检索结果-南通市图书馆

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

陈峰落马海航进入下一阶段

商业周刊（中文版） 2021年第18期 10-12页

作者： shirley zhao 邵璐宁(译) 简远(译) 不详

陈峰导演的400亿美元的全球资产并购盛宴,如今破产重组不到10年前,陈峰还处在人生巅峰,以征服世界为使命,似乎势不可挡。1993年,陈峰与合作伙伴王健(已故)参与创建了海南航空公司,也就是海航集团这个庞大商业帝国的前身。此后,海航集团... 详细信息

陈峰导演的400亿美元的全球资产并购盛宴,如今破产重组不到10年前,陈峰还处在人生巅峰,以征服世界为使命,似乎势不可挡。1993年,陈峰与合作伙伴王健(已故)参与创建了海南航空公司,也就是海航集团这个庞大商业帝国的前身。此后,海航集团逐渐成为争相收购欧美标志性资产的中资企业典型代表。

关键词：陈峰破产重组中资企业资产并购王健海航集团海南航空公司合作伙伴

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

5G商用正探路全球6G研发战已开启

商业周刊（中文版） 2021年第4期 44-45页

作者： Mark Gurman shirley zhao Scott Moritz Thomas Seal 不详

2020年10月中旬才推出首款5G手机的苹果公司现在正着手.于6G开发工作,表明该公司希望成为该技术的领导者,而不是依赖其他企业。苹果在2021年2月中旬发布了招聘广告,为当前和下一代的网络寻求无线系统研发工程师。工作地点为苹果在硅谷... 详细信息

2020年10月中旬才推出首款5G手机的苹果公司现在正着手.于6G开发工作,表明该公司希望成为该技术的领导者,而不是依赖其他企业。苹果在2021年2月中旬发布了招聘广告,为当前和下一代的网络寻求无线系统研发工程师。工作地点为苹果在硅谷和圣迭戈的办公室,苹果正在当地进行无线技术开发和芯片设计。

关键词：招聘广告苹果公司无线系统圣迭戈技术开发研发工程师芯片设计

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

借力韩剧和免费订阅李嘉诚次子成功阻击奈飞

商业周刊（中文版） 2021年第15期 19-19页

作者： shirley zhao 不详

李泽楷旗下平台Viu是东南亚第二大流媒体服务商,仅次于Disney Plu香港超级富豪李嘉诚的次子李泽楷的流媒体业务现在如曰中天,其平台Viu在亚洲竞争最激烈的市场之一的订户数超过了Netflix(奈飞),并且可能进行首次公开募股(IPO)。彭博新闻... 详细信息

李泽楷旗下平台Viu是东南亚第二大流媒体服务商,仅次于Disney Plu香港超级富豪李嘉诚的次子李泽楷的流媒体业务现在如曰中天,其平台Viu在亚洲竞争最激烈的市场之一的订户数超过了Netflix(奈飞),并且可能进行首次公开募股(IPO)。彭博新闻社2021年8月17曰报道称,根据研究公司Media Partners Asia,按付费用户计,Viu目前是东南亚第二大流媒体服务商。

关键词：超级富豪彭博新闻社流媒体服务李嘉诚韩剧东南亚

一种基于Kalman滤波和能量原理的实时损伤识别方法(英文)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2015年第2期16卷 105-116页

作者： Xing-huai HUANG shirley DYKE zhao-dong XU Key Laboratory of C&PC Structures of the Ministry of Education Southeast University School of Civil Engineering Purdue University

目的:建立一种损伤识别方法,能够实时地监测多自由度复杂结构中构件的损伤情况。方法:1.用能量原理对结构刚度进行解构,建立结构单元刚度和节点响应之间的关系;2.用Kalman滤波原理分析结构刚度的预测值和测量值,迅速对结构的刚度进行识... 详细信息

目的:建立一种损伤识别方法,能够实时地监测多自由度复杂结构中构件的损伤情况。方法:1.用能量原理对结构刚度进行解构,建立结构单元刚度和节点响应之间的关系;2.用Kalman滤波原理分析结构刚度的预测值和测量值,迅速对结构的刚度进行识别(图6–9);3.对每一步计算进行耗时监测,确保算法的实时性(图10)。结论:1.该方法能够较准确地得到结构的刚度信息,同时得出损伤单元的损伤位置和损伤量;并且收敛速度快,计算量小,具有很强的实时性和抗噪能力;2.对于本文的桁架结构,所有杆件刚度均能在0.4 s内收敛,平均每一荷载步计算时间约为0.0012 s,小于采样周期1/256 s,说明该方法可以迅速、准确地对结构进行实时的监测。

关键词：实时模型修正能量平衡原理 Kalman滤波原理损伤识别健康监测

Genome-Wide Analysis of Histone Modifications： H3K4me2, H3K4me3, H3K9ac, and H3K27ac in Oryza sativa L. Japonica

