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Ferroptosis:a critical mechanism of N^(6)-methyladenosine modification involved in carcinogenesis and tumor progression

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Science China(Life Sciences) 2024年第6期67卷 1119-1132页

作者： Qingqing Wei Changning Xue Mengna Li Jianxia Wei Lemei Zheng shipeng chen Yumei Duan Hongyu Deng Faqing Tang Wei Xiong Ming Zhou NHC Key Laboratory of Carcinogenesis Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangsha 410013China Cancer Research Institute and School of Basic Medical Sciences Central South UniversityChangsha 410078China The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education Central South UniversityChangsha 410078China Hunan Key Laboratory of Oncotarget Gene Hunan Key Laboratory of Cancer MetabolismHunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangsha 410013China

Ferroptosis is an iron-dependent regulatory cell necrosis induced by iron overload and lipid *** occurs when multiple redoxactive enzymes are ectopically expressed or show abnormal ***,the precise regulation of ferroptosis-related molecules is mediated across multiple levels,including transcriptional,posttranscriptional,translational,and epigenetic levels.N^(6)-methyladenosine(m^(6)A)is a highly evolutionarily conserved epigenetic modification in *** m^(6)A modification is commonly linked to tumor proliferation,progression,and therapy resistance because it is involved in RNA metabolic ***,accumulating evidence suggests that dysregulated ferroptosis caused by the m^(6)A modification drives tumor *** this review,we summarized the roles of m^(6)A regulators in ferroptosis-mediated malignant tumor progression and outlined the m^(6)A regulatory mechanism involved in ferroptosis *** also analyzed the potential value and application strategies of targeting m^(6)A/ferroptosis pathway in the clinical diagnosis and therapy of tumors.

关键词： ferroptosis m6A modification RNA methylation m^(6)A regulator tumor progression

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基于AHK中德职教项目构建“六步三环”学习模式的实践探索

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模具制造 2024年第3期24卷 106-108页

作者：孙跃岗陈世鹏陈紫晗集美工业学校福建厦门361022

汲取学习德国双元制课程体系的优势,将德国职业标准和职业资格认证内容引入教学实际中,将课程体系进行本地化的改造提升。以专业核心课程《机电设备安装与调试》为例进行实践探索,以项目为载体、任务为驱动、工作过程为导向开展教学研究... 详细信息

汲取学习德国双元制课程体系的优势,将德国职业标准和职业资格认证内容引入教学实际中,将课程体系进行本地化的改造提升。以专业核心课程《机电设备安装与调试》为例进行实践探索,以项目为载体、任务为驱动、工作过程为导向开展教学研究,构建行动领域课程体系;依托“六步三环”组织教学,培养新时代融合性技术人才,服务本地高端制造产业。

关键词：行动领域 AHK 三教改革

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全自动家用小型山药削皮机创新设计

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南方农机 2024年第20期55卷 51-53,66页

作者：买伊纯陈世鹏刘浩陈智娟河南工学院车辆与交通工程学院河南新乡453003 甘肃农业大学财经学院甘肃兰州730070

[目的]家庭食用山药多采用手工削皮,山药中含有的皂角素及植物碱会对皮肤产生刺激,造成过敏发痒,亟需探索更高效的削皮方法。[方法]文章在长矩形固定机架的基础上增加动力源、控制装置、传动机构、固定机构、削皮机构和间歇运动机构,阐... 详细信息

[目的]家庭食用山药多采用手工削皮,山药中含有的皂角素及植物碱会对皮肤产生刺激,造成过敏发痒,亟需探索更高效的削皮方法。[方法]文章在长矩形固定机架的基础上增加动力源、控制装置、传动机构、固定机构、削皮机构和间歇运动机构,阐述了三维模型的设计参数、整体结构、工作原理及工作过程,并进行了主要结构部件的设计,以实现山药削皮的全自动化。[结果]该削皮机能够顺利完成直径在20~50 mm范围内、长度在100~350 mm范围内的山药的切削工作,能够适应市场上多数尺寸的山药,整体性能良好,削皮洁净率均在93%以上。[结论]该装置结构简单、体积小、适合于家用,还可以对芦笋等较细的根茎类食物进行削皮,从根本上实现了山药的全自动削皮和家庭厨房机械化,更广泛地提高了山药的食用价值,传承并弘扬了河南省非物质文化遗产——怀山药的文化价值。

