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Surveillance and Analysis of SARS-CoV-2 Variant Importation—China,January–June 2022

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China CDC weekly 2022年第50期4卷 1136-1142页

作者： Yenan Feng Xiang Zhao Zeyuan Yin Changcheng Wu Zhixiao Chen Kai Nie Ruhan A Lili Li Peihua Niu Ji wang Yuchao Wu shiwen wang Dayan wang Wenjie Tan Huanyu wang Xuejun Ma George FGao Cao Chen Wenbo Xu National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina National Health Commission Key Laboratory for Medical Virology and Viral Diseases BeijingChina.

Introduction:The severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)Omicron variant is the dominant circulating strain *** assess the importation of SARS-CoV-2 variants in the mainland of China during the Omicron epidemic,the genomic surveillance data of SARS-CoV-2 from imported coronavirus disease 2019(COVID-19)cases in the mainland of China during the first half of 2022 were ***:Sequences submitted from January to July 2022,with a collection date before June 30,2022,were *** proportions of SARS-CoV-2 variants as well as the relationships between the origin and destination of each Omicron imported case were ***:4,946 sequences of imported cases were submitted from 27 provincial-level administrative divisions(PLADs),and the median submission interval was within 1 month after *** 3,851 Omicron sequences with good quality,1 recombinant(XU)and 4 subvariants under monitoring(BA.4,BA.5,BA.2.12.1,and BA.2.13)were recorded,and 3 of them(BA.4,BA.5,and BA.2.12.1)caused local transmissions in the mainland of China later than that recorded in the *** subvariants dominated in the first half of 2022 and shifted from BA.1 to BA.2 then to BA.4 and *** percentage of BA.2 in the imported SARS-CoV-2 surveillance data was far higher than that in the Global Initiative on Sharing All Influenza Data(GISAID).The imported cases from Hong Kong Special Administrative Region,China,accounted for 32.30%of Omicron cases sampled,and 98.71%of them were ***:The Omicron variant showed the intra-Omicron evolution in the first half of 2022,and all of the Omicron subvariants were introduced into the mainland of China multiple times from multiple different locations.

关键词： mainland imported submitted

Anti-inflammatory and profibrinolytic effect of tetramethylpyrazine in acute coronary syndromes

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Journal of Geriatric Cardiology 2005年第4期2卷 233-235页

作者： Haiyun WU Chengyun WEI Qiang XU shiwen wang Institute of Geriatric Cardiology General Hospital of Chinese PLA Beijing Hospital of Intergrated Traditional and Western Medicine attached to Beijing University of TCM Beijing Institute of Geriatric Cardiology General Hospital of Chinese PLA Beijing Institute of Geriatric Cardiology General Hospital of Chinese PLA Beijing

Background and Objectives Tetramethylpyrazine (TMP) is a herb used widely in Traditional Chinese Medicine (TCM) as an antianginal drug. The exact mechanism whereby TMP treat ischemic heart disease is still not fully understood. The purpose of this study is to examine the anti-inflammatory effect of TMP in patients with acute coronary syndromes (ACS). Methods Thirty-two patients with acute myocardial infarction or unstable angina were randomly assigned to TMP group or control group. All patients received the same standard treatment. Patients in TMP group received TMP 3mg/kg every 12 hours for 5 days. Plasma concentrations of high-sensitivity C-reactive protein (CRP), serum amyloid A (SAA) and plasminogen activator inhibitor-1 (PAI-1) were measured at baseline and after 5 days of therapy. Results Both CRP and SAA concentrations increased significantly in control group (P<0.05) whilst in TMP group, only SAA had a significant increase (P<0.05); the absolute increase of CRP, SAA, and PAI-1 were significantly less in TMP group than in control group (P<0.05). Conclusion TMP has an anti-inflammatory and profibrinolytic effect in patients with ACS. These effects may contribute to the clinical benefits of TMP in ischemic heart disease.

