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Mental health in the virtual world:Are we ready for the metaverse era?

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World Journal of Methodology 2024年第4期14卷 1-5页

作者： Tuffy Mamede Patrícia lordêlo Post Graduation in Medicine and Human Health Bahiana School of Medicine and Public HealthSalvador 40290-000Brazil Pelvic Floor Care Center and Postgraduate Patricia Lordelo InstituteBahiana School of Medicine and Public HealthSalvador 40290-000Brazil

The advent of the metaverse,including virtual reality,augmented reality,andartificial intelligence,is an undeniable issue that health care scientists need *** influences all fields of knowledge,interpersonal relationships,*** mental health since the post-coronavirus disease 2019 pandemic,it is necessary to consider and understand the potential,possibilities,weaknesses,and consequences arising from and provided by this new *** tothe increasing need for mental health monitoring and care,mental health treatmentsrequire in-depth training and preparation to achieve the maximum use of themetaverse advantages and ***,very little is known about theeffectiveness of remote mental health treatment,but it is certainly suggested thataccessibility and the characteristics associated with the use of metaverse technologiesmay represent new horizons for accessibility and approach tools,as long asmore studies are carried out and more evidence is collected to develop accurateguidelines,safe training,solve ethical concerns,and overcome limitations.

关键词： Mental health Metaverse Artificial intelligence Augmented reality Virtualreality

^(15)N tracers and microbial analyses reveal in situ N_(2)O sources in contrasting water regimes of a drained peatland forest

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Pedosphere 2024年第4期34卷 749-758页

作者： Mohit MASTA Mikk ESPENBERG Laura KUUSEMETS Jaan PÄRN Sandeep THAYAMKOTTU Holar SEPP Kalle KIRSIMÄE Fotis SGOURIDIS Kuno KASAK Kaido SOOSAAR Ülo MANDER Institute of Ecology and Earth Sciences University of TartuVanemuise Street 46Tartu 51003Estonia School of Geographical Sciences University of BristolUniversity RoadBristol BS81SSUK

Managed peatlands are a significant source of nitrous oxide(N_(2)O),a powerful greenhouse gas and stratospheric ozone *** to the complexity and diversity of microbial N_(2)O processes,different methods such as tracer,isotopomer,and microbiological technologies are required to understand these *** combined application of different methods helps to precisely estimate these processes,which is crucial for the future management of drained peatlands,and to mitigate soil degradation and negative atmospheric *** this study,we investigated N_(2)O sources by combining tracer,isotopomer,and microbial analysis in a drained peatland forest under flooded and drained *** average,the nitrification genes showed higher abundances in the drained treatment,and the denitrification genes showed higher abundances in the flooded *** is consistent with the underlying chemistry,as nitrification requires oxygen while denitrification is *** observed significant differences in labelled N_(2)O fluxes between the drained and flooded *** emissions of N_(2)O from the flooded treatment were nearly negligible,whereas the N_(2)O evolved from the nitrogen-15(^(15)N)-labelled ammonium(^(15)NH4+)in the drained treatment peaked at 147μg ^(15)N m^(-2) h^(-1).This initially suggested nitrification as the driving mechanism behind N_(2)O fluxes in drained peatlands,but based on the genetic data,isotopic analysis,and N_(2)O mass enrichment,we conclude that hybrid N_(2)O formation involving ammonia oxidation was the main source of N_(2)O emissions in the drained *** on the ^(15)N-labelled nitrate(^(15)NO3-)tracer addition and gene copy numbers,the low N_(2)O emissions in the flooded treatment came possibly from complete denitrification producing inert *** atomic level,we observed selective enrichment of mass 45 of N_(2)O molecule under ^(15)NH4+amendment in the drained treatment and enrichment of both masses 45 and 46 under

关键词： denitrification nitrification N_(2)O quantitative polymerase chain reaction

Cellular zinc metabolism and zinc signaling:from biological functions to diseases and therapeutic targets

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Signal Transduction and Targeted Therapy 2024年第2期9卷 401-441页

