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Inferior mesenteric arteriovenous fistula during treatment with bevacizumab in colorectal cancer patient: A case report

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World Journal of Gastrointestinal Oncology 2020年第11期12卷 1364-1371页

作者： Ayako Doi Hiroyuki Takeda Kumiko Umemoto Ryosuke Oumi shinji wada Shingo Hamaguchi Hidefumi Mimura Hiroyuki Arai Yoshiki Horie Takuro Mizukami Naoki Izawa Takashi Ogura Takako EguchiNakajima Yu Sunakawa Department of Clinical Oncology St.Marianna University School of MedicineKanagawa 216-8511Japan Department of Gastroenterology St.Marianna University School of MedicineKanagawa 216-8511Japan Department of Radiology St.Marianna University School of MedicineKanagawa 216-8511Japan Innovation Center for Next Generation Clinical Trials and iPS Cell Therapy Kyoto University HospitalKyoto 606-8507Japan

BACKGROUND Fistula formation is a severe adverse event related to antiangiogenetic agents such as bevacizumab and inferior mesenteric arteriovenous fistula(IMAVF) is a result of acquired factor, especially colon surgery. However, IMAVF occurs very rarely and there are few reports in patients during chemotherapy. We report a case of a patient who developed IMAVF during treatment with bevacizumab in metastatic colorectal cancer(mCRC) after colon *** SUMMARY An 81-year-old man was diagnosed with descending colon cancer and underwent left hemicolectomy without any complications. He was definitely diagnosed with high-risk stage 2 and received tegafur-uracil plus leucovorin as adjuvant chemotherapy. Three years and 6 mo after the operation, the cancer relapsed with peritoneal dissemination. The patient underwent CyberKnife radiosurgery targeting the recurrent tumor and received chemotherapy with S-1 plus bevacizumab. At 1 year after chemotherapy, he complained of severe diarrhea, which is suspected drug-induced colitis. As diarrhea worsened despite the termination of treatment, he underwent colonoscopy and computed tomography (CT) scans that revealed edematous change from sigmoid to rectosigmoid colon. CT scans also revealed an aneurysm adjacent to the inferior mesenteric vein and multidetector CT angiography showed the IMAVF. Elective angiography confirmed the diagnosis of an IMAVF and it was successfully treated by arterial embolization. The patient resumed chemotherapy with only S-1 6 mo after *** Clinicians should keep in mind the probability of severe diarrhea arose from IMAVF in mCRC patients treated with bevacizumab.

关键词： Metastatic cancer Colon surgery Chemotherapy Fistula formation Inferior mesenteric artery Interventional radiology Case report

Simultaneous detection of the shuttling motion of liquid metal droplets in channels under alternating pressure and capacitive sensor signals

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Microsystems & Nanoengineering 2024年第2期10卷 83-90页

作者： shinji Bono Ryotaro Nakai Satoshi Konishi Research Organization of Science and Technology Ritsumeikan UniversityShigaJapan Ritsumeikan Advanced Research Academy KyotoJapan Ritsumeikan Global Innovation Research Organization Ritsumeikan UniversityShigaJapan Graduate School of Science and Engineering Ritsumeikan UniversityShigaJapan

Implementing a signal-switching mechanism for the selective use of integrated sensors and actuators plays a crucial role in streamlining the functionality of miniaturized ***,a liquid metal droplet(LMD)-based signal-switching mechanism is introduced to achieve such *** modulation with a 100-μm spatial resolution enabled precise control of the position of the LMDs within a *** integrating the channel with asymmetrically structured electrodes,the effect of the shuttle-like movement of LMD on the temporal changes in the overall capacitance was ***,analysis of the capacitive peaks revealed the directional movement of the LMDs,enabling estimation of the position of the LMDs without direct *** addition,we achieved successful signal extraction from the capacitive sensor that was linked to the activated electrodes,thereby enabling selective data *** proposed signal-switching mechanism method achieved a detection accuracy of~0.1 *** sensor’s ability to simultaneously detect the LMD position and generate a signal underscores its significant potential for multiplexing in multisensing systems,particularly in concealed environments,such as in vivo settings.