关键词： acute coronary syndromes inflammation tetramethylpyrazine

A Tightly Coupled Dipole Array with Diverse Element Reflection Phases for RCS Reduction

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Chinese Journal of Electronics 2024年第2期33卷 449-455页

作者： Yuewen GOU Yikai CHEN shiwen YANG University of Electronic Science and Technology of China

This paper proposes a novel low scattering tightly coupled dipole array(TCDA), aiming to reduce the radar cross section(RCS) of phased antenna arrays under a certain oblique incident wave. First, we build three types of antenna elements that exhibit similar radiation characteristics but diverse reflection phase differences based on the proposed theoretical analysis. The required reflection phase difference is achieved by using different dielectric superstrates for each antenna element. Then, by arranging the three types of subarrays next to each other, a low scattering TCDA(8 × 9) is designed. Meanwhile, a reference antenna array with a single type of antenna element is also constructed. To demonstrate the effectiveness of the proposed RCS reduction technique, simulated and measured results of the reference and proposed antenna array are compared. Both antenna arrays operate over the 6–18 GHz frequency band and can scan up to ±45° in the E-/H-planes. However, the proposed antenna array achieves a significant monostatic RCS reduction over 8–12 GHz, with a maximum reduction value of 7.55 d B. It indicates that this diverse element reflection phase technique is a good candidate for wideband RCS reduction.

关键词： Antenna measurements Phased arrays Dipole antennas Antenna theory Scattering Reflector antennas Reflection

Fine-Grained Ship Recognition Based on Visible and Near-Infrared Multimodal Remote Sensing Images: Dataset,Methodology and Evaluation

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Computers, Materials & Continua 2024年第6期79卷 5243-5271页

作者： shiwen Song Rui Zhang Min Hu Feiyao Huang Department of Aerospace Science and Technology Space Engineering UniversityBeijing101416China

Fine-grained recognition of ships based on remote sensing images is crucial to safeguarding maritime rights and interests and maintaining national ***,with the emergence of massive high-resolution multi-modality images,the use of multi-modality images for fine-grained recognition has become a promising ***-grained recognition of multi-modality images imposes higher requirements on the dataset *** key to the problem is how to extract and fuse the complementary features of multi-modality images to obtain more discriminative fusion *** attention mechanism helps the model to pinpoint the key information in the image,resulting in a significant improvement in the model’s *** this paper,a dataset for fine-grained recognition of ships based on visible and near-infrared multi-modality remote sensing images has been proposed first,named Dataset for Multimodal Fine-grained Recognition of Ships(DMFGRS).It includes 1,635 pairs of visible and near-infrared remote sensing images divided into 20 categories,collated from digital orthophotos model provided by commercial remote sensing *** provides two types of annotation format files,as well as segmentation mask images corresponding to the ship ***,a Multimodal Information Cross-Enhancement Network(MICE-Net)fusing features of visible and near-infrared remote sensing images,has been *** the network,a dual-branch feature extraction and fusion module has been designed to obtain more expressive *** Feature Cross Enhancement Module(FCEM)achieves the fusion enhancement of the two modal features by making the channel attention and spatial attention work cross-functionally on the feature map.A benchmark is established by evaluating state-of-the-art object recognition algorithms on ***-Net conducted experiments on DMFGRS,and the precision,recall,mAP0.5 and mAP0.5:0.95 reached 87%,77.1%,83.8%and 63.9%,*** experiments demons

关键词： Multi-modality dataset ship recognition fine-grained recognition attention mechanism

Overexpressed NEDD8 as a potential therapeutic target in esophageal squamous cell carcinoma

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Cancer Biology & Medicine 2022年第4期19卷 504-517页

作者： Jingrong Xian shiwen wang Yanyu Jiang Lihui Li Lili Cai Ping Chen Yue Liu Xiaofei Zeng Guoan Chen Chen Ding Robert MHoffman Lijun Jia Hu Zhao Yanmei Zhang Department of Laboratory Medicine Huadong Hospital Affiliated to Fudan UniversityShanghai 200040China Cancer Institute Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Research Center on Aging and Medicine Fudan UniversityShanghai 200040China Shanghai Key Laboratory of Clinical Geriatric Medicine Shanghai 200040China Department of Basic Science of Oncology College of Basic Medical SciencesZhengzhou UniversityCollaborative Innovation Center of Henan Province for Cancer ChemopreventionZhengzhou 450001China School of Medicine Southern University of Science and TechnologyShenzhen 518055China State Key Laboratory of Genetic Engineering Human Phenome InstituteInstitutes of Biomedical SciencesSchool of Life SciencesZhongshan HospitalFudan UniversityShanghai 200032China State Key Laboratory of Cell Differentiation and Regulation Henan International Joint Laboratory of Pulmonary FibrosisHenan Center for Outstanding Overseas Scientists of Pulmonary FibrosisCollege of Life ScienceInstitute of Biomedical ScienceHenan Normal UniversityXinxiang 453007China Department of Surgery University of CaliforniaSan Diego 92101USA Anticancer Inc. San Diego 92101USA

