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Helianthus tuberosus(Jerusalem artichoke) tubers improve glucose tolerance and hepatic lipid profile in rats fed a high-fat diet

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Asian Pacific Journal of Tropical Medicine 2017年第5期10卷 418-422页

作者： Naoto Okada shinya Kobayashi Kouta Moriyama Kohsuke Miyataka Shinji Abe ChiemiSato Kazuyoshi Kawazoe Department of Clinical Pharmacy Practice Pedagogy Institute of Biomedical SciencesTokushima University Graduate School Department of Pharmacy Tokushima University Hospital Faculty of Pharmaceutical Sciences Tokushima University Faculty of Medicine Tokushima University

Objective:To analyze the effects of feeding Helianthus tuberosus(HT) tubers on glucose tolerance and lipid profile in rats fed a high-fat diet(HFD). Methods:A normal HFD or HFD including 10 w/w% HT tubers(HFD + HT) was fed to F334/Jcl rats. After 10 weeks,organ weights,glucose tolerance,and lipid profile were analyzed. Results:The body weight,liver weight,and epidermal fat content in the HFD group were higher than those of the normal group,and similar to those of the HFD + HT group. The oral glucose tolerance test at 10 weeks revealed that the blood glucose level 30 minutes after beginning the test in the HFD + HT group was significantly lower than that in the HFD group. Liver triglyceride and total cholesterol levels in the HFD + HT group were significantly lower than those in the HFD group. Fecal triglyceride and total cholesterol levels in the HFD + HT group were higher than those in the HFD group. Histological analyses revealed that fat and glycogen accumulation increased in the HFD group,but decreased in the HFD + HT group. Conclusions:These results indicate that HT tubers have anti-fatty liver effects based on improvements in glucose tolerance and the hepatic lipid profile.

关键词： Helianthus tuberosus Glucose tolerance Hepatic lipid profile

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3DS MAX

艺术与设计．数码设计 2003年第6期 92-93页

作者： shinya

Ruptured high flow gastric varices with an intratumoral arterioportal shunt treated with balloon-occluded retrograde transvenous obliteration during temporary balloon occlusion of a hepatic artery

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World Journal of Gastroenterology 2006年第33期12卷 5404-5407页

作者： Motoki Nakai Morio Sato Hirohiko Tanihata Tetsuo Sonomura shinya Sahara Nobuyuki Kawai Masashi Kimura Masaki Terada Department of Radiology Hidaka General Hospital 116-2 Sono Gobo Shi Wakayama 644-8655 Japan Department of Radiology Wakayama Medical University 811-1 Kimiidera Wakayama Shi Wakayama 641-8510 Japan

A patient presented with hematemesis due to gastric variceal bleeding with an intratumoral arterioportal shunt. Contrast-enhanced CT revealed gastric varices and hepatocellular carcinoma with tumor thrombi in the right portal vein. Angiography and angio-CT revealed a marked intratumoral arterioportal shunt accompanied with reflux into the main portal vein and gastric varices. Balloon-occluded retrograde venography from the gastro-renal shunt showed no visualization of gastric varices due to rapid blood flow through the intratumoral arterioportal shunt. The hepatic artery was temporarily occluded with a balloon catheter to reduce the blood flow through the arterioportal shunt, and then concurrent balloon-occluded retrograde transvenous obliteration （BRTO） was achieved. Vital signs stabilized immediately thereafter, and contrast-enhanced CT revealed thrombosed gastric varices. Worsening of hepatic function was not recognized. BRTO combined with temporary occlusion of the hepatic artery is a feasible interventional procedure for ruptured high flow gastric varices with an intratumoral arterioportal shunt.

关键词： Gastric varices Hepatocellular carcinoma Arterioportal shunt Balloon-occluded retrogradeobliteration Hematemesis

Transhepatic catheter-directed thrombolysis for portal vein thrombosis after partial splenic embolization in combination with balloon-occluded retrograde transvenous obliteration of splenorenal shunt

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World Journal of Gastroenterology 2006年第31期12卷 5071-5074页

作者： Motoki Nakai Morio Sato shinya Sahara Nobuyuki Kawai Masashi Kimura Yoshimasa Maeda Yumiko Ibata Katsuhiko Higashi Department of RadiologyWakayama Medical University 811-1KimiideraWakayama ShiWakayama 641-8510Japan the First Department of Internal MedicineHidaka General Hospital 116-2 SonoGobo ShiWakayama 644-8655Japan

A 66-year-old woman underwent partial splenic embolization （PSE） for hypersplenisrn with idiopathic portal hypertension （IPH）. One week later, contrast-enhanced CT revealed extensive portal vein thrombosis （PVT） and dilated portosystemic shunts. The PVT was not dissolved by the intravenous administration of urokinase. The right portal vein was canulated via the percutaneous transhepatic route under ultrasonic guidance and a 4 Fr. straight catheter was advanced into the portal vein through the thrombus. Transhepatic catheter-directed thrombolysis was performed to dissolve the PVT and a splenorenal shunt was concurrently occluded to increase portal blood flow, using balloon-occluded retrograde transvenous obliteration （BRTO） technique. Subsequent contrast-enhanced CT showed good patency of the portal vein and thrombosed splenorenal shunt. Transhepatic catheter-directed thrombolysis combined with BRTO is feasible and effective for PVT with portosystemic shunts.

