentiation in mesenchymal stem cells(MSCs). Mechanistically, Alpl deficiency in MSCs enhances ATP release and reduces ATP hydrolysis. Then, the excessive extracellular ATP is, in turn, internalized by MSCs and causes an elevation in the intracellular ATP level, which consequently inactivates the AMPKα pathway and contributes to the cell fate switch of MSCs. Reactivating AMPKα by metformin treatment successfully prevents premature bone ageing in Alpl+/-mice by improving the function of endogenous *** results identify a previously unknown role of Alpl in the regulation of ATP-mediated AMPKα alterations that maintain MSC stemness and prevent bone ageing and show that metformin offers a potential therapeutic option.

关键词： Alpl prevents bone ageing sensitivity by specifically regulating senescence and differentiation in mesenchymal stem cells ATP

补气类中药多糖对动物结肠癌细胞作用的研究进展

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中国民族民间医药 2024年第1期33卷 67-72页

作者：钱一雯薛珺瑜钱诗雨胡业鸿方志军南京中医药大学附属中西医结合医院江苏南京210028 江苏省中医药研究院江苏南京210028

结肠癌是我国高发的消化道恶性肿瘤之一,严重危害人类健康。迄今为止,结肠癌的治疗手段仍然是以西医治疗为主,疗效有限且具有毒副作用的风险。因此,研发新药物对结肠癌的治疗具有深远意义。近年来,国内外的相关研究已经证实,中草药中多... 详细信息

结肠癌是我国高发的消化道恶性肿瘤之一,严重危害人类健康。迄今为止,结肠癌的治疗手段仍然是以西医治疗为主,疗效有限且具有毒副作用的风险。因此,研发新药物对结肠癌的治疗具有深远意义。近年来,国内外的相关研究已经证实,中草药中多糖提取物的抗肿瘤功效显著,具有多途径、多靶点的特点。而补气类中药具有“扶正”与“祛邪”两大功效,既可以扶助正气,提升机体免疫力,又可以发挥抗肿瘤、抗病毒、抗炎等作用,与结肠癌的中医核心治法十分契合,在未来有较大的应用潜力。文章对国内外近15年文献中报道且在《中国药典(2020年版)》中记载的补气类中草药的多糖成分对结肠癌的干预作用进行总结,旨在为结肠癌的中医药治疗提供理论支持,为今后多糖类药物的研发提供参考依据。

关键词：中药多糖结肠癌抗肿瘤补气

腹膜前间隙补片修补对切口疝大鼠碱性成纤维生长因子(bFGF)的影响

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中华疝和腹壁外科杂志（电子版） 2024年第1期18卷 70-74页

作者：贵诗雨方向黄丹朱佳琳周小雨郭文恺德阳市人民医院疝外科四川省618099

目的观察大鼠切口疝腹膜前间隙补片修补术后不同时间腹膜及周围组织中碱性成纤维生长因子(bFGF)的变化趋势,分析植入补片对术后修复作用的影响。方法选用48只SD大鼠,随机分为正常组(n=8)、切口疝模型组(n=8)、有疝补片修补术后1、4、8... 详细信息

目的观察大鼠切口疝腹膜前间隙补片修补术后不同时间腹膜及周围组织中碱性成纤维生长因子(bFGF)的变化趋势,分析植入补片对术后修复作用的影响。方法选用48只SD大鼠,随机分为正常组(n=8)、切口疝模型组(n=8)、有疝补片修补术后1、4、8、12周组(n=8)。将聚丙烯补片植入有疝补片修补组大鼠的腹膜前间隙。正常组取正常腹膜及周围组织,切口疝模型组及有疝补片修补组取切口旁腹膜及周围组织进行RT-PCR检测,获得各组大鼠腹膜及周围组织中bFGF mRNA基因相对表达量并进行比较。结果与正常组比较,切口疝模型组、有疝补片修补术后1周组腹膜及周围组织中bFGF mRNA表达明显升高(P0.05)。有疝补片修补术后1、4周组与切口疝模型组比较,差异无统计学意义(P>0.05),术后8、12周组腹膜及周围组织中bFGF mRNA表达较切口疝模型组显著降低(P0.05)。结论在行切口疝腹膜前间隙补片修补术时,手术创伤可能是刺激腹膜及其周围组织产生bFGF的主要因素,此反应在术后1周最明显。聚丙烯补片理论上可以作为bFGF的载体,让其缓慢释放,但本研究并未提示有明显的作用,这可能需要后续进一步研究确认。

