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World Journal of Gastroenterology 2007年第28期13卷 3873-3877页

作者： Tze Jui lam Benjamin CY Wong Chris JJ Mulder A Salvador Pea Wai Mo Hui shiu kum lam Annie On On Chan Department of Gastroenterology VU University Medical CentreAmsterdamThe Netherlands Department of Medicine University of Hong KongHong KongChina Department of Gastroenterology VU University Medical CentreAmsterdamThe Netherlands Department of PathologyVU University Medical CentreAmsterdamThe Netherlands

AIM： To investigate the distribution and frequency of advanced polyps over eight years.METHODS：6424 colonoscopies were reviewea aunng the study period 1998 to 2005. The study period was subdivided into period I ： 1998 to 2001 and period 11： 2002-2005. RESULTS： 1856 polyps （33% advanced polyps） and 328 CRCs were detected. The mean ages of the patients with advanced polyps and cancer were 69.2 ± 12.0 and 71.6± 13.8 years, respectively. Advanced polyps were mainly lerc sided （59.5%）. Advanced polyps were found in patients ≤60 years from 17.7% in period Ⅰto 26.3% in period Ⅱ（P 〈 0.05）, especially in male subjects ≤60 years （21.6% vs 31.6%, P 〈 0.05）. Advanced tubuloviUous polyps rose from 21.5% in period I to 29.5% in period Ⅱ （P 〈 0.05）. Whereas cancers in male patients ≤ 60 years were similar in both periods： 23.2% vs 16.5% （P 〉 0.05）.CONCLUSION： Advanced polyps increased significantly in the younger male group in the most recent period and there seems to be a shiE towards a proximal location.

关键词： Colonic polyps Colonoscopy Chinese

Differing coping mechanisms, stress level and anorectal physiology in patients with functional constipation

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World Journal of Gastroenterology 2005年第34期11卷 5362-5366页

作者： Annie OO Chan Cecilia Cheng Wai Mo Hui Wayne HC Hu Nina YH Wong KF lam Wai Man Wong Kam Chuen Lai shiu kum lam Benjamin CY Wong Department of Medicine the University of Hong Kong Hong Kong China Division of Social Science the Hong Kong University of Science and Technology Hong Kong China Department of Medicine the University of Hong Kong Hong Kong China Department of Statistics the University of Hong Kong Hong Kong China

AIM: To investigate coping mechanisms, constipation symptoms and anorectal physiology in 80 constipated subjects and 18 ***: Constipation was diagnosed by Rome Ⅱ *** ability and anxiety/depression were assessed by validated questionnaires. Transit time and balloon distension test were ***: 34.5% patients were classified as slow transit type of constipation. The total colonic transit time (56 h vs 10 h, P＜0.0001) and rectal sensation including urge sensation (79 mL vs 63 mL, P = 0.019) and maximum tolerable volume (110 mL vs95 mL, P = 0.03) differed in patients and controls. Constipated subjects had significantly higher anxiety and depression scores and lower SF-36 scores in all categories. They also demonstrated higher scores of'monitoring' coping strategy (14+6 vs9+3, P = 0.001),which correlated with the rectal distension sensation (P = 0.005), urge sensation (P=0.002), and maximum tolerable volume (P = 0.035). The less use of blunting strategy predicted slow transit constipation in both univariate (P = 0.01) and multivariate analysis (P = 0.03).CONCLUSION: Defective or ineffective use of coping strategies may be an important etiology in functional constipation and subsequently reflected in abnormal anorectal physiology.

关键词： Constipation Anorectal physiology Coping mechanism

Chemoprevention of gastric cancer: current status

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Chinese Medical Journal 2003年第1期116卷 5-10页

作者： Harry Hua-Xiang Xia Benjamin Chun-Yu Wong shiu-kum lam Department of Medicine Department of MedicineDepartment of Medicine The University of Hong Kong Queen Mary Hospital Hong Kong SAR ChinaThe University of Hong Kong Queen Mary Hospital Hong Kong SAR ChinaThe University of Hong Kong Queen Mary Hospital Hong Kong SAR China

The development of gastric cancer is a multi-factor process. In addition to genetic factors, environmental factors including smoking, low gastric acidity, excessive intake of salt or salty food and low consumption of fresh fruits and vegetables all contribute to the development of gastric cancer. Of particular interest, epidemiological and experimental studies have demonstrated that Helicobacter pylori (H. pylori) infection is causally linked to gastric cancer. Most studies using micronutrient supplementation have failed to demonstrate any preventive effect against the development of gastric cancer. The use of non-steroidal anti-inflammatory drugs has been consistently observed to protect against the development of gastric cancer. Recently, eradication of H. pylori infection by a chemopreventative approach is being studied in a number of trials. Studies using precancerous lesions as an end point of the treatment have produced conflicting and mostly negative results. Trials using cancer as an end point are being cautiously carried out in high-risk populations, and will provide the definitive answer to this important question. In the end, vaccination may be proven to be the optimal strategy in human for the management of H. pylori infection and prevention of gastric cancer.