Objective:The hyperactivated neddylation pathway plays an important role in tumorigenesis and is emerging as a promising anticancer *** aimed to study whether NEDD8(neural precursor cell expressed,developmentally down-regulated 8)might serve as a therapeutic target in esophageal squamous cell carcinoma(ESCC).Methods:The clinical relevance of NEDD8 expression was evaluated by using The Cancer Genome Atlas(TCGA)database and tissue ***8-knockdown ESCC cells generated with the CRISPR/Cas9 system were used to explore the anticancer effects and *** proteomic analysis was used to examine the variations in NEDD8 knockdown-induced biological *** cell cycle and apoptosis were assessed with fluorescence activated cell sorting.A subcutaneous-transplantation mouse tumor model was established to investigate the anticancer potential of NEDD8 silencing in ***:NEDD8 was upregulated at both the mRNA and protein expression levels in ESCC,and NEDD8 overexpression was associated with poorer overall patient survival(mRNA level:P=0.028,protein level:P=0.026,log-rank test).Downregulation of NEDD8 significantly suppressed tumor growth both in vitro and in *** proteomic analysis revealed that downregulation of NEDD8 induced cell cycle arrest,DNA damage,and apoptosis in ESCC *** studies demonstrated that NEDD8 knockdown led to the accumulation of cullin-RING E3 ubiquitin ligases(CRLs)substrates through inactivation of CRLs,thus suppressing the malignant phenotype by inducing cell cycle arrest and apoptosis in *** experiments demonstrated that the induction of apoptosis after NEDD8 silencing was attenuated by DR5 ***:Our study elucidated the anti-ESCC effects and underlying mechanisms of NEDD8 knockdown,and validated NEDD8 as a potential target for ESCC therapy.

关键词： NEDD8 esophageal squamous cell carcinoma cullin-RING E3 ubiquitin ligases apoptosis anticancer target

The Frontiers and Hot Spots of Information Behavior Research at Domestic and Foreign: 2010-2019

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The Frontiers and Hot Spots of Information Behavior Research...

作者： shiwen wang Zhimin Wu College of Management Tianjin Normal University

Based on the bibliometric and visualization methods, this paper related to information behavior research analyzes 2093 journal papers included in CNKI and WOS in the field of information behavior research, from 2010 to *** hot domains, research fronts and the knowledge base are investigated respectively by means of knowledge mapping generated by visualization software. Conclusions at home and abroad for the past ten years are as flows. Firstly, investigations reveal that user demand, technology, network, retrieval, and medical health information have been the five research hot domains in IBR. Secondly, investigations reveal that medicine, informatics, virtual community of network, semantic information retrieval have been research fronts in IBR. Thirdly, the knowledge base collection of information behavior for the past ten years includes high yield author and representative works which have a significant impact.

关键词： Information behavior Comparative Study Research Fronts Hot domains Knowledge map

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老年非心脏手术患者的心脏保障

中华老年医学杂志 1999年第4期18卷 201-203页

作者：王士雯解放军总医院老年心血管病研究所老年心血管病急救中心

据统计，美国每年有２５００万患者行非心脏手术，其中超过６５岁并诊断为冠心病和其他疾病者近８００万人，约占围手术期心脏患病率和病死率的８０．０％〔１〕。我院１９９６年统计３０００余例老年非心脏手术患者，其中并存各种类型... 详细信息

据统计，美国每年有２５００万患者行非心脏手术，其中超过６５岁并诊断为冠心病和其他疾病者近８００万人，约占围手术期心脏患病率和病死率的８０．０％〔１〕。我院１９９６年统计３０００余例老年非心脏手术患者，其中并存各种类型冠心病者约占７６．６％，相当部分的...

