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临床与实验病理学杂志 2010年第5期26卷 608-608页

作者： Lucas d R shukla A Thomas d G 李岩(摘译 ) 张仁亚(审校) 不详济宁医学院附属医院病理科济宁272029

Cell Stem Cell：利用干细胞制造出的心肌细胞有助精准心血管医疗取得进展

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现代生物医学进展 2016年第32期16卷 I0001-I0002页

作者： Elena Matsa Paul W. Burridge Kun-Hsing Yu John H. Ahrens Vittavat Termglinchan Haodi Wu Chun Liu Praveen shukla Nazish Sayed Jared M. Churko Ningyi Shao Nicole A. Woo Alexander S. Chao Joseph d. Gold Ioannis Karakikes Michael P. Snyder Joseph C. Wu Biomedical Informatics Training Program Stanford University School of Medicine Stanford CA 94305 USA

在一项新的研究中。来自美国斯坦福大学医学院的研究人员发现利用人诱导性多能干细胞（iPS细胞）制造的心肌细胞忠实地反映供者天然的心脏组织中关键基因的表达模式。因此，这些细胞能够被用来预测病人是否可能经历药物相关的心脏损伤... 详细信息

在一项新的研究中。来自美国斯坦福大学医学院的研究人员发现利用人诱导性多能干细胞（iPS细胞）制造的心肌细胞忠实地反映供者天然的心脏组织中关键基因的表达模式。因此，这些细胞能够被用来预测病人是否可能经历药物相关的心脏损伤。相关研究结果在线发表在Cell Stem Cell期刊上。论文标题为＂Transcriptome Profiling of Patient -Specific Human iPSC - ardiomyocytes Predicts Individual drug Safety and Efficacy Responses In Vitro＂.

关键词：多能干细胞 Cell 心肌细胞 Stem 制造利用心血管美国斯坦福大学

Geochemical constraints on the tectonic setting of the Sonakhan Greenstone Belt, Bastar Craton, Central India

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Acta Geochimica 2018年第3期37卷 489-499页

作者： S.d.deshmukh K.R.Hari P.diwan M.P.Manu Prasanth department of Geology Govt. V. Y. T. P G Autonomous College School of Studies in Geology and W.R.M. Pt. Ravishankar Shukla University department of Applied Geology National Institute of TechnologyRaipur India

The Neo-Archean Sonakhan Greenstone Belt(SGB) located in the north-eastern fringes of Bastar craton,Central India, is dominated by Basalts, Andesites, dacites and Rhyolites association. Partial melting modeling on the SGB metabasalts indicates that these rocks were derived by20% melting of spinel peridotite. Fractional crystallisation modeling with REE reveal that the most evolved samples represent the product of fractional crystallization of least evolved magma with 35% plagioclase, 35% clinopyroxene,20% olivine, 5% magnetite and 5% ilmenite as fractionating minerals with 40% remaining magma. depletion of HFSE with reference to the LILE and LREE/HFSE ratios and Nb, Zr anomalies in the multi-element diagram of the mafic rocks of SGB indicate Island arc magmatic *** enriched Th/Yb values further substantiate that the mantle arrays were modified by subduction-related fluids or melts. The general conclusions drawn indicate that the metabasalts from the SGB were formed as a result of subduction of an intraoceanic lithosphere in a fore-arc suprasubduction zone environment.

关键词： Supra-subduction Neo-Archean SonakhanGreenstone terrain Bastar craton

Valsava视网膜病的光学相干断层扫描结果

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世界核心医学期刊文摘（眼科学分册） 2005年第12期1卷 14-14页

作者： shukla d Naresh K.B Kim R 黎黎 Aravind Eye Hospital Postgraduate Institute of Ophthalmology 1 Anna Nagar Madurai 625 020 Tamil Nadu India.Dr

PURPOSE: To demonstrate the plane of premacular hemorrhage in Valsalva retinopathy with optical coherence ***: Observational case report METHOdS: Two young men with Valsalva stress-related premacular hemorrhage were evaluated by OCT scans, taken just above the level of sedimented blood. RESULTS: In both cases, OCT demonstrated two distinct membranes: a highly reflective band immediately above the premacular hemorrhage, corresponding to the internal limiting membrane, and an overlying patchy membrane with low optical reflectivity consistent with posterior hyaloid. CONCLUSION: OCT supported the clinical impression that the plane of premacular hemorrhage in Valsalva retinopathy is probably under ILM. Larger case studies are required to confirm this finding.