关键词： chemoprevention gastric cancer Helicobacter pylori

Macrophage migration inhibitory factor stimulated by He/icobacter py/oriincreases proliferation of gastric epithelial cells

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World Journal of Gastroenterology 2005年第13期11卷 1946-1950页

作者： Harry Hua-Xiang Xia shiu kum lam Annie O.O.Chan Marie Chia Mi Lin Hsiang Fu Kung Keiji Ogura Douglas E.Berg Benjamin Chun-Yu Wong Department of Medicine Institute of Molecular Biology Department of Molecular Microbiology

AIM: Helicobacter pylori (H pylori) is associated with increased gastric inflammatory and epithelial expression of macrophage migration inhibitory factor (MIF) and gastric epithelial cell proliferation. This study aimed at determining whether H pylori directly stimulates release of MIF in monocytes, whether the cag pathogenicity island (PAI) is involved for this function, and whether MIF stimulated by H pylori increases gastric epithelial cell proliferation in vitro. METHODS: A cytotoxic wild-type H pylori strain (TN2), its three isogenic mutants (TN2Δcag,TN2ΔcagA and TN2ΔcagE) were co-cultured with cells of a human monocyte cell line, THP-1, for 24 h at different organism/ cell ratios. MIF in the supernatants was measured by an ELISA. Cells of a human gastric cancer cell line, MKN45, were then co-cultured with the supernatants, with and without monoclonal anti-MIF antibody for 24 h. The cells were further incubated for 12 h after addition of 3H-thymidine, and the levels of incorporation of 3H-thymidine were measured with a liquid scintillation counter. RESULTS: The wild-type strain and the isogenic mutants, TN2ΔcagA and TN2ΔcagE, increased MIF release at organism/cell ratios of 200/1 and 400/1, but not at the ratios of 50/1 and 100/1. However, the mutant TN2Δcag did not increase the release of MIF at any of the four ratios. 3H-thymidine readings for MKN-45 cells were significantly increased with supernatants derived from the wild-type strain and the mutants TN2ΔcagA and TN2ΔcagE, but not from the mutant TN2Δcag. Moreover, in the presence of monoclonal anti-MIF antibody, the stimulatory effects of the wild-type strain on cell proliferation disappeared. CONCLUSION: H pylori stimulates MIF release in monocytes, likely through its cag PAI, but not related to cagA or cagE. H pylori-stimulated monocyte culture supernatant increases gastric cell proliferation, which is blocked by anti-MIF antibody, suggesting that MIF plays an important role in H pylori-induced gastric ep

关键词： H pylori MIF PAI

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World Journal of Gastroenterology 2008年第28期14卷 4535-4539页

作者： Guo-Shuang Feng Jun-Ling Ma Benjamin CY Wong Lian Zhang Wei-Dong Liu Kai-Feng Pan Lin Shen Xiao-Dong Zhang Jie Li Harry HX Xia Ji-You Li shiu kum lam Wei-Cheng You Department of Cancer Epidemiology Peking University School ofOncology Beijing Cancer Hospital & Institute Beijing 100036 China Department of Medicine University of Hong Kong Hong Kong China Department of Medical Oncology Peking University School of Oncology Beijing Cancer Hospital & Institute Beijing 100036 China Department of Pathology Peking University School of Oncology Beijing Cancer Hospital & Institute Beijing 100036 China Healthy Bureau of Linqu County Weifang 262600 Shandong Province China

AIM: To evaluate the long-term risk of gastroduodenal ulcer and cardiovascular events induced by celecoxib in a population-based, randomized, double-blind, placebo-controlled ***: From 2004 to 2006, a total of 1024 Chinese patients (aged 35 to 64 years) with severe chronic atrophic gastritis, intestinal metaplasia or dysplasia were randomly assigned to receive 200 mg of celecoxib twice daily or placebo in Linqu County (Shandong Province, China), a high-risk area of gastric cancer. All gastroduodenal ulcer and cardiovascular events occurred were recorded and the patients were followed up for 1.5 years after treatment. At the end of the trial, a systematic interview survey about other adverse events was conducted. RESULTS: Gastroduodenal ulcer was detected in 19 of 463 (3.72%) patients who received celecoxib and 17 of 473 (3.31%) patients who received placebo, respectively (odds ratio = 1.13, 95% CI = 0.58-2.19). Cardiovascular (CV) events occurred in 4 patients who received celecoxib and in 5 patients who received placebo, respectively. Compared with those who received placebo, patients who received celecoxib had no signif icant increase in occurrence of CV events (hazard ratio = 0.84, 95% CI = 0.23-3.15). Among the adverse events acquired by interview survey, only the frequency of bloating was signif icantly higher in patients treated with celecoxib than in those treated with placebo. CONCLUSION: Treatment of gastric cancer with celecoxib is not associated with increased risk of gastroduodenal ulcer and cardiovascular events.

