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Hepatobiliary & Pancreatic Diseases International 2023年第2期22卷 154-159页

作者： Dakyum shin jaewoo Kwon jae Hoon Lee Seo Young Park Yejong Park Woohyung Lee Ki Byung Song Dae Wook Hwang Song Cheol Kim Division of Hepato-Biliary and Pancreatic Surgery Department of SurgeryAsan Medical CenterUniversity of Ulsan College of Medicine88 Olympic-ro 43-gilSongpa-guSeoul 05505Korea Department of Surgery Kangbuk Samsung HospitalSungkyunkwan University School of Medicine29 Saemunan-roJongno-guSeoul 03181Korea Department of Statistics and Data Science Korea National Open University86 Daehak-roJongno-guSeoul 03087Korea

Background: Minimally invasive surgery is becoming increasingly popular in the field of pancreatic surgery. However, there are few studies of robotic distal pancreatectomy(RDP) for pancreatic ductal adenocarcinoma(PDAC). This study aimed to investigate the efficacy and feasibility of RDP for PDAC. Methods: Patients who underwent RDP or laparoscopic distal pancreatectomy(LDP) for PDAC between January 2015 and September 2020 were reviewed. Propensity score matching analyses were performed. Results: Of the 335 patients included in the study, 24 underwent RDP and 311 underwent LDP. A total of 21 RDP patients were matched 1:1 with LDP patients. RDP was associated with longer operative time(209.7 vs. 163.2 min;P = 0.003), lower open conversion rate(0% vs. 4.8%;P ikelihood of achieving R0 margins than LDP.

关键词： Minimally invasive surgery Robotic distal pancreatectomy Laparoscopic distal pancreatectomy Pancreatic ductal adenocarcinoma Propensity score matching

Variation in Summer Surface Air Temperature over Northeast Asia and Its Associated Circulation Anomalies

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Advances in Atmospheric Sciences 2016年第1期33卷 1-9页

作者： Wei CHEN Xiaowei HONG Riyu LU Aifen JIN Shizhu JIN jae-Cheol NAM Jin-Ho shin Tae-Young GOO Baek-Jo KIM State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric Physics Chinese Academy of Sciences Beijing 100029 University of Chinese Academy of Sciences Beijing 100049 Department of Geography Yanbian University Yanji 133002 National Institute of Meteorological Research Korea Meteorological Administration deju Korea

This study investigates the interannual variation of summer surface air temperature over Northeast Asia（NEA） and its associated circulation *** leading modes for the temperature variability over NEA are obtained by EOF *** first EOF mode is characterized by a homogeneous temperature anomaly over NEA and therefore is called the NEA *** anomaly extends from southeast of Lake Baikal to Japan,with a central area in Northeast *** second EOF mode is characterized by a seesaw pattern,showing a contrasting distribution between East Asia（specifically including the Changbai Mountains in Northeast China,Korea,and Japan） and north of this *** mode is named the East Asia（EA） *** modes contribute equivalently to the temperature variability in *** two leading modes are associated with different circulation anomalies.A warm NEA mode is associated with a positive geopotential height anomaly over NEA and thus a weakened upper-tropospheric westerly *** the other hand,a warm EA mode is related to a positive height anomaly over EA and a northward displaced *** addition,the NEA mode tends to be related to the Eurasian teleconnection pattern,while the EA mode is associated with the East Asia-Pacific/PacificJapan pattern.

关键词： surface air temperature Northeast Asia East Asia circulation anomaly interannual variability

Gut microbiome composition can predict the response to nivolumab in advanced hepatocellular carcinoma patients

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World Journal of Gastroenterology 2021年第42期27卷 7340-7349页

作者： Min-Woo Chung Moon-Ju Kim Eun Jeong Won Yu Jeong Lee Yong-Woon Yun Sung Bum Cho Young-Eun Joo Jun-Eul Hwang Woo Kyun Bae ik-Joo Chung Myung Geun shin Jong Hee shin Department of Internal Medicine Chonnam National University Hospital and College of MedicineHwasun 58128Jeollanam-doSouth Korea Department of Parasitology and Tropical Medicine Chonnam National University Medical SchoolHwasun 58128Jeollanam-doSouth Korea Department of Laboratory Medicine Chonnam National University Hwasun HospitalHwasun 58128Jeollanam-doSouth Korea Department of Preventive Medicine Chonnam National University Medical SchoolHwasun-eupHwasun 58128Jeollanam-doSouth Korea Department of Laboratory Medicine Chonnam National University HospitalGwangju 61469South Korea

