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Resolving the developmental mechanisms of cardiac microthrombosis of SARS-CoV-2 based on single-cell transcriptome analysis

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Science China Life Sciences 2025年第1期 103-115页

作者： Xizi Luo Nan Zhang Yuntao Liu Beibei Du Xuan Wang Tianxu zhao Bingqiang Liu shishun zhao Jiazhang Qiu Guoqing Wang State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases Key Laboratory for Zoonosis Research of the Ministry of EducationCollege of Basic MedicineJilin University State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases Key Laboratory for Zoonosis Research of the Ministry of EducationCollege of Veterinary MedicineJilin University College of Mathematics Jilin University Bioinformatic Lab School of MathematicsShandong University Department of Cardiology China-Japan Union HospitalJilin University

The coronavirus disease 2019（COVID-19） outbreak caused by the severe acute respiratory syndrome coronavirus-2（SARS-CoV-2） developed into a global health emergency. Systemic microthrombus caused by SARS-CoV-2 infection is a common complication in patients with COVID-19. Cardiac microthrombosis as a complication of SARS-CoV-2 infection is the primary cause of cardiac injury and death in patietns with severe COVID-19. In this study, we performed single-cell sequencing analysis of the right ventricular free wall tissue from healthy donors,patients who died during the hypercoagulable period of characteristic coagulation abnormality（CAC）, and patients who died during the fibrinolytic period of CAC. We collected 61,187 cells enriched in 24 immune cell subsets and 13 cardiac-resident cell subsets. We found that in the course of SARS-CoV-2 infected heart microthrombus, MYO1EhighRASGEF1Bhighmonocyte-derived macrophages promoted hyperactivation of the immune system and initiated the extrinsic coagulation pathway by activating chemokines CCL3, CCL5. This series of events is the main cause of cardiac microthrombi following SARS-CoV-2 infection. In a SARS-CoV-2 infected heart microthrombus, excessive immune activation is accompanied by an increase in cellular iron content, which in turn promotes oxidative stress and intensifies intercellular competition. This induces cells to alter their metabolic environment, resulting in increased sugar uptake via the glycosaminoglycan synthesis pathway. In addition, high levels of reactive oxygen species generated by elevated iron levels promote increased endogenous malondialdehyde synthesis in a subpopulation of cardiac endothelial cells. This exacerbates endothelial cell dysfunction and exacerbates the coagulopathy process.

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Regression Analysis of Interval-Censored Data with Informative Observation Times Under the Accelerated Failure Time Model

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Journal of Systems Science & Complexity 2022年第4期35卷 1520-1534页

作者： zhao shishun DONG Lijian SUN Jianguo Center for Applied Statistical Research School of MathematicsJilin UniversityChangchun130012China Department of Statistics University of MissouriColumbiaMO65211USA

This paper discusses regression analysis of interval-censored failure time data arising from the accelerated failure time model in the presence of informative *** the problem,a sieve maximum likelihood estimation approach is proposed and in the method,the copula model is employed to describe the relationship between the failure time of interest and the censoring or observation *** I-spline functions are used to approximate the unknown functions in the model,and a simulation study is carried out to assess the finite sample performance of the proposed approach and suggests that it works well in practical *** addition,an illustrative example is provided.

关键词： Accelerated failure time model copula models informative censoring interval-censored data splines

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Regression Analysis of Misclassified Current Status Data with Informative Observation Times

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Journal of Systems Science & Complexity 2023年第3期36卷 1250-1264页

作者： WANG Wenshan XU Da zhao shishun SUN Jianguo Center for Applied Statistical Research School of MathematicsJilin UniversityChangchun 130012China Key Laboratory of Applied Statistics of MOE and School of Mathematics and Statistics Northeast Normal UniversityChangchun 130024China Department of Statistics University of MissouriColumbiaMO 65211USA

Misclassified current status data arises if each study subject can only be observed once and the observation status is determined by a diagnostic test with imperfect sensitivity and *** the situation,another issue that may occur is that the observation time may be correlated with the interested failure time,which is often referred to as informative censoring or observation *** is well-known that in the presence of informative censoring,the analysis that ignores it could yield biased or even misleading *** this paper,the authors consider such data and propose a frailty-based inference *** particular,an EM algorithm based on Poisson latent variables is developed and the asymptotic properties of the resulting estimators are *** numerical results show that the proposed method works well in practice and an application to a set of real data is provided.