关键词：山药削皮机家用全自动

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Formation behaviors of rod-like reactive shaped charge penetrator and their effects on damage capability

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Defence Technology（防务技术） 2024年第2期32卷 242-253页

作者： Tao Sun Haifu Wang shipeng Wang Chao Ge Die Hu Pengwan chen Yuanfeng Zheng Beijing Institute of Technology State Key Laboratory of Explosion Science and TechnologyBeijing100081China Xi'an Institute of Electromechanical Information Technology Xi'an710065China

Formation behaviors of rod-like reactive shaped charge penetrator(RRSCP)and their effects on damage capability are investigated by experiments and numerical *** pulsed X-ray technology and a spaced aluminum/steel plate with the thicknesses of 5 mm/100 mm are *** types of sphericalsegment aluminum-polytetrafluoroethylene-copper(Al-PTFE-Cu)reactive liners with Cu contents of 0%,46.6%,and 66%are fabricated and *** experimental results show that the reactive liners can form excellent rod-shaped penetrators with tail skirts under the shaped charge effect,but the tail skirts disappear over ***,rupturing damage to the aluminum plate and penetration to the steel plate are caused by the RRSCP *** simulation analysis,the RRSCP is formed by a mechanically and chemically coupled response with the reactive liner activated by shock in its outer walls and bottom and then backward overturning,forming a leading reactive penetrator and a following chemical energy *** unique formation structure determines the damage modes of the aluminum plate and the steel *** analysis indicates that the formation behaviors and damage capability of Al-PTFE-Cu RRSCP strongly depend on Cu *** increasing Cu content,the velocity,activation extent,and reaction extent of Al-PTFE-Cu RRSCP decrease,which contribute to elongation and alleviate the negative effects of chemical reactions on elongation,significantly increasing the length-diameter ratio and thus enhancing the capability of steel plate ***,the lower activation extent and energetic density will weaken the RRSCP's capability of causing rupturing damage to the aluminum plate.

关键词： Reactive materials Al-PTFE composites Reactive liner X-ray Penetration

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Key role of interferon regulatory factor 1(IRF-1)in regulating liver disease:progress and outlook

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第6期25卷 451-470页

作者： Tao chen shipeng LI Dewen DENG Weiye ZHANG Jianjun ZHANG Zhongyang SHEN First Central Clinical School Tianjin Medical UniversityTianjin 300192China Department of Organ Transplant Tianjin First Central HospitalTianjin 300192China Research Institute of Transplant Medicine Nankai UniversityTianjin 300192China Department of Hepatobiliary Surgery Henan Provincial People’s HospitalZhengzhou 450000China Key Laboratory of Organ Transplant Tianjin First Central HospitalTianjin 300192China

Interferon regulatory factor 1(IRF-1)is a member of the IRF *** is the first transcription factor to be identified that could bind to the interferon-stimulated response element(ISRE)on the target gene and displays crucial roles in the interferoninduced signals and ***-1,as an important medium,has all of the advantages of full cell cycle regulation,cell death signaling transduction,and reinforcing immune surveillance,which are well *** studies indicate that IRF-1 is of vital importance to the occurrence and evolution of multifarious liver diseases,including but not limited to inhibiting the replication of the hepatitis virus(A/B/C/E),alleviating the progression of liver fibrosis,and aggravating hepatic ischemiareperfusion injury(HIRI).The tumor suppression of IRF-1 is related to the clinical characteristics of liver cancer patients,which makes it a potential indicator for predicting the prognosis and recurrence of liver cancer;additionally,the latest studies have revealed other effects of IRF-1 such as protection against alcoholic/non-alcoholic fatty liver disease(AFLD/NAFLD),cholangiocarcinoma suppression,and uncommon traits in other liver diseases that had previously received little ***,several compounds and drugs have featured a protective function in specific liver disease models in which there is significant involvement of the IRF-1 *** this paper,we hope to propose a prospective research basis upon which to help decipher translational medicine applications of IRF-1 in liver disease treatment.

