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Interacting with α7 nAChR is a new mechanism for AChE to enhance the inflammatory response in macrophages

Acta Pharmaceutica Sinica B 2020年第10期10卷 1926-1942,2020页

作者： Etta Y.L.Liu Yingjie Xia Xiangpeng Kong Maggie S.S.Guo Anna X.D.Yu Brody Z.Y.Zheng shinghung mak Miranda L.Xu Karl W.K.Tsim Key Laboratory of Food Quality and Safety of Guangdong Province College of Food ScienceSouth China Agricultural UniversityGuangzhou 510642China Shenzhen Key Laboratory of Edible and Medicinal Bioresources the Hong Kong University of Science and TechnologyShenzhen 518057China Division of Life Science Center for Chinese Medicinethe Hong Kong University of Science and TechnologyHong kongChina

Acetylcholine(ACh)regulates inflammation viaα7 nicotinic acetylcholine receptor(α7 nAChR).Acetylcholinesterase(AChE),an enzyme hydrolyzing ACh,is expressed in immune cells suggesting non-classical function in inflammatory ***,the expression of PRiMA-linked G4 AChE was identified on the surface of *** lipopolysaccharide-induced inflammatory processes,AChE was upregulated by the binding of NF-κB onto the ACHE ***,the overexpression of G4 AChE inhibited ACh-suppressed cytokine release and cell migration,which was in contrast to that of applied AChE ***,a DNA construct without enzymatic activity,was adopted to identify the protein role of AChE in immune *** of G4 AChEmt induced cell migration and inhibited ACh-suppressed cell *** co-localization ofα7 nAChR and AChE was found in macrophases,suggesting the potential interaction ofα7 nAChR and ***,immunoprecipitation showed a close association ofα7 nAChR and AChE protein in cell ***,the novel function of AChE in macrophage by interacting withα7 nAChR was *** with hydrolysis of ACh,AChE plays a direct role in the regulation of inflammatory *** such,AChE could serve as a novel target to treat age-related diseases by antiinflammatory responses.

关键词： Macrophage AChE Cholinergic anti-inflammatory pathway α7 nAChR

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Much Stronger Anti-Aβ Fibrillization Activities of bis(12)-hupyridone Than Its Natural Analogue

Much Stronger Anti-Aβ Fibrillization Activities of bis(12)-...

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第十四届全国中药和天然药物学术研讨会

作者： Shengquan Hu Rui Wang Wei Cui shinghung mak Daping Xu Zaijun Zhang Chunglit Choi Paul R.Carlier Yifan Han The Hong Kong Polytechnic University The Hong Kong Polytechnic University Shenzhen Research Institute East China University of Science and Technology Jinan University University of Macau Virginia Tech

The aggregation of p-amyloid protein(Ap)into fibrils contributes significantly to the pathogenesis of Alzheimer’s disease(AD),and hence the attractive therapeutic strategies focusing on the inhibition of Aβfibrillization are *** this study,the anti-APfibrillization effect of bis(12)-hupyridone,a multifunctional homo-dimer derived from huperzine

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