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橡胶参考资料 1997年第7期27卷 25-28页

作者： shingo Futamura 苗社会

前言轮胎的许多重要性能,如撕裂性能、干湿路面抓着力、滚动阻力及冰雪路面抓着力已经依据胎面胶性能作了分析。在早期的文献中提出了形变指数的概念,用于确定胎面胶的哪种动态粘弹性能与轮胎性能的相关性最好。利用形变指数的概念为几... 详细信息

前言轮胎的许多重要性能,如撕裂性能、干湿路面抓着力、滚动阻力及冰雪路面抓着力已经依据胎面胶性能作了分析。在早期的文献中提出了形变指数的概念,用于确定胎面胶的哪种动态粘弹性能与轮胎性能的相关性最好。利用形变指数的概念为几种重要的轮胎性能。

关键词：橡胶轮胎胎面胶冰雪路面抓着力

SRT1720, a SIRT1 Activator, Aggravates Bleomycin-Induced Lung Injury in Mice

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Food and Nutrition Sciences 2012年第2期3卷 157-163页

作者： shingo Imanishi Ryuji Hayashi Tomomi Ichikawa Kensuke Suzuki Masakiyo Sasahara Takashi Kondo Hirofumi Ogawa Kazuyuki Tobe Department of Pathology Graduate School of Medicine and Pharmaceutical Sciences University of Toyama Toyama Japan Department of Radiological Sciences Graduate School of Medicine and Pharmaceutical Sciences University of Toyama Toyama Japan. First Department of Internal Medicine Graduate School of Medicine and Pharmaceutical Sciences University of Toyama Toyama Japan

Diagnosis and management of interstitial lung diseases (ILDs), caused by lung epithelial injury followed by apoptosis, are often challenging. It has been controversial whether the SIRT1 protein, a principal modulator of longevity due to caloric restriction, ameliorates or aggravates ILD in animal models. Here we examined the effect of SRT1720, a syn- thetic activator of SIRT1, on bleomycin-induced lung injury in a mouse model and apoptosis in cultured epithelial cells. Oral intubation of SRT1720 over a period of 15 days caused body weight loss and a high mortality rate among bleomy- cin-treated mice. Histological examinations showed that the SRT1720 load increased fibrosis in the bleomycin-treated lung. An analysis of bronchoalveolar lavage fluid revealed remarkably increased numbers of inflammatory cells in the SRT1720-treated group. Moreover, the apoptosis of A549 lung cancer cells, caused by X-ray irradiation and an anti-Fas activating antibody, was promoted by SRT1720. These results indicate that SRT1720 not only aggravates bleomy- cin-induced ILD, but stimulates the apoptosis of physically and biologically stimulated A549 cells. While SIRT1 acti- vators are considered promising for the treatment of conditions such as diabetes mellitus, fatty liver, and chronic ob- structive pulmonary diseases, an excess of food containing SIRT1 activators may be harmful depending on the disease state, especially in the case of acute inflammation.

关键词： Interstitial Lung Diseases (ILDs) Lung Injury SIRT1 Bleomycin X-Ray Irradiation Oxidative Stress

材料性能对轮胎特性的影响——第二部分:胎面材料

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橡胶参考资料 1992年第2期22卷 17-22页

作者： shingo Futamura 盛德修

1、前言要对一种聚合物在结构上进行处理,以获得轮胎所需的某种“性能—温度”关系,也就是要使每一种胎面材料的性能都与轮胎所要求的性能相一致。但在恒定的最大拉伸变形及最大压缩变形条件下。

关键词：轮胎胶料性能胎面材料

Early effects of oral administration of omeprazole and roxatidine on intragastric pH

