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Journal of Ocean University of China 2013年第1期12卷 125-133页

作者： Yun Hee Kang jae Ran Hwang ik Kyo Chung Sang Rul Park Marine and Environmental Research Institute Jeju National University Marine Environmental Research Division National Fisheries Research and Development Institute Division of Earth Environmental System Pusan National University School of Marine Biomedical Sciences Jeju National University

Integrated multi-trophic aquaculture (IMTA) has been proposed as a concept that combines the cultivation of fed aquaculture species (e.g., finfish/shrimp) with extractive aquaculture species (e.g., shellfish/seaweed). In seaweed-based integrated aquaculture, seaweeds have the capacity to reduce the environmental impact of nitrogen-rich effluents on coastal ecosystems. Thus, selection of optimal species for such aquaculture is of great importance. The present study aimed to develop a seaweed species-selection index for selecting suitable species in seaweed-based integrated aquaculture system. The index was synthesized using available literature-based information, reference data, and physiological seaweed experiments to identify and prioritize the desired species. Undaria pinnatifida, Porphyra yezoensis and Ulva compressa scored the highest according to a seaweed-based integrated aquaculture suitability index (SASI). Seaweed species with the highest scores were adjudged to fit the integrated aquaculture systems. Despite the application of this model limited by local aquaculture environment, it is considered to be a useful tool for selecting seaweed species in IMTA.

关键词： seaweed IMTA species-selection model water temperature physiological characteristics uptake rate

The hidden switches undertying RORα-mediated circuits that critically regulate uncontrolled cell proliferation

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Journal of Molecular Cell Biology 2014年第4期8卷 338-348页

作者： Dongkwan shin ik Soo Kim Ji Min Lee Sung-Young shin Jong-Hoon Lee Sung Hee Baek Kwang-Hyun Cho Department of Bio and Brain Engineering Korea Advanced Institute of Science and Technology (KAIST) Daejeon 305-701 Republic of Korea Department of Biological Sciences Creative Research Initiative Center for Chromatin Dynamics Seoul National University Seou1151-742 Republic of Korea

Prostaglandin E2 （PGE2） is known to have a key role in the development of colorectal cancer, but previous experiments showed its contrasting （i.e. tumor-promoting or tu mor-suppressive） roles depending on experimental conditions. To elucidate the mechanisms underlying such contrasting roles of PG E2 in tumorigenesis, we investigated all the previous experiments and found a new signal transduction pathway mediated by retinoic acid receptor-related orphan receptor （ROR）α, in which PGE2/PKCα-dependent phosphorylation of RORα attenuates Wnt target gene expression in colon cancer ceils. From mathematical simulations combined with biochemical experimentation, we revealed that RORα induces a biphasic response of Wnt target genes to PGE2 stimulation through a regulatory switch formed by an incoherent feedforward loop, which provides a mechanistic explanation on the contrasting roles of PGE2 observed in previous experiments. More interestingly, we found that RORα constitutes another regulatory switch formed by coupled positive and negative feedback loops, which regulates the hysteretic response of Wnt signaling and eventually converts a proliferative cellular state into an anti-proliferative state in a very delicate way. Our results indicate that RORα is the key regulator at the center of these hidden switches that critically regulate cancer celt proliferation and thereby being a promising anti-cancer therapeutic target.

关键词： colorectal cancer Wnt signaling RORα mathematical modeling biphasic response hysteresis systems biology

Colors of vegetables and fruits and the risks of colorectal cancer

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World Journal of Gastroenterology 2017年第14期23卷 2527-2538页

作者： Jeeyoo Lee Aesun shin jae Hwan Oh Jeongseon Kim Department of Preventive Medicine Seoul National University College of Medicine Center for Colorectal Cancer National Cancer Center Molecular Epidemiology Branch Division of Cancer Epidemiology and PreventionResearch InstituteNational Cancer Center

