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Inverse relationship between platelet Akt activity and hippocampal atrophy:A pilot case-control study in patients with diabetes mellitus

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World Journal of Clinical Cases 2024年第2期12卷 302-313页

作者： Haruhiko Tokuda Takamitsu Hori Daisuke Mizutani Tomoyuki Hioki Kumi Kojima Takashi Onuma Yukiko Enomoto Tomoaki Doi Rie Matsushima-Nishiwaki Shinji Ogura Hiroki iida Toru Iwama Takashi Sakurai Osamu Kozawa Department of Metabolic Research Research InstituteNational Center for Geriatrics and GerontologyObu 474-8511Japan Department of Clinical Laboratory National Center for Geriatrics and GerontologyObu 474-8511Japan Department of Pharmacology Gifu University Graduate School of MedicineGifu 501-1194Japan Department of Neurosurgery Gifu University Graduate School of MedicineGifu 501-1194Japan Department of Dermatology Central Japan International Medical CenterMinokamo 505-8510Japan Department of Anesthesiology and Pain Medicine Gifu University Graduate School of MedicineGifu 501-1194Japan Department of Emergency Medicine Faculty of MedicineUniversity of ToyamaToyama 930-0194Japan Department of Emergency and Disaster Medicine Gifu University Graduate School of MedicineGifu 501-1194Japan Research Institute National Center for Geriatrics and GerontologyObu 474-8511Japan

BACKGROUND Akt plays diverse roles in *** is involved in the pathogenesis of type 2 diabetes mellitus(T2DM),which is caused by insulin *** also plays a vital role in human platelet ***,the hippocampus is closely associated with memory and