关键词： Current status data EM algorithm informative censoring misclassification proportional hazard model

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A Simulation-Extrapolation Approach to the Analysis of Interval-Censored Failure Time Data with Mis-Measured Covariates

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Journal of Systems Science & Complexity 2024年第6期37卷 2721-2737页

作者： FENG Fan zhao shishun LI Shuwei SUN Jianguo School of Economics and Statistics Guangzhou UniversityGuangzhou 510006China School of Mathematics Jilin UniversityChangchun 130021China Department of Statistics University of MissouriMO 6521lUSA

Interval-censored failure time data arise frequently in periodical follow-up studies including clinical trials and epidemiological *** addition,some covariates may be subject to measurement errors due to the instrumental contamination,biological variation or other *** the analysis of interval-censored data with mis-measured covariates,the existing methods either assume a parametric model or rely on the availability of replicated surrogate measurements for the error-prone covariate,which both have obvious *** overcome these shortcomings,the authors propose a simulation-extrapolation estimation procedure under a general class of transformation *** resulting estimators are shown to be consistent and asymptotically *** numerical results obtained from a simulation study indicate that the proposed method performs reasonably well in *** particular,the proposed method can reduce the estimation bias given by the naive method that does not take measurement errors into ***,the proposed method is applied to a real data set on hypobaric decompression sickness.

关键词： Interval censoring measurement error regression analysis semiparametric model SIMEX

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Recent development of E-field control of interfacial magnetism in multiferroic heterostructures

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Nano Research 2023年第4期16卷 5983-6000页

作者： Yuxin Cheng shishun zhao Ziyao Zhou Ming Liu The Electronic Materials Research Laboratory Key Laboratory of the Ministry of Education&International Center for Dielectric ResearchSchool of Electronic Science and EngineeringState Key Laboratory for Mechanical Behavior of Materialsthe International Joint Laboratory for Micro/Nano Manufacturing and Measurement TechnologyXi'an Jiaotong UniversityXi'an 710049China

The full E-field control of multiferroic interfacial magnetism is a long-standing challenge for micro-electromechanical systems(MEMS)and has the potential to transform electronics operation *** scaling down conventional complementary metal-oxide semiconductor(CMOS)devices,increased heating dissipation becomes a top *** the highly correlated ferroic orders,notably the strongly coupled interfacial magnetoelectric(ME)interactions,may lead to devices beyond *** devices use the electric field to regulate magnetization,which opens up the prospect of downsizing,improved performance,and lower power *** broadly survey this tremendous scope within the last five years,this review summarizes advances in voltage control of interfacial magnetism(VCIM)with various material system selection;controlling effects with different gating methods are also *** classic mechanisms are demonstrated:strain,exchange bias,orbital reconstruction,and the electrostatic and *** encouraging photovoltaic approach is also *** method’s capabilities and application scenarios are *** of the comprehensive gating results of different magnetic coupling effects such as perpendicular magnetic anisotropy(PMA)and Ruderman-Kittel-Kasuya-Yosida(RKKY)are additionally *** last,controlling of skyrmions and two-dimensional(2D)material magnetization is summarized,indicating that E-field gating offers a universal approach with few limitations for material *** results point to potential for E-field control interfacial magnetism and predict significant future advancements for spintronics.

