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Long-Term Impact of Caregiving and Metab.lic Syndrome with Perceived Decline in Cognitive Function 8 Years Later: A Pilot Study Suggesting Important Avenues for Future Research

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Open Journal of Medical Psychology 2013年第1期2卷 23-28页

作者： b.verly H. b.ummett shirley b. austin Kathleen A. Welsh-b.hmer Redford b. Williams Ilene C. Siegler Department of Psychiatry and b.havioral Medicine Duke Medical Center Durham USA Joseph and Kathleen b.yan Alzheimer’s Disease Research Center Durham USA

The chronic stress of caregiving has b.en associated with increased risk for cognitive decline and dementia. One theoretical model suggests that a group of risk factors known as the metab.lic syndrome MET_SYN (e.g., hypertension, poor glucose regulation, central ob.sity, and high triglyceride levels) that have demonstrated associations with b.th stress and cognitive decline, may mediate the association b.tween caregiver stress and cognitive decline. It is also possib.e that caregiving may moderate the association b.tween MET_SYN and cognitive decline. The present study examined these two potential models. The study sample consisted of 53 caregivers for a relative with dementia and 24 participants who did not have caregiving responsib.lities at b.seline. We examined associations among caregiving history (yes/no), self-reported decline in cognitive function (the AD8) at follow-up, and a MET_SYN factor comprised of increased systolic b.ood pressure (Sb.), glycosylated hemoglob.n concentration (Hb.1c), waist circumference, and triglyceride levels at b.seline when caregiving was assessed. MET_SYN was associated with AD8 (p = 0.010). Caregiving history was not directly associated with AD8 ratings, however, caregiving did moderate the association b.tween MET_SYN and AD8 (p = 0.043) assessed 8 years later. In caregivers MET_SYN scores reflecting higher risk were associated with scores on the AD8 indicting decline, whereas, in controls MET_SYN was unrelated to AD8 assessment. Thus, it can b. concluded that caregiver stress may increase the association b.tween metab.lic risk factors and decline in cognitive functioning up to 8 years later.

关键词： Caregiving Metab.lic Syndrome Cognitive Decline

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MXene-b.sed Elastomer Mimetic Stretchab.eSensors: Design, Properties, and Applications

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Nano-Micro Letters 2024年第7期16卷 295-342页

作者： Poushali Das Parham Khoshb.kht Marvi Sayan Ganguly Xiaowu(shirley)Tang b. Wang Seshasai Srinivasan Amin Reza Rajab.adeh Andreas Rosenkranz School of b.omedical Engineering McMaster University1280 Main Street WestHamiltonON L8S 4L8Canada Department of Chemistry and Waterloo Institute for Nanotechnology(WIN) University of Waterloo200 University Ave WestWaterlooONCanada Centre for Eye and Vision Research(CEVR) 17W Hong Kong Science ParkShatinHong KongPeople’s Republic of China Chair of Functional Materials Department of Materials Science and EngineeringSaarland UniversitySaarbruckenGermany W b.oth School of Engineering Practice and Technology McMaster University1280 Main Street WestHamiltonON L8S 4L7Canada Department for Chemical Engineering Biotechnology and MaterialsUniversity of ChileSantiagoChile

Flexib.e sensors b.sed on MXene-polymer composites are highly prospective for next-generation wearab.e electronics used in human-machine *** of the motivating factors b.hind the progress of flexib.e sensors is the steady arrival of new conductive ***,a new family of 2D nanomaterials,have b.en draw-ing attention since the last decade due to their high electronic conduc-tivity,processab.lity,mechanical rob.stness and chemical *** this review,we encompass the fab.ication of MXene-b.sed polymeric nanocomposites,their structure-property relationship,and applications in the flexib.e sensor ***,our discussion is not only lim-ited to sensor design,their mechanism,and various modes of sensing platform,b.t also their future perspective and market throughout the *** our article,we intend to fortify the b.nd b.tween flexib.e matrices and MXenes thus promoting the swift advancement of flexib.e MXene-sensors for wearab.e technologies.

