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Direct and rapid detection of serum amino acid and monoamine neurotransmitters to assist the diagnosis of panic disorder

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Science China Chemistry 2025年第01期 377-384页

作者： shiwen liu Xuerui Wan Meng Zhao Jiaqi Wang Weilan Wu Linlin You Yonggui Yuan Qian Xu Rong Gao Key Laboratory of Environmental Medicine Engineering Ministry of Education School of Public Health Southeast University Key Laboratory of Modern Toxicology of Ministry of Education Department of Hygienic Analysis and Detection School of Public HealthNanjing Medical University Department of Psychosomatics and Psychiatry Zhongda Hospital School of Medicine Southeast University

The measurement of amino acid and monoamine neurotransmitters（NTs） in serum plays a central role in the identification and monitoring of clinical panic disorder（PD）. However, the strong polarity and chemical heterogeneity of NTs make direct extraction and rapid detection extremely challenging. Herein, we developed a strategy that integrated solid phase extraction based on magnetic Fe3O4coated with polydopamine（Fe3O4@PDA） and direct analysis of mass spectrometry in real time（DART-MS） for quantification of 10 NTs. We systematically investigated the optimal conditions of this strategy to achieve good accuracy and precision. Compared with existing magnetic solid phase extraction methods for NTs detection in biological samples, this strategy could adsorb more targets while having similar adsorption efficiencies, and the total process time was reduced by an average of 69.42%. We rapidly determined the metabolic abnormality of 6 types of NTs in the serum of PD patients and demonstrated their diagnostic accuracy. In addition, an outstanding feature of PD in which tryptophan was more metabolized by the KYN pathway and the 5-hydroxytryptamine pathway was inhibited could be elucidated by this strategy. Our results highlighted the potential ability of Fe3O4@PDA coupled with DART-MS to assist in the clinical diagnosis of PD.

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A study on periodic boundary condition in direct numerical simulation for gas–solid flow

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Chinese Journal of Chemical Engineering 2020年第1期28卷 236-241页

作者： shiwen liu Xiaowen liu Feiguo Chen Limin Wang Wei Ge State Key Laboratory of Multiphase Complex Systems Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China

Direct numerical simulation(DNS) of gas–solid flow at high resolution has been carried out by coupling the lattice Boltzmann method(LBM) for gas flow and the discrete element method(DEM) for solid particles. However,the body force periodic boundary condition(FPBC) commonly used to cut down the huge computational cost of such simulation has faced accuracy concerns. In this study, a novel two-region periodic boundary condition(TPBC) is presented to remedy this problem, with the flow driven in the region with body force and freely evolving in the other region. With simulation cases for simple circulating fluidized bed risers, the validity and advantages of TPBC are demonstrated with more reasonable heterogeneity of the particle distribution as compared to the corresponding case with FPBC.

关键词： Direct numerical simulation Periodic boundary condition Two-region periodic boundary condition Gas–solid flow Heterogeneity

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NURBS-based DEM for non-spherical particles

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Particuology 2020年第2期18卷 65-76页

作者： shiwen liu Feiguo Chen Wei Ge Philippe Ricoux State Key Laboratory of Multiphase Complex Systems Institute of Process EngineeringChinese Academy of SciencesP.O.Box 353Beijing 100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China Data Processing and Modeling TOTAL Scientific DivisionFrance

The discrete element method(DEM)is used to analyze complex practical granular systems;however,the representation of real shapes is an important consideration because behavior of non-spherical particles is unlike that of spherical particles both individually and *** this study,we use non-uniform rational basis-splines(NURBS)to describe the shapes of non-spherical particles and introduce a contact detection scheme based on quadratic convergence,to simulate the behaviors of elliptical *** simulation results are compared with those based on polygons,in terms of the shape description and contact treatment,to demonstrate the high accuracy and efficiency of NURBS-based DEM.

关键词： Non-spherical particle Discrete element method NURBS Facet-based DEM Granular system

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Mitochondrial DNA mutation in essential hypertension

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Journal of Geriatric Cardiology 2008年第1期5卷 60-64页

作者： Yuqi liu shiwen Wang 　 Instititute of Geriatric Cardiology Chinese PLA General HospitalBeijing 100853China

Essential hypertension (EH) is an escalating problem for developed and developing *** is currently seen as a 'complex' genetic trait caused by multiple susceptibility genes which are modulated by gene-environment and gene-gene *** the past 10 years,mitochondrial defects have been implicated in a wide variety of degenerative diseases,aging,and *** several studies showed that human essential hypertension has excess maternal transmission which suggests a possible mitochondrial ***,the exact pathophysiology of mitochondrial DNA mutation (mtDNA) in essential hypertension still remains *** the application of a variety of imaging approaches and successive mouse model of mitochonddal diseases we convince that these problems will be resolved in the near future.(J Geriatr Cardiol 2008;5(1):60-64)