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第1期13卷 29-34页

作者： Hiroshi IIDA shingo KATO Yusuke SEKINO Eiji SAKAI Takashi UCHIYAMA Hiroki ENDO Kunihiro HOSONO Yasunari SAKAMOTO Koji FUJITA Masato YONEDA Tomoko KOIDE Hirokazu TAKAHASHI Chikako TOKORO Ayumu GOTO Yasunobu ABE Noritoshi KOBAYASHI Kensuke KUBOTA Eiji GOTOH Shin MAEDA Atsushi NAKAJIMA Masahiko INAMORI Gastroenterology Division Yokohama City University School of Medicine Department of Medical Education Yokohama City University School of Medicine Office of Postgraduate Medical Education Yokohama City University Hospital

Objective： The ideal medication for the treatment of acid-related diseases, e.g., peptic ulcers, stress- related gastric bleeding, functional dyspepsia, and gastroesophageal reflux disease, should have a rapid onset of action to promote hemostasis and relieve the symptoms. The aim of our study was to investigate the inhibitory effects on gastric acid secretion of a single oral administration of a proton pump inhibitor, omeprazole 20 mg, and an H2-receptor antagonist, roxatidine 75 mg. Methods： Ten Heficobacterpylori-negative male subjects participated in this randomized, two-way crossover study. Intragastric pH was monitored continuously for 6 h after single oral admini- stration of omeprazole 20 mg and roxatidine 75 mg. Each administration was separated by a 7-d washout period. Results： During the 6-h study period, the average pH after administration of roxatidine was higher than that after administration of omeprazole （median： 4.45 vs. 2.65; P=0.0367）. Also during the 6-h study period, a longer duration of maintenance at pH above 2, 5, and 6 was observed after administration of roxatidine 75 mg than after administration of omeprazole 20 mg （median： 90.6% vs. 55.2%, P=-0.0284; 43.7% vs. 10.6%, P=0.0125; 40.3% vs. 3.3%, P=0.0125; respectively）. Conclusions： In Helicobacter pylori-negative healthy male subjects, oral administration of roxatidine 75 mg increased the intragastric pH more rapidly than that of omeprazole 20 mg.

关键词： Proton pump inhibitor H2-receptor antagonist Intragastric pH Omeprazole Roxatidine

Successful treatment of acrodermatitis continua of Hallopeau with infliximab in a patient with hepatitis C virus infection

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Successful treatment of acrodermatitis continua of Hallopeau...

森林草莓FvZF-HD7基因的鉴定及表达分析

The Second Eastern Asia Dermatology Congress(EADC2012)

作者： Susumu Murata Sakae Kaneko shingo Matsuki Masataka Ota Yasuyuki Sumikawa Eishin Morita Shimane University Faculty of medicine Department of Dermatology

＜正＞Acrodermatitis continua of Hallopeau（ACH） is a rare skin disease,characterized by chronic,recurrent sterile acropustular eruptions on the fingers and *** skin changes and onychodystrophy are often *** pathogen...

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西北植物学报 2020年第1期40卷 19-27页

作者：刘敏名川信吾福建农林大学园艺学院福州350002 福建农林大学海峡联合研究院园艺植物生物学及代谢组学研究中心福州350002

锌指同源蛋白ZF-HD(zinc finger homeodomain)家族是植物中所特有的一类转录因子家族,在响应植物逆境胁迫,调控花发育以及种子寿命等方面具有重要作用,但其在草莓中的功能尚不清楚。该研究从森林草莓(Fragaria vesca)基因组数据库分离... 详细信息