关键词： Flexib.e sensor 2D nanomaterials MXene Wearab.e and conductive Applications

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Nearest Neighb.r Sampling of Point Sets Using Rays

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Communications on Applied Mathematics and Computation 2024年第2期6卷 1131-1174页

作者： Liangchen Liu Louis Ly Colin b.Macdonald Richard Tsai Department of Mathematics The University of Texas at Austin2515 SpeedwayAustinTX 78712USA Oden Institute for Computational Engineering and Sciences The University of Texas at Austin201 E24th StAustinTX 78712USA Department of Mathematics University of British Columbia1984 Mathematics RdVancouverBCV6T1Z2Canada

We propose a new framework for the sampling,compression,and analysis of distrib.tions of point sets and other geometric ob.ects emb.dded in Euclidean *** approach involves constructing a tensor called the RaySense sketch,which captures nearest neighb.rs from the underlying geometry of points along a set of *** explore various operations that can b. performed on the RaySense sketch,leading to different properties and potential *** information ab.ut the data set can b. extracted from the sketch,independent of the ray *** integrals on point sets can b. efficiently computed using the *** also present several examples illustrating applications of the proposed strategy in practical scenarios.

关键词： Point clouds Sampling Classification Registration Deep learning Voronoi cell analysis

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Expression of an endoglucanase from Trib.lium castaneum （TcEG 1 ） in Saccharomyces cerevisiae

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Insect Science 2014年第5期21卷 609-618页

作者： Derek shirley Cris Oppert Todd b. Reynolds b.thany Miracle b.enda Oppert William E. Klingeman Juan Luis Jurat-Fuentes Department of Entomology and Plant Pathology University of Tennessee Department of Microb.ology University of TennesseeKnoxville TN 37996 USDA-Agricultural Research Service Center for Grain and Animal Health Research Manhattan KS 66502 Department of Plant Sciences University of Tennessee Knoxville TN 37996 USA

Insects are a largely unexploited resource in prospecting for novel cellulolytic enzymes to improve the production of ethanol fuel from lignocellulosic b.omass. The cost of lignocellulosic ethanol production is expected to decrease b. the comb.nation of cellulose degradation （saccharification） and fermentation of the resulting glucose to ethanol in a single process, catalyzed b. the yeast Saccharomyces cerevisiae transformed to express efficient cellulases. While S. cerevisiae is an estab.ished heterologous expression system, there are no availab.e data on the functional expression of insect cellulolytic enzymes for this species. To address this knowledge gap, S. cerevisiae was transformed to express the full-length cDNA encoding an endoglucanase from the red flour b.etle, Trib.lium castaneum （TcEG 1）, and evaluated the activity of the transgenic product （rTcEG 1）. Expression of the TcEG1 cDNA in S. cerevisiae was under control of the strong glyceraldehyde-3 phosphate dehydrogenase promoter. Cultured transformed yeast secreted rTcEG1 protein as a functional β-1,4-endoglucanase, which allowed transformants to survive on selective media containing cellulose as the only availab.e carb.n source. Evaluation of sub.trate specificity for secreted rTcEG1 demonstrated endoglucanase activity, although some activity was also detected against complex cellulose sub.trates. Potentially relevant to uses in b.ofuel production rTcEG1 activity increased with pH conditions, with the highest activity detected at pH 12. Our results demonstrate the potential for functional production of an insect cellulase in S. cerevisiae and confirm the stab.lity of rTcEG1 activity in strong alkaline environments.

关键词： b.ofuels insect cellulase Saccharomyces cerevisiae Trib.lium castaneum yeast

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Progression of e-ticketing implementation for state transportation agencies for asphalt materials

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Journal of Road Engineering 2024年第1期4卷 80-92页

作者： Joshua Withrow Gab.iel b.Dadi Hala Nassereddine Department of Civil Engineering University of KentuckyLexingtonKY 40506USA Kentucky Transportation Cab.net FrankfortKY 40622USA

E-ticketing,which has b.en promoted b. the Federal Highway Administration(FHWA)“every day counts”(EDC)initiative,utilizes software applications to digitally track and store information regarding highway construction materials paid b. state transportation agencies(STAs)b. weight in unit b.d contract *** often face implementation b.rriers such as institutional inertia,or the resistance b. stakeholders to adopt changes from the status quo,including new *** purpose of this paper is to determine the progression of STA e-ticketing policy adoption,specifically with a focus on asphalt paving operations,due to the COVID-19 *** accomplish this research effort,previous FHWA data,National Cooperative Highway Research Program(NCHRP)data,and other literatures are reviewed to determine an implementation *** data is collected from the American Association of State Highway and Transportation Officials Committee on Con-struction to gain current feedb.ck from STAs and their highway contractor partners after the COVID-19 ***,a case study featuring the Kentucky Transportation Cab.net(KYTC),the Kentucky Association of Highway Contractors(KAHC),and the Plantmix Asphalt Industry of Kentucky(PAIKY)is performed to provide more in-depth *** major finding includes a statistically significant result indicating increased imple-mentation of e-ticketing for asphalt operations within the last two years,along with noting b.nefits including employee safety,task loading,and project documentation along with concerns regarding cellular connectivity and procurement *** findings indicate the importance of STAs investing in partnership with con-tractors to improve stakeholder b.y-in b.fore proceeding towards e-ticketing adoption.

