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现代冶金（内蒙古） 2010年第1期 62-65页

作者： shih—hsien chang 台湾

为评价AISIH13工具钢氮氧化处理的氧化层效果和有效改善耐蚀性，本研究使用了3种不同的氮化表面处理，即氮氧化过程为：①（用空气）氮氧化过程；②（用蒸汽）或一般气体氮化。AISIH13工具钢不同氮化处理后，评价其显微组织作用和电镜... 详细信息

为评价AISIH13工具钢氮氧化处理的氧化层效果和有效改善耐蚀性，本研究使用了3种不同的氮化表面处理，即氮氧化过程为：①（用空气）氮氧化过程；②（用蒸汽）或一般气体氮化。AISIH13工具钢不同氮化处理后，评价其显微组织作用和电镜微观组织耐蚀性，试验结果表明，氧化层可防止和改善AISIH13工具钢的铝腐蚀，进行了显微硬度、腐蚀试验和SEMi显微组织评价。处理过程①中，腐蚀试验2h和4h氮氧化能产生一定厚度的复杂氧化层，具有较高的硬度（HV!021．9），可视失重（0．16％）。这个过程可有效减少A380合金腐蚀试验时Al—Fe—si化合物的比率。

关键词：耐腐蚀 AISI H13工具钢氮氧化 A380合金

通过氧化处理提高AISIH13工具钢的铝侵蚀行为和耐腐蚀性

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现代冶金（内蒙古） 2011年第3期 54-58页

作者： shih—hsien chang[台湾] 安琪（译）

在此研究中，准备了经过不同氧化处理用于试验的H13工具钢，以研究氧化温度和保温时间的影响。为了提高耐侵蚀和抗腐蚀性，本研究分别在氧化温度560℃、580℃和600℃，保温时间1h,2h和3h条件下进行了测试。试验结果表明：当氧化温度为60... 详细信息

在此研究中，准备了经过不同氧化处理用于试验的H13工具钢，以研究氧化温度和保温时间的影响。为了提高耐侵蚀和抗腐蚀性，本研究分别在氧化温度560℃、580℃和600℃，保温时间1h,2h和3h条件下进行了测试。试验结果表明：当氧化温度为600℃、保温时间为3h时是最佳工艺操作参数，氧化层平均厚度为9．2μm，说明氧化层（Fe3O4）能保护和提高H13钢的铝侵蚀。在A380合金溶解侵蚀试验过程中，证明了经过氧化工艺处理的试样能有效减少Al—Fe—Si化合物比。除此之外，结果表明：氧化层能提高极化电阻，并且快速产生钝化层，提高耐腐蚀能力。

关键词： H13工具钢侵蚀腐蚀氧化 A380合金

Advanced wastewater treatment with microalgae-indigenous bacterial interactions

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Environmental Science and Ecotechnology 2024年第4期20卷 198-207页

作者： Xue Li Shengnan Li Peng Xie Xi Chen Yuhao Chu Haixing chang Jian Sun Qing Li Nanqi Ren shih-Hsin Ho State Key Laboratory of Urban Water Resource and Environment School of EnvironmentHarbin Institute of TechnologyHarbin150090PR China College of Chemistry and Chemical Engineering Chongqing University of TechnologyChongqing400054PR China Central Southern China Municipal Engineering Design and Research Institute Co. LtdWuhan430010PR China