BACKGROUND Immunotherapy has revolutionized the clinical outcomes of intractable cancer *** is known about the intestinal nonpathogenic bacterial composition of hepatocellular carcinoma(HCC)patients treated by *** To determine whether there is a correlation between gut bacterial composition and prognosis in HCC *** From September 2019 to March 2020,we prospectively collected fecal samples and examined the gut microbiome of 8 advanced HCC patients treated with nivolumab as a second-or third-line systemic *** samples were collected before the start of *** samples of patients with progression during treatment were collected at the time of progression,and fecal samples of patients who showed good response to nivolumab were collected after 5-7 mo as *** data from 16S ribosomal RNA sequencing were analyzed using CLC Genomics *** data were analyzed according to therapeutic *** All 8 patients were male,of which 6 had underlying chronic hepatitis B.A higher Shannon index was found in the responders than in the non-responders after nivolumab therapy(P=0.036).The unweighted beta diversity analysis also showed that the overall bacterial community structure and phylogenetic diversity were clearly distinguished according to therapeutic *** was no significant difference in the diversity or composition of the patient gut microbiome according to the immunotherapy *** taxa specific to therapeutic response were designated as follows:Dialister pneumosintes,Escherichia coli,Lactobacillus reteri,Streptococcus mutans,Enterococcus faecium,Streptococcus gordonii,Veillonella atypica,Granulicatella sp.,and Trchuris trichiura for the nonresponders;Citrobacter freundii,Azospirillum *** Enterococcus durans for the *** note,a skewed Firmicutes/Bacteroidetes ratio and a low Prevotella/Bacteroides ratio can serve as predictive markers of non-response,wh

关键词： Microbiome Nivolumab Firmicutes/Bacteroidetes ratio Prevotella/Bacteroides ratio Hepatocellular carcinoma Prognosis

Profit Analysis by Soil Carbon Sequestration with Different Composts and Cooperated with Biochar during Corn (Zea mays) Cultivation Periods in Sandy Loam Soil

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Journal of Agricultural Chemistry and Environment 2016年第3期5卷 107-112页

作者： Joung Du shin Yong-Su Choi jae-Hoon shin Department of Climate Change & Ecology National Institute of Agricultural Science RDA Wanju Korea Organic Agricultural Division National Institute of Agricultural Sciences Korea

Despite the ability of biochar to enhance soil fertility and to sequester soil carbon, its potential reduction of green house gas emissions and profit analysis with different organic composts and cooperated with biochar for crop cultivation have been a few evaluated. This study was conducted to estimate their greenhouse gas emission reduction and profit analysis by soil carbon sequestration with different organic composts and cooperated with biochar application during corn cultivation periods. For the experiment, the treatments were consisted of aerobic digestate of swine wastes (AD), pig compost as the control (PC), cow compost (CC) and pig compost cooperated with 1% biochar (PC + 1% biochar). The soil texture used in this study was sandy loam, and application rates of chemical fertilizer were 190-39-221 kg·ha-1 (N-P2O5-K2O) as recommended amount after soil test. The soil samples were periodically taken at every 15 day intervals during the experimental periods. It was observed that soil carbon sequestration by AD, CC and PC + 1% biochar application was estimated to be 429 kg·ha-1, 2366 kg·ha-1, and 3978 kg·ha-1, and their CO2-e emission reductions were estimated to be 0.16 tones for AD, 0.87 tones for CC, and 14.58 tones for PC + 1% biochar per hectar for corn cultivation periods. Their profits were estimated at $14.58 for lowest and $451.90 for highest. In Korea Climate Exchange, it was estimated to be $115.20 per hectar of corn cultivation with PC + 1% biochar. So, the price of CO2 per hectar for corn cultivation with PC + 1% biochar was high at 16.8 times relative to cow compost treatment only. For the plant growth response, it was observed that plant height and fresh ear yield were not significantly different among the treatments. Therefore, these experimental results might be fundamental data for assuming a carbon trading mechanism exists for biochar soil applica

关键词： Biochar Greenhouse Gas Emission Mitigation Soil Carbon Sequestration Compost