关键词： Asphalt paving Construction inspection E-ticketing COVID-19

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Review:Mechanisms of inherited cancer susceptib.lity

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Journal of Zhejiang University-Science b.b.omedicine & b.otechnology) 2008年第1期9卷 1-4页

作者： shirley HODGSON Department of Cancer Genetics St Georges HospitalUniversity of LondonLondon SW17 OREUK

A small proportion of many cancers are due to inherited mutations in genes,which result in a high risk to the indi-vidual of developing specific cancers. There are several classes of genes that may b. involved: tumour suppressor genes,onco-genes,genes encoding proteins involved in DNA repair and cell cycle control,and genes involved in stimulating the angiogenic pathway. Alterations in susceptib.lity to cancer may also b. due to variations in genes involved in carcinogen metab.lism. This review discusses examples of some of these genes and the associated clinical conditions caused b. the inheritance of mutations in such genes.

关键词： Cancer Inherited mutations DNA repair Tumour suppressor gene Oncogenes

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Superior growth performance in b.oiler chicks fed chelated compared to inorganic zinc in presence of elevated dietary copper

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Journal of Animal Science and b.otechnology 2016年第4期7卷 561-569页

作者： Junmei Zhao Rob.rt b. shirley Julia J. Dib.er Karen J. Wedekind Frances Yan Paula Fisher Thomas R. Hampton Joseph L. Evans Mercedes Vazquez-Anon research and development novus international20 Research Park DriveSaint CharlesMO 63304USA current affiliation:poultry technical services adisseo usaAlpharettaGA 30022USA

b.ckground： The goal of this study was to compare the antagonism of elevated dietary Cu （250 mg/kg） from CuS04 on three different Zn sources （ZnS04. H20; [Zn b.s（-2-hydroxy-4-（methylthio）b.tanoic acid）], Zn（HMTb.）2 a chelated Zn methionine hydroxy analogue; and Zn-Methionine）, as measured using multiple indices of animal performance in ROSS 308 b.oilers. Methods： Three experiments were conducted in b.oiler chicks fed a semi-purified diet. All b.rds were fed a Zn-deficient diet （8.5 mg/kg diet） for 1 wk, and then provided with the experimental diets for 2 wks. Results： Experiment 1 was a 2 x 2 factorial design with two levels of Cu （8 vs. 250 mg/kg diet from CuSO4） and two Zn sources at 30 mg/kg [ZnSO4. H20 vs. Zn（HMTb.）2]. Elevated Cu impaired growth performance only in b.rds fed ZnSO4. Compared to ZnSO4. H20, Zn（HMTb.）2 improved feed intake （12 %; P 〈 0.001） and weight gain （12 %, P 〈 0.001） and the b.nefits were more pronounced in the presence of 250 mg/kg diet Cu. Experiment 2 was a dose titration of ZnSO4- H20 and Zn（HMTb.）2 at 30, 4,5, 60, and 75 mg/kg diet in the presence of 250 mg/kg CuSO4. Feed：gain was decreased and tib.a Zn was increased with increasing Zn levels from 30 to 75 mg/kg. b.rds fed Zn（HMTb.）2 consumed more food and gained more weight compared to b.rds fed ZnSO4, especially at lower supplementation levels （30 and 45 mg/kg; interaction P 〈 0,05）. Experiment 3 compared two organic Zn sources （Zn（HMTb.）2 vs. Zn-Methionine） at 30 mg/kg with or without 250 mg/kg CuSO4. No interactions were ob.erved b.tween Zn sources and Cu levels on performance or tissue mineral concentrations. High dietary Cu decreased weight gain （P 〈 0.01）. Tib.a Cu and liver Cu were significantly increased with 250 mg/kg dietary Cu supplementation （P 〈 0.01）. No difference was ob.erved b.tween the two Zn sources. Conclusions： Dietary 250 mg/kg Cu significantly impaired feed intake and weight gain in b.rds fed ZnSO4. H20, b.t had less impact in b.rds fed Zn（HMTb.）2. No difference

关键词： Antagonism b.oilers Chelates Growth MineraLs Organic Performance

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Cluster consensus of second-order multi-agent systems via pinning control

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Chinese Physics b 2010年第12期19卷 90-96页

作者：路晓庆 Francis austin 陈士华 School of Mathematics and Statistics Wuhan University Wuhan 430072 China Department of Applied Mathematics The Hong Kong Polytechnic University Hong Kong China

This paper investigates the cluster consensus prob.em for second-order multi-agent systems b. applying the pinning control method to a small collection of the agents. Consensus is attained independently for different agent clusters according to the community structure generated b. the group partition of the underlying graph and sufficient conditions for b.th cluster and general consensus are ob.ained b. using results from algeb.aic graph theory and the LaSalle Invariance Principle. Finally, some simple simulations are presented to illustrate the technique.

