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Large non-pedunculated colorectal polyp management: The elephant in the room

World Journal of Gastroenterology 2024年第25期30卷 3126-3131页

作者： shirley x jiang Neal Shahidi Department of Medicine University of British ColumbiaVancouver V6Z 2K5BCCanada

Minimally invasive innovations have transformed *** to colorectal cancer(CRC),there has been a shift towards less invasive surgical techniques and use of endoscopic resection as an alternative for low risk T1 *** role of endoscopic resection is however much more extensive:It is now considered the first line management strategy for most large(≥20 mm)non-pedunculated colorectal polyps,the majority of which are *** is due to the well-established efficacy,safety,and cost-effectiveness of endoscopic techniques compared to *** endoscopic modalities now exist with distinct risk-benefit profiles and their outcomes are further improved by site-specific technical modifications,auxiliary techniques,and adverse event miti-gation *** capacity continues to evolve with emerging endoscopic techniques and expanding applications,particularly in the confines of a multi-disciplinary setting.

关键词： Cancer Colonoscopy Endoscopy Polyp Endoscopic mucosal resection Endoscopic submucosal dissection

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T1 colorectal cancer management in the era of minimally invasive endoscopic resection

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2284-2294页

作者： shirley xue jiang Aein Zarrin Neal Shahidi Department of Medicine University of British ColumbiaVancouver V6Z2K5British ColumbiaCanada Division of Gastroenterology St.Paul’s HospitalVancouver V6Z2K5British ColumbiaCanada

T1 colorectal cancer(CRC),defined by tumor invasion confined to the submucosa,has historically been managed by *** understanding of recurrence and lymph node metastases risk,coupled with advances in endoscopic resection techniques,have led to an increasing capacity for organ-sparing local *** invasive management of T1 CRC begins with optical evaluation of the lesion to diagnose invasive disease and quantify depth of invasion,which informs therapeutic decision *** selection between various available endoscopic resection techniques depends upon lesion characteristics,technique risk-benefit profiles,and location-specific *** endoscopic resection,established histopathology features determine the risk of recurrence and subsequent management including surveillance or adjuvant surgical *** management of non-operative candidates deviates from conventional recommendations with emerging treatment strategies in select populations.

关键词： Cancer Colonoscopy Endoscopy Polyp Surgery

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CRISPR Screens Identify Essential Cell Growth Mediators in BRAF Inhibitor-resistant Melanoma

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Genomics, Proteomics & Bioinformatics 2020年第1期18卷 26-40页

作者： Ziyi Li Binbin Wang Shengqing Gu Peng jiang Avinash Sahu Chen-Hao Chen Tong Han Sailing Shi xiaoqing Wang Nicole Traugh Hailing Liu Yin Liu Qiu Wu Myles Brown Tengfei xiao Genevieve M.Boland x.shirley Liu Clinical Translational Research Center Shanghai Pulmonary HospitalSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China Department of Medical Oncology Dana-Farber Cancer Institute and Harvard Medical SchoolBostonMA 02215USA Department of Data Sciences Dana-Farber Cancer InstituteHarvard T.H.Chan School of Public HealthBostonMA 02115USA Department of Clinical Laboratory Shanghai Pulmonary HospitalTongji University School of MedicineShanghai 200433China Center for Functional Cancer Epigenetics Dana-Farber Cancer InstituteBostonMA 02115USA Center for Cancer Research Massachusetts General HospitalHarvard Medical SchoolBostonMA 02114USA Department of Surgery Massachusetts General HospitalHarvard Medical SchoolBostonMA 02114USA

BRAF is a serine/threonine kinase that harbors activating mutations in^7%of human malignancies and^60%of *** initial clinical responses to BRAF inhibitors,patients frequently develop drug *** identify candidate therapeutic targets for BRAF inhibitor resistant melanoma,we conduct CRISPR screens in melanoma cells harboring an activating BRAF mutation that had also acquired resistance to BRAF *** investigate the mechanisms and pathways enabling resistance to BRAF inhibitors in melanomas,we integrate expression,ATAC-seq,and CRISPR screen *** identify the JUN family transcription factors and the ETS family transcription factor ETV5 as key regulators of CDK6,which together enable resistance to BRAF inhibitors in melanoma *** findings reveal genes contributing to resistance to a selective BRAF inhibitor PLx4720,providing new insights into gene regulation in BRAF inhibitor resistant melanoma cells.

关键词： Drug resistance CRISPR screen Melanoma BRAF inhibitor Gene regulation

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