关键词：切口疝腹膜前间隙补片疝修补术碱性成纤维生长因子

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鲜药在肿瘤临床治疗中的应用

中医临床研究 2024年第12期16卷 110-113页

作者：钱诗雨钱一雯薛珺瑜胡业鸿方志军南京中医药大学附属中西医结合医院江苏南京210028 南京中医药大学江苏南京210023

鲜药,或称新鲜中药、原生药材,即采摘后即行使用、未经加工的药材,是传统中医药的重要组成部分,是中医治疗用药的特色之一,在我国历史悠久、应用广泛。相关文字记载最早可追溯至战国时期的《五十二病方》,其中已出现鲜山药治疗牝痔的记... 详细信息

鲜药,或称新鲜中药、原生药材,即采摘后即行使用、未经加工的药材,是传统中医药的重要组成部分,是中医治疗用药的特色之一,在我国历史悠久、应用广泛。相关文字记载最早可追溯至战国时期的《五十二病方》,其中已出现鲜山药治疗牝痔的记录。不同时代的医家也常常应用鲜药临证治疗,获得了良好的疗效。其中最为人熟知的,便是晋代医家葛洪《肘后备急方》中记载的鲜品青蒿冷浸绞汁的服用方法,为现代青蒿素的冷萃取治疗疟疾提供了依据。鲜品中药在药性、药味、归经、化学成分及药理作用上区别于干品中药及炮制品,在临床杂病、外感、温病、热病、急危重症等病证的救治方面效果显著,其中在治疗肿瘤方面有独特之处,特别是抗肿瘤、增强免疫、减少放化疗带来的不良反应等功效较干品中药更佳。临床常见的抗肿瘤鲜药单药有鲜龙葵、鲜人参、鲜金钱白花蛇、鲜芦荟等,而金龙胶囊、龙葵合剂、金水鲜胶囊等鲜药制剂在抗肿瘤方面也有显著的疗效。文章整理归纳近几年鲜药在临床抗肿瘤方面相关的文献,整合其抗肿瘤的临床疗效,分析相关鲜药和鲜药制剂的功用、主治以及现代药理,以推动鲜药在临床抗肿瘤方面的进一步运用以及推广,为临床使用鲜药进行抗肿瘤治疗提供参考。

关键词：鲜药中药鲜用抗肿瘤临床应用

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基于藏象理论探讨恶性肿瘤化疗后骨髓抑制

光明中医 2024年第4期39卷 790-793页

作者：薛珺瑜钱一雯钱诗雨胡业鸿方志军南京中医药大学第三临床医学院江苏南京210028 南京中医药大学附属中西医结合医院肿瘤科江苏南京210028

化疗后骨髓抑制是指临床表现为恶性肿瘤化疗后以白细胞为主的全血细胞数量减少的疾病,是肿瘤患者化疗后最常见的毒副反应,严重干扰患者化疗进程,甚至影响患者生命。中医药在治疗化疗后骨髓抑制方面不断深入,该病主要与脾肾密切相关,五... 详细信息

化疗后骨髓抑制是指临床表现为恶性肿瘤化疗后以白细胞为主的全血细胞数量减少的疾病,是肿瘤患者化疗后最常见的毒副反应,严重干扰患者化疗进程,甚至影响患者生命。中医药在治疗化疗后骨髓抑制方面不断深入,该病主要与脾肾密切相关,五脏六腑对化疗后骨髓抑制的影响受到越来越多的学者重视。此文基于藏象理论探讨五脏与化疗后骨髓抑制的关联,探析藏象理论指导下各脏腑同治在该病中的运用。

