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Research on star-tracking correction technology for near-earth flight vehicles

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Journal of Systems Engineering and Electronics 2010年第3期21卷 485-490页

作者： Longxu Xiao shihui Wei Hongbin lin Equipment Institute of the Second Artillery Beijing 100085 R R. China

By analyzing the traditional star-tracking correction technology,this paper studies the star-tracking direct correction method which is based on star sensor dynamic separation initial displacement angles and main errors of inertial measure unit（IMU） in order to carry out automatic navigation and improve the hitting accuracy and quick reaction capability of near-earth flight *** comprehensive application and improvement of the best correction factor method,this paper proposes the startracking comprehensive correction method which combines the two methods above-mentioned and the accelerometer dynamic error separation *** simulation results show that obvious effects can be achieved by using the star-tracking integrated correction method.

关键词： near-earth flight vehicle laser SIMU/star sensor combined system star-tracking correction combined guidance.

“互联网+”背景下重症医学研究生《急危重症医学》课程思政建设研究

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中国继续医学教育 2024年第11期16卷 32-37页

作者：叶林徐昉张皑频吴婧张苜林时辉重庆医科大学附属第一医院重症医学科重庆400016 重庆医科大学附属第一医院研究生管理处重庆400016 重庆医科大学附属第一医院研究生院重庆400016

基于“互联网+”背景下,医学高校为深入学习贯彻落实全国高校思想政治工作会议精神,进一步深化学校管理和教学改革,提高医学院校思想政治工作的实效性,提升医学高端人才培养质量,学校了提出以“课程思政”为目标的教学改革。“互联网+... 详细信息

基于“互联网+”背景下,医学高校为深入学习贯彻落实全国高校思想政治工作会议精神,进一步深化学校管理和教学改革,提高医学院校思想政治工作的实效性,提升医学高端人才培养质量,学校了提出以“课程思政”为目标的教学改革。“互联网+课程思政”教学具有传统课堂教学无法比拟的优势,其优化了课程设置及教学模式,加入了思政元素,完善了教学设计,有效地做到了每门课程在立德树人过程中的重要作用,是新时代高等医学院校教育发展的要求与趋势。《急危重症医学》是医学院校重症医学专业研究生重要的专业课,为充分发挥此门专业课程的育人功能,文章从重症医学《急危重症医学》课程思政建设的重要性、课程思政构建存在的问题以及课程思政建设路径探索等方面,对重症医学研究生专业课程融入课程思政进行了探索,旨在提高《急危重症医学》课堂教学效果及课程思政建设,最终实现教书与育人的有机结合。

关键词：互联网+ 重症医学研究生教育课程思政急危重症医学医学研究生

Quantitative Evaluation of Pseudo Strain Signals Caused by Yarn Structural Deformation

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Advanced Fiber Materials 2022年第2期4卷 214-225页

作者： shihui lin Leitao Cao Zhuochen Lv Jing Ren Shengjie ling School of Physical Science and Technology ShanghaiTech University393 Middle Huaxia RoadShanghai 201210China

Yarn-based strain sensors(YSSs)have shown great promising in the fabrication of wearable devices for their good comfortability and fexible ***,the false signals generated by the changes in the yarn structure of the YSSs are usually *** this study,the generation,the characteristic,and the prediction of these signals were *** recognized that these signals are composed of two negative pseudo peaks and a spurious resistance response *** responses are found to have nothing in common with a true tensile strain,but be attributed to plastic deformation of the *** is due to the fact that the deformation of YSSs exceeds the linear elastic range of the *** the use of pure elastic fbers can eliminate the spurious resistance response plateau,it will lead to an increase in the pseudo peak to the value compared with a true strain signal ***,a theoretical model was established to decouple the real signals from the false responses,ensuring the high sensing accuracy of YSSs for applications in wearable devices and artifcial intelligence *** work provides an in-depth understanding of the response of the YSSs,which might provide inspiration and guidance in the design of high-accuracy fber-based strain sensors.

关键词： Textile strain sensor Pseudo-signal Structure-property relationship Contact resistance

Reproduction strategy of nocturnal marine molluscs:running for love

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Integrative Zoology 2023年第5期18卷 906-923页

作者： Xiaolong GAO Mo ZHANG shihui lin Mingxin LYU Xuan LUO Weiwei YOU Caihuan KE State Key Laboratory of Marine Environmental Science College of Ocean and Earth SciencesXiamen UniversityXiamenChina Fujian Key Laboratory of Genetics and Breeding of Marine Organisms Xiamen UniversityXiamenChina