锌指同源蛋白ZF-HD(zinc finger homeodomain)家族是植物中所特有的一类转录因子家族,在响应植物逆境胁迫,调控花发育以及种子寿命等方面具有重要作用,但其在草莓中的功能尚不清楚。该研究从森林草莓(Fragaria vesca)基因组数据库分离获得了10个ZF-HD家族的基因。进化树分析显示,按照亲缘关系远近该基因家族可分为6个不同的亚族;启动子顺式元件分析发现,该基因家族基因的启动子区域含有较多的逆境胁迫和激素响应相关的元件。荧光定量PCR检测发现,FvZF-HD7基因在花中的表达量显著大于其他基因;组织特异性表达分析表明,FvZF-HD7基因在花中表达量最高,在叶和茎中也有表达,在果实发育的前期表达量较高,而在果实发育后期急剧降低。利用森林草莓‘Yellow Wonder 5AF7’(YW)的cDNA成功克隆到FvZF-HD7基因,生物学信息学分析表明FvZF-HD7基因全长1083 bp,编码360个氨基酸;序列比对结果显示,其编码的蛋白质同时含有ZF以及HD保守结构域;蛋白质的相对分子质量为39153.89 Da,结构中富含α螺旋和无规则卷曲。成功构建表达载体pGWB5-FvZF-HD7,将目的基因载体转入烟草中,Confocal激光共聚焦显微镜观察发现,转基因烟草的细胞核中检测到GFP信号,表明FvZF-HD7蛋白定位于细胞核中。研究表明,FvZF-HD7可能广泛参与了植物花发育和逆境胁迫调控,为进一步分析森林草莓ZF-HD基因家族的功能奠定了理论与分子基础。

关键词：森林草莓生物信息学 FvZF-HD7 亚细胞定位基因表达

A Change in Bathing Style May Improve Mental Fitness

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Health 2015年第2期7卷 270-278页

作者： Takaaki Kubo Tomonori Yasuda Yoshihisa Masumitsu Yoshihiro Iwashita Satoshi Watanabe Taichi Ishizawa Mitsuo Tsunakawa shingo Yano Junichi Iimaya Department of Rehabilitation Faculty of Health Sciences Kumamoto Health Science University Kumamoto Japan Products Development Department Bathclin Corporation Ibaraki Japan

Frequent bathtub bathing (BB) improves the mental health of middle-aged and older Japanese in-dividuals. This study investigated the chronic mental health effects of BB, maintaining warmth using an insulating sheet and sleeping bag after bathtub bathing (BBW), and bathtub bathing with herbal extracts (BBH) in healthy young adults. The study involved healthy young adults who habitually showered, as opposed to bathing. In the first experiment, 18 participants were randomly assigned to either the BB or BBW groups for 14 consecutive nights. After a 2-week washout period, the participants were asked to switch their bathing styles (a cross-over design). In the second experiment, 20 participants were randomly assigned to the BB or BBH group. The herbal extracts for the BBH group contained angelicae radix, aurantii nobilis pericarpium, chamomile, and zingiberis rhizoma. After a 2-week washout period, these participants also switched to the other bathing style. The participants’ mental conditions pre- and post-intervention were assessed using the Profile of Mood States-Brief Form questionnaire, Japanese version, and were statistically analyzed. The participants’ Anger-Hostility score converged to an average (50 points) in the post-BBW and post-BBH participants, and there were no significant differences in BB. The Confusion change rate was significantly different in the first experiment (BB versus BBW). The Depression-Dejection and Fatigue change rates were significantly different in the second experiment (BB versus BBH). Our findings suggest that changing bathing style from showering to BBW or BBH improves the POMS Anger-Hostility scores of healthy young adults.

关键词： Bathtub Bathing Warmth Herbal Extracts Mental Fitness Healthy Young Adults

The Associated Risk Factors for Entrapment Neuropathy in the Upper Extremity: The Locomotive Syndrome and Health Outcome in Aizu Cohort Study (LOHAS)

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Health 2018年第6期10卷 823-837页

作者： Kenichi Otoshi Shinichi Kikuchi Nobuyuki Sasaki Miho Sekiguchi Koji Otani Tsukasa Kamitani shingo Fukuma Shunichi Fukuhara Shinichi Konno Department of Sports Medicine School of Medicine Fukushima Medical University Fukushima Japan Department of Orthopaedic Surgery School of Medicine Fukushima Medical University Fukushima Japan Department of Healthcare Epidemiology Graduate School of Medicine and Faculty of Medicine Kyoto University Kyoto Japan