Microalgal-indigenous bacterial wastewater treatment(MBWT)emerges as a promising approach for the concurrent removal of nitrogen(N)and phosphorus(P).Despite its potential,the prevalent use of MBWT in batch systems limits its broader ***,the success of MBWT critically depends on the stable self-adaptation and synergistic interactions between microalgae and indigenous bacteria,yet the underlying biological mechanisms are not fully *** we explore the viability and microbial dynamics of a continuous flow microalgae-indigenous bacteria advanced wastewater treatment system(CFMBAWTS)in processing actual secondary effluent,with a focus on varying hydraulic retention times(HRTs).The research highlights a stable,mutually beneficial relationship between indigenous bacteria and *** and indigenous bacteria can create an optimal environment for each other by providing essential cofactors(like iron,vitamins,and indole-3-acetic acid),oxygen,dissolved organic matter,and *** collaboration leads to effective microbial growth,enhanced N and P removal,and energy *** study also uncovers crucial metabolic pathways,functional genes,and patterns of microbial ***,the effluent NH4 t-N and P levels complied with the Chinese national Class-II,Class-V,Class-IA,and Class-IB wastewater discharge standards when the HRT was reduced from 15 to 6 *** results,including the highest rates of CO2 fixation(1.23 g L^(-1)),total energy yield(32.35 kJ L^(-1)),and the maximal lipid(33.91%)and carbohydrate(41.91%)content,were observed at an HRT of 15 ***,this study not only confirms the feasibility of CFMBAWTS but also lays a crucial foundation for enhancing our understanding of this technology and propelling its practical application in wastewater treatment plants.

关键词： Continuous flow systems Microalgal-indigenous bacterial interactions Advanced treatment Self-adaptation mechanisms Nutrient removal mechanisms

Quercetin inhibits truncated isoform of dopamine-and cAMP-regulated phosphoprotein as adjuvant treatment for trastuzumab therapy resistance in HER2-positive breast cancer

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Food Science and Human Wellness 2024年第5期13卷 2653-2667页

作者： Han-Sheng chang Tzu-Chun Cheng shih-Hsin Tu Chih-Hsiung Wu You-Cheng Liao Jungshan chang Min-Hsiung Pan Li-Ching Chen Yuan-Soon Ho Department of Biological Science&Technology College of Life SciencesChina Medical UniversityTaichung 406TaiwanChina Institute of Biochemistry and Molecular Biology College of Life SciencesChina Medical UniversityTaichung 406TaiwanChina Department of Surgery School of MedicineCollege of MedicineTaipei Medical UniversityTaipei 110TaiwanChina Department of Surgery Taipei Medical University HospitalTaipei 110TaiwanChina Graduate Institute of Medical Sciences College of MedicineTaipei Medical UniversityTaipei 110TaiwanChina Institute of Food Sciences and Technology National Taiwan UniversityTaipei 106TaiwanChina

Trastuzumab resistance is one of the causes of poor prognosis in patients with human epidermal growth factor receptor 2(HER2)-positive(HER2+)breast cancer(BC).The truncated isoform of dopamine-and cAMPregulated phosphoprotein(t-DARPP)has been reported to be involved in trastuzumab therapy resistance and promoting tumor *** evaluate the t-DARPP expression in BC,paired tumors and surrounding normal tissues were analyzed by real-time polymerase chain reaction and confirmed higher DARPP-32 kDa family mRNA expression in HER2+BC tumor *** established 2 patient-derived xenografts(PDX)mice models to test the efficacy of trastuzumab,named model 1(non-responder)and model 2(responder).t-DARPP and p95-HER2 protein-protein interactions were detected in PDX tumor tissue from non-responders using Förster resonance energy transfer ***,there is no response from the ***,mechanistic studies using transwell and western blot assays demonstrated that t-DARPP could upregulate epithelial-mesenchymal transition signaling proteins,enhance p95-HER2 expression and promote cell *** found that quercetin effectively reduced t-DARPP expression in HER2+BC *** t-DARPP ShRNA-suppressed cells,quercetin synergistically enhanced trastuzumab-induced apoptotic cell death and G2/M phase *** conclusion,the combination of quercetin and trastuzumab treatment by targeting t-DARPP in HER2+BC patients has the potential as a biomarker for mitigating drug resistance.

