检索结果-南通市图书馆

TiO2-Coated TCO (SnO2:F) Films Prepared by AP-CVD with High Durability against Hydrogen Radicals

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

TiO2-Coated TCO (SnO2:F) Films Prepared by AP-CVD with High ...

Aquaporin 9 facilitated the movement of DMSO and acetamide through the plasma membrane in mouse morulae

第十五届国际光伏科学与工程大会

作者： Mika Kambe Kazuo Sato Yasuyoshi Kurokawa shinsuke Miyajima Makoto Fukawa Naoki Taneda Makoto Konagai Research Center Asahi Glass Co. Ltd. 1150 Hazawa-cho Kanagawa-ku Yokohama 221-8755 Japan Department of Physical Electronics Tokyo Institute of Technology 2-12-1 Ookayama Meguro-ku Tokyo 152-8552 Japan

Durability of textured transparent conductive oxide (TCO) film against hydrogen radicals was investgated. An ultra thin TiO film of 2 nm in thickness was deposited on textured fluorine-doped tin oxide (SnO:F) film, successively by atmospheric pressure chemical vapor deposition (AP-CVD). TCO films with and without TiO layer were exposed to hydrogen radicals generated by VHF exited plasma. TCO films with TiO layer showed higher optical transmittatice and lower resistivity after exposure to hydrogen radicals, while TCO films without TiO layer showed lower optical transmittance and higher resistivity after the exposure. These TCO films were characterized by X-ray photoelectron spectroscopy (XPS) and secondary ion mass spectroscopy (SIMS) before and after the exposure to hydrogen radicals.

关键词： transparent conductive oxide TiO2 SnO2 hydrogen radical

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Aquaporin 9 facilitated the movement of DMSO and acetamide t...

Determination of Telomere Length by the Quantitative Fluorescence <i>in Situ</i>Hybridization (Q-FISH) Method

中国畜牧兽医学会动物繁殖学分会第十五届学术研讨会

作者： Keisuke Edashige shinsuke Seki Hayato Arimura Kan Matsuo Yu-ichi Nakata Chihiro Koshimoto Magosaburo Kasai College of Agriculture Kochi University Frontier Science Research Center University of Miyazaki

The permeability to water and cryoprotectants of the plasma membrane affects suitable conditions for cryopreservation of the ***,we showed that water, glycerol,ethylene glycol,DMSO,and acetamide move through mouse oocytes predominantly by simple diffusion across the plasma membrane,whereas water and these cryoprotectants move through morulae predominantly by facilitated diffusion via channel *** also showed that aquaporin 3,an aquaglyceroporin,plays an important role in the facilitated diffusion of water,glycerol,and ethylene glycol,but that other channels are involved in the movement of DMSO and *** this study,we try to clarify the relevance of aquaporin 9,another aquaglyceroporin,in the movement of DMSO and acetamide in mouse *** oocytes,the expression of mRNA of aquaporin 9 and that of aquaporin 9 protein were quite *** morulae,those were higher than in *** suppress the expression of aquaporin 9 in morulae,double-stranded(ds) RNA of mouse aquaporin 9 was injected in 1-cell zygotes and the embryos were cultured to the morula *** expression of aquaporin 9 in morulae was markedly suppressed by injecting the *** permeability of ds-RNA-injected morulae to DMSO and acetamide was markedly lower than that of intact morulae,but the permeability to water,glycerol,and ethylene glycol was not significantly affected by the injection of *** results strongly suggest that aquaporin 9 plays an important role in the facilitated diffusion of DMSO and acetamide in mouse *** results will provide valuable information for understanding the movement of water and cryoprotectants in mouse embryos.