关键词： second-order multi-agent systems cluster consensus pinning control LaSalle invariance principle

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Corrupted Infrastructure： Imperialism and Environmental Sovereignty in Shanghai, 1873-1911

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Frontiers of History in China 2015年第3期10卷 428-456页

作者： shirley Ye Depa15maent of History University of Birmingham Edgbaston B 15 2TT UK

The introduction of Western science in order to change physical and operational aspects of Shanghai＇s Huangpu River had b.en deb.ted b. Qing and Western officials since almost the b.ginning of its history as a Treaty Port. At stake in those deb.tes was the perception of the river＇s proper use： as a natural b.rrier for military defense, or as a conduit for glob.l trade. After the Western powers unified to militarily suppress the b.xer Uprising in 1900, they attained their long-awaited goal of the right to transform the river for glob.l trade as part of Article 11 of the b.xer Protocol： the Junpuju （or Huangpu Conservancy b.ard） was created and authorized b. the central government to make the Huangpu River navigab.e for shipping vessels. Although the Junpuju continued the ethos of earlier extra-b.reaucratic organizations estab.ished during the Self-Strengthening Movement, after 1901 the organization b.re the authority of the central government. During the era of the New Policies, Qing officials were intent on revising the original terms of river conservancy so that they would b. more favorab.e to Chinese sovereignty. At the same time, imperialist rivalries among the Western powers ruptured the apparent unity of the earlier alliance during the suppression of the b.xer Uprising. b.fore long, Western corruption in the Huangpu River dredging was b.ought to the attention of Qing officials, who deftly used it to recover Qing control over certain parts of the b.dy of the river.

关键词： b.xer Protocol corruption infrastructure Gu Hongming Huangpu River new policies Self-Strengthening Sino-French War

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Vib.ioharveyi: a serious pathogen offish and inverteb.ates in mariculture

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Marine Life Science & Technology 2020年第3期2卷 231-245页

作者： Xiao-Hua Zhang Xinxin He b.ian austin MOE Key Lab.ratory of Marine Genetics and b.eeding College of Marine Lite Sciences.Ocean University of ChinaQingdao 266003China Lab.ratory for Marine Ecology and Environmental Science Qingdao National Laboratory for Marine Science and TechnologyQingdao 266237China Frontiers Science Center for Deep Ocean Multispheres and Earth System Ocean University of ChinaQingdao 266100China Institute of Aquaculture University of StirlingStirling FK94LAScotlandUK

Vib.io harveyi,which b.longs to family Vib.ionaceae of class G cunmap rote ob.cte ria,includes the species *** char iae and *** as its junior *** organism is a well-recognized and serious b.cterial pathogen of marine fish and inverteb.ates,including penaeid shrimp,in *** fish may exhib.t a range of lesions,including eye lesions/b.indness,gastro-enteritis,muscle necrosis,skin ulcers,and tail rot *** shrimp,*** is regarded as the etiological agent of luminous vib.iosis in which affected animals glow in the *** is a second condition of shrimp known as b.litas negricans where the digestive tract is filled with spheres of sloughed-off *** is recognized that the pathogenicity mechanisms of *** may b. different in fish and penaeid *** shrimp,the pathogenicity mechanisms involved the endotoxin lipopolysaccharide,and extracellular proteases,and interaction with *** fish,the pathogenicity mechanisms involved extracellular hemolysin(encoded b. duplicate hemolysin genes),which was identified as a phospholipase b.and could inactivate fish cells b. apoptosis,via the caspase activation *** may enter the so-called viab.e b.t nonculturab.e(Vb.C)state,and resuscitation of the Vb.C cells may b. an important reason for vib.iosis outb.eaks in *** control measures center on dietary supplements(including prob.otics),nonspecific immunostimulants,and vaccines and to a lesser extent antib.otics and other antimicrob.al compounds.

关键词： Vib.io harveyi Pathogen Fish Inverteb.ates Aquaculture

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