Purpose: Although carpal tunnel syndrome (CTS) and cubital tunnel syndrome (CuTS) are the most common neuropathies in the upper extremities, there have been few studies describing the etiology and associated factors in the general population. The purpose of this study was to investigate and clarify the etiology and associated factors for CTS and CuTS in the Japanese general population. Methods: A total of 1875 participants, who participated in health checkups conducted in rural areas in Japan in 2010, were enrolled. The prevalence of CTS and CuTS was investigated. Logistic regression models were performed to examine the relationship between CTS and CuTS and correlated factors such as occupational status, smoking and alcohol preferences, and medical characteristics. Results: The overall prevalence of CTS and CuTS was 2.0% and 2.2%, respectively. With regards to CTS, female subjects showed 7.33-times higher risk of CTS compared with male subjects. In addition, hypertension was also at high risk of CTS (5.56-times higher in borderline and 4.55-times higher in definite hypertension compared with normal blood pressure). However, there were no significant associations between CuTS and age, gender, occupation, smoking and alcohol preferences, or metabolic factors. Conclusions: CTS was associated with female gender and hypertension, whereas there was no obvious risk factor contributing to the onset of CuTS.

关键词： Risk Factor Carpal Tunnel Syndrome Cubital Tunnel Syndrome Metabolic Factor Prevalence

26S proteasome inhibitors inhibit dexamethasone-dependent increase of tyrosine aminotransferase and tryptophan 2,3-dioxygenase mRNA levels in primary cultured rat hepatocytes

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Journal of Biophysical Chemistry 2012年第4期3卷 348-356页

作者： Mizuho Harashima Masashi Hyuga Youko Nagaoka Chieko Saito Minako Furukawa Taiichiro Seki Toyohiko Ariga Nana Kawasaki shingo Niimi Department of Nutrition and Physiology Nihon University College of Bioresource Sciences Fujisawa Japan Division of Biological Chemistry and Biologicals National Institute of Health Sciences Tokyo Japan

Dexamethasone (Dex), a ligand for transcriptional enhancement of tyrosine aminotransferase (TAT) and tryptophan 2,3-dioxygenase (TO) genes, (100 nM) maximally increased these mRNA levels at 12 h and 7 h in primary cultured rat hepatocytes and the nuclear fraction, respectively. Lactacystin (5 μM) and epoxomicin (0.5 μM), 26S proteasome inhibitors, significantly suppressed the Dex-dependent maximum increase of TAT and TO mRNA levels in the cells and the nuclear fraction. Electrophoretic mobility shift assay demonstrated that lactacystin did not affect binding of glucocorticoid receptor to glucocorticoid responsive element. Furthermore, lactacystin did not affect the activation of GRE luciferase reporter by Dex transfected to the cells. The results demonstrate that 26S proteasome is positively involved in the Dex-dependent increase of TAT and TO mRNA levels in the cells and suggest that the mechanism of action of 26S proteasome may be degradation of some RNase(s), which breaks down TAT and TO mRNAs.

关键词： Glucocorticoid 26S proteasome Inhibitor Tyrosine Aminotransferase Tryptophan 2 3-Dioxygenase Genes

A NEW ARISTOLOCHIC ACID FROM ARISTOLOCHIA CINNABARINA

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Chinese Chemical Letters 1994年第3期5卷 201-202页

作者： Hong LI Youji SAKAGAMI shingo MARUMO Xin Min CHEN(Chengdu Institute of Biology, Acadcmia Sinica, Chengdu, 610041)(Department of AgricultUral Chemistry, Nagoys University, Chikusa-Ku, Nagoya 464,Japan.)

A new compound, aristolochoc acid Ⅲ a- 6-0-β-D-glucoside, was isolated along with four known compounds from Aristolochia cinnabarina. The structure of the new,compound was elucidated on the basis of spectral evidences

关键词： ACID A NEW ARISTOLOCHIC ACID FROM ARISTOLOCHIA CINNABARINA