The cost of reproduction is the core driver of life history evolution in *** paper demonstrates that the cumulative distance moved and the duration of movement of sexually immature abalones,Haliotis discus hannai,kept in various male and female groups,were significantly higher than those of sexually mature individuals,except when kept in mixed cultures of mature males and *** mixed-culture,sexually mature males moved significantly further and for a longer duration than mature female abalones,and even more so than mature male abalones of any other *** of the LC-MS metabolomics of mature males cultured with sexually mature females(AM)and those cultured with sexually immature females(JM)showed that cyclic adenosine monophosphate(cAMP)acted as a differential metabolic *** 24-h uninterrupted sampling,the concentration of 5-HT and the expression levels of the 5-HT2 and 5-HT6 receptors in AM were significantly higher than those in *** further injection of 5-HT2 and 5-HT6 receptor antagonists,the concentrations of cAMP and PKA rose again,but the cumulative movement duration and distance of male abalones decreased significantly,showing that 5-HT was involved in the regulation of movement behavior of male abalones through the 5-HT2 and 5-HT6 receptor-activated cAMP-PKA *** results demonstrated a significant increase in the movement endurance of mature male abalones cultured with mature females,providing a theoretical basis for understanding the adaptive life history strategies of abalones and suggesting ways to protect diverse benthic resources for abalones during the reproductive stage.

关键词： 5-HT receptor behavior Haliotis discus hannai metabolism reproduction cost

Nanofibril Organization in Silk Fiber as Inspiration for Ductile and Damage-Tolerant Fiber Design

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Advanced Fiber Materials 2019年第3期1卷 231-240页

作者： shihui lin Chao Ye Wenwen Zhang Anchang Xu Shixian Chen Jing Ren Shengjie ling School of Physical Science and Technology ShanghaiTech University393 Middle Huaxia RoadShanghai 201210China Jiangsu Co‑Innovation Center of Efficient Processing and Utilization of Forest Resources Jiangsu Key Lab of Biomass‑Based Green Fuel and ChemicalsCollege of Chemical EngineeringNanjing Forestry UniversityNanjing 210037China State Key Laboratory of New Textile Materials and Advanced Processing Technology School of Textile Science and EngineeringWuhan Textile UniversityWuhan 430200China

Ductile and damage-tolerant fibers(DDTFs)are desired in aerospace engineering,mechanical engineering,and biomedical engineering because of their ability to prevent the catastrophic sudden structural/mechanical ***,in practice,design and fabrication of DDTFs remain a major challenge due to finite fiber size and limited processing *** this regard,animal silks can provide *** are hierarchically structured protein fibers with an elegant trade-off of mechanical strength,extensibility and damage tolerance,making them one of the toughest materials *** this article,we confirmed that nanofibril organization could improve the ductility and damage-tolerance of silk fibers through restricted fibril shearing,controlled slippage and *** by these strategies,we further established a rational strategy to produce polyamide DDTFs by combining electrospinning and yarn-spinning *** resultant polymeric DDTFs show a silk-like fracture resistance behavior,indicating potential applications in smart textile,biomedicine,and mechanical engineering.

关键词： Fiber Silk Mechanical property Damage tolerance Bioinspired materials

CRISPR/Cas9-mediated NlinR2 mutants:Analyses of residual mRNA and truncated proteins

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Journal of Integrative Agriculture 2024年第6期23卷 2006-2017页

作者： Jun Lü Jingxiang Chen Yutao Hu lin Chen shihui Li Yibing Zhang Wenqing Zhang State Key Laboratory of Biocontrol/School of Life Sciences Sun Yat-sen UniversityGuangzhou 510275China Development of Food Science and Engineering Moutai InstituteRenhuai 564507China

CRISPR/Cas9 technology is a powerful genome manipulation tool in ***,little is known about whether mRNA and protein of a target gene are completely cleared in homozygous *** study generated homozygous mutants of the insulin receptor gene 2(NlinR2)in the brown planthopper(Nilaparvata lugens)using CRISPR/Cas9 genome *** frameshift mutants,E5_D17 and E6_I7,differentiated towards long wings,but there were differences in wing morphology,with E5_D17 showing wing *** investigations revealed the presence of residual expression of NlinR2 mRNA in both mutants,as well as the occurrence of spliceosomes featuring exon skipping splicing in E5_***,the E5_D17 exhibited the detection of N-terminally truncated NlinR2 *** interference experiments indicated that the knockdown of NlinR2 expression in the E5_D17 mutant line increased the proportion of wing deformities from 11.1 to 65.6%,suggesting that the residual NlinR2 mRNA of the E5_D17 mutant might have retained some genetic *** results imply that systematic characterization of residual protein expression or function in CRISPR/Cas9-generated mutant lines is necessary for phenotypic interpretation.