关键词： mitochondrial DNA,essential hypertension,maternal,genetic trait,modulated

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Analysis of the operating parameters of a vortex electrostatic precipitator

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Plasma Science and Technology 2017年第2期19卷 69-78页

作者： Congxiang LU Chengwu YI Rongiie YI shiwen liu School of the Environment and Safety Engineering Jiangsu UniversityZhenjiang 212013People's Republic of China School of Mechatronics Engineering Yancheng Institute of Industry TechnologyYancheng 224005 People's Republic of China

A vortex electrostatic precipitator （VEP） forms a vortex flow field within a precipitator by means of the vertical staggered layout of the double-vortex collecting plate facing the direction of the gas flow. The ion concentrations within the precipitator can be significantly increased. Correspondingly, the charging and coagulation rates of fine particles and particle migration velocity are significantly improved within the VEP. Since it can effectively collect fine particles and reduce precipitator size, VEPs represent a new type of electrostatic precipitator with great application potential. In this work the change curve of the external voltage, gas velocity, row spacing and effective collecting area influencing the precipitation efficiency were acquired through a single-factor experiment. Using an orthogonal regression design, attempts were made to analyze the major operating parameters influencing the collecting efficiency of fine particles, establish a multiple linear regression model and analyze the weights of factors and then acquire quantitative rules relating experimental indicators and factors. The regression model was optimized by MATLAB programming, and we then obtained the optimal factor combination which can enhance the efficiency of fine particle collection. The final optimized result is that： when gas velocity is 3.4 m s-1, the external voltage is 18 kV, row spacing is 100 mm and the effective collecting area is 1.13 m2, the rate of fine particle collection is 89.8867%. After determining and analyzing the state of the internal flow field within the VEP by particle image velocimetry （PIV）, the results show that, for a particular gas velocity, a vortex zone and laminar zone are distinctly formed within the VEP, which increases the ion transport ratio as well as the charging, coagulation and collection rates of fine particles within the precipitator, thus making further improvements in the efficiency of fine particle collection.

关键词： fine particles vortex electrostatic precipitator regression model optimization design,vortex flow field

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Synthesis of Acrylonitriles via Mild Base Promoted Tandem Nucleophilic Substitution-Isomerization ofα-Cyanohydrin Methanesulfonates

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Chinese Journal of Chemistry 2021年第4期39卷 913-917页

作者： shiwen liu Lingling Meng Xiaojun Zeng Gerald B.Hammond Bo Xu College of Textiles and Clothing&Key Laboratory for Advanced Technology in Environmental Protection of Jiangsu Province Yancheng Institute of TechnologyYanchengJiangsu 224003China Key Laboratory of Science and Technology of Eco-Textiles Ministry of EducationCollege of ChemistryChemical Engineering and BiotechnologyDonghuo UniversityShanghai 201620China Department of Chemistry University of LouisvilleLouisvilleKentucky 40292United States

Main observation and conclusion We have developed an efficient synthesis of acrylonitriles via mild base promoted tandem nucleophilic substitution-isomerization ofα-cyanohydrin methanesulfonates with alkenylboronic *** transition metal-free protocol works under simple and mild conditions and offers good chemical yields for a wide range of substrates and demonstrates good functional group tolerance.

关键词： Acrylonitriles Nucleophilic substitution Isomerization α-Cyanohydrin methanesulfonates Alkenyl boronic acids

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Robust hydrogen production from HCOOH over amino-modified KIT-6-confined Pd Ir alloy nanoparticles

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Chinese Chemical Letters 2022年第3期33卷 1403-1406页

作者： Wenfang Peng shiwen liu Xiugang Li Gang Feng Jianhui Xia Zhang-Hui Lu Key Laboratory of Functional Small Molecules for Ministry of Education College of Chemistry and Chemical EngineeringJiangxi Normal UniversityNanchang 330022China Jiangxi Provincial Center for Disease Control and Prevention Nanchang 330029China College of Chemistry Nanchang UniversityNanchang 330031China

Formic acid (FA), which can be produced via CO_(2) reduction and biomass conversion, has received extensive interest as a convenient and safe hydrogen carrier due to its wide range of sources, renewable, high hydrogen content (4.4 wt%), and convenient storage/transportation. Designing highly efficient catalysts is the main challenge to realize the hydrogen production from FA. In this work, well-dispersed and electron-rich PdIr alloy nanoparticles with a size of 1.8 nm are confined in amino-modified 3D mesoporous silica KIT-6 and applied as a highly efficient catalyst for robust hydrogen production from FA at ambient temperature. Small PdIr alloy nanoparticles confined by amino-modified KIT-6 (PdIr/KIT-6-NH_(2)) lead to better catalytic activity compared to that of Pd/KIT-6-NH_(2) and PdIr confined by bare KIT-6, achieving a high turnover frequency (TOF) value of 3533 h-1 at ambient temperature (303 K), 100% H_(2) selectivity and conversion toward the dehydrogenation of FA, which is comparable to the best heterogeneous catalysts ever reported. The high catalytic activity of PdIr/KIT-6-NH_(2) can be attributed to the synergistic effect between Pd and Ir, strong interaction between PdIr and KIT-6-NH_(2), as well as the amino-groups of KIT-6-NH_(2) which can act as a proton scavenger to promote the breaking of O-H bond of formic acid.