关键词： water cryoprotectant permeability cryopreservation mouse oocyte embryo aquaporin

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

American Journal of Analytical Chemistry 2014年第12期5卷 775-783页

作者： Junko Aida Naotaka Izumiyama-Shimomura Ken-ichi Nakamura Naoshi Ishikawa Masanori Terai Yoko Matsuda shinsuke Aida Tomio Arai Kaiyo Takubo Department of Pathology International University of Health and Welfare Mita Hospital Tokyo Japan Department of Pathology Tokyo Metropolitan Geriatric Hospital Tokyo Japan Research Team for Geriatric Pathology Tokyo Metropolitan Institute of Gerontology Tokyo Japan

Telomeres are nucleoprotein complexes located at the ends of eukaryotic chromosomes and are shorten with aging or various causes. Shortened telomere plays an important role for chromosomal instability in carcinogenesis, or a number of diseases in relation to aging. FISH using peptide-nucleic acid (PNA) probe is suitable for analyzing telomeres, because telomere is a part of DNA molecule and localized in chromosomal end in loop shape structure (T-loop). We introduce our telomere analysis for tissue sections and cultured cells in this paper. On the tissue sections, we analyze telomere length with telomere intensity to centromere intensity ratio (TCR), centromere as an inner control. In the cultured cells, we analyze telomere lengths on each chromosome with karyotyping. Those Q-FISH methods by PNA probe are an accurate and reliable tool for research on telomere lengths in various conditions in biology.

关键词： Telomere Telomere Length Q-FISH Tissue Section Chromosome

Identification of the Stress Which Causes Optineurin Aggregation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neuroscience & Medicine 2019年第2期10卷 150-161页

作者： Satoshi Inagaki Michinori Funato Junko Seki Chizuru Kawase Kazuki Ohuchi Shiori Ando shinsuke Nakamura Masamitsu Shimazawa Hideo Kaneko Hideaki Hara Molecular Pharmacology Department of Biofunctional Evaluation Gifu Pharmaceutical University Gifu Japan Department of Clinical Research National Hospital Organization Nagara Medical Center Gifu Japan

Glaucoma is a common neurodegenerative disease that can cause blindness and occurs worldwide. Currently, lowering intraocular pressure is the only therapy available to protect retinal ganglion cells (RGCs). However, this therapy does not prevent RGC death in all patients. Therefore, new therapeutic approaches for glaucoma are urgently required, and neuroprotection of RGCs is a focus for many researchers. Optineurin (OPTN) is one of the normal tension glaucoma (NTG) relative genes, while mutant OPTN can form a characteristic aggregation, causing RGC death. Hence, elucidation of the mechanism of OPTN aggregation might provide a clue to help understand RGC death. To examine whether non-mutant OPTN could also aggregate, we pharmacologically induced some glaucoma-related stresses, such as endoplasmic reticulum (ER) stress, glutamate toxicity, activation of TNF-α signaling, mitochondrial dysfunction, and autophagic flux impairment. Our results showed that ER stress, TNF-α signaling, and autophagic flux are involved in OPTN aggregation. Furthermore, our data indicated that increased ER stress, activation of TNF-α signaling, and impaired autophagic flux induce OPTN aggregation, suggesting that OPTN aggregation might be an important therapeutic target not only for familial NTG with mutated OPTN but also for patients with glaucoma more generally.

关键词： Glaucoma Induced Pluripotent Stem Cells Retinal Ganglion Cells Optineurin Protein Aggregation

Phenotypes and Chronic Organ Damage May Be Different among Siblings with Wilson's Disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Clinical and Translational Hepatology 2017年第1期5卷 27-30页

作者： shinsuke Yahata Seitetsu Yung Mari Mandai Takakazu Nagahara Daisaku Kuzume Hiroshi Sakaeda Shinya Wakusawa Ayako Kato Yasuaki Tatsumi Koichi Kato Hisao Hayashi Ryohei Isaji Yoji Sasaki Motoyoshi Yano Kazuhiko Hayashi Masatoshi Ishigami Hidemi Goto Division of Community Medicine and Career Development Kobe University Graduate School of Medicine2-1-5Arata-choHyogo-kuKobe 652-0032Japan Department of Gastroenterology Hyogo Prefectural Kakogawa Medical CenterKakogawaHyogoJapan Department of Gastroenterology and Hepatology Tottori Prefectural Kousei HospitalKurayoshiTottoriJapan Departments of Neurology and Gastroenterology Chikamori HospitalKochiJapan Medical Laboratory Sciences Nagoya University Graduate School of MedicineHigashi-kuNagoyaJapan Department of Medicine Aichi Gakuin University School of PharmacyChikusa-kuNagoyaJapan Department of Gastroenterology Konan Kosei HospitalTakaya-choKonanAichiJapan Department of Gastroenterology Yokkaichi Municipal HospitalYokkaichiMieJapan Department of Gastroenterology and Hepatology Nagoya University Graduate School of MedicineShowa-kuNagoyaJapan