作者： Bonan Chen Peiyao Yu Wai Nok Chan Fuda Xie Yigan Zhang Li Liang Kam Tong Leung Kwok Wai lo Jun Yu Gary M.K.Tse Wei Kang Ka Fai To Department of Anatomical and Cellular Pathology State Key Laboratory of Translational OncologyPrince of Wales HospitalThe Chinese University of Hong KongHong KongChina State Key Laboratory of Digestive Disease Institute of Digestive DiseaseThe Chinese University of Hong KongHong KongChina CUHK-Shenzhen Research Institute The Chinese University of Hong KongShenzhenChina Department of Pathology Nanfang Hospital and Basic Medical CollegeSouthern Medical UniversityGuangdong Province Key Laboratory of Molecular Tumor PathologyGuangzhouChina Institute of Biomedical Research Taihe HospitalHubei University of MedicineShiyanChina Department of Pediatrics The Chinese University of Hong KongHong KongChina Department of Medicine and Therapeutics The Chinese University of Hong KongHong KongChina

Zinc metabolism at the cellular level is critical for many biological processes in the body.A key observation is the disruption of cellular homeostasis,often coinciding with disease *** an essential factor in maintaining cellular equilibrium,cellular zinc has been increasingly spotlighted in the context of disease *** research suggests zinc’s involvement in promoting malignancy and invasion in cancer cells,despite its low tissue *** has led to a growing body of literature investigating zinc’s cellular metabolism,particularly the functions of zinc transporters and storage mechanisms during cancer *** transportation is under the control of two major transporter families:SLC30(ZnT)for the excretion of zinc and SLC39(ZIP)for the zinc ***,the storage of this essential element is predominantly mediated by metallothioneins(MTs).This review consolidates knowledge on the critical functions of cellular zinc signaling and underscores potential molecular pathways linking zinc metabolism to disease progression,with a special focus on *** also compile a summary of clinical trials involving zinc *** the main localization of zinc transporters at the cell membrane,the potential for targeted therapies,including small molecules and monoclonal antibodies,offers promising avenues for future exploration.

关键词： metabolism invasion involvement

Influence of the Nature of the Incoming Sludge on the Performance of a Vertical Flow Reed Beds in Dakar-Senegal

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Journal of Water Resource and Protection 2024年第6期16卷 429-449页

作者： Elhadji Mamadou Sonko Diomaye Dieng Maïmouna lo Cheikh Diop Laboratoire dEtude Environnemental des Milieux Urbains (LEEMUR) Institut des Sciences de lEnvironnement (ISE) Facult des Sciences et Technique (FST) Universit Cheikh Anta Diop de Dakar (UCAD) Dakar-Fann Sngal

This work investigates the influence of the type sludge on drainage, plant development, purification performances and biosolids quality. Drainage properties were measured through the frequency of clogging, the percentage of leachate recovered and the dryness of accumulated sludge. Plant development was measured through the density, the height and the stem diameter. Purification performance was evaluated from the reduction rate. Biosolids quality was measured after 3 months of maturation. The results show that the clogging frequencies were 9.5%;0% and 3.7%;the volume of leachate recovered was 42.2%;20.4% and 24.7% and, the dryness was 33.4%;61.1% and 52.4% for FS-ST, FS-STT and SS respectively. Plants densities were about, with densities 197.1, 171.3 and 178.3 plants/m2 in beds fed respectively with FS-ST, FS-STT and SS. Despite the high removal rates, the concentrations of pollutants in the leachates are above the Senegalese standard NS 05-061 for discharge into the environment. The biosolids are all mature with C/N and NH4+/NO3?ratios lower than 12 and 1 respectively. The biosolids are also rich in organic and mineral elements. The concentrations of Ascaris eggs are higher than the WHO recommendations. These biosolids should be stored for additional time or composted.

关键词： Biosolid Quality Dewatering Performance Planted Drying Beds Purification Performance Sludge Type

基于先进绝热压缩空气储能站的电-热综合能源系统优化运行方法

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电测与仪表 2024年第2期61卷 25-33页

作者：时帅刘杰米阳 Kwok Lun lo 林哲敏上海电力大学电气工程学院上海200090 斯特拉斯克莱德大学电子与电气工程系格拉斯哥安徽电力交易有限公司合肥230061

为加强先进绝热压缩空气储能(Advanced Adiabatic Compressed Air Energy Storage,AA-CAES)与综合能源系统(Integrated Energy Systems,IES)的多能互补协同,提高系统运行效率,文中提出了一种含AA-CAES能源站的电-热综合能源系统优化运行方法。构建了含AA-CAES能源站的IES基本调度架构,详细分析了AA-CAES装置在压缩和膨胀工况下的储热、换热及供热等特性,建立了AA-CAES电热联供联储运行模型;基于热网管道传热延迟和损耗等动态特性,建立了考虑供热网储热惯性的热网方程;在此基础上,考虑了用户侧可调度资源,提出了计及综合需求响应的含AA-CAES能源站的IES日前优化运行模型;在修改的IEEE 33节点配电网和巴厘岛32节点区域供热网进行算例分析。仿真结果表明,所提方法可有效降低IES运行成本,提高IES可再生能源消纳能力。