关键词： Interferon regulatory factor(IRF-1) Hepatitis virus Liver fibrosis Hepatic ischemia-reperfusion injury(HIRI) Liver cancer

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A Wind Power Prediction Framework for Distributed Power Grids

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Energy Engineering 2024年第5期121卷 1291-1307页

作者： Bin chen Ziyang Li shipeng Li Qingzhou Zhao Xingdou Liu Power Grid Design Institute Shandong Electric Power Engineering Consulting Institute Co.Ltd.Jinan250013China School of Electrical Engineering Shandong UniversityJinan250012China

To reduce carbon emissions,clean energy is being integrated into the power *** power is connected to the grid in a distributed form,but its high variability poses a challenge to grid *** article combines wind turbine monitoring data with numerical weather prediction(NWP)data to create a suitable wind power prediction framework for distributed ***,high-precision NWP of the turbine range is achieved using weather research and forecasting models(WRF),and Kriging interpolation locates predicted meteorological data at the turbine ***,a preliminary predicted power series is obtained based on the fan’s wind speed-power conversion curve,and historical power is reconstructed using variational mode decomposition(VMD)filtering to form input variables in chronological ***,input variables of a single turbine enter the temporal convolutional network(TCN)to complete initial feature extraction,and then integrate the outputs of all TCN layers using Long Short Term Memory Networks(LSTM)to obtain power prediction sequences for all turbine *** proposed method was tested on a wind farm connected to a distributed power grid,and the results showed it to be superior to existing typical methods.

关键词： Wind power prediction distributed power grid WRF mode deep learning variational mode decomposition

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Hot deformation behavior and microstructure evolution of GH3536-TiB_(2) composites fabricated by powder metallurgy

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Science China(Technological Sciences) 2024年第7期67卷 2107-2124页

作者： ZHOU shipeng WANG Shuai HUANG LuJun ZHANG Rui chen Xin MENG FanChao chen Run SUN FengBo WANG CunYu GENG Lin School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001China Waikato Centre for Advanced Materials and Manufacturing School of EngineeringUniversity of WaikatoHamilton 3240New Zealand State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin 150001China

The hot deformation behavior and microstructure evolution of GH3536-TiB2composites fabricated by powder metallurgy(PM)were examined in the temperature range of 950–1150℃ and strain rate range of 0.001–1 s^(-1). The hot compression stress-strain curves and the constitutive equation were obtained. In addition, the hot processing map was drawn, which indicated that the appropriate hot working window was 950–1050℃/0.001–0.1 s^(-1)and 1050–1100℃/0.001–0.01 s^(-1). The microstructure analysis showed that the splitting and spheroidization of M3B2led to a decrease in size and volume fraction at 950–1100℃. At 1150℃,the eutectic microstructure of M_(3)B_(2)+ γ was formed due to the dissolution of M_(3)B_(2), which caused macroscopic cracking of the deformed sample. Additionally, the deformation temperature and the strain rate had little effect on the size and volume fraction of M_(3)B_(2). Besides, discontinuous dynamic recrystallization(DDRX) and continuous dynamic recrystallization(CDRX) were found in the deformed microstructure, while the former was dominant. Within the test range of this work, the dynamic recrystallization(DRX) fraction of the deformed composites was high due to the bulging nucleation of numerous interfaces. The DRX grain size increased with increasing deformation temperature or decreasing strain rate. Texture analysis showed that the deformation texture of //compression direction RD existed in the matrix when the deformation temperature was below 1100℃, and the texture type became //RD at 1100℃. Additionally, it was also found that the //RD texture was formed in M3B2under the strain rates of 0.1 and 0.01 s^(-1).

关键词： GH3536 alloy matrix composites powder metallurgy hot deformation behavior microstructure evolution

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Building a High-Performance Graph Storage on Top of Tree-Structured Key-Value Stores

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Big Data Mining and Analytics 2024年第1期7卷 156-170页

作者： Heng Lin Zhiyong Wang shipeng Qi Xiaowei Zhu Chuntao Hong Wenguang chen Yingwei Luo School of Computer Science Peking UniversityBeijing 100871China Ant Group Beijing 100020China Department of Computer Science and Technology Tsinghua UniversityBeijing 100084China

Graph databases have gained widespread adoption in various industries and have been utilized in a range of applications,including financial risk assessment,commodity recommendation,and data lineage *** the principles and design of these databases have been the subject of some investigation,there remains a lack of comprehensive examination of aspects such as storage layout,query language,and *** present study focuses on the design and implementation of graph storage layout,with a particular emphasis on tree-structured key-value *** also examine different design choices in the graph storage layer and present our findings through the development of TuGraph,a highly efficient single-machine graph database that significantly outperforms well-known Graph DataBase Management System(GDBMS).Additionally,TuGraph demonstrates superior performance in the Linked Data Benchmark Council(LDBC)Social Network Benchmark(SNB)interactive benchmark.