关键词：骨髓抑制藏象理论化疗中医药疗法脏腑同治

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贯叶金丝桃化学成分的分离与鉴定

沈阳药科大学学报 2024年第5期41卷 551-556页

作者：胡诗雨张梦雪方容杨金花雷亮宋红萍毕晓宾湖北中医药大学药学院湖北武汉430061 武汉市第四医院湖北武汉430033 华中科技大学药学院湖北武汉430030

目的研究藤黄科(Guttiferae)金丝桃属(Hypericum)贯叶金丝桃(Hypericum perforatum L.)的化学成分。方法采用正相硅胶色谱、反相ODS色谱、凝胶色谱及高效液相色谱等多种色谱方法对贯叶金丝桃体积分数95%乙醇提取物进行分离纯化。利用紫... 详细信息

目的研究藤黄科(Guttiferae)金丝桃属(Hypericum)贯叶金丝桃(Hypericum perforatum L.)的化学成分。方法采用正相硅胶色谱、反相ODS色谱、凝胶色谱及高效液相色谱等多种色谱方法对贯叶金丝桃体积分数95%乙醇提取物进行分离纯化。利用紫外、红外、核磁共振光谱,高分辨质谱及X-ray单晶衍射法对化合物的结构进行鉴定。结果从贯叶金丝桃中分离鉴定8个化合物,分别为perforxanthone A(1)、8-hydroxy-1,2,3-trimethoxyxanthone(2)、绵马酚D(3)、(S)-5-hydroxy-3,4-dimethyl-5-pentylfuran-2(5H)-one(4)、ent-4(15)-eudesmene-1β,6α-diol(5)、methyl-(E)-8-oxooctadec-9-enoate(6)、模绕酮酸(7)、白桦脂酸(8)。结论化合物1为新的氧杂蒽酮类化合物,化合物2-7为首次从该植物中分离得到。

关键词：贯叶金丝桃提取分离结构鉴定

Incorporating element doping and quantum dot embedding effects to enhance the thermoelectric properties of higher manganese silicides

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Journal of Materiomics 2021年第2期7卷 377-387页

作者： Qing Wang shiyu Song Xiaofeng Yang Ziyang Liu Yufei Ma Xingyuan San Jianglong Wang Dan Zhang Shu-fang Wang Zhiliang Li Key Laboratory of High-precision Computation and Application of Quantum Field Theory of Hebei Province College of Physics Science and TechnologyHebei UniversityBaoding071002China Institute of Life Science and Green Development Hebei UniversityBaoding071002China

Element doping and nano-inclusion embedding are effective approaches to enhance the electrical conductivities and decrease the lattice thermal conductivities of thermoelectric(TE)materials,***,the intrinsic low electrical thermal conductivities and high electrical properties are severely sacrificed,and the final figure of merit(ZT)is usually *** this study,Ag doping and Pt quantum dot(QD)embedding were synchronously achieved via embedding Ag/Pt alloy QDs into the higher manganese silicides to avoid the conventional single-element doping *** power factor(at 823 K)was enhanced from 1.57×10^(-3) W m^(-1) K^(-2) to 1.82×10^(-3) W m^(-1) K^(-2)(-16%)due to the-18%increase in carrier concentration that was derived from the Ag doping ***,the lattice thermal conductivity(at 823 K)decreased from 2.65 W m^(-1) K^(-1) e1.92 W m^(-1) K^(-1)(-28%)because of the broadband phonon scattering effect that resulted from the residual Pt QDs ***,the optimal ZT value increased by-52%from 0.42 to 0.64 at 823 *** study demonstrated that incorporating metastable alloy QDs to obtain element doping and nano-inclusion embedding effects is a novel and feasible means to enhance the ZT value of *** method is also possibly applicable to other alloy QD/TE composites.