关键词：先进绝热压缩空气储能综合能源系统优化运行供热网储热可再生能源消纳

Retrospective analysis of discordant results between histology and other clinical diagnostic tests on helicobacter pylori infection

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World Journal of Gastrointestinal Endoscopy 2024年第2期16卷 64-71页

作者： Xiaohua Qi Kevin Kuan Tony El Jabbour Yungtai lo Qiang Liu Yanan Fang Department of Pathology Albert Einstein College of Medicine/Montefiore Medical CenterBronxNY 10467United States Department of Pathology Albert Einstein College of Medicine/Montefiore Medical CenterNew YorkNY 10467United States Department of Epidemiology&Population Health Albert Einstein College of MedicineBronxNY 10461United States Department of Pathology Montefiore Medical Center/Albert Einstein College of MedicineBronxNY 10467United States

BACKGROUND A reliable test is essential for diagnosing Helicobacter pylori(***)infection,and crucial for managing ***-related *** as an excellent method for detecting *** infection,histologic examination is a test that clinicians heavily rely on,especially when complemented with immunohistochemistry(IHC).Additionally,other diagnostic tests for ***,such as the rapid urease test(Clo test)and stool antigen test(SA),are also highly sensitive and ***,the results of histology and other tests align with each ***,on rare occasions,discrepancy between histopathology and other *** diagnostic tests *** To investigate the discordance between histology and other *** tests,the underlying causes,and the impact on clinical *** Pathology reports of gastric biopsies were retrieved spanning August 2013 and July *** were included in the study only if there were other *** tests within seven days of the *** additional tests include Clo test,SA,and *** *** between histopathology and other tests was determined based on the consistency of *** instances where histology results were negative while other tests were positive,the slides were retrieved for re-assessment,and the clinical chart was *** Of 1396 pathology reports were identified,each accompanied by one additional *** *** concordance rates in detecting *** infection between biopsy and other tests did not exhibit significant differences based on the number of biopsy fragments.117 discrepant cases were *** 20 cases(9 with Clo test and 11 with SA)had negative biopsy but positive results in other *** cases initially stained with Warthin-Starry turned out to be positive for *** with subsequent IHC *** the remaining 16 true discrepant cases,10 patients were on proton pump inhibitors before the biopsy and/or other *** patients underwe

关键词： Helicobacter pylori Discordance Gastric biopsy Histology Rapid urease test Stool antigen test Helicobacter pylori culture

What Makes a Greener Building? Lessons from Taiwan

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Journal of Environmental Protection 2018年第9期9卷 957-972页

作者： Chou-yen Wu shih-Fang lo Center for Green Economy Chung Hua Institution for Economic Research Taiwan

Buildings consume vast amounts of resources and energy contributing to climate change. Some countries have developed green building certification systems. Compared to other developed areas, Taiwan lags behind in green building construction and in response created its own certification for sub-tropical countries called Ecology, Energy Saving, Waste Reduction, and Health (EEWH). But what economic factors truly drive green building construction and quality? Our study sample analyzes 1355 Taiwan green building cases from 2000 to June 2018 to determine the influence of various economic, structural, and policy factors. Results suggest that while public ownership led to more green building certifications, private ownership led to a higher environment rating. Proper incentives are needed to further increase the ratings of public buildings and to expand the construction of highly rated private buildings, especially for small and medium sized buildings.

关键词： Green Buildings EEWH Empirical Study Regressions Certification

Humoral Response and Tolerance of Vaccination against SARS-CoV-2 in Adults Senegalese Patients Undergoing Hemodialysis: A Multicenter Prospective Study

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Open Journal of Nephrology 2024年第1期14卷 70-80页

作者： lot Nehemie Motoula Latou Moustapha Mbow Modou Ndongo Gnagna Faye Gora lo Sidy Mohamed Seck Department of Nephrology and Dialysis Military Hospital of Ouakam Dakar Senegal Immunology Laboratory Military Hospital of Ouakam Dakar Senegal Department of Nephrology and Dialysis Regional Hospital of Kedougou Kedougou Senegal Department of Nephrology Idrissa Pouye General Hospital Dakar Senegal Bacterioloy and Virology Laboratory CMIA Dakar Senegal IRL-3189 ESS/UGB/CNRS/UCAD/CNRST/USTB Faculty of Health Sciences University Gaston Berger Saint-Louis Senegal