关键词： multiferroic magnetoelectric coupling strain charge photovoltaic

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Regression Analysis of Dependent Current Status Data with Left-Truncation Under Linear Transformation Model

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Journal of Systems Science & Complexity 2024年

作者： ZHANG Mengyue zhao shishun XU Da HU Tao SUN Jianguo Center for Applied Statistical Research School of Mathematics Jilin University Key Laboratory of Applied Statistics of MOE and School of Mathematics and Statistics Northeast Normal University School of Mathematical Sciences Capital Normal University Department of Statistics University of MissouriColumbia

The paper discusses the regression analysis of current status data, which is common in various fields such as tumorigenic research and demographic studies. Analyzing this type of data poses a significant challenge and has recently gained considerable interest. Furthermore, the authors consider an even more difficult scenario where, apart from censoring, one also faces left-truncation and informative censoring, meaning that there is a potential correlation between the examination time and the failure time of interest. The authors propose a sieve maximum likelihood estimation (MLE) method and in the proposed method for inference, a copula-based procedure is applied to depict the informative censoring. Also the authors utilise the splines to estimate the unknown nonparametric functions in the model, and the asymptotic properties of the proposed estimator are established. The simulation results indicate that the developed approach is effective in practice, and it has been successfully applied a set of real data.

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平衡损失函数下几乎无偏估计的统计性质

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吉林大学学报（理学版） 2018年第4期56卷 871-876页

作者：王文钐赵世舜吉林大学数学学院长春130012

在平衡损失函数下,讨论线性回归模型中几乎无偏Liu估计与几乎无偏Stein岭型主成分估计的统计性质.分别给出几乎无偏Liu估计与几乎无偏Stein岭型主成分估计在平衡损失函数下的风险,并在不同条件下讨论这两种风险的关系.

关键词：线性模型几乎无偏Liu估计几乎无偏Stein岭型主成分估计平衡损失函数

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相依序列加权和的几乎处处中心极限定理

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数学物理学报（A辑） 2009年第6期29卷 1487-1491页

作者：张勇董志山赵世舜吉林大学数学研究所(前卫南区) 长春130012

该文讨论了非平稳负(正)相依序列加权和的几乎处处中心极限定理,改进并推广了相依序列几乎处处中心极限定理的相关结果.

关键词：几乎处处中心极限定理加权和负(正)相依

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线性过程的强逼近和重对数律

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应用概率统计 2008年第3期24卷 225-239页

作者：谭希丽赵世舜杨晓云北华大学数学学院吉林132013 吉林大学(前卫校区)数学研究所长春130012

本文讨论由独立同分布随机变量列产生的线性过程的泛函型重对数律和强逼近,同时又给出由NA随机变量列产生的线性过程的重对数律.

关键词：线性过程泛函型重对数律强逼近重对数律

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健康中国背景下西藏自治区小学“立体循环式大课间”模式构建与实践

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科学咨询(教育科研) 2024年第6期 264-267页

作者：赵士顺西藏职业技术学院

在广泛开展“全国亿万学生阳光体育运动”的活动之际，西藏自治区各小学根据国家相关要求开展大课间体育活动，但开展情况却不容乐观，普遍存在学生多、师资少、活动场地受限等问题。本文采用文献资料法、问卷调查法、数据统计法、逻辑... 详细信息

在广泛开展“全国亿万学生阳光体育运动”的活动之际，西藏自治区各小学根据国家相关要求开展大课间体育活动，但开展情况却不容乐观，普遍存在学生多、师资少、活动场地受限等问题。本文采用文献资料法、问卷调查法、数据统计法、逻辑分析法调查分析西藏自治区的部分小学大课间活动现状、存在问题及影响因素，提出“小场地立体循环式”建议，从场地、人员、内容、游戏、自编操、循环跑等方面丰富大课间的内容，为相关教育管理部门制定政策提供理论和实践参考，促进阳光体育运动的横纵向发展。

关键词：阳光体育运动小场地立体循环式大课间

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