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Pyronaridine combined with diminazene aceturate inhibits Babesia in vitro and in vivo

Asian Pacific Journal of Tropical Biomedicine 2024年第3期14卷 93-99页

作者： shimaa abd el-salam el-s.yed Mohamed Z.s.yed-Ahmed shaimaa Ahmed Awad Ali Nourah Alsadaan Nawazish Alam Mahmoud s.Alkhoudary Ikuo Igarashi Mohamed abdo Rizk National Research Center for Protozoan Diseases Obihiro University of Agriculture and Veterinary MedicineInada-ChoObihiroHokkaido 080-8555Japan Department of Biochemistry and Chemistry of Nutrition Faculty of Veterinary MedicineMansoura UniversityMansoura 35516Egypt Department of Clinical Pharmacy College of PharmacyJazan UniversityJazan 45142Saudi Arabia Medical-surgical Department College of NursingJouf UniversitySakaka 72388Saudi Arabia Critical Care and Emergency Nursing Faculty of NursingMansoura UniversityEgypt College of Nursing Jouf UniversitySakaka 72388Saudi Arabia Faculty of Pharmacy Mansoura UniversityMansoura 35516DakahliaEgypt Department of Internal Medicine and Infectious Diseases Faculty of Veterinary MedicineMansoura UniversityMansoura 35516Egypt

Objective:To evaluate the combination therapy of pyronaridine tetraphosphate and diminazene aceturate against Babesia in vitro and in ***:Bioinformatic analysis was performed using atom pair *** in vitro combination test was performed against Babesia bovis and Theileria ***,the in vivo chemotherapeutic efficacy of pyronaridine tetraphosphate in combination with diminazene aceturate was investigated against the growth of Babesia microti in mice using a fluorescence inhibitory ***:Pyronaridine tetraphosphate and diminazene aceturate exhibited nearly similar molecular *** in vitro combination of pyronaridine tetraphosphate and diminazene aceturate was synergistic on Babesia bovis and additive on Theileria *** addition,5 mg/kg pyronaridine tetraphosphate combined with 10 mg/kg diminazene aceturate inhibited Babesia microti growth significantly compared with those observed after treatment with 25 mg/kg diminazene aceturate alone from day 6 post treatment to day 12 post *** combination therapy also normalized the hematological parameters of infected ***:An oral dose of pyronaridine tetraphosphate combined with a subcutaneous dose of diminazene aceturate inhibits Babesia in vitro and in mice,suggesting it might be a new paradigm for the treatment of babesiosis.

关键词： Babesia Pyronaridine tetraphosphate Diminazene aceturate Babesiosis Theileria

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Comparative study between three carbonaceous nanoblades and nanodarts for antimicrobial applications

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Journal of Environmental sciences 2024年第2期136卷 594-605页

作者： Mohamed s.selim Ahmed M.Azzam Mohamed A.shenashen shimaa A.Higazy Bayaumy B.Mostafa sherif A.el-safty National Institute for Materials science(NIMs) 1-2-1 SengenTsukuba-ShiIbaraki-Ken 305-0047Japan Petroleum Application Department Egyptian Petroleum Research InstituteNasr City 11727Egypt Department of Environmental Research Theodor Bilharz Research InstituteGizaEgypt

The design of nanostructured materials occupies a privileged position in the development and management of affordable and effective technology in the antibacterial ***,we discuss the antimicrobial properties of three carbonaceous nanoblades and nanodarts materials of graphene oxide(GO),reduced graphene oxide(RGO),and single-wall carbon nanotubes(sWCNTs)that have a mechano-bactericidal effect,and the ability to piercing or slicing bacterial *** demonstrate the significance of size,morphology and composition on the antibacterial activity mechanism,the designed nanomaterials have been *** minimum inhibitory concentration(MIC),standard agar well diffusion,and transmission electron microscopy were utilized to evaluate the antibacterial activity of GO,RGO,and *** on the evidence obtained,the three carbonaceous materials exhibit activity against all microbial strains tested by completely encapsulating bacterial cells and causing morphological disruption by degrading the microbial cell membrane in the order of RGO>GO>*** of the external cell wall structure and outer membrane proteins,the synthesized carbonaceous nanomaterials exhibited higher antibacterial activity against Gram-positive bacterial strains than Gram-negative and fungal *** had the lowest MIC values(0.062,0.125,and 0.25 mg/mL against ***,***,and ***,respectively),as well as minimum fungal concentrations(0.5 mg/mL for both *** and ***).At 12 hr,the cell viability values against tested microbial strains were completely *** lysis and death occurred as a result of severe membrane damage caused by microorganisms perched on RGO *** work gives an insight into the design of effective graphene-based antimicrobial materials for water treatment and remediation.

