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Citalopram increases the differentiation efficacy of bone marrow mesenchymal stem cells into neuronal-like cells

Neural Regeneration Research 2014年第8期9卷 845-850页

作者： Javad Verdi Seyed Abdolreza Mortazavi-Tabatabaei shiva sharif Hadi Verdi Alireza Shoae-Hassani Department of Applied Cell Sciences School of Advanced Technologies in MedicineTehran University of Medical Sciences Department of Stem Cells and Tissue Engineering Research Center for Science and Technology in MedicineTehran University of Medical Sciences Department of Tissue Engineering School of Advanced Technologies in MedicineIran University of Medical Sciences

Several studies have demonstrated that selective serotonin reuptake inhibitor antidepressants can promote neuronal cell proliferation and enhance neuroplasticity both in vitro and in vivo. It is hypothesized that citalopram, a selective serotonin reuptake inhibitor, can promote the neuronal differentiation of adult bone marrow mesenchymal stem cells. Citalopram strongly enhanced neuronal characteristics of the cells derived from bone marrow mesenchymal stem cells. The rate of cell death was decreased in citalopram-treated bone marrow mesenchymal stem cells than in control cells in neurobasal medium. In addition, the cumulative population doubling level of the citalopram-treated cells was signiifcantly increased compared to that of control cells. Also BrdU incorporation was elevated in citalopram-treated cells. These ifndings suggest that citalopram can improve the neuronal-like cell differentiation of bone marrow mesenchymal stem cells by increasing cell proliferation and survival while maintaining their neuronal characteristics.

关键词： nerve regeneration citalopram stem cells bone marrow mesenchymal stem cells survival proliferation differentiation neurons neural regeneration

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