关键词： Celecoxib Gastroduodenal ulcer Cardiovascular diseases Adverse effects Epidemiology Randomized controlled trial

幽门螺杆菌慢性感染诱导胃上皮细胞产生凋亡耐受

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中华医学杂志 2003年第1期83卷 42-45页

作者：何兴祥胡品津 Benjamin Chun Yu Wong shiu kum lam Harry Hua Xiang Xia 中山医科大学第一附属医院消化内科广州510080 DepartmentofMedicine TheUniversityofHongKongQueenMaryHospital

目的　建立幽门螺杆菌 (Hp)慢性感染胃上皮细胞模型 ,并分析Hp慢性感染与胃上皮细胞凋亡的关系。方法　用HpSS1与人非肿瘤性胃上皮细胞株GES 1共培养 16周 ,建立GES 1模型细胞 ,然后采用流式细胞术分析这种模型细胞对Hp和其它肠道细菌... 详细信息

目的　建立幽门螺杆菌 (Hp)慢性感染胃上皮细胞模型 ,并分析Hp慢性感染与胃上皮细胞凋亡的关系。方法　用HpSS1与人非肿瘤性胃上皮细胞株GES 1共培养 16周 ,建立GES 1模型细胞 ,然后采用流式细胞术分析这种模型细胞对Hp和其它肠道细菌以及抗肿瘤药物凋亡诱导剂的应答。结果　成功获得了Hp慢性感染胃上皮细胞模型 (GES 1模型细胞 )。这种模型细胞不仅对Hp诱导的凋亡耐受 ,而且对其他肠道细菌和一些凋亡诱导剂也是耐受的。结论　幽门螺杆菌慢性感染诱导胃上皮细胞产生凋亡耐受 ,由此可能增加了胃上皮细胞癌变的危险性。

关键词：胃上皮细胞细胞凋亡幽门螺杆菌感染胃癌

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东西方酸相关性疾病的未来

中华消化杂志 2000年第5期20卷 333-334页

作者： Guido Tytgat shiu-kum lam James W.Freston Jose D.Sollano 戎兰陆玮荷兰阿姆斯丹大学医学中心胃肠和肝胆科上海医科大学华山医院消化科

许多著名胃肠病学专家于1998年11月消化病周聚集在菲律宾马尼拉一起讨论并报道了有关胃肠病学、肝病学和内镜方面的进展,这次会议引起了亚洲和西方消化界的极大兴趣.现将有关'胃食管反流性疾病'以及'兰索拉唑是安全和有效的'二部分内容... 详细信息

许多著名胃肠病学专家于1998年11月消化病周聚集在菲律宾马尼拉一起讨论并报道了有关胃肠病学、肝病学和内镜方面的进展,这次会议引起了亚洲和西方消化界的极大兴趣.现将有关'胃食管反流性疾病'以及'兰索拉唑是安全和有效的'二部分内容报告如下.

关键词：胃食管反流性疾病症状诊断治疗

Antralization at the edge of proximal gastric ulcers:Does Helicobacter pylori infection play a role?

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World Journal of Gastroenterology 2003年第6期9卷 1265-1269页

作者： Harry Hua-Xinag Xia shiu kum lam Wai Man Wong Wayne Hsing Cheng Hu Kam Chuen Lai Sau Hing Wong Suet Yi Leung Siu Tsan Yuen Nicholas A.Wright Benjamin Chun-Yu Wong Department of Medicine The University of Hong KongHong Kong SARChina Department of Pathology The University of Hong KongHong Kong SARChina Histopathology Unit London Research InstituteCancer ResearchUK

AIM: To determine the prevalence of antralization at the edge of proximal gastric ulcers, and the effect ofH. pylori eradication on the mucosal appearances.METHODS: Biopsies were taken from the antrum, body and the ulcer edge of patients with benign proximal gastric ulcers before and one year after treatment. Gastric mucosa was classified as antral, transitional or body type.H. pylori positive patients receivedeither triple therapy, or omeprazole.RESULTS: Patients with index ulcers in the incisura, body or fundus (n=116) were analyzed. Antral-type mucosa was more prevalent at the ulcer edge inH. pylori-positive patients ***-negative patients (93% vs 60%, OR=8.95,95%CI: 2.47-32.4, P=0.001). At one year, there was a significant reduction in the prevalence of antralization (from 93 % to 61%, P=0.004) at the ulcer edge in patients with H. pyloribeing eradicated. However, there was no difference in the prevalence of antralization at the ulcer edge in those with persistent infection.CONCLUSION: H. pylori infection is associated with antralization at the edge of proximal gastric ulcers, which may be reversible in some patients after eradication of the infection.