关键词： liquid thereby integrating

Pathological and physiological functional cross-talks ofα-synuclein and tau in the central nervous system

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Neural Regeneration Research 2024年第4期19卷 855-862页

作者： Mingyue Jin Shengming Wang Xiaodie Gao Zhenyou Zou shinji Hirotsune Liyuan Sun Guangxi Key Laboratory of Brain and Cognitive Neuroscience Guilin Medical University Department of Genetic Disease Research Osaka Metropolitan University Graduate School of Medicine Department of Scientific Research Brain Hospital of Guangxi Zhuang Autonomous Region

α-Synuclein and tau are abundant multifunctional brain proteins that are mainly expressed in the presynaptic and axonal compartments of neurons,*** works have revealed that intracellular deposition ofα-synuclein and/or tau causes many neurodegenerative disorders,including Alzheimer’s disease and Parkinson’s *** intense investigation,the normal physiological functions and roles ofα-synuclein and tau are still unclear,owing to the fact that mice with knockout of either of these proteins do not present apparent ***,the co-occurrence ofα-synuclein and tau aggregates was found in post-mortem brains with synucleinopathies and tauopathies,some of which share similarities in clinical ***,the direct interaction ofα-synuclein with tau is considered to promote the fibrillization of each of the proteins in vitro and in *** the other hand,our recent findings have revealed thatα-synuclein and tau are cooperatively involved in brain development in a stage-dependent *** findings indicate strong cross-talk between the two proteins in physiology and *** this review,we provide a summary of the recent findings on the functional roles ofα-synuclein and tau in the physiological conditions and pathogenesis of neurodegenerative diseases.A deep understanding of the interplay betweenα-synuclein and tau in physiological and pathological conditions might provide novel targets for clinical diagnosis and therapeutic strategies to treat neurodegenerative diseases.

关键词： alpha-synuclein microtubule-associated protein neurodegenerative disease tau

Hydrogen Permeation Characteristics of Pd-CuMembrane in Plasma Membrane Reactor

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Energy Engineering 2024年第2期121卷 259-272页

作者： Muhd Hadi Iskandar Abd Razak Motoki Tsuda YukioHayakawa shinji Kambara Graduate School of Engineering Gifu UniversityGifu501-1193Japan

Hydrogen is an alternative energy source that has the potential to replace fossil *** of the hydrogen applications is as a material for Polymer Electrolyte Membrane Fuel Cells(PEMFC)in fuel cell ***-purity hydrogen can be obtained using a hydrogen separation membrane to prevent unwanted contaminants from potentially harming the PEMFC *** this study,we fabricated a plasma membrane reactor and investigated the permeation performance of a hydrogen separation membrane in a plasma membrane reactor utilizing atmospheric pressure *** result showed the hydrogen permeation rate increasing with time as reactor temperature is increased through joule *** decreasing the gap length of the reactor from 2 to 1 mm,the hydrogen permeation rate increases by up to 40%.The hydrogen permeation rate increases by 30%when pressure is applied to the plasma membrane reactor by up to 100 kPa.

关键词： Hydrogen energy hydrogen separation membrane atmospheric pressure plasma

Assessing mixing uniformity in microreactors via in-line spectroscopy

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Chinese Journal of Chemical Engineering 2024年第2期66卷 119-124页

作者： Shusaku Asano shinji Kudo Taisuke Maki Yosuke Muranaka Kazuhiro Mae Jun-ichiro Hayashi Institute for Materials Chemistry and Engineering Kyushu UniversityKasuga 816-8580Japan Department of Chemical Engineering Graduate School of EngineeringKyoto UniversityJapan

Mixing behavior is critical for enhancing the selectivity of fast chemical reactions in microreactors.A high Reynolds number(Re)improves the mixing rate and selectivity of the reactions,but some exceptions of increasing side product yield with the higher Re have been *** study investigated the mixing uniformity in microreactors with in-line UV-vis spectroscopy to clarify the relationship between reaction selectivity and chaotic mixing with the higher Re.A colorization experiment of thymolphthalein in an acidic solution was conducted with an excess acid amount to the base to indicate a non-uniformly mixed ***-uniformity significantly increased with *** the same time,the degree of mixing,which was measured by a usual decolorization experiment,showed that the mixing rate increased with *** in-line analysis of the Villermaux-Dushman reaction during the mixing clarified that side product yield significantly increased with Re at around 300 and then decreased at around *** results suggest the compensation effect between the mixing uniformity and mixing rate on the selectivity of the mixing-sensitive *** mixing,characterized by a larger Re,can disturb mixing uniformity and,in some cases,decrease reaction selectivity.