High level of preoperative carbohydrate antigen 19-9 is a poor survival predictor in gastric cancer

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World Journal of Gastroenterology 2013年第32期19卷 5302-5308页

作者： A Ra Choi Jun Chul Park Jie-Hyun Kim Sung Kwan shin Sang Kil Lee Yong Chan Lee jae Bock Chung Department of Internal Medicine and Institute of Gastroenterology Yonsei University College of Medicine

AIM:To assess the clinical significance and the prognostic value of preoperative serum carbohydrate antigen 19-9(CA 19-9)level in gastric ***:Between January 2005 and December2006,1960 patients underwent surgery for histologically confirmed gastric *** these,163 patients had elevated serum levels of CA 19-9 preoperatively,and1628 patients had normal serum levels of CA 19-9 *** this study,325 patients were selected from the group of 1628 patients by age,sex,and cancer stage to serve as *** significant differences in survival rates were calculated using the log-rank test.A P value less than 0.05 was considered statistically significant and was determined using SAS ***:The baseline characteristics showed some differences between the two groups with regard to *** survival(OS)in the elevated and nonelevated group was 37.90 and 68.67 mo,respectively(P<0.001).N stage(P=0.001)was a significant predictor of disease-free survival by multivariate ***,N stage(P<0.001),and the presence of peritoneal metastasis(P<0.001)remained independent factors in predicting OS by multivariate ***,preoperative serum CA 19-9 levels were significantly associated with OS in univariate(P=0.009)and multivariate(P=0.021)***:Serum CA 19-9 can be considered an independent prognostic factor in predicting OS in patients anticipating surgery for gastric cancer.

关键词： Gastric cancer Carbohydrate antigen 19-9 Disease-free survival Overall survival

Flexible and transparent thin-film light-scattering photovoltaics about fabrication and optimization for bifacial operation

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npj Flexible Electronics 2023年第1期7卷 388-397页

作者： Soo-Won Choi jae-Ho Park Ji-Woo Seo Chaewon Mun Yonghun Kim Pungkeun Song Myunghun shin Jung-Dae Kwon Surface&Nano Materials Division Korea Institute of Materials ScienceChangwonGyeongnam 51508Republic of Korea Department of Materials Science and Engineering Pusan National UniversityBusan 46241Republic of Korea Cell R&D Team Hanhwa QCells202 Sansusandan 2-roLwol-myeonJincheon-gunChungcheongbuk-do 27816Republic of Korea School of Electronics and Information Engineering Korea Aerospace UniversityGoyangGyeonggi 10540Republic of Korea Department of Advance Materials Engineering University of Science and Technology(UST)217 Gajeong-roYuseong-guDaejeon 34113Republic of Korea

Flexible and transparent thin-film silicon solar cells were fabricated and optimized for building-integrated photovoltaics and bifacial operation.A laser lift-off method was developed to avoid thermal damage during the transfer of light-scattering structures onto colorless polyimide substrates and thus enhance front-incidence photocurrent,while a dual n-type rear window layer was introduced to reduce optical losses,facilitate electron transport for rear incidence,and thus enhance performance during bifacial *** introduction of the window layer increased the rear-to-front power conversion efficiency ratio to~86%.The optimized bifacial power conversion efficiency for front and rear irradiances of 1 and 0.3 sun,respectively,equaled 6.15%,and the average transmittance within 500–800 nm equaled 36.9%.Additionally,the flexible and transparent solar cells fabricated using laser lift-off exhibited good mechanical reliability(i.e.,sustained 500 cycles at a bending radius of 6 mm)and were therefore suitable for building-integrated photovoltaics.

关键词： transparent scattering film

The hidden switches undertying RORα-mediated circuits that critically regulate uncontrolled cell proliferation

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Journal of Molecular Cell Biology 2014年第4期8卷 338-348页

作者： Dongkwan shin ik Soo Kim Ji Min Lee Sung-Young shin Jong-Hoon Lee Sung Hee Baek Kwang-Hyun Cho Department of Bio and Brain Engineering Korea Advanced Institute of Science and Technology (KAIST) Daejeon 305-701 Republic of Korea Department of Biological Sciences Creative Research Initiative Center for Chromatin Dynamics Seoul National University Seou1151-742 Republic of Korea