Background and Aims:Cloning of ATP7B provided evidence that Wilson's disease is a hepatic copper toxicosis with a variety of extrahepatic *** siblings with the same genetic background and exposure to similar environmental factors may be a good model for the study of genotype-phenotype ***:Twenty-three affected siblings in 11 families were selected from a *** first phenotypes were determined according to the international *** final types of chronic organ damage were re-evaluated for life-long ***:Phenotypes were identical in 5 of the families and different in 6 of the *** acute hepatic phenotype H1 was found in 3 younger siblings and 1 older *** survived an acute episode of hemolysis with underlying chronic liver *** also presented complication with neurological *** neurological phenotype N1 with neuropsychiatric symptoms and hepatic disease was found in 2 aged siblings of 1 family,in an older sibling in 3 families and in the oldest sibling in 1 *** in siblings were mainly split by either H1 occurring in random order or age-dependent *** of chronic organ damage were identical in 8 of the families and different in 3 of the *** same combination of chronic liver disease was found in 6 families and chronic liver disease complicated with neurological disease in 2 *** organ damage in siblings was found when an older sibling was complicated by neurological *** was no reverse combination of a younger sibling being complicated by neurological disease in any of the ***:Phenotype combinations of siblings were mainly modified by externally-induced hemolytic episodes,while chronic organ damage in siblings was split by age-dependent neurological complications.

关键词： Hemolysis Liver disease Neurological disease Wilson's disease

Altered expression of gap junctions, desmosomes and adherens junctions in ischemic rat heart

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Altered expression of gap junctions, desmosomes and adherens...

Recent Progress in Plasma Control Studies on the Improvement of Plasma Performance in Heliotron J

Third Congress of the Asian-Pacific Organization for Cell Biology

作者： Tsutomu Matsushita Masahito Oyamada shinsuke Masuda Keiichi Yokoyama Kazushi Fujimoto Yuko Yasuda Setsuya Fujita Tetsuro Takamatsu Dept. of Path.and Cell Regul. Kyoto Pref. Univ. Med.Kamikyo-kuKyoto-shiKyoto 602 Japan Dept. of Anat. Kyoto Univ.Sakyo-kuKyoto-shiKyoto 606Japan L. Pasteur Ctr. Med. Res. Sakyo-kuKyoto-shiKyoto 606Japan

Altered distribution of gap junctions in ischemic hearts has been recognized as an important factor in arrhythmogenesis. Gap junctional intercellular communication is influenced by other cell junctions. To investigate

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Plasma Science and Technology 2011年第1期13卷 21-25页

作者： Tohru MIZUUCHI Kazunobu NAGASAKI Hiroyuki OKADA Shinji KOBAYASHI Satoshi YAMAMOTO Takashi MINAMI shinsuke OHSHIMA Masaki TAKEUCHI Kiyofumi MUKAI Hyunyong LEE Linge ZANG Kohta NOMURA Masashige SUWA Kento YAMAMOTO Hiroaki YASHIRO Hayao YOSHINO Shouhei ARAI Tasuku KAGAWA Takayuki MINAMI Kouji MIZUNO Yoshinobu WADA Hiroto WATADA Nobuhiro NISHINO Yosuke NAKASHIMA Kiyoshi HANATANI Yuji NAKAMURA Shigeru KONOSHIMA Fumimichi SANO Institute of Advanced Energy Kyoto Univ. Kyoto University Pioneering Research Unit for Next Generation Graduate School of Energy Science Kyoto University Graduate School of Engineering Hiroshima University Plasma Research Center University of Tsukuba