关键词： Antimicrobial properties Nanoblades Mechano-bactericidal effect RGO nanosheets Gram-positive bacteria Cell viability

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Optimization of Cooperative RelayingMolecular Communications for Nanomedical Applications

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Computer Modeling in Engineering & sciences 2024年第2期138卷 1259-1275页

作者： Eman s.Attia Ashraf A.M.Khalaf Fathi E.abd el-samie saied M.abd el-atty Konstantinos A.Lizos Osama Alfarraj Heba M.el-Hoseny Department of electrical Engineering Faculty of EngineeringMinia UniversityMinia61111Egypt Department of electronics and electrical Communications Engineering Faculty of Electronic EngineeringMenoufia UniversityMenouf32952Egypt Department of Informatics Faculty of Mathematics and Natural SciencesUniversity of Oslo(UiO)OsloNorway Computer science Department Community CollegeKing Saud UniversityRiyadh11437Saudi Arabia Department of Computer science The Higher Future Institute for Specialized Technological StudiesEl ShoroukEgypt

Recently,nano-systems based on molecular communications via diffusion(MCvD)have been implemented in a variety of nanomedical applications,most notably in targeted drug delivery system(TDDs)***,because the MCvD is unreliable and there exists molecular noise and inter symbol interference(IsI),cooperative nano-relays can acquire the reliability for drug delivery to targeted diseased cells,especially if the separation distance between the nano transmitter and nano receiver is *** this work,we propose an approach for optimizing the performance of the nano system using cooperative molecular communications with a nano relay scheme,while accounting for blood flow effects in terms of drift *** fractions of the molecular drug that should be allocated to the nano transmitter and nano relay positioning are computed using a collaborative optimization problem solved by theModified Central Force Optimization(MCFO)*** the previous work,the probability of bit error is expressed in a closed-form *** is used as an objective function to determine the optimal velocity of the drug molecules and the detection threshold at the nano *** simulation results show that the probability of bit error can be dramatically reduced by optimizing the drift velocity,detection threshold,location of the nano-relay in the proposed nano system,and molecular drug budget.

关键词： Nanomedical system molecular communication cooperative relay optimization

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Agmatine ameliorates diabetes type 2-induced nephropathy in rats

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Asian Pacific Journal of Tropical Biomedicine 2024年第1期14卷 8-16页

作者： Fatemah O.Kamel Ohoud shagroud Mai AAlim A.sattar Ahmad Gamal s abd el-Aziz abdulhadi s.Burzangi Duaa Bakhshwin Maha Jamal shahid Karim Department of Clinical Pharmacology Faculty of MedicineKing Abdulaziz UniversityJeddah 21589Saudi Arabia Department of Anatomy Faculty of MedicineKing Abdulaziz UniversityJeddah 21589Saudi Arabia

Objective:To assess the nephroprotective potential of agmatine in a rat model of streptozotocin-induced diabetic ***:A single dose of streptozotocin(40 mg/kg)coupled with a fructose diet induced diabetes in Wistar ***(40 and 80 mg/kg)was administered to rats for 12 *** body weight and fasting blood glucose were measured *** level,urine output,total protein,albumin,blood urea nitrogen,creatinine,and cystatin-C were also determined at the end of the ***,superoxide dismutase,glutathione,interleukin-1β,interleukin-6,and tumor necrosis factor-alpha were evaluated in kidney *** study was also performed using hematoxylin and eosin ***:Agmatine at both doses significantly increased final body weight,and lowered fasting blood glucose,urine output,insulin,total protein,albumin,blood urea nitrogen,creatinine,and cystatin-C levels compared with the diabetic group(Ps and antioxidant effect were significantly improved in agmatine-treated ***,the histopathological changes in renal structure were ameliorated by agmatine ***:Agmatine alleviates diabetic nephropathy by improving renal functions and reducing inflammation and oxidative *** molecular mechanisms of its nephroprotective actions need to be investigated in future study.