Prostaglandin E2 （PGE2） is known to have a key role in the development of colorectal cancer, but previous experiments showed its contrasting （i.e. tumor-promoting or tu mor-suppressive） roles depending on experimental conditions. To elucidate the mechanisms underlying such contrasting roles of PG E2 in tumorigenesis, we investigated all the previous experiments and found a new signal transduction pathway mediated by retinoic acid receptor-related orphan receptor （ROR）α, in which PGE2/PKCα-dependent phosphorylation of RORα attenuates Wnt target gene expression in colon cancer ceils. From mathematical simulations combined with biochemical experimentation, we revealed that RORα induces a biphasic response of Wnt target genes to PGE2 stimulation through a regulatory switch formed by an incoherent feedforward loop, which provides a mechanistic explanation on the contrasting roles of PGE2 observed in previous experiments. More interestingly, we found that RORα constitutes another regulatory switch formed by coupled positive and negative feedback loops, which regulates the hysteretic response of Wnt signaling and eventually converts a proliferative cellular state into an anti-proliferative state in a very delicate way. Our results indicate that RORα is the key regulator at the center of these hidden switches that critically regulate cancer celt proliferation and thereby being a promising anti-cancer therapeutic target.

关键词： colorectal cancer Wnt signaling RORα mathematical modeling biphasic response hysteresis systems biology

Features of extrahepatic metastasis after radiofrequency ablation for hepatocellular carcinoma

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World Journal of Gastroenterology 2020年第32期26卷 4833-4845页

作者： jae H Yoon Young J Goo Chae-Jun Lim Sung K Choi Sung B Cho Sang S shin Chung H Jun Department of Gastroenterology Chonnam National University Hospital and Medical SchoolGwangju 61469South Korea Department of Gastroenterology Hwasun Chonnam National University Hospital and Medical SchoolHwasun 58128South Korea Department of Radiology Chonnam National University Hospital and Medical SchoolGwangju 61469South Korea Department of Internal Medicine Mokpo Hankook HospitalMokpo 58643South Korea

BACKGROUND Extrahepatic metastasis(EHM)of hepatocellular carcinoma(HCC)is associated with poor ***,the clinical features and risk factors of EHM of HCC after radiofrequency ablation(RFA)remain *** To elucidate the characteristics and risk factors of EHM after RFA for *** From January 2008 to December 2017,we retrospectively enrolled 661 patients who underwent RFA as first-line treatment for HCC at 2 tertiary *** inclusion criteria were age≥18 years,a diagnosis of HCC,and *** computed tomography(CT)or magnetic resonance imaging(MRI)and alpha-fetoprotein measurements were routinely performed at 1 mo after RFA and followed-up at intervals of 3-6 *** analyses were performed using the chi-squared test or Student’s t-test,and univariate and multivariate analyses were performed via logistic regression,as *** EHM was diagnosed in 44 patients(6.7%)during a median follow-up period of 1204 *** 10-year cumulative rate of HCC recurrence and EHM was 92.7%and 33.7%,*** recurrence was most often intrahepatic,and the rate of extrahepatic recurrence at initial recurrence was only 1.2%.The median time to the diagnosis of EHM was 2.68 years,and 68.2%of patients developed EHM within 2 years of the first recurrence,regardless of recurrence-free survival and 75.0%of patients developed EHM within 5 years after first *** was mostly diagnosed via abdominal CT/MRI in 33(75.0%)and 38 of 44 patients(86.4%)with EHM had either positive abdominal CT scan results or serum AFP level *** multivariate analysis,recurrence-free survival400 IU/mL were associated with a high EHM *** EHM occurs following multiple intrahepatic recurrences after RFA and combined contrast-enhanced abdominal CT and serum AFP were useful for *** especially with high-risk factors require close follow-up for

关键词： Hepatocellular carcinoma Metastasis Radiofrequency ablation Surveillance Risk factor

Sarcomatoid carcinoma of the pancreas—multimodality imaging findings with serial imaging follow-up:A case report and review of literature

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World Journal of Clinical Cases 2021年第13期9卷 3102-3113页