关键词： p95-Human epidermal growth factor receptor 2 (HER2) HER2-positive breast cancer Quercetin Trastuzumab resistance Truncated isoform of dopamine-and cAMPregulated phosphoprotein

Effect of heat treatment on microstructure and mechanical properties of selective laser-melted PH13-8Mo stainless steel

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Journal of Iron and Steel Research International 2024年第4期31卷 945-955页

作者： Yuan Zhang Xiang Liu chang-jun Wang chang Liu School of Material Science and Engineering Kunming University of Science and TechnologyKunming 650093YunnanChina Central Iron&Steel Research Institute Co. Ltd.Beijing 100081China

PH13-8Mo stainless steel powder with high sphericity and well fluidity was prepared by the plasma rotating electrode *** formed parts with ultra-high purity were manufactured by selective laser *** tensile and impact mechanical properties of the printed parts under three heat treatment regimes were compared to those without heat *** microstructure,grain orientation and phase composition were characterized by electron-backscatter diffraction,X-ray diffraction and transmission electron *** characterization results reveal that the addition of heat treatment makes the grains enlarge,and after different heat treatments,the average grain size from 1.51μm in the printed state increases to 2.78,3.09 and 2.06μm,*** formed parts are mainly composed of martensite and retained ***,the NiAl and M23C precipitates form,which are the major strengthening phases of PH13-8Mo stainless *** optimal heat treatment process is 925℃×1 h water cooling(WC)+0℃×2 h air cooling(AC)+540℃×4 h *** this heat treatment process,PH13-8Mo formed parts have the optimal comprehensive mechanical properties:the tensile strength,yield strength and impact energy KU2 are 1492 MPa,1432 MPa and 63 J,*** strengthening and toughening via heat treatment are mainly attributed to dislocation strengthening,the formation of NiAl and M23Co precipitates and the change of volume fraction of the retained austenite.

关键词： High-strength stainless steel-Selective laser melting-Heat treatment Microstructure Mechanical property

Inverse-time Backup Protection Based on Unified Characteristic Equation for Distribution Networks with High Proportion of Distributed Generations

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Journal of Modern Power Systems and Clean Energy 2024年第1期12卷 202-212页

作者： Nana chang Guobing Song Zhongxue chang Yuping Zheng Xingang Yang the School of Electrical Engineering Xi’an Jiaotong UniversityXi’anChina State Key Laboratory of Smart Grid Protection and Control NARI Group CorporationNanjingChina Electric Power Research Institute of State Grid Shanghai Electric Power Company ShanghaiChina

The setting work of backup protection using steady-state current is tedious,and mismatches occasionally occur due to the increased proportion of distributed generations(DGs)connected to the power ***,there is a practical need to study a backup protection technology that does not require step-by-step setting and can be adaptively *** paper proposes an action sequence adaptive to fault positions that uses only positive sequence fault component(PSFC)*** the influence of DGs,the unified time dial setting can be obtained by selecting specific *** protection performance is improved by using the adjacent upstream and downstream protections to meet the coordination time interval in the case of metallic faults at the near-and far-ends of the ***,the expression and implementation scheme for inverse-time backup protection(ITBP)based on the unified characteristic equation is *** results show that this scheme can adapt to DG penetration scenarios and can realize the adaptive coordination of multi-level relays.

关键词： Inverse-time backup protection(ITBP) distributed generation(DG) positive sequence fault component(PSFC)voltage unified characteristic equation adaptive coordination

Polymeric piezoelectric accelerometers with high sensitivity,broad bandwidth,and low noise density for organic electronics and wearable microsystems

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Microsystems & Nanoengineering 2024年第3期10卷 63-74页

作者： chang Ge Edmond Cretu The Department of Electrical and Computer Engineering The University of British ColumbiaVancouverBCCanada

Piezoelectric accelerometers excel in vibration *** the emerging trend of fully organic electronic microsystems,polymeric piezoelectric accelerometers can be used as vital front-end components to capture dynamic signals,such as vocal vibrations in wearable speaking assistants for those with speaking ***,high-performance polymeric piezoelectric accelerometers suitable for such applications are *** organic compounds such as PVDF have inferior properties to their inorganic counterparts such as ***,most existing polymeric piezoelectric accelerometers have very unbalanced performance *** often sacrifice resonance frequency and bandwidth for a flat-band sensitivity comparable to those of PZT-based accelerometers,leading to increased noise density and limited application *** this study,a new polymeric piezoelectric accelerometer design to overcome the material limitations of PVDF is *** new design aims to simultaneously achieve high sensitivity,broad bandwidth,and low *** samples were manufactured and characterized,demonstrating an average sensitivity of 29.45 pC/g within a±10 g input range,a 5%flat band of 160 Hz,and an in-band noise density of 1.4μg/√*** results surpass those of many PZT-based piezoelectric accelerometers,showing the feasibility of achieving comprehensively high performance in polymeric piezoelectric accelerometers to increase their potential in novel applications such as organic microsystems.