关键词： Portal vein thrombosis Idiopathic portal hypertension Partial splenic embolization Portosystemic shunts Transhepatic catheter-directed thrombolysis Balloon-occluded retrograde transvenous obliteration

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中国美术学院博物馆

Investigating drivers of active nitrification in organic horizons of tropical forest soils

城市环境设计 2024年第1期147卷 76-81页

作者：藤原徹平寺川奈穂子小岛伸也加纳永一

中国美术学院博物馆位于中国美院杭州象山校区，坐落在一片曾经的茶场上。为了与大地融为一体，创造出能够感受大地的博物馆，沿着山坡的倾斜地面进行了连续的设计。通过以平行四边形为单位的几何分割系统，进行了复杂地形的规划，并通...

中国美术学院博物馆位于中国美院杭州象山校区，坐落在一片曾经的茶场上。为了与大地融为一体，创造出能够感受大地的博物馆，沿着山坡的倾斜地面进行了连续的设计。通过以平行四边形为单位的几何分割系统，进行了复杂地形的规划，并通过为每个单位建造小屋顶，形成了连续的瓦屋顶的“村庄”景观。外墙上覆盖着一道“屏风”，由不锈钢丝外挂瓷砖构成，有助于控制进入房间的阳光。屏风和屋顶的旧瓷砖都来自本地烧的瓦。瓦片尺寸的变化使建筑更好地与大地融合。

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来源：博看期刊

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Soil Ecology Letters 2023年第3期5卷 89-99页

作者： Shinichi Watanabe Makoto Shibata Yoshiko Kosugi Lion Marryanna Keitaro Fukushima Arief Hartono shinya Funakawa Graduate School of Global Environmental Studies Kyoto UniversityKitashirakawa Oiwake-choSakyo-kuKyoto606-8502Japan Graduate School of Agriculture Kyoto UniversityKitashirakawa Oiwake-choSakyo-kuKyoto606-8502Japan Forest Research Institute Malaysia 52109 KepongSelangorMalaysia Center for Ecological Research Kyoto University509-3Hirano 2-chomeOtsu-shiShiga520-2113Japan Faculty of Agriculture Bogor Agricultural UniversityJalan MerantiKampus IPB Darmaga 16680BogorIndonesia

High nitrate leaching has been observed from the O horizons of some tropical forests;however,the drivers of high nitrate production(active nitrification)in these O horizons have not yet been *** study investigated the drivers of active nitrification in the O horizon of tropical forest soils by focusing on two of the most widely recognized controlling factors of nitrification,total N,and *** collected mineral and O horizons from eight tropical forests in Cameroon,Indonesia,and Malaysia and measured gross nitrification *** O horizons showed significantly higher gross nitrification rates than mineral horizons,indicating that these O horizons have a high potential for *** nitrification rates in the O horizons were positively correlated with both total N and pH,and the chemical properties(e.g.,total content of N,P,and base cations)were *** correlations suggested that the underlying driver of nitrification in the O horizon was nutrient richness in the *** also indicated a threshold of gross nitrification rates around pH values of 5.5–*** elucidate that active nitrification and subsequent high nitrate leaching from the O horizon could be driven by nutrient-rich litter,possibly derived from soil fertility and tree species.

关键词： nitrogen dynamics gross nitrification rate organic horizon forest floor acidic soil leguminous trees

miR-23a promotes invasion of glioblastoma via HOXD10-regulated glial-mesenchymal transition

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Signal Transduction and Targeted Therapy 2018年第1期3卷 1-10页

作者： Kazuhiro Yachi Masumi Tsuda Shinji Kohsaka Lei Wang Yoshitaka Oda Satoshi Tanikawa Yusuke Ohba shinya Tanaka Department of Cancer Pathology Faculty of MedicineHokkaido UniversitySapporoJapan Global Station for Soft Matter Global Institution for Collaborative Research and EducationHokkaido UniversitySapporoJapan Institute for Chemical Reaction Design and Discovery(WPI-ICReDD) Hokkaido UniversitySapporoJapan Department of Cell Physiology Faculty of MedicineHokkaido UniversitySapporoJapan Present address:Division of Cellular Signaling National Cancer Center Research InstituteTokyoJapan

Glioblastoma is the most aggressive and invasive brain tumor and has a poor prognosis;elucidating the underlying molecular mechanisms is essential to select molecular targeted ***,we investigated the effect of microRNAs on the marked invasiveness of glioblastoma.U373 glioblastoma cells were infected with 140 different microRNAs from an OncomiR library,and the effects of the invasion-related microRNAs and targeted molecules were investigated after repeated Matrigel invasion *** of the OncomiR library identified miR-23a as a key regulator of glioblastoma *** six glioblastoma cell lines,a positive correlation was detected between the expression levels of miR-23a and invasiveness.A luciferase reporter assay demonstrated that homeobox D10(HOXD10)was a miR-23a-target molecule,which was verified by high scores from both the PicTar and miRanda *** expression of miR-23a induced expression of invasion-related molecules,including uPAR,RhoA,and RhoC,and altered expression of glial-mesenchymal transition markers such as Snail,Slug,MMP2,MMP9,MMP14,and E-cadherin;however,these changes in expression levels were reversed by HOXD10 ***,miR-23a significantly promoted invasion of glioblastoma cells with polarized formation of focal adhesions,while exogenous HOXD10 overexpression reversed these ***,we identify miR-23a-regulated HOXD10 as a pivotal regulator of invasion in glioblastoma,providing a novel mechanism for the aggressive invasiveness of this tumor and providing insight into potential therapeutic targets.