关键词： Agmatine Type 2 diabetes Nephropathy Oxidative stress Nephroprotection

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electrochemical anodization of cast titanium alloys in oxalic acid for biomedical applications

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Frontiers of Chemical science and Engineering 2024年第1期18卷 13-24页

作者： Engie M.safwat soha A.abdel-Gawad Madiha A.shoeib shimaa el-Hadad Restorative and Dental Materials Department National Research CentreGiza 12622Egypt Chemistry Department Faculty of ScienceCairo UniversityGiza 12613Egypt Central Metallurgical Research and Development Institute Helwan 11421Egypt

Titanium and its alloys have numerous biomedical applications thanks to the composition and morphology of their oxide *** this study,the colorful oxide films were formed by anodizing cast Ti-6Al-4V and Ti-6Al-7Nb alloys in a 10%oxalic acid solution for 30 s at different voltages(20–80 V)of a direct current power *** force microscopy was used as an accurate tool to measure the surface roughness of thin films on the nanometer *** electron microscopy and X-ray diffraction were performed to analyze surface morphology and phase *** to the results,the produced titanium oxide layer showed high surface roughness,which increased with increasing anodizing *** impact of anodizing voltages on the color and roughness of anodized layers was *** corrosion resistance of the anodized samples was studied in simulated body fluid at pH 7.4 and a temperature of 37℃ utilizing electrochemical impedance spectroscopy and the potentiodynamic polarization *** anodized samples for both alloys at 40 V were at the optimal voltage,leading to a TiO_(2) layer formation with the best compromise between oxide thickness and corrosion ***,findings showed that TiO_(2) films produced on Ti-6Al-7Nb alloys had superior surface roughness properties compared to those of Ti-6Al-4V alloys,making them more appropriate for orthopedic *** the obtained data and the fruitful discussion,it was found that the utilized procedure is simple,low-cost,and ***,anodization in 10%oxalic acid proved a viable alternative for the surface finishing of titanium alloys for biomedical applications.

关键词： DC anodization Ti-6Al-4V alloy Ti-6Al-7Nballoy oxidefilm corrosion

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A Low Complexity ML-Based Methods for Malware Classification

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Computers, Materials & Continua 2024年第9期80卷 4833-4857页

作者： Mahmoud E.Farfoura Ahmad Alkhatib Deema Mohammed Alsekait Mohammad Alshinwan sahar A.el-Rahman Didi Rosiyadi Diaa salama abd elminaam Cybersecurity Department Al-Zaytoonah University of JordanAmman11733Jordan Department of Computer science and Information Technology Applied CollegePrincess Nourah Bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Faculty of Information Technology Applied Science Private UniversityAmman11931Jordan Computer systems Program-electrical Engineering Department Faculty of Engineering-ShoubraBenha UniversityCairo11629Egypt Research Center for Artificial Intelligence and Cybersecurity Electronics and Informatics OrganizationNational Research and Innovation Agency(BRIN)KST Samaun SamadikunBandung40135Republic of Indonesia Jadara Research Center Jadara UniversityIrbid21110Jordan MEU Research Unit Middle East UniversityAmman11831Jordan

