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*** rescue in retinitis pigmentosa by the treatment of Lycium barbarum(Random Clinical Trial)

Annals of Eye Science 2017年第1期 356-356页

作者： Henry Chan Hang-I lam Kwok-Fai So Raymond Chuen-Chung Chang shiu-Ming Lai Chi-Wai Do Iris F.F.Benzie Chin-Pan Leung Kai-Yip Choi Man-Pan Chin Zhe-Chuang Li Wing-Yan Yu Laboratory of Experimental Optometry(Neuroscience) School of OptometryThe Hong Kong Polytechnic UniversityHong Kong SARChina Guangdong-Hongkong-Macao(GHM)Institute of CNS Regeneration Jinan UniversityGuangzhouChina School of Biomedical Sciences The University of Hong KongHong Kong SARChina Department of Ophthalmology The University of Hong KongHong Kong SARChina Laboratory of Experimental Optometry(Biophysic) School of OptometryThe Hong Kong Polytechnic UniversityHong Kong SARChina Department of Health Technology and Informatics The Hong Kong Polytechnic UniversityHong Kong SARChina Private practice Chinese medical doctor

Retinitis pigmentosa(RP)is a group of heredofamilial retinal diseases which is characterized by night blindness and progressive visual field *** study aims to study the treatment effect of Lycium barbarum(LB)on retinal functions and structure of RP *** study is a double-masked randomized controlled *** subjects received scheduled eye examination including visual acuity(VA),Humphrey field analysis(HFA),ganzfeld flash electroretinogram(ffERG)and optical coherence tomography(OCT).The suitable subjects were randomly allocated to either LB-treatment or placebo groups with the supply of LB or placebo for 12 *** were total 41 RP subjects(22 in LB group and 19 in placebo group)completed the 12 months *** compliance rates for LB and placebo groups were 89.8%±12.5%and 85.3%±7.7%*** compared with placebo group,there were no deteriorations of both high and low contrast VA in LB group(P<0.01).In addition,certain improvements of scotopic rod response and photopic cone response of ffERG were obtained in LB group(P<0.05).In the OCT measurement,an obvious thinning of macular thickness was observed in placebo group but not found in LB group(P<0.05).However,there were no changes found in the sensitivity of central visual field between two *** results confirm that the 12-month LB treatment for RP patients had neuroprotective effect on retina and is believed to delay or minimize the deterioration of visual function in RP.

关键词： Retinitis pigmentosa(RP) Lycium barbarum(LB) neuroprotection cone retina

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