Introduction: Following the COVID-19 pandemic, vaccination has been proposed in several countries as the main preventive measure despite very limited data, particularly in dialysis patients. We conducted this study to assess the immunological response to vaccination in Senegalese hemodialysis patients. Patients and Methods: We conducted a prospective study, in two dialysis centers in Dakar from March 30th to August 30th, 2021 including patients on hemodialysis for >6 months, vaccinated against SARS-CoV-2 according to the vaccination schedule recommended by WHO. A vaccine response was considered positive when seroconversion was observed after one dose of vaccine. The clinical efficacy of immunization was defined as the absence of new COVID-19 infection in patients who received a complete vaccination. Results: Among the 81 patients included in the study, 7.4% had anti-Spike IgM antibodies before their first vaccination. Seroprevalence of IgM antibodies was 38.3% one month after the first vaccine dose (at M1) and 8.6% one month after the second dose (at M4). Anti-Spike IgG antibodies were present in 40.3% of patients before vaccination, in 90.1% at M1, and in 59.7% at M4. Among patients previously infected with SARS-CoV-2, 10.2% had IgM antibodies at M0, 31.6% at M1, and 10.5% at M4 post-vaccination. Similarly, seroprevalences of IgG antibodies in this subgroup were 31.5%, 61.3%, and 50.0% respectively at M0, M1, and M4 post-vaccination. A comparison of seroconversion rates between M0 and M4 showed significant differences only for IgG in COVID-19 naive patients. Mean duration in dialysis and the existence of previous COVID-19 infection were associated with patients’ vaccinal response after the two doses. Age, gender and the use of immunosuppressive treatment did not influence post-vaccinal antibody production. Conclusion: Vaccination against COVID-19 in Senegalese hemodialysis patients induced a low seroconversion rate but it was well tolerated. M

关键词： SARS-Cov2 Vaccination Humoral Response Tolerance Hemodialysis Senegal

Global multifaceted biodiversity patterns,centers,and conservation needs in angiosperms

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Science China(Life Sciences) 2024年第4期67卷 817-828页

作者： Ao Luo Yaoqi Li Nawal Shrestha Xiaoting Xu Xiangyan Su Yichao Li Tong Lyu Kilara Waris Zhiyao Tang Xiaojuan Liu Luxiang Lin Yongsheng Chen Kuiling Zu Wenqi Song Shijia Peng Niklaus E.Zimmermann loïc Pellissier Zhiheng Wang Institute of Ecology and Key Laboratory for Earth Surface Processes of the Ministry of Education College of Urban and Environmental SciencesPeking UniversityBeijing 100871China Department of Health and Environmental Sciences Xi’an Jiaotong-Liverpool UniversitySuzhou 215123China State Key Laboratory of Grassland Agro-Ecosystems College of EcologyLanzhou UniversityLanzhou 730000China Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education College of Life SciencesSichuan UniversityChengdu 610065China Land Consolidation and Rehabilitation Center Ministry of Natural ResourcesBeijing 100035China State Key Laboratory of Vegetation and Environmental Change Institute of BotanyChinese Academy of SciencesBeijing 100093China CAS Key Laboratory of Tropical Forest Ecology Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesKunming 650201China Swiss Federal Research Institute WSL Birmensdorf 8903Switzerland Department of Environmental Systems Science ETH ZürichZürich 8092Switzerland

The Convention on Biological Diversity seeks to conserve at least 30%of global land and water areas by 2030,which is a challenge but also an opportunity to better preserve biodiversity,including flowering plants(angiosperms).Herein,we compiled a large database on distributions of over 300,000 angiosperm species and the key functional traits of 67,024 *** this database,we constructed biodiversity-environment models to predict global patterns of taxonomic,phylogenetic,and functional diversity in terrestrial angiosperms and provide a comprehensive mapping of the three diversity *** further evaluated the current protection status of the biodiversity centers of these diversity *** results showed that geographical patterns of the three facets of plant diversity exhibited substantial spatial mismatches and nonoverlapping conservation *** centers of functional diversity,particularly of herbaceous species,were primarily distributed in temperate regions and under weaker protection compared with other biodiversity centers of taxonomic and phylogenetic *** global assessment of multifaceted biodiversity patterns and centers highlights the insufficiency and unbalanced conservation among the three diversity facets and the two growth forms(woody ***),thus providing directions for guiding the future conservation of global plant diversity.

关键词： angiosperms species richness phylogenetic diversity functional diversity plant traits woody species herbaceous species