AIM To investigate the relationship between the colors of vegetables and fruits and the risk of colorectal cancer in *** A case-control study was conducted with 923 colorectal cancer patients and 1846 controls recruited from the National Cancer Center in Korea. We classified vegetables and fruits into four groups according to the color of their edible parts(e.g., green, orange/yellow, red/purple and white). Vegetable and fruit intake level was classified by sex-specific tertile of the control group. Logistic regression models were used for estimating the odds ratios(OR) and their 95% confidence intervals(CI).RESULTS High total intake of vegetables and fruits was strongly associated with a reduced risk of colorectal cancer in women(OR = 0.32, 95%CI: 0.21-0.48 for highest vs lowest tertile) and a similar inverse association was observed for men(OR = 0.60, 95%CI: 0.45-0.79). In the analysis of color groups, adjusted ORs(95%CI) comparing the highest to the lowest of the vegetables and fruits intake were 0.49(0.36-0.65) for green, and 0.47(0.35-0.63) for white vegetables and fruits in men. An inverse association was also found in women for green, red/purple and white vegetables and fruits. However, in men, orange/yellow vegetables and fruits(citrus fruits, carrot, pumpkin, peach, persimmon, ginger) intake was linked to an increased risk of colorectal cancer(OR = 1.61, 95%CI: 1.22-2.12).CONCLUSION Vegetables and fruits intake from various color groups may protect against colorectal cancer.

关键词： Vegetable and fruits Colorectal cancer Korea

Goniosynechialysis for secondary angle closure glaucoma in a pseudophakic patient after vitrectomy and silicone oil injection

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International Journal of Ophthalmology(English edition) 2014年第5期7卷 914-916页

作者： Jonghoon shin Hyeshin Jeon ik Soo Byon Ji-Woong Lee Department of Ophthalmology Pusan National University School of Medicine Medical Research Institute Pusan National University Hospital Department of Ophthalmology Pusan National University Yangsan Hospital

Dear Sir,Iam Jonghoon shin,from the Department of Ophthalmology of Pusan National University Hospital,Busan,Korea.I write to present a patient with secondary angle closure glaucoma(SACG)after vitrectomy and silicone o... 详细信息

关键词： SO IOP Goniosynechialysis for secondary angle closure glaucoma in a pseudophakic patient after vitrectomy and silicone oil injection UBM

Technical advances in external radiotherapy for hepatocellular carcinoma

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World Journal of Gastroenterology 2016年第32期22卷 7311-7321页

作者： shin-Hyung Park jae-Chul Kim Min Kyu Kang Department of Radiation Oncology Kyungpook National University Hospital Department of Radiation Oncology Kyungpook National University School of Medicine

Radiotherapy techniques have substantially improved in the last two decades. After the introduction of 3-dimensional conformal radiotherapy, radiotherapy has been increasingly used for the treatment of hepatocellular carcinoma(HCC). Currently, more advanced techniques, including intensity-modulated radiotherapy(IMRT), stereotactic ablative body radiotherapy(SABR), and charged particle therapy, are used for the treatment of HCC. IMRT can escalate the tumor dose while sparing the normal tissue even though the tumor is large or located near critical organs. SABR can deliver a very high radiation dose to small HCCs in a few fractions, leading to high local control rates of 84%-100%. Various advanced imaging modalities are used for radiotherapy planning and delivery to improve the precision of radiotherapy. These advanced techniques enable the delivery of high dose radiotherapy for early to advanced HCCs without increasing the radiation-induced toxicities. However, as there have been no effective tools for the prediction of the response to radiotherapy or recurrences within or outside the radiation field, future studies should focus on selecting the patients who will benefit from radiotherapy.

关键词： Hepatocellular carcinoma Radiotherapy 3D-conformal Radiotherapy Intensity-modulated Radiotherapy stereotactic ablative body Radiotherapy Charged particle therapy Image-guided Radiotherapy

Die Casting Mold Design of the Thin-walled Aluminum Case by Computational Solidification Simulation

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Journal of Materials Science & Technology 2008年第3期24卷 383-388页

作者： Young-Chan Kim Chang-Seog Kang jae-ik Cho Chang-Yeol Jeong Se-Weon Choi Sung-Kil Hong Korea Institute of Industrial Technology Chonnam National University

Recently, demand for the lightweight alloy in electric/electronic housings has been greatly increased. However, among the lightweight alloys, aluminum alloy thin-walled die casting is problematic because it is quite difficult to achieve sufficient fluidity and feedability to fill the thin cavity as the wall thickness becomes less than 1mm. Therefore, in this study, thin-walled die casting of aluminum （Al-Si-Cu alloy： ALDC 12） in size of notebook computer housing and thickness of 0.8 mm was investigated by solidification simulation （MAGMA soft） and actual casting experiment （Buhler Evolution B 53D）. Three different types of gating design, finger, tangential and split type with 6 vertical runners, were simulated and the results showed that sound thin-walled die casting was possible with tangential and split type gating design because those gates allowed aluminum melt to flow into the thin cavity uniformly and split type gating system was preferable gating design comparing to tangential type gating system at the point of view of soundness of casting and distortion generated after solidification. Also, the solidification simulation agreed well with the actual die-casting and the casting showed no casting defects and distortion.