关键词： CRISPR/Cas9 Nilaparvata lugens residual mRNA skipping exon truncated protein

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RNA干扰技术与肺部疾病的基因治疗

重庆医科大学学报 2014年第7期39卷 905-908页

作者：林时辉刘琼重庆医科大学附属第一医院急诊科重庆400016 重庆医科大学附属第一医院重症医学科重庆400016

RNA干扰（RNAinterference，RNAi）是一种转录后水平的基因沉默，它通过人为引入一段与体内基因同源的双链RNA（double—stranded RNA，dsRNA），诱导与之同源的mRNA降解，致使转录后水平的基因沉默（post—transcriptional gene silenc... 详细信息

RNA干扰（RNAinterference，RNAi）是一种转录后水平的基因沉默，它通过人为引入一段与体内基因同源的双链RNA（double—stranded RNA，dsRNA），诱导与之同源的mRNA降解，致使转录后水平的基因沉默（post—transcriptional gene silence，PTGS），也称RNA沉默，

关键词： RNA干扰技术基因治疗肺部疾病基因沉默 RNA降解 RNA沉默 gene 转录

有创-无创序贯性机械通气治疗产科重症患者的疗效评价

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重庆医科大学学报 2016年第2期41卷 196-200页

作者：林时辉高峰徐昉重庆医科大学附属第一医院急诊医学科重庆400016

目的:探讨有创-无创序贯性机械通气在产科重症患者中的疗效评价。方法:纳入采用有创-无创序贯性机械通气的产科重症患者47例,采用单纯有创机械通气的产科重症患者42例,记录患者行机械通气前的基本生命体征和病种分类,统计分析两组患者... 详细信息

目的:探讨有创-无创序贯性机械通气在产科重症患者中的疗效评价。方法:纳入采用有创-无创序贯性机械通气的产科重症患者47例,采用单纯有创机械通气的产科重症患者42例,记录患者行机械通气前的基本生命体征和病种分类,统计分析两组患者预后指标和并发症的发病情况。结果:序贯组与对照组一般情况基本处于同一基线水平,序贯组在住院病死率、有创通气时间、住ICU时间和VAP的发生率等情况都明显低于对照组(P<0.05)。结论:产科危重患者采用有创-无创序贯性机械通气预后指标和并发症的情况明显改善,有效地提高了治疗效果,有创-无创序贯性机械通气针对产科危重患者这类特殊人群,有很好的临床实用价值。

关键词：有创-无创序贯性机械通气重症产科重症监护病房

颗粒蛋白前体通过调控调节性T细胞影响急性肺损伤白细胞介素-10表达和肺巨噬细胞极化的实验研究

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重庆医科大学学报 2020年第10期45卷 1382-1387页

作者：陈彦青林时辉重庆医科大学附属第一医院急诊科&重症医学科重庆400016

目的:研究颗粒蛋白前体(progranulin,PGRN)在小鼠急性肺损伤(acute lung injury,ALI)模型中对调节性T细胞(regulatory T cells,Tregs)的调控及其对白细胞介素-10(interleukin-10,IL-10)表达和肺巨噬细胞极化的影响。方法:将C57BL/6小鼠随机分为Control组、脂多糖(lipopolysaccharides,LPS)组、LPS+PGRN治疗组。用LPS气道滴注诱导小鼠ALI模型,LPS+PGRN治疗组在LPS处理半小时后采用0.1 mg/kg的PGRN气道滴注。给药24 h后用水合氯醒麻醉小鼠,取小鼠肺组织及肝素抗凝血。肺组织病理切片HE染色评估肺损伤;流式细胞术检测外周血Tregs;酶联免疫吸附法检测血浆IL-6、肿瘤坏死因子(tumor necrosis factor,TNF)-α、IL-10表达;免疫荧光检测肺巨噬细胞表型。结果:不同处理组间外周血Tregs,血浆中IL-6、TNF-α、IL-10,肺组织中M1、M2型肺巨噬细胞存在统计学差异(F=69.340,P=0.000;F=73.100,P=0.000;F=17.800,P=0.000;F=11.780,P=0.003;F=67.560,P=0.000;F=197.100,P=0.000)。并且PGRN治疗后,ALI小鼠肺损伤明显减轻,外周血Tregs明显增高[LPS:(4.714±0.265)%,LPS+PGRN:(8.930±0.255)%,P=0.000],血浆中促炎因子IL-6[LPS:(3 021.000±294.900)pg/mL,LPS+PGRN:(276.700±148.000)pg/mL,P=0.000]和TNF-α表达[LPS:(90.980±10.240)pg/mL,LPS+PGRN:(20.410±9.190)pg/mL,P=0.002]明显降低,血浆抑炎因子IL-10表达明显上升[LPS:(296.400±44.280)pg/mL,LPS+PGRN:(2 551.000±0 655.100)pg/mL,P=0.014],M1型肺巨噬细胞减少[LPS:(17.870±1.890)%,LPS+PGRN:(4.436±0.248)%,P=0.000],M2型肺巨噬细胞增多[LPS:(2.284±0.444)%,LPS+PGRN:(11.920±0.458)%,P=0.000]。结论:在小鼠ALI模型中,PGRN能够通过调控Tregs改变IL-10的表达,影响肺巨噬细胞极化。

关键词：颗粒蛋白前体急性呼吸窘迫综合征急性肺损伤调节性T细胞白细胞介素-10