关键词：视网膜病 Valsava 内界膜高反射带出血程度年轻男性病例研究临床诊断观察性

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Orbita板在下颌骨体骨折中的新用途

中国口腔颌面外科杂志 2018年第6期16卷 558-558页

作者： Anchlia S dhuvad JM shukla d 赵泽亮

Anchlia S,dhuvad JM,shukla d,et *** of orbita plates in mandibular body *** Oral Surg,2018dec.背景:下颌骨体部的孤立性骨折将牙边缘分开。并在受到咀嚼力时压缩下边缘。本研究旨在评估2块Orbita板在Champy的接骨线中的作用,同... 详细信息

Anchlia S,dhuvad JM,shukla d,et *** of orbita plates in mandibular body *** Oral Surg,2018dec.背景:下颌骨体部的孤立性骨折将牙边缘分开。并在受到咀嚼力时压缩下边缘。本研究旨在评估2块Orbita板在Champy的接骨线中的作用,同时实现3d重塑和预防颏孔损伤。目的:通过使2块板的末端部分充分接触来实现3d重塑:保留由2块Orbita板产生的椭圆内的颏神经;防止损伤根尖。材料与方法:纳入20例经颏孑L的下颌骨体骨折患者。通过口内前庭入路,在Champy的接骨线中固定2块Orbita微型板。在椭圆形状中实现了几何闭合的四边形关系,四边形中包括了神经。结果:所有病例的骨折愈合良好.咬合关系满意.不需要术后颌间固定。颏神经功能障碍不明显。结论:使用Orbita板固定.有助于在下颌骨骨折患者中获得令人满意的功能结果而不会对牙根部造成损伤:并且即使在无法放置3d微型钛板的情况下.也能实现几何上接近的四边形关系。

关键词：骨折患者下颌骨神经功能障碍微型钛板颌间固定咬合关系骨折愈合咀嚼力

BEST PROXIMITY PAIR THEOREM IN METRIZABLE TOPOLOGICAL VECTOR SPACES

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Analysis in Theory and Applications 2010年第1期26卷 59-68页

作者： H. K. Nashine C. L. dewangan Z. d. Mitrovic Pt. Ravishankar shukla University India/Disha Institute of Management and Technology India disha Institute of Management and Technology India University of Banja Luka Basnia and Herzegovina

The object of this paper is to prove an existence result on best proximity pair. For this purpose, the class of factorizable multifunctions in approximately weakly compact, convex subset of metrizable topological vector space is used. As consequence, our theorem generalizes the result of Basha and Veeramani. Finally, certain known results have also been obtained as corollaries in this work.

关键词： almost affine almost quasi convex approximately weakly compact best proximity pair Metrizable TVS relative almost quasi convex Kakutani factorizable multifunction

GRAdE指南：Ⅶ.证据质量评价--不一致性

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中国循证医学杂志 2011年第12期11卷 1444-1451页

作者： Gordon H.Guyatt Andrew d.Oxman Regina Kunz James Woodcock Jan Brozek Mark Helfand Pablo Alonso-Coello Paul Glasziou Roman Jaeschke Elie A.Akl Susan Norris Gunn Vist Philipp dahm Vijay K.shukla Julian Higgins Yngve Falck-Ytter Holger J.Schünemann 代表GRAdE小组李幼平杨晓妍王莉蔡羽嘉陈群飞机构不详

本文针对二分类变量结局指标相对(而非绝对)治疗效果的不一致性。证据本身不会因不同研究结果具有一致性而升级,但可能因不一致而降低质量级别。衡量一致性的标准包括点估计值的相似性、可信区间的重叠程度以及统计学判定标准包括异质... 详细信息

本文针对二分类变量结局指标相对(而非绝对)治疗效果的不一致性。证据本身不会因不同研究结果具有一致性而升级,但可能因不一致而降低质量级别。衡量一致性的标准包括点估计值的相似性、可信区间的重叠程度以及统计学判定标准包括异质性检验和I2。系统评价作者应提出并检验少数几个与患者、干预措施、结局指标以及方法学相关的先验假设以探寻异质性来源。当不一致性很大且无法解释时,因不一致性而降低质量级别是恰当的,特别当某些研究显示有显著益处而其他显示无益甚至有害时(而非仅是疗效大与疗效小的比较)。明显的亚组效应可能不可靠。如果亚组效应满足以下条件,其可信度将会增加:基于少数几个有具体方向的先验假设、亚组比较来自研究内而非研究间、交互检验的P值小、结果有生物学意义。