关键词：胃溃疡幽门螺杆菌感染胃粘膜活组织检查

幽门螺杆菌慢性感染诱导胃上皮细胞产生凋亡耐受

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现代消化及介入诊疗 2002年第3期7卷 34-38页

作者：何兴祥胡品津 Benjamin Chun Yu Wong~2 shiu kum~2 lam Harry Hua Xiang Xia~2 广州中山医科大学第一附属医院消化科 510080 Departments of Medicine The University of Hong KongQueen MaryHospitalHong Kong

目的建立幽门螺杆菌(***)慢性感染胃上皮细胞模型,并分析***慢性感染与胃上皮细胞凋亡的关系.方法首先用*** SSI与人非肿瘤性胃上皮细胞株GES-1共培养16周,建立GES-1模型细胞,然后采用流式细胞术分析这种模型细胞对***和其它肠道细菌以... 详细信息

目的建立幽门螺杆菌(***)慢性感染胃上皮细胞模型,并分析***慢性感染与胃上皮细胞凋亡的关系.方法首先用*** SSI与人非肿瘤性胃上皮细胞株GES-1共培养16周,建立GES-1模型细胞,然后采用流式细胞术分析这种模型细胞对***和其它肠道细菌以及抗肿瘤药物凋亡诱导剂的应答.结果成功获得了***慢性感染胃上皮细胞模型(GES-1模型细胞).这种模型细胞不仅对***诱导的凋亡耐受,而且对其他肠道细菌和一些凋亡诱导剂也是耐受的。结论幽门螺杆菌慢性感染诱导胃上皮细胞产生凋亡耐受,由此可能增加了胃上皮细胞癌变的危险性.

关键词：幽门螺杆菌慢性感染诱导胃上皮细胞产生凋亡耐受

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胃癌预防亚太地区共识指南

胃肠病学 2008年第4期13卷 231-240页

作者： Kwong Ming Fock Nick Talley Paul Moayyedi Richard Hunt Takeshi Azuma Kentaro Sugano Shu Dong Xiao shiu kum lam Khean Lee Goh Tsutomu Chiba Naomi Uemura Jae G Kim Nayoung Kim Tiing Leong Ang Varocha Mahachai Hazel Mitchell Abdul Aziz Rani Jyh Ming Liou Ratha-korn Vilaichone Jose Sollanor 钱本余 Changi General Hospital Singapore Mayo Clinic College of Medicine Rochester USA McMaster University Medical Center Ontario Canada University of Fukui Fukui Jichi Medical University Tochigi Shanghai Institrte of Digestive Disease Shanghai University of Hong Kong Hong Kong University of Malaya Kuala Lumpur Malaysia Kyoto University Kyoto Kure Kyousai General Hospital Kure Japan Chung Ang University College of Medicine Seoul National University College of Medicine Seoul Korea Chulalongkorn University Hospital Bangkok University of New South Wales Sydney New South Wales Australia University of Indonesia Jakarta Indonesia National Taiwan University Hospital Taipei China Thammasat University Hospital Pathumthani Thailand University of Santo Tomas Manila Philippines

背景与目的:胃癌是亚太地区的主要健康负担之一,但对其预防策略尚缺乏共识。本共识会议旨在评价预防胃癌的策略。方法:多学科专家组应用德尔菲(Delphi)法制订共识条文,提呈相关数据,对证据等级、推荐强度以及共识水平予以分级。结果:幽... 详细信息

背景与目的:胃癌是亚太地区的主要健康负担之一,但对其预防策略尚缺乏共识。本共识会议旨在评价预防胃癌的策略。方法:多学科专家组应用德尔菲(Delphi)法制订共识条文,提呈相关数据,对证据等级、推荐强度以及共识水平予以分级。结果:幽门螺杆菌(***)感染是非贲门胃腺癌必要但非充分的致病因子。盐的高摄入与胃癌强烈相关。新鲜果蔬对胃癌具有预防作用,但维生素和其他饮食补充并不能预防胃癌。***感染中的宿主-细菌相互作用导致不同类型的胃炎和胃酸分泌,从而决定疾病结局。胃癌阳性家族史是一个重要的危险因素。低血清胃蛋白酶原反映胃萎缩程度,可作为检出胃癌高危人群的标志物。***筛查和治疗被推荐作为减少高危人群胃癌危险性的一种策略,该策略在萎缩性胃炎发生前实施最为有效,但并不排除对胃癌高危人群的内镜监测。对胃癌低危人群不推荐行***筛查。***感染的一线治疗应遵循国家治疗指南。结论:高危人群中***筛查和根除策略可能会减少胃癌的发生率,本共识根据现有证据予以推荐。

关键词：癌指南幽门螺杆菌预防