关键词： Formic acid Hydrogen production Palladium Metal nanoparticle 3D mesoporous silica

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Cryopreservation of strip spawned sperm using programmable freezing technique in the blue mussel Mytilus galloprovincialis

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Journal of Oceanology and Limnology 2018年第6期36卷 2351-2357页

作者： liu Yibing liu shiwen liu Bingli QIN Jianguang XU Tong LI Xiaoxu Liaoning Ocean and Fisheries Science Research Institute Dalian 116023China College of Science and Engineering The Flinders University of South AustraliaAdelaideSouth Australia 5042Australia College of Fisheries and Life Science Dalian Ocean UniversityDalian 116023China South Australian Research and Development Institute West BeachSouth Australia 5024Australia

In this study, a programmable freezing technique has been developed for strip spawned sperm in the blue mussel, M ytilus galloprovincialis. The optimized key parameters include cooling rate, endpoint temperature, thawing temperature, sugar addition and sperm to oocyte ratio. The sperm quality was assessed by the fertilization rate or the integrity of sperm component and organelle. The highest post-thaw sperm fertilization rate was 91%, which was produced with sperm cryopreserved in 8% dimethyl sulfoxide at the cooling rate of-4°C/min from 2°C to-30°C before being plunged into liquid nitrogen for at least 12 h, thawed in a 20°C seawater bath and fertilized at sperm to egg ratio of 50 000:1. The addition of glucose, sucrose or trehalose to 8% dimethyl sulfoxide could not further improve fertilization rates. The fluorescent assessments showed that the post-thaw sperm plasma membrane integrity and acrosome integrity were significantly damaged in comparison with fresh sperm.

关键词： blue mussel Mytilus galloprovincialis strip spawning sperm cryopreservation

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Relations between structural properties and synchronizability on local world dynamical networks

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Progress in Natural Science:Materials International 2007年第8期17卷 956-961页

作者： Sun shiwen~(**) liu Zhongxin Chen Zengqiang Yuan Zhuzhi (Department of Automation,Nankai University,Tianjin 300071,China) [a]Department of Automation Nankai University Tianjin China

In this paper,the effects of various structural properties on the synchronization of coupled oscillators with local-world coupling configurations are *** is found that for local world networks,the larger heterogeneity of the degree distribution,the enhanced interconnection of nodes,and the increased clustering do not improve the synchronizability of dynamical *** the con- trary,the increase of the maximum betweenness centrality appears to be responsible for the decrease of the synchronizability.

关键词： complex dynamical network local-world evolving model synchronizability structural properties betweenness centrality

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Structure, function, and mechanism of the TNFAIP8 (TIPE) family of proteins in cancer and inflammation

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BIOCELL 2023年第10期47卷 2217-2232页

作者： ZIPENG LIN CHUXI TANG LE KANG GUANXI LAI shiwen liu YIXIANG WU HUIQUN TIAN SONG liu School of Pharmacy&Clinical Pharmacy School of Integrative PharmacyGuangdong Pharmaceutical UniversityGuangzhou510006China Department of Biomedical Sciences Laboratory Affiliated Dongyang Hospital of Wenzhou Medical UniversityDongyang322100China The Second People’s Hospital of China Three Gorges University Yichang443000China Guangdong Province Key Laboratory for Biotechnology Drug Candidates Guangdong Pharmaceutical UniversityGuangzhou510006China Key Specialty of Clinical Pharmacy The First Affiliated Hospital of Guangdong Pharmaceutical UniversityGuangzhou510080China

The multiple roles of the tumor necrosis factor(TNF)-α-inducible protein 8(TNFAIP8),also named TIPE family of proteins have been shown in tumor and inflammation progression and regulation of cellular autophagy and *** this review,we found that the TIPE family showed highly homologous sequences and conserved functional domains,such as the death effector domain(DED)-like domain but displayed different roles and mechanisms in different biological *** example,while TIPE is primarily associated with tumor progression and antitumor drug resistance,TIPE1 suppresses tumor progression in most ***2 has multiple roles in tumor progression regulation,and antitumor drug ***,TIPE2 was also involved in inflammatory response regulation,tumor typing,and staging.A few studies reported that TIPE3 was engaged in tumor development by activating the phosphatidylinositol-3-kinase(PI3K)/protein kinase B(AKT)signaling *** structure,function,and mechanism of the TIPE family in cancer and inflammation have been summarized in this *** might serve as a reference for further research on the TIPE family and shed new light on the crosstalk among antitumor responses,inflammation,and immunology.

关键词： TIPE TIPE1 TIPE2 TIPE3 DED-like domain

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