关键词： GRAdE 不一致性异质性变异性亚组分析交互作用

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优良籼稻感温基因雄不育系的遗传偏差

国外作物育种 2004年第4期23卷 1-1页

作者： S．K．shukla 谢国禄

了解优良感温基因雄不育(TGMS)系的有用遗传多样性在用两系法培育热带杂交稻时具有极为重要的意义。本研究用30个籼型TGMS品系和4个品种即Pant dhan4和Ajaya(籼型)、台中65(粳型)以及IR65598—112—2(热带粳型)来测定了遗传多样性，以... 详细信息

了解优良感温基因雄不育(TGMS)系的有用遗传多样性在用两系法培育热带杂交稻时具有极为重要的意义。本研究用30个籼型TGMS品系和4个品种即Pant dhan4和Ajaya(籼型)、台中65(粳型)以及IR65598—112—2(热带粳型)来测定了遗传多样性，以便培养不同熟期的水稻亚种间和亚种内杂种。试验于2000年在RBd进行，设两个重复；每个基因型种植4m长的4行区，行间和行内距离为20×15cm，调查了11种性状。用Mahalanobis d^2统计学来分析偏差，并按Tocher的方法划分基因型组群。

关键词：籼稻感温基因雄不育系遗传偏差

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磁共振胰胆管造影在梗阻性黄疸患者中的应用

世界核心医学期刊文摘（胃肠病学分册） 2005年第4期1卷 52-52页

作者： Vaishali M.d. Agarwald A.K. Upadhyaya N. V.K. shukla 赵丽娜 department of General Surgery Institute of Medical Sciences Banaras Hindu University Varanasi 221 005 IndiaProf.

Goals: To determine the ability of magnetic resonance cholangiopancreatography (MRCP) to diagnose the level and cause of obstruction in patients with obstructive jaundice. Background: The limitations of available imaging modalities have led to the increasing use of MRCP, which is a noninvasive and highly accurate technique in evaluating patients with biliary obstruction. Study: Thirty patients were included in this study. MRCP was done using a fat suppressed heavily T2 weighted fast spin echo sequence. The MRCP findings were confirmed on surgical exploration or clinical follow-up. Results: MRCP could correctly identify ductal dilatation and the level of obstruction in all cases, except one. All causes of obstruction, except three, were detected. It failed to detect a common bile duct calculus in a minimally dilated ductal system and misdiagnosed a case of focal chronic pancreatitis as carcinoma head pancreas and a small pancreatic head mass as cholangiocarcinoma. It had a sensitivity of 94.44%, specificity of 81.81%, positive predictive value of 89.47%, and negative predictive value of 90%for the detection of malignant causes. The overall diagnostic accuracy for detection of level and cause of obstruction was 96.3%and 89.65%, respectively. Conclusion: The high diagnostic accuracy of MRCP in evaluating patients with obstructive jaundice indicates that it has the potential to become the diagnostic modality of choice in such patients.

关键词：阻性脂肪抑制技术胆管梗阻成像设备胆总管结石梗阻程度梗阻原因胰头癌慢性胰腺炎阴性预测值

Neurology：生物标志物突破可能改进帕金森病的治疗

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现代生物医学进展 2016年第32期16卷 I0004-I0004页

作者： Roxana G. Burciu, Phd Jae Woo Chung, MSc Priyank shukla, Phd Edward Ofori, Phd Hong Li, Phd Nikolaus R. McFarland, Md, Phd Michael S. Okun, Md david E. Vaillancourt, Phd From the department of Applied Physiology and Kinesiology (R.G.B. J.W.C. P.S. E.O. D.E.V.) and the Departments of Neurology (N.R.M. M.S.O. D.E.V.) and Neurosurgery (M.S.O.) Center for Movement Disorders and Neurorestoration and Department of Biomedical Engineering (D.E.V.) University of Florida Gainesville and department of Public Health Sciences (H.L.) Medical University of South Carolina Charleston. Correspondence to dr. Vaillancourt: vcourt{at}ufl.edu

在最近发表于《Neurology）期刊的研究中。佛罗里达大学（University of Florida）研究人员使用功能性磁共振成像（fMRI）来揭示帕金森病和相关疾病导致大脑活动进行性衰退的区域。这种追踪疾病进展的新型无创方法，可能有助于评估实验... 详细信息

在最近发表于《Neurology）期刊的研究中。佛罗里达大学（University of Florida）研究人员使用功能性磁共振成像（fMRI）来揭示帕金森病和相关疾病导致大脑活动进行性衰退的区域。这种追踪疾病进展的新型无创方法，可能有助于评估实验性疗法，从而延缓或停止疾病的发展。

关键词：帕金森病生物标志物功能性磁共振成像治疗佛罗里达大学相关疾病大脑活动研究人员