在线全文

学校读者我要写书评

暂无评论

Molecular Plant 2013年第5期6卷 1463-1472页

作者： Zhou Du Hui Li Qiang Wei Xin zhao Chunchao Wang Qilin Zhu Xin Yi Wenying Xua X. shirley Liu Weiwei Jin Zhen Su State Key Laboratory of Plant Physiology and Biochemistry College of Biological Sciences China Agricultural University Beijing 100193 China National Maize Improvement Center of China Key Laboratory of Biology and Genetic Improvement of Maize Ministry of Agriculture China Agricultura University Beijing 100193 China Department of Biostatistics and Computational Biology Dana-Farber Cancer Institute and Harvard School of Public Health 450 Brookline Ave Boston MA 02215 USA These authors contributed equally to the article. Present address: Department of Bioinformatics School of Life Sciences andTechnology Tongji University 1239 Siping Road Shanghai 200092 China

While previous studies have shown that histone modifications could influence plant growth and devel- opment by regulating gene transcription, knowledge about the relationships between these modifications and gene expression is still limited. This study used chromatin immunoprecipitation followed by high-throughput sequencing （ChlP-Seq）, to investigate the genome-wide distribution of four histone modifications： di and trimethylation of H3K4 （H3K4me2 and H3K4me3） and acylation of H3K9 and H3K27 （H3K9ac and H3K27ac） in Oryza sativa L. japonica. By analyz- ing published DNase-Seq data, this study explored DNase-Hypersensitive （DH） sites along the rice genome. The histone marks appeared mainly in generic regions and were enriched around the transcription start sites （TSSs） of genes. This analysis demonstrated that the four histone modifications and the DH sites were all associated with active transcription. Furthermore, the four histone modifications were highly concurrent with transcript regions-a promising feature that was used to predict missing genes in the rice gene annotation. The predictions were further validated by experimentally confirming the transcription of two predicted missing genes. Moreover, a sequence motif analysis was constructed in order to identify the DH sites and many putative transcription factor binding sites.

关键词： bioinformatics chromatin structure and remodeling epigenetics gene regulation genomics rice.

Superior growth performance in broiler chicks fed chelated compared to inorganic zinc in presence of elevated dietary copper

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Animal Science and Biotechnology 2016年第4期7卷 561-569页

作者： Junmei zhao Robert B. shirley Julia J. Dibner Karen J. Wedekind Frances Yan Paula Fisher Thomas R. Hampton Joseph L. Evans Mercedes Vazquez-Anon research and development novus international20 Research Park DriveSaint CharlesMO 63304USA current affiliation:poultry technical services adisseo usaAlpharettaGA 30022USA

Background： The goal of this study was to compare the antagonism of elevated dietary Cu （250 mg/kg） from CuS04 on three different Zn sources （ZnS04. H20; [Zn bis（-2-hydroxy-4-（methylthio）butanoic acid）], Zn（HMTBa）2 a chelated Zn methionine hydroxy analogue; and Zn-Methionine）, as measured using multiple indices of animal performance in ROSS 308 broilers. Methods： Three experiments were conducted in broiler chicks fed a semi-purified diet. All birds were fed a Zn-deficient diet （8.5 mg/kg diet） for 1 wk, and then provided with the experimental diets for 2 wks. Results： Experiment 1 was a 2 x 2 factorial design with two levels of Cu （8 vs. 250 mg/kg diet from CuSO4） and two Zn sources at 30 mg/kg [ZnSO4. H20 vs. Zn（HMTBa）2]. Elevated Cu impaired growth performance only in birds fed ZnSO4. Compared to ZnSO4. H20, Zn（HMTBa）2 improved feed intake （12 %; P 〈 0.001） and weight gain （12 %, P 〈 0.001） and the benefits were more pronounced in the presence of 250 mg/kg diet Cu. Experiment 2 was a dose titration of ZnSO4- H20 and Zn（HMTBa）2 at 30, 4,5, 60, and 75 mg/kg diet in the presence of 250 mg/kg CuSO4. Feed：gain was decreased and tibia Zn was increased with increasing Zn levels from 30 to 75 mg/kg. Birds fed Zn（HMTBa）2 consumed more food and gained more weight compared to birds fed ZnSO4, especially at lower supplementation levels （30 and 45 mg/kg; interaction P 〈 0,05）. Experiment 3 compared two organic Zn sources （Zn（HMTBa）2 vs. Zn-Methionine） at 30 mg/kg with or without 250 mg/kg CuSO4. No interactions were observed between Zn sources and Cu levels on performance or tissue mineral concentrations. High dietary Cu decreased weight gain （P 〈 0.01）. Tibia Cu and liver Cu were significantly increased with 250 mg/kg dietary Cu supplementation （P 〈 0.01）. No difference was observed between the two Zn sources. Conclusions： Dietary 250 mg/kg Cu significantly impaired feed intake and weight gain in birds fed ZnSO4. H20, but had less impact in birds fed Zn（HMTBa）2. No difference

关键词： Antagonism Broilers Chelates Growth MineraLs Organic Performance

在线全文

学校读者我要写书评

暂无评论

基于应变监测的连续梁支承差异沉降识别

吉林大学学报（工学版） 2016年第4期46卷 1090-1096页

作者：王少杰徐赵东李舒王凯洋 Dyke shirley J 东南大学混凝土及预应力混凝土结构教育部重点实验室南京210096 普渡大学土木工程学院美国西拉斐特47907 南京东瑞减震控制科技有限公司南京210033