Recent progress in plasma control studies on the improvement of plasma performance in Heliotron J is reviewed. The supersonic molecular beam injection （SMBI） fueling is successfully applied to Heliotron J plasma. A supersonic H2-beam is effectively injected to increase fueling efficiency and generate a peaked density profile. Local fueling with a short-pulsed SMBI can increase the core plasma density and avoid the degradation arising from edge cooling. Second harmonic electron cyclotron current drive （ECCD） experiments were conducted by launching a focused Gaussian beam with a parallel refractive index of -0.05 ≤ Nil 〈 0.6. Results show that the electron cyclotron （EC） driven current is determined not only by Nil but also by local magnetic field （B） structure where the EC power is deposited. Detailed analysis of the observed NI and B dependences is in progress with a ray-tracing simulation using the TRAVIS code. Fast ion velocity distribution was investigated using fast protons generated by ion cyclotron resonant frequency （ICRF） minority heating. For the standard configuration in Heliotron J, charge ex- change neutral particle analysis （CX-NPA） measurements show higher effective temperature of fast minority protons in the on-axis resonance case compared to that in the HFS （high field side） off-axis resonance case. However, the increase in bulk ion temperature in the HFS resonance case is larger than that in the on-axis resonance.

关键词： plasma control. Heliotron J improved confinement ECH/ECCD NBI ICRF. minority heating fueling control

Acute Hepatic Phenotype of Wilson Disease: Clinical Features of Acute Episodes and Chronic Lesions Remaining in Survivors

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of Clinical and Translational Hepatology 2015年第4期3卷 239-245页

作者： Hisao Hayashi Yasuaki Tatsumi shinsuke Yahata Hiroki Havashi Kenji Nomose Ryohei Isaji Youji Sasaki Department of Medicine Aichi-Gakuin University School of PharmacyNagoyaJapan Department of Gastroenterology Hyogo Prefectural Kakogawa Medical CenterKakogawaJapan Department of Gastroenterology Kita-Harima Medical CenterOnoJapan Department of Gastroenterology Kobe University School of MedicineKobeJapan Department of Gastroenterology Konan Kosei HospitalKonanJapan

Background and Aims:Wilson disease(WD)is an inherited disorder of copper metabolism,and an international group for the study of WD(IGSW)has proposed three phenotypes for its initial presentation:acute hepatic,chronic hepatic,and neurologic *** of the acute hepatic phenotype may improve our understanding of the ***:Clinical features of 10 WD patients with the acute hepatic phenotype and characteristics of chronic lesions remaining in survivors were assessed by the European Association for the Study of the Liver(EASL)***:All six patients younger than 30 years had survived an acute episode of hemolytic anemia with residual liver disease of cirrhosis or chronic *** acute episode was self-limiting in two of the four patients over the age of 30 years and progressed to acute liver failure in the other two *** of the two survivors had residual liver disease of chronic hepatitis,while the other had chronic hepatitis and neurologic *** disease remained in a patient who successfully received a liver *** acute episodes,serum levels of aspartate aminotransferase(AST)and alanine aminotransferase(ALT)changed rapidly along with ***-specific ALT levels were age-dependently correlated with hemoglobin(Hb)*** reduction was milder for AST than ALT which resulted in a high AST/ALT ratio in the anemic *** anemic stage in two patients transformed to acute liver ***:All survivors of an acute episode of the acute hepatic phenotype had residual liver disease or both liver and neurologic *** rapid changes in liver enzymes during the acute episode and the liver and neurologic diseases remaining in survivors may provide a better understanding of WD.

关键词： Aminotransferase Neurologic disease Liver disease Hemoglobin

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

流行就是“飘逸华丽”

国际服装技术 2007年第3期 111-117页

作者： Masami Yoshida Gong Yunzhe（翻译） Momoko Katsucka（摄影） shinsuke Kojima（摄影）

春装的焦点，时尚界中，飘逸的细节正在大地其道！只要在一个单品中使用，就能够大幅提升时尚感，同时还充满高贵的富贵气息，真是人气非常的高。就让我们来看看眼下最流行的“飘逸华丽”单品吧。

关键词：飘逸时尚春装