关键词： piezoelectric polymeric overcome

Aldo-keto reductase family member C3(AKR1C3)promotes hepatocellular carcinoma cell growth by producing prostaglandin F2α

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Oncology Research 2024年第1期32卷 163-174页

作者： KUO-SHYANG JENG PO-YU CHENG YUEH-hsien LIN PO-CHUN LIU PING-HUI TSENG YU-CHAO WANG CHIUNG-FANG chang CHUEN-MIIN LEU Division of General Surgery Far Eastern Memorial HospitalNew Taipei City22060Taiwan Institute of Microbiology and Immunology National Yang Ming Chiao Tung UniversityTaipei City11221Taiwan Institute of Biochemistry and Molecular Biology National Yang Ming Chiao Tung UniversityTaipei City11221Taiwan Institute of Biomedical Informatics National Yang Ming Chiao Tung UniversityTaipei City11221Taiwan Department of Medical Research Far Eastern Memorial HospitalNew Taipei City22060Taiwan

Hepatocellular carcinoma(HCC)is a leading cause of death *** therapies are effective for HCC patients with early disease,but many patients suffer recurrence after surgery and have a poor response to ***,new therapeutic targets are *** analyzed gene expression profiles between HCC tissues and normal adjacent tissues from public databases and found that the expression of genes involved in lipid metabolism was significantly *** analysis showed that AKR1C3 was upregulated in tumors,and high AKR1C3 expression was associated with a poorer prognosis in HCC *** vitro,assays demonstrated that the knockdown of AKR1C3 or the addition of the AKR1C3 inhibitor indomethacin suppressed the growth and colony formation of HCC cell *** of AKR1C3 in Huh7 cells reduced tumor growth in *** explore the mechanism,we performed pathway enrichment analysis,and the results linked the expression of AKR1C3 with prostaglandin F2 alpha(PGF2a)downstream target *** of AKR1C3 activity reduced the production of PGF2a,and supplementation with PGF2a restored the growth of indomethacin-treated Huh7 *** of the PGF receptor(PTGFR)and treatment with a PTGFR inhibitor significantly reduced HCC *** showed that indomethacin potentiated the sensitivity of Huh7 cells to *** summary,our results indicate that AKR1C3 upregulation may promote HCC growth by promoting the production of PGF2α,and suppression of PTGFR limited HCC ***,targeting the AKR1C3-PGF2a-PTGFR axis may be a new strategy for the treatment of HCC.

关键词： Hepatocellular carcinoma Aldo-keto reductase family member C3 Prostaglandin F2 alpha Prostaglandin F receptor

Recent Progresses of the DAMPE Mission

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空间科学学报 2024年第4期44卷 633-642页

作者： chang Jin Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210033 School of Astronomy and Space Science University of Science and Technology of ChinaHefei 230026

The DArk Matter Particle Explorer(DAMPE)is a space high-energy particle andγ-ray detector whose major scientific goals are the indirect detection of dark matter particles,the origin of cosmic rays and highenergyγ-ray *** its successful launch in December 2015,the DAMPE has been operated smoothly in orbit for more than 8 *** direct measurements of the boron-to-carbon and boron-to-oxygen flux ratios,and the proton+Helium spectrum up to 316 TeV have been obtained,revealing new spectral features with very high *** search results ofγ-ray spectral line and fractionally charged particles indicate a good potential of DAMPE for indirect dark matter detection and new physical discovery in *** DAMPE measurements are expected to significantly advance our understanding of the fundamental problems in astroparticle physics.

关键词： DAMPE Dark matter Indirect detection Cosmic rays