首先,运用基本力学原理,以三跨相等连续梁为对象,推导了梁体应变改变量与支承差异沉降量之间的解析式;并以某刚性轻轨桥为例,证明了微小支承差异沉降导致的应变改变量是可测的。其次,通过三跨不等连续梁模型试验,采用顶升方法模拟差异沉... 详细信息

首先,运用基本力学原理,以三跨相等连续梁为对象,推导了梁体应变改变量与支承差异沉降量之间的解析式;并以某刚性轻轨桥为例,证明了微小支承差异沉降导致的应变改变量是可测的。其次,通过三跨不等连续梁模型试验,采用顶升方法模拟差异沉降,深入分析了梁底应变改变量与顶升量之间的关系,同时验证了FBG新型传感器的优越性能。再次,推导了与试验模型对应的梁底应变改变量与桥墩差异沉降之间的关系式,对两种模式(边墩顶升、中墩顶升)在不同差异沉降下的理论解与试验测试结果进行比较分析,结果表明二者吻合程度较高。最后,对识别基本流程与策略作了简要叙述。

关键词：结构工程应变差异沉降连续梁模型试验

Computational inference of mRNA stability from histone modification and transcriptome profiles

在线全文

学校读者我要写书评

暂无评论

Computational inference of mRNA stability from histone modif...

第五届全国生物信息学与系统生物学学术大会暨国际生物信息学前沿研讨会高通量时代的生物信息学与系统生物学

作者： Chengyang Wang Rui Tian Qian zhao Han Xu Clifford A.Meyer Cheng Li Yong Zhang Xiaole shirley Liu Department of Bioinformatics School of Life Science and TechnologyTongji University Department of Biostatistics and Computational Biology Dana-Farber Cancer InstituteHarvard school of Public Health450 Brookline AveBostonMA02215USA

Histone modifications play important roles in regulating eukaryotic gene expression and have been used to model expression ***,we present a regression model to systematically infer mRNA stability by comparing transcriptome profiles with ChlP-seq of H3K4me3,H3K27me3 and *** results from multiple human and mouse cell lines show that the inferred unstable mRNAs have significantly longer 3’Untranslated Regions (UTRs) and more microRNA binding sites within 3’UTR than the inferred stable mRNAs. Regression residuals derived from RNA-seq,but not from GRO-seq,are highly correlated with the half-lives measured by pulse-labeling experiments,supporting the rationale of our ***,the functions enriched in the inferred stable and unstable mRNAs are consistent with those from pulse-labeling experiments,we found the unstable mRNAs have higher cell-type specificity under functional *** conclude that the systematical use of histone modifications can differentiate non-expressed mRNAs from unstable mRNAs. In summary,we represent the first computational model of mRNA stability inference that compares transcriptome and epigenome profiles,and provides an alternative strategy for directing experimental measurements. Background:Histone modifications are predictive of gene expression in multiple cell lines,so it may reflect steady-state transcription ***,the expression index, measured by either microarray or RNA-seq,represents the balance between transcript production and *** study is aimed to illuminate the biological meaning of the difference between mRNA level and histone modifications level. Methods:Using the information from histone modifications-H3K4me3,H3K27me3 and H3K36me3,we derive regression model to fit mRNA level in multiple cell *** mRNAs, whose expression levels(true values) are significantly lower than histone modifications level (prediction value),are inferred as unstable mRNAs(faster degraded),and vice versa.

关键词： Histone modification mRNA level mRNA stability

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

活性污泥合成聚羟基烷酸酯中单体组分的调控

化工学报 2007年第10期58卷 2427-2431页

作者：蔡萌萌蔡宏单羿王玉洁何丹赵庆良哈尔滨工业大学市政环境工程学院黑龙江哈尔滨150090 香港理工大学土木与结构工程系

聚羟基烷酸酯(PHAs)是一类生物合成的环境友好高分子塑料,具有广泛应用前景。活性污泥合成PHAs可降低PHAs生产成本,实现废物资源化。PHAs的物化性质取决于其单体组分的结构和含量。基于优化PHAs产量的工艺研究,总结了调控活性污泥合成... 详细信息

聚羟基烷酸酯(PHAs)是一类生物合成的环境友好高分子塑料,具有广泛应用前景。活性污泥合成PHAs可降低PHAs生产成本,实现废物资源化。PHAs的物化性质取决于其单体组分的结构和含量。基于优化PHAs产量的工艺研究,总结了调控活性污泥合成的聚羟基丁酸-羟基戊酸(PHBV)中羟基戊酰含量的工艺措施和生化原理。已有研究表明,好氧时,碳源类型决定PHBV中的单体组分;一般地,溶解氧浓度(DO)降低,PHBV中HV含量会增加;污泥来源、pH值以及碳源与氮磷浓度比的变化都会影响HV含量;各参数对PHAs组分的影响存在关联性。展望了调控活性污泥合成PHAs中单体组分的进一步研究方向。

关键词：活性污泥聚羟基烷酸酯工艺条件控制代谢途径聚合物组分