关键词： graph database high-performance graph storage

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Optimized thyroid transcription factor-1 core promoter-driven microRNA-7 expression effectively inhibits the growth of human non-small-cell lung cancer cells

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2022年第11期23卷 915-930页

作者： shipeng chen Lian GUAN Xu ZHAO Jing YANG Longqing chen Mengmeng GUO Juanjuan ZHAO Chao chen Ya ZHOU Yong HAN Lin XU Special Key Laboratory of Gene Detection and Therapy&Base for Talents in Biotherapy of Guizhou Province Zunyi 563000China Department of Immunology Zunyi Medical UniversityZunyi 563000China Department of Medical Physics Zunyi Medical UniversityZunyi 563000China Department of Physiology Zunyi Medical UniversityZunyi 563000China

Targeted gene therapy has become a promising approach for lung cancer *** our previous work,we reported that the targeted expression of microRNA-7(miR-7)operated by thyroid transcription factor-1(TTF-1)promoter inhibited the growth of human lung cancer cells in vitro and in vivo;however,the intervention efficiency needed to be further *** this study,we identified the core promoter of TTF-1(from-1299 bp to-871 bp)by 5’deletion assay and screened out the putative transcription factors nuclear factor-1(NF-1)and activator protein-1(AP-1).Further analysis revealed that the expression level of NF-1,but not AP-1,was positively connected with the activation of TTF-1 core promoter in human non-small-cell lung cancer(NSCLC)***,the silencing of NF-1 could reduce the expression level of miR-7 operated by TTF-1 core *** note,we optimized four distinct sequences to form additional NF-1-binding sites(TGGCA)in the sequence of TTF-1 core promoter(termed asTTF-1 promoter),and verified the binding efficiency of NF-1 on theTTF-1 promoter by electrophoretic mobility shift assay(EMSA).As expected,theTTF-1 promoter could more effectively drive miR-7 expression and inhibit the growth of human NSCLC cells in vitro,accompanied by a reduced transduction of NADH dehydrogenase(ubiquinone)1αsubcomplex 4(NDUFA4)/protein kinase B(Akt)***,TTF-1 promoter-driven miR-7expression could also effectively abrogate the growth and metastasis of tumor cells in a murine xenograft model of human ***,no significant changes were detected in the biological indicators or the histology of some important tissues and organs,including heart,liver,and *** the whole,our study revealed that the optimized TTF-1 promoter could more effectively operate miR-7 to influence the growth of human NSCLC cells,providing a new basis for the development of microRNA-based targeting gene therapy against clinical lung cancer.

关键词： Lung cancer Thyroid transcription factor-1(TTF-1) Promoter MicroRNA-7(miR-7) Nuclear factor-1(NF-1)

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高效液相色谱法测定盐酸安罗替尼胶囊中主成分含量

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中国药业 2024年第20期33卷 95-97页

作者：谢瑞杰黄蘭岚陆晖陈仕鹏黄月灵卓思珺黄敏州广西壮族自治区柳州市人民医院广西柳州545006 广西医科大学药学院广西南宁530021

目的建立测定盐酸安罗替尼胶囊中主成分含量的高效液相色谱(HPLC)法。方法色谱柱为Waters SunFire C_(18)柱(250 mmÍ4.6 mm,5μm),流动相为甲醇-乙腈-25 mmol/L磷酸二氢钾(15∶30∶55,V/V/V),流速为1.0 mL/min,检测波长为242 nm,柱温... 详细信息

目的建立测定盐酸安罗替尼胶囊中主成分含量的高效液相色谱(HPLC)法。方法色谱柱为Waters SunFire C_(18)柱(250 mmÍ4.6 mm,5μm),流动相为甲醇-乙腈-25 mmol/L磷酸二氢钾(15∶30∶55,V/V/V),流速为1.0 mL/min,检测波长为242 nm,柱温为40℃,进样量为20μL。结果盐酸安罗替尼质量浓度在24.73~395.60μg/mL范围内与峰面积线性关系良好(r=0.9999,n=6);精密度、稳定性、重复性试验结果的RSD均小于2.0%;平均加样回收率为97.90%,RSD为1.17%(n=6)。结论该方法操作简单、出峰时间短、准确度高、重复性好,可用于盐酸安罗替尼胶囊主成分的含量测定。

关键词：盐酸安罗替尼高效液相色谱法含量测定

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