关键词： Quantum dot Inclusion Higher manganese silicide Thermoelectric material Figure of merit

Wrinkling modes of graphene oxide assembled on curved surfaces

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Nano Research 2023年第2期16卷 1801-1809页

作者： Kaiwen Li Zhanpo Han Lidan Wang Jiaqing Wang Chuanwei Zhang Jiahao Lin shiyu Luo Li Peng Wenzhang fang Yingjun Liu Ziliang Wu Yeqiang Tan Chao Gao Zhen Xu MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringKey Laboratory of Adsorption and Separation Materials&Technologies of Zhejiang ProvinceZhejiang UniversityHangzhou 310027China State Key Laboratory of Bio-Fibers and Eco-Textiles Collaborative Innovation Center of Marine Biobased Fiber and Ecological Textile TechnologySchool of Materials Science and EngineeringQingdao UniversityQingdao 266071China MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering Taiyuan 030000China

Assembling two-dimensional(2D)sheets into macroscopic three-dimensional(3D)forms has created a promising material family with rich *** wrinkles are intrinsic features of 2D sheets in their 3D ***,the precise wrinkling modulation optimizes the transition of outstanding properties of 2D sheets to expected performances of assembled materials and dominates their fabrication *** wrinkling evolution of 2D sheets assembling onto flat surfaces has been extensively understood,however,the wrinkling behaviors on the more generally curved surface still remain ***,we investigate the wrinkling behaviors of graphene oxide sheets assembled onto curved surfaces and reveal the selection rule of wrinkling modes that determined by the curvature mismatch between 2D sheets and target *** uncover that three wrinkling modes including isotropic cracked land,labyrinth,and anisotropic curtain phases,respectively emerge on flat,spherical,and cylindrical surfaces.A favorable description paradigm is offered to quantitatively measure the complex wrinkling patterns and assess the curvature mismatch constraint underlying the wrinkling mode *** research provides a general and quantitative description framework of wrinkling modulation of 2D materials such as high performance graphene fibers,and guides the precise fabrication of particles and functional coatings.

关键词： two-dimensional(2D)sheets three-dimensional(3D)assembles curved surfaces wrinkling modes selection curvature mismatch constraint wrinkling modulation

ERRATUM TO:Cholesterol homeostasis regulated by ABCA1 is critical for retinal ganglion cell survival

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Science China(Life Sciences) 2024年第7期67卷 1548-1548页

作者： Jialiang Yang Yuhong Chen Tongdan Zou Bai Xue fang Yang Xiangzhou Wang Yibo Huo Boyun Yan Yuxia Xu shiyu He Yi Yin Jing Wang Xiong Zhu Lin Zhang Yu Zhou Zhengfu Tai Ping Shuai Man Yu Qian Luo Yilian Cheng Bo Gong Xianjun Zhu Jing Zhang Xinghuai Sun Ying Lin Houbin Zhang Zhenglin Yang Key Laboratory for Human Disease Gene Study of Sichuan Province and Institute of Laboratory Medicine Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072China Department of Ophthalmology and Visual Science Eye and Ear Nose Throat(ENT)HospitalFudan UniversityShanghai 200032China School of Optoelectronic Science and Engineering University of Electronic Science and Technology of ChinaChengdu 611731China Institute of Chengdu Biology Sichuan Translational Medicine HospitalChinese Academy of SciencesChengdu 610093China Department of Ophthalmology Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072China Research Unit for Blindness Prevention of Chinese Academy of Medical Sciences Sichuan Academy of Medical Sciences&Sichuan Provincial People’s HospitalChengdu 610072China

Erratum to:SCIENCE CHINA Life Sciences,Volume 66,Issue 2:211-225(2022),https://***/10.1007/s11427-021-2126-2 This paper contains an error in Figure 4C,where the representative images of filipin staining of retinal sections from 6-month-old mice were *** provide the correct picture for Figure 4C as *** statistical result in Figure 4D was corrected as *** new Figure 4 does not affect the conclusion of this article.

关键词： Figure critical conclusion