关键词：老年人非心脏手术患者心脏保障

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霍山石斛种植技术及其比较分析

现代农业科技 2024年第14期 209-212,220页

作者：王诗文黄跃华尚亮亮纵瑞叶杨燕杰戴亚峰九仙尊霍山石斛股份有限公司安徽六安237012

霍山石斛目前成熟的种植技术有大棚种植、贴树种植、林下碎石仿原生态种植以及林下山谷原石拟境种植,其种植所用的种苗均来自植物组培苗,植物组培苗生产成本高,且在培育过程都存在变异倾向。本文对大棚种植、贴树种植、林下碎石仿原生... 详细信息

霍山石斛目前成熟的种植技术有大棚种植、贴树种植、林下碎石仿原生态种植以及林下山谷原石拟境种植,其种植所用的种苗均来自植物组培苗,植物组培苗生产成本高,且在培育过程都存在变异倾向。本文对大棚种植、贴树种植、林下碎石仿原生态种植以及林下山谷原石拟境种植这4种种植技术进行了总结,并从投资成本、收获产量、品质等方面对4种种植技术进行比较,提出了利用共生菌让种子在野外环境下自然萌发的新技术,以期为霍山石斛的高效种植提供参考。

关键词：霍山石斛种植技术现状新技术

Antibody Cocktail Exhibits Broad Neutralization Activity Against SARS-CoV-2 and SARS-CoV-2 Variants

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Virologica Sinica 2021年第5期36卷 934-947页

作者： Yuanyuan Qu Xueyan Zhang Meiyu wang Lina Sun Yongzhong Jiang Cheng Li Wei Wu Zhen Chen Qiangling Yin Xiaolin Jiang Yang Liu Chuan Li Jiandong Li Tianlei Ying Dexin Li Faxian Zhan Youchun wang Wuxiang Guan shiwen wang Mifang Liang State Key Laboratory for Molecular Virology and Genetic Engineering National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China Center for Emerging Infectious Diseases Wuhan Institute of VirologyChinese Academy of SciencesWuhan 430071HubeiChina Division of HIV/AIDS and Sex-Transmitted Virus Vaccines Institute for Biological Product ControlNational Institutes for Food and Drug Control(NIFDC)Beijing 102629China Hubei Provincial Center for Disease Control and Prevention Wuhan 430065China Key Laboratory of Medical Molecular Virology(MOE/NHC/CAMS) School of Basic Medical SciencesFudan UniversityShanghai 200032China Shandong Center for Disease Control and Prevention Jinan 250014China University of Chinese Academy of Sciences Beijing 100049China Peking Union Medical College Beijing 100730China

Severe acute respiratory syndrome coronavirus 2(SARS-Co V-2)has precipitated multiple variants resistant to therapeutic *** this study,12 high-affinity antibodies were generated from convalescent donors in early outbreaks using immune antibody phage display *** them,two RBD-binding antibodies(F61 and H121)showed high-affinity neutralization against SARS-Co V-2,whereas three S2-target antibodies failed to neutralize SARS-Co *** structure analysis,F61 identified a linear epitope located in residues G446–S494,which overlapped with angiotensinconverting enzyme 2(ACE2)binding sites,while H121 recognized a conformational epitope located on the side face of RBD,outside from ACE2 binding *** the cocktail of the two antibodies achieved better performance of neutralization to SARS-Co ***,these two antibodies also showed efficient neutralizing activities to the variants including B.1.1.7 and B.1.351,and reacted with mutations of N501 Y,E484 K,and L452 R,indicated that it may also neutralize the recent India endemic strain *** unchanged binding activity of F61 and H121 to RBD with multiple mutations revealed a broad neutralizing activity against variants,which mitigated the risk of viral *** findings revealed the therapeutic basis of cocktail antibodies against constantly emerging SARS-Co V-2 variants and provided promising candidate antibodies to clinical treatment of COVID-19 patients infected with broad SARS-Co V-2 variants.

关键词： Antibody cocktail Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) Broad neutralization SARS-CoV-2 variants Angiotensin-converting enzyme 2(ACE2)