关键词： Microreactor Villermaux-Dushman reaction In-line analysis Mixing Mass transfer Uniformity

Low skeletal muscle mass and high visceral adiposity are associated with recurrence of acute cholecystitis after conservative management:A propensity score-matched cohort study

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 64-70页

作者： Yudai Koya Michihiko Shibata Yuki Maruno Yoshitaka Sakamoto shinji Oe Koichiro Miyagawa Yuichi Honma Masaru Harada Department of Gastroenterology Kyushu Rosai HospitalMoji Medical Center3-1 HigashiminatomachiMoji-kuKitakyushu 801-8502Japan Third Department of Internal Medicine School of MedicineUniversity of Occupational and Environmental HealthKitakyushu 807-8555Japan Department of Surgery Kyushu Rosai Hospital Moji Medical CenterKitakyushu 801-8502Japan

Background:Recurrent acute cholecystitis(RAC)can occur after non-surgical treatment for acute cholecystitis(AC),and can be more severe in comparison to the first episode of *** skeletal muscle mass or adiposity have various effects in several *** aimed to clarify the relationship between RAC and body ***:Patients with AC who were treated at our hospital between January 2011 and March 2022 were *** psoas muscle mass and adipose tissue area at the third lumbar level were measured using computed tomography at the first episode of *** areas were divided by height to obtain the psoas muscle mass index(PMI)and subcutaneous/visceral adipose tissue index(SATI/VATI).According to median VATI,SATI and PMI values by sex,patients were divided into the high and low PMI *** performed propensity score matching to eliminate the baseline differences between the high PMI and low PMI groups and analyzed the cumulative incidence and predictors of ***:The entire cohort was divided into the high PMI(n=81)and low PMI(n=80)*** the propensity score-matched cohort there were 57 patients in each *** Kaplan-Meier analysis,the low PMI group and the high VATI group had a significantly higher cumulative incidence of RAC than their counterparts(log-rank P=0.001 and 0.015,respectively).In a multivariate Cox regression analysis,the hazard ratios of low PMI and low VATI for RAC were 5.250(95%confidence interval 1.083-25.450,P=0.039)and 0.158(95%confidence interval:0.026-0.937,P=0.042),***:Low skeletal muscle mass and high visceral adiposity were independent risk factors for RAC.

关键词： Acute cholecystitis Low skeletal muscle mass Recurrent acute cholecystitis Sarcopenia Visceral adiposity

Towards an ultrafast 3D imaging scanning LiDAR system:a review

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Photonics Research 2024年第8期12卷 1709-1729页

作者： ZHI LI YAQI HAN LICAN WU ZIHAN ZANG MAOLIN DAI SZE YUN SET shinji YAMASHITA QIAN LI H.Y.FU Tsinghua Shenzhen International Graduate School Tsinghua UniversityShenzhen 518055China Department of Electrical Engineering and Information Systems The University of TokyoTokyo 113-8656Japan Research Center for Advanced Science and Technology The University of TokyoTokyo 153-8904Japan School of Electronic and Computer Engineering Peking UniversityShenzhen 518055China

Light detection and ranging(LiDAR),as a hot imaging technology in both industry and academia,has undergone rapid innovation and *** current mainstream direction is towards system miniaturization and *** are many metrics that can be used to evaluate the performance of a LiDAR system,such as lateral resolution,ranging accuracy,stability,size,and *** recently,with the continuous enrichment of LiDAR application scenarios,the pursuit of imaging speed has attracted tremendous research ***,for autonomous vehicles running on motorways or industrial automation applications,the imaging speed of LiDAR systems is a critical *** this review,we will focus on discussing the upper speed limit of the LiDAR *** on the working mechanism,the limitation of optical parts on the maximum imaging speed is *** beam scanner has the greatest impact on imaging *** provide the working principle of current popular beam scanners used in LiDAR systems and summarize the main constraints on the scanning ***,we highlight the spectral scanning LiDAR as a new paradigm of ultrafast ***,to further improve the imaging speed,we then review the parallel detection methods,which include multiple-detector schemes and multiplexing ***,we summarize the LiDAR systems with the fastest point acquisition rate reported *** the outlook,we address the current technical challenges for ultrafast LiDAR systems from different aspects and give a brief analysis of the feasibility of different approaches.