作者： Hyun jae Lim Hye Seon Kang Jeong Eun Lee Ji Hye Min Kyung Sook shin Sun Kyoung You Kyung-Hee Kim Department of Radiology Chungnam National University HospitalDaejeon 35015South Korea Department of Radiology Chungnam National University HospitalChungnam National University College of MedicineDaejeon 35015South Korea Department of Radiology and Center for Imaging Science Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351South Korea Department of Pathology Cancer Research InstituteCollege of MedicineChungnam National UniversityDaejeon 35015South Korea

BACKGROUND Sarcomatoid carcinoma of the pancreas is extremely rare and has an extremely poor *** a few cases of sarcomatoid carcinoma of pancreas have been reported,most are focused on a histopathological *** the best of our knowledge,there are no reports documenting multimodality imaging characteristics and chronological changes with emphasis on radiologic *** SUMMARY A 64-year-old woman was admitted to Chungnam National University Hospital with acute ***-enhanced computed tomography of the abdomen revealed a 2.6 cm×2.8 cm multilobular cystic mass in the pancreatic *** pancreatic lesion showed suspected mural nodules and thin ***,mucinous cystic neoplasm of pancreas was *** 7 mo,the patient was readmitted for repeated epigastric abdominal pain and ***-up contrast-enhanced computed tomography of the abdomen and magnetic resonance imaging revealed a marked enlargement(5.4 cm×4 cm),with a predominant internal solid *** mass showed low signal intensity on a T1-weighted image and heterogeneously intermediate high signal intensity on a T2-weighted image. It showed diffusion restriction and peripheral rimenhancement on an arterial phase image, and progressive enhancement on portalvenous and delayed phase images. Distal pancreatectomy was performed. Basedon the morphology and immunohistochemical staining of the specimen,pancreatic sarcomatoid carcinoma was *** present the computed tomography, magnetic resonance imaging, and positronemission tomography computed tomography findings, pathologic features, andchronological changes for preoperative diagnosis.

关键词： Carcinosarcoma Pancreas Computed tomography Magnetic resonance imaging Pancreatectomy Case report

Long-term outcomes of endoscopic submucosal dissection and surgery for undifferentiated intramucosal gastric cancer regardless of size

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World Journal of Gastroenterology 2022年第8期28卷 840-852页

作者： Gil Ho Lee Eunyoung Lee Bumhee Park Jin Roh Sun Gyo Lim Sung jae shin Kee Myung Lee Choong-Kyun Noh Department of Gastroenterology Ajou University School of MedicineSuwon 16499South Korea Department of Biomedical Informatics Ajou University School of MedicineSuwon 16499South Korea Department of Pathology Ajou University School of MedicineSuwon 16499South Korea

BACKGROUND The clinical outcomes of endoscopic submucosal dissection(ESD)for undifferentiated(UD)intramucosal early gastric cancer(EGC)compared with those of surgery,regardless of lesion size,are not well ***,there is a concern regarding the treatment plan before and after ESD in cases of UD intramucosal EGC within expanded *** To evaluate clinical outcomes of ESD compared with those of surgery in UD intramucosal EGC patients regardless of tumor *** We enrolled patients with UD intramucosal EGC after ESD with complete resection or surgery from January 2005 to August 2020 who met the within or beyond expanded indications with lesion size>2 cm(the only non-curative factor).Overall,123 and 562 patients underwent ESD and surgery,*** propensity-score matching,clinical and long-term outcomes,i.e.,recurrencefree survival(RFS)and overall survival(OS),were *** multivariable Cox proportional hazard model with treatment modality and ESD indication was used to evaluate the recurrence *** After matching,119 patients each were finally enrolled in the ESD and surgery *** median length of hospital stay was shorter in the ESD group than surgery group(4.0 vs 9.0 days,P<0.001).Four cases of recurrence after ESD were local recurrences,all of which occurred within 1 *** recurrence was seven(5.9%)and two(1.7%)in the ESD and surgery groups,*** difference was observed between the two groups with respect to OS(P=0.948).However,the ESD group had inferior RFS compared with the surgery group(P=0.031).ESD was associated with the risk of recurrence after initial treatment in all enrolled patients(hazard ratio,5.2;95%confidence interval:1.0-25.8,P=0.045).CONCLUSION Although OS was similar between the two groups,surveillance endoscopy was important for the ESD than for the surgery group because RFS was inferior and local recurrence was an issue.

关键词： Early gastric cancer Undifferentiated cancer Expanded indication Endoscopic submucosal dissection Surgery