关键词： HOXD10 invasion miR

Intracranial malignant solitary fibrous tumor metastasized to the chest wall:A case report and review of literature

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World Journal of Clinical Cases 2020年第20期8卷 4844-4852页

作者： Daisuke Usuda shinya Yamada Toshihide Izumida Ryusho Sangen Toshihiro Higashikawa Ken Nakagawa Masaharu Iguchi Yuji Kasamaki Department of General Medicine Kanazawa Medical University Himi Municipal HospitalHimi-shi 935-8531Toyama-kenJapan Department of Infectious Diseases Kanazawa Medical UniversityUchinadamachi 920-0293Ishikawa-kenJapan Department of Respiratory Medicine Kanazawa Medical University Himi Municipal HospitalHimi-shi 935-8531Toyama-kenJapan Department of Geriatric Medicine Kanazawa Medical University Himi Municipal HospitalHimi-shi 935-8531Toyama-kenJapan

BACKGROUND Solitary fibrous tumor(SFT)is a rare fibroblastic mesenchymal neoplasm that affects spindle cell soft tissues with broad-spectrum biological behavior;it is predominantly benign,and rarely *** occurs mainly in the tissue structure of the serosa in the pleura and the thorax,and can be found throughout the body,though extra-thoracic localization,including the cephalic region,is *** reported the first case of intracranial malignant SFT metastasized to the chest *** SUMMARY An 81-year-old Japanese man was referred to our hospital due to progressive gait disturbance and appetite *** medical history included partial resection due to brain tumor,four times,and 50-Gray radiation therapy at another hospital,starting when he was 74 years *** unenhanced head computed tomography(CT)scan revealed an 8 cm×5.1 cm×6.5 cm mixed-density mass at the left frontal lobe,accompanying a midline shift,and an unenhanced chest-abdomen CT scan revealed a 6 cm×4.1 cm×6.5 cm low-density mass in the left chest wall.A CT-guided percutaneous lung biopsy was performed,and the pathological findings were SFT corresponding to brain ***,the correct diagnosis of his brain tumor in history of past illness revealed to be SFT,and the unremovable tumor,namely present brain lesions enlarged and metastasized to the chest *** established a definitive diagnosis of intracranial malignant SFT metastasized to the chest *** notified him and his family of the disease,and offered palliative *** passed away on the 29 th hospital *** This case suggests the need for careful,detailed examination,and careful followup when encountering patients presenting with a mass.

关键词： Solitary fibrous tumor Intracranial malignant solitary fibrous tumor Metastasized chest wall tumor Cluster of differentiation 34 STAT6 Case report

Differential Expression of Two Cytosolic Ascorbate Peroxidases and Two Superoxide Dismutase Genes in Response to Abiotic Stress in Rice

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Rice science 2011年第3期18卷 157-166页

作者： Shigeto MORITA shinya NAKATANI Tomokazu KOSHIBA Takehiro MASUMURA Yasunari OGIHARA Kunisuke TANAKA Laboratory of Genetic Engineering Graduate School of Life and Environmental Sciences Kyoto Prefectural University Basic Research Division Kyoto Prefectural Institute of Agricultural Biotechnology Department of Biological Sciences Tokyo Metropolitan University Kihara Institute for Biological Research Yokohama City University

Superoxide dismutase (SOD) and ascorbate peroxidase (APX) play central roles in the pathway for scavenging reactive oxygen species in plants, thereby contributing to the tolerance against abiotic stress. Here we report the responses of cytosolic SOD (cSOD; sodCc1 and sodCc2) and cytosolic APX (cAPX; OsAPX1 and OsAPX2) genes to oxidative and abiotic stress in rice. RNA blot analyses revealed that methyl viologen treatment caused a more prominent induction of cAPXs compared with cSODs, and hydrogen peroxide treatment induced the expression of cAPXs whereas cSODs were not affected. These results suggest that cAPXs play more important roles in defense against oxidative stress compared with cSODs. It is noted that cSODs and cAPXs showed coordinate response to abscisic acid treatment which induced both sodCc1 and OsAPX2. However, cSODs and cAPXs responded differentially to drought, salt and chilling stress, which indicates that cSOD and cAPX genes are expressed differentially in response to oxidative and abiotic stress in rice.

关键词： ascorbate peroxidase superoxide dismutase reactive oxygen species abiotic stress rice