关键词： LiDAR scanner system

Preoperative albumin-bilirubin score and liver resection percentage determine postoperative liver regeneration after partial hepatectomy

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World Journal of Gastroenterology 2024年第14期30卷 2006-2017页

作者： Kazuhiro Takahashi Masahiko Gosho Yoshihiro Miyazaki Hiromitsu Nakahashi Osamu Shimomura Kinji Furuya Manami Doi Yohei Owada Koichi Ogawa Yusuke Ohara Yoshimasa Akashi Tsuyoshi Enomoto shinji Hashimoto Tatsuya Oda Department of Gastrointestinal and Hepatobiliary-Pancreatic Surgery University of TsukubaTsukuba 3058-575IbarakiJapan Department of Biostatistics University of TsukubaTsukuba 3058-575IbarakiJapan

BACKGROUND The success of liver resection relies on the ability of the remnant liver to *** of the knowledge regarding the pathophysiological basis of liver regeneration comes from rodent studies,and data on humans are ***,there is limited knowledge about the preoperative factors that influence postoperative *** To quantify postoperative remnant liver volume by the latest volumetric software and investigate perioperative factors that affect posthepatectomy liver *** A total of 268 patients who received partial hepatectomy were *** were grouped into right hepatectomy/trisegmentectomy(RH/Tri),left hepa-tectomy(LH),segmentectomy(Seg),and subsegmentectomy/nonanatomical hepatectomy(Sub/Non)*** regeneration index(RI)and late rege-neration rate were defined as(postoperative liver volume)/[total functional liver volume(TFLV)]×100 and(RI at 6-months-RI at 3-months)/RI at 6-months,*** lower 25th percentile of RI and the higher 25th percentile of late regeneration rate in each group were defined as“low regeneration”and“delayed regeneration”.“Restoration to the original size”was defined as regeneration of the liver volume by more than 90%of the TFLV at 12 months *** The numbers of patients in the RH/Tri,LH,Seg,and Sub/Non groups were 41,53,99 and 75,*** RI plateaued at 3 months in the LH,Seg,and Sub/Non groups,whereas the RI increased until 12 months in the RH/Tri *** to our multivariate analysis,the preoperative albumin-bilirubin(ALBI)score was an independent factor for low regeneration at 3 months[odds ratio(OR)95%CI=2.80(1.17-6.69),P=0.02;per 1.0 up]and 12 months[OR=2.27(1.01-5.09),P=0.04;per 1.0 up].Multivariate analysis revealed that only liver resection percentage[OR=1.03(1.00-1.05),P=0.04]was associated with delayed ***,multivariate analysis demonstrated that the preoperative ALBI score[OR=2.63(1.00-1.05),P=0.02;per 1.

关键词： Liver regeneration Albumin-bilirubin score Liver resection percentage Partial hepatectomy Human Regeneration index

Mesenchymal stem cells-derived extracellular vesicles as‘natural’drug delivery system for tissue regeneration

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BIOCELL 2022年第4期46卷 899-902页

作者： KENJI TSUJI shinji KITAMURA JUN wada Department of Nephrology RheumatologyEndocrinology and MetabolismOkayama University Academic Field of MedicineDentistry and Pharmaceutical SciencesOkayama700-8558Japan

Mesenchymal stem cells(MSCs)have abilities to mediate tissue protection through mechanisms of antiapoptosis,anti-oxidative stress and anti-fibrosis as well as tissue regeneration through mechanisms of cell proliferation,differentiation and *** effects by MSCs are mediated by a variety of factors,including growth factors,cytokines and extracellular vesicles(EVs).Among these factors,EVs,containing proteins,mRNA and microRNAs(miRNA),may carry their contents into distant tissues with high ***,the treatment with MSC-derived EVs may be promising as‘natural’drug delivery systems(DDS).Especially,the treatment of MSCderived EVs with the manipulation of specific miRNAs expression has been reported to be beneficial under a variety of diseases and tissue *** overexpression of specific miRNAs in the EVs might be through pre-loading method using the gene editing system by plasmid vector or post-loading method to load miRNA mimics into EVs by electroporation or calcium chloride-mediated *** current several challenges for clinical use,it should open the next era of regenerative medicine for a variety of *** this article,we highlight the therapeutic potential of MSC-derived EVs as‘natural’DDS and current challenges.

关键词： Mesenchymal stem cells Extracellular vesicles Drug delivery system microRNA Regeneration