The article describes a new method for malware classification,based on a Machine Learning(ML)model architecture specifically designed for malware detection,enabling real-time and accurate malware *** an innovative feature dimensionality reduction technique called the Interpolation-based Feature Dimensionality Reduction Technique(IFDRT),the authors have significantly reduced the feature space while retaining critical information necessary for malware *** technique optimizes the model’s performance and reduces computational *** proposed method is demonstrated by applying it to the BODMAs malware dataset,which contains 57,293 malware samples and 77,142 benign samples,each with a 2381-feature *** the IFDRT method,the dataset is transformed,reducing the number of features while maintaining essential data for accurate *** evaluation results show outstanding performance,with an F1 score of 0.984 and a high accuracy of 98.5%using only two reduced *** demonstrates the method’s ability to classify malware samples accurately while minimizing processing *** method allows for improving computational efficiency by reducing the feature space,which decreases the memory and time requirements for training and *** new method’s effectiveness is confirmed by the calculations,which indicate significant improvements in malware classification accuracy and *** research results enhance existing malware detection techniques and can be applied in various cybersecurity applications,including real-timemalware detection on resource-constrained *** and scientific contribution lie in the development of the IFDRT method,which provides a robust and efficient solution for feature reduction in ML-based malware classification,paving the way for more effective and scalable cybersecurity measures.

关键词： Malware detection ML-based models dimensionality reduction feature engineering

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Effect of Conductive Fillers on the Cyclic stress-strain and Nano-scale Free Volume Properties of silicone Rubber

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Chinese Journal of Polymer science 2014年第5期32卷 558-567页

作者： M.H.abd-el salam s.el-Gamal M.Mohsen D.M.abd el-Maqsoud Physics Department Faculty of Education Ain Shams University Physics Department Faculty of Science Ain Shams University

The effect of carbon black （CB） and graphite （G） powders on the macroscopic and nano-scale free volume properties of silicone rubber based on poly（di-methylsiloxane）（PDMs） was studied through thermal and cyclic mechanical measurements, as well as with positron annihilation lifetime spectroscopy （PALs）. The melting temperature of the composites （Tm） and the endothermic enthalpy of melting （ΔHm） were estimated by differential scanning calorimetry （DsC）. Tm and the degree of crystallinity （χc） of PDMs composites were found to decrease with increasing the CB content. This can be explained due to the increase in physical cross-linking which results in a decrease in the crystallite thickness. Besides, χc was found to be dependent on the filler type. Cyclic stress-strain behavior of PDMs loaded with different contents of filler has been studied. Mullins ratio （RM） was found to be dependent on the filler type and content. It was found that, RM increases with increasing the filler content due to the increase in physical cross-linking which results in a decrease in the size of free volume, as observed through a decrease of the o-Ps lifetime τ3 measured by PALs. Moreover, the hysteresis in PDMs-CB composites was more pronounced than in PDMs-G composites. Furthermore, a correlation was established between the free volume Vf and the mechanical properties of PDMs composites containing different fillers. A negative correlation was observed between Vf and RM.

关键词： Positron annihilation Positronium Free volume si-rubber Composite Cyclic mechanical properties.

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Physical studies of some Hydrazinobenzoic Acid Complexes

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Journal of Materials science & Technology 2005年第1期21卷 140-144页

作者： M.G.abd el Wahed s.abd el Wanees M.el Gamel s.abd el Haleem Faculty of science Zagazig University Zagazig EgyptFaculty of Science Zagazig University Zagazig EgyptFaculty of Science Zagazig University Zagazig EgyptFaculty of Science Zagazig University Zagazig Egypt

The stability constants of complexes of 2-hydrazinobenzoic acid and 4-hydrazinobenzoic acid with Ni (Ⅱ), Cu (Ⅱ), Zn (Ⅱ), Cd (Ⅱ), and Hg (Ⅱ) were determined potentiometricaIly at different temperatures. The thermodynamic parameters, △G0, △H0, and △s0 were calculated and proved that the complexation process is spontaneous and endothermic. The thermodynamic functions were analyzed in terms of electrostatic and non-electrostatic components and the results reveal that ionic bonds are formed between the studied ligands and metal ions. Conductometric titration was shown that the stoichiometry of the formed complexes are M:L and M:2L. The structure of the prepared solid complexes was characterized using IR, 1H NMR, 13C NMR spectroscopies as well as X-ray diffraction technique. Finally electrical conductivity of the ligands and their copper complexes was measured and shown that the ligands have a semiconductor behaviour.