关键词： Aluminum casting alloy Thin-wall die casting Solidification simulation

Comparative study of chitosan/fibroin–hydroxyapatite and collagen membranes for guided bone regeneration in rat calvarial defects: micro-computed tomography analysis

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International Journal of Oral Science 2014年第2期6卷 87-93页

作者： jae Min Song Sang Hun shin Yong Deok Kim jae Yeol Lee Young jae Baek Sang Yong Yoon Hong Sung Kim Department of Oral and Maxillofacial Surgery School of Dentistry Pusan National University Yangsan Korea Department of Biomaterial Science Pusan National University Miryang Korea

This study aimed to utilize micro-computed tomography （micro-CT） analysis to compare new bone formation in rat calvarial defects using chitosan/fibroin-hydroxyapatite （CFB-HAP） or collagen （Bio-Gide） membranes. Fifty-four （54） rats were studied. A circular bony defect （8 mm diameter） was formed in the centre of the calvaria using a trephine bur. The CFB-HAP membrane was prepared by thermally induced phase separation. In the experimental group （n= 18）, the CFB-HAP membrane was used to cover the bony defect, and in the control group （n= 18）, a resorbable collagen membrane （Bio-Gide） was used. In the negative control group （n= 18）, no membrane was used. In each group, six animals were euthanized at 2, 4 and 8 weeks after surgery. The specimens were then analysed using micro-CT. There were significant differences in bone volume （BV） and bone mineral density （BMD）（P〈O.05） between the negative control group and the membrane groups. However, there were no significant differences between the CFB-HAP group and the collagen group. We concluded that the CFB-HAP membrane has significant potential as a guided bone regeneration （GBR） membrane.

关键词： chitosan/fibroin-hydroxyapatite collagen membrane guided bone regeneration micro-computed tomography rat calva rial defect

Tailoring uniform γ-MnO2 nanosheets on highly conductive three-dimensional current collectors for high-performance supercapacitor electrodes

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Nano Research 2015年第3期8卷 990-1004页

作者： Sangbaek Park Hyun-Woo Shim Chan Woo Lee Hee Jo Song ik jae Park jae-Chan Kim Kug Sun Hong Dong-Wan Kim Department of Materials Science and Engineering Seoul National University Seou1151-744 R. O. Korea School of Civil Environmental and Architectural Engineering Korea University Seou1136-713 R. O. Korea

Recent efforts have focused on the fabrication and application of three- dimensional （3-D） nanoarchitecture electrodes, which can exhibit excellent electrochemical performance. Herein, a novel strategy towards the design and synthesis of size- and thickness-tunable two-dimensional （2-D） MnO2 nanosheets on highly conductive one-dimensional （l-D） backbone arrays has been developed via a facile, one-step enhanced chemical bath deposition （ECBD） method at a low temperature （-50 ℃）. Inclusion of an oxidizing agent, BrO3-, in the solution was crucial in controlling the heterogeneous nucleation and growth of the nanosheets, and in inducing the formation of the tailored and uniformly arranged nanosheet arrays. We fabricated supercapacitor devices based on 3-D MnO2 nanosheets with conductive Sb-doped SnO2 nanobelts as the backbone. They achieved a specific capacitance of 162 F·g-1 at an extremely high current density of 20 A·g% and good cycling stability that shows a capacitance retention of -92% of its initial value, along with a coulombic efficiency of almost 100% after 5,000 cycles in an aqueous solution of I M Na2SO4. The results were attributed to the unique hierarchical structures, which provided a short diffusion path of electrolyte ions by means of the 2-D sheets and direct electrical connections to the current collector by 1-D arrays as well as the prevention of aggregation by virtue of the well-aligned 3-D structure.

关键词： nanosheets manganese oxide chemical bath deposition SnO2 nanobelts supercapacitor

Predictors of post-treatment stenosis in cervical esophageal cancer undergoing high-dose radiotherapy

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World Journal of Gastroenterology 2018年第7期24卷 862-869页

作者： Jun Won Kim Tae Hyung Kim Jie-Hyun Kim ik jae Lee Department of Radiation Oncology Gangnam Severance Hospital Yonsei University College of Medicine Department of Internal Medicine Gangnam Severance Hospital Yonsei University College of Medicine

AIM To evaluate toxicity and treatment outcome of highdose radiotherapy(RT) for cervical esophageal cancer(CEC).METHODS We reviewed a total of 62 consecutive patients who received definitive RT for stage Ⅰ to Ⅲ cervical esophageal cancer between 2001 and 2015. Patients who received < 45 Gy, treated for lesions below sternal notch, treated with palliative aim, treated with subsequent surgical resection, or diagnosed with synchronous hypopharyngeal cancer were excluded. Treatment failures were divided into local(occurring within the RT field), outfield-esophageal, and regional [occurring in regional lymph node(s)] failures. Factors predictive of esophageal stenosis requiring endoscopic dilation were *** Grade 1, 2, and 3 esophagitis occurred in 19(30.6%), 39(62.9%), and 4 patients(6.5%), respectively, without grade ≥ 4 toxicities. Sixteen patients(25.8%) developed post-RT stenosis, of which 7 cases(43.8%) were malignant. Four patients(6.5%) developed tracheoesophageal fistula(TEF), of which 3(75%) cases were malignant. Factors significantly correlated with post-RT stenosis were stage T3/4(P = 0.001), complete circumference involvement(P < 0.0001), stenosis at diagnosis(P = 0.024), and endoscopic complete response(P = 0.017) in univariate analysis, while complete circumference involvement was significant in multivariate analysis(P = 0.003). A higher dose(≥ 60 Gy) was not associated with occurrence of postRT stenosis or TEF. With a median follow-up of 24.3(range, 3.4-152) mo, the 2 y local control, outfield esophageal control, progression-free survival, and overall survival(OS) rates were 78.9%, 90.2%, 49.6%, and 57.3%, respectively. Factors significantly correlated with OS were complete circumference involvement(P = 0.023), stenosis at diagnosis(P < 0.0001), and occurrence of post-RT stenosis or TEF(P < 0.001) in univariate analysis, while stenosis at diagnosis(P = 0.004) and occurrence of post-RT stenosis or TEF(P = 0.023) were significant in multivariate

关键词： Chemoradiotherapy Post-radiotherapy stenosis High-dose radiotherapy Cervical esophageal cancer

Driving inward growth of lithium metal in hollow microcapsule hosts by heteroatom‐controlled nucleation

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Carbon Energy 2024年第8期6卷 262-272页

作者： Siwon Kim Hong Rim shin Ki jae Kim Min‐Sik Park Jong‐Won Lee Division of Materials Science and Engineering Hanyang UniversitySeoulRepublic of Korea Department of Energy Science and Engineering Daegu Gyeongbuk Institute of Science and Technology(DGIST)DaeguRepublic of Korea Department of Energy Science Sungkyunkwan UniversitySuwonRepublic of Korea Department of Advanced Materials Engineering for Information and Electronics Integrated Education for Frontier Science and Technology(BK21 Four)Kyung Hee UniversityYonginRepublic of Korea

The application of Li metal anodes in rechargeable batteries is impeded by safety issues arising from the severe volume changes and formation of dendritic Li ***‐dimensional hollow carbon is receiving increasing attention as a host material capable of accommodating Li metal inside its cavity;however,uncontrollable and nonuniform deposition of Li remains a *** this study,we synthesize metal–organic framework‐derived carbon microcapsules with heteroatom clusters(Zn and Ag)on the capsule walls and it is demonstrated that Ag‐assisted nucleation of Li metal alters the outward‐to‐inward growth in the microcapsule ***‐incorporated microcapsules are prepared via chemical etching of zeolitic imidazole framework‐8 polyhedra and are subsequently decorated with Ag by a galvanic displacement reaction between Ag^(+) and metallic *** introduced Ag significantly reduces the energy barrier and increases the reaction rate for Li nucleation in the microcapsule host upon Li *** combined electrochemical,microstructural,and computational studies,we verify the beneficial role of Ag‐assisted Li nucleation in facilitating inward growth inside the cavity of the microcapsule host and,in turn,enhancing electrochemical *** study provides new insights into the design of reversible host materials for practical Li metal batteries.

关键词： hollow carbon hosts lithium metal batteries lithium plating metal-organic frameworks nucleation