关键词： Potentiometric titration stability constants Thermodynamic parameters structure of metal complexes

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Biochemical changes in phenols,flavonoids,tannins,vitamin E,β-carotene and antioxidant activity during soaking of three white sorghum varieties

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Asian Pacific Journal of Tropical Biomedicine 2012年第3期2卷 203-209页

作者： abd el-Moneim MR Afify Hossam s el-Beltagi samiha M abd el-salam Azza A Omran Department of Biochemistry Faculty of AgricultureCairo University Department of Crops Technology Food Technology Research InstituteAgricultural Research CenterEgypt

Objective:To investigate the changes in total phenols,flavonoids,tannins,vitamin E, β-carotene and antioxidant activity during soaking of three white sorghum ***: The changes in total phenols,total ilavonoids,tannins,phenolic acids compounds,flavonoid components,vitamin E,P-carotene and antioxidant activity during soaking of sorghum grains were ***:Total phenols,total flavonoids,tannins,vitamin E,P-carotene and antioxidant activity in raw sorghum were ranged from 109.21 to 116.70,45.91 to 54.69,1.39 to 21.79 mg/100 g,1.74 to 5.25,0.54 to 1.19 mg/kg and 21.72%to 27.69%and 25.29%to 31.97%,respectively. The above measured compounds were significantly decreased after soaking.p-Hydroxybenzoic acid,vanillic acid,syringic acid and cinnamic acid represent the major phenolic acids in Dorado *** ferulic acid,p-coumaric acid,gallic acid and caffeic acid represent the major phenolic acids in *** the other hand,protocatechuic acid represents the major phenolic acids in *** flavonoids components,Dorado was the highest variety in kampferol and naringenin while shandaweel-6 was the highest variety in luteolin, apigenin,hypersoid,quercelin and ***,Giza-15 was the highest variety in catechin. Phenolic acids,flavonoid compounds and antioxidant activities were decreased after soaking. Conclusions:sorghum varieties have moderate quantities from total phenols,total flavonoids, tannins,phenolic acids compounds,flavonoid components,vitamin E,P-carotene and antioxidant activity which decreased after soaking.

关键词： sorghum soaking Total phenols Flavonoids Tannins Vitamin E β-carotene Antioxidant activity Phenolic acids Flavonoid components Biochemical change

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A Robust Tuned Random Forest Classifier Using Randomized Grid search to Predict Coronary Artery Diseases

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Computers, Materials & Continua 2023年第5期75卷 4633-4648页

作者： sameh abd el-Ghany A.A.abd el-Aziz Department of Information systems College of Computer and Information SciencesJouf UniversityKSA Department of Information systems Faculty of Computers and InformationMansoura UniversityEgypt Department of Information systems and Technology Faculty of Graduate Studies for Statistical ResearchCairo UniversityEgypt

Coronary artery disease(CAD)is one of themost authentic cardiovascular afflictions because it is an uncommonly overwhelming heart *** breakdown of coronary cardiovascular disease is one of the principal sources of death all over *** deterioration is a challenge,especially in youthful and rural countries where there is an absence of humantrained *** heart diseases happen without apparent signs,high-level detection is *** paper proposed a robust and tuned random forest model using the randomized grid search technique to *** proposed framework increases the ability of CADpredictions by tracking down risk pointers and learning the confusing joint efforts between ***,the healthcare industry has a lot of data but needs to gain more *** proposed framework is used for extracting knowledge from data stores and using that knowledge to help doctors accurately and effectively diagnose heart disease(HD).We evaluated the proposed framework over two public databases,Cleveland and Framingham *** datasets were preprocessed by using a cleaning technique,a normalization technique,and an outlier detection ***,the principal component analysis(PCA)algorithm was utilized to lessen the feature dimensionality of the two ***,we used a hyperparameter tuning technique,randomized grid search,to tune a random forest(RF)machine learning(ML)*** randomized grid search selected the best parameters and got the ideal CAD *** proposed framework was evaluated and compared with traditional *** proposed framework’s accuracy,sensitivity,precision,specificity,and f1-score were 100%.The evaluation of the proposed framework showed that it is an unrivaled perceptive outcome with tuning as opposed to other ongoing existing frameworks.

关键词： Coronary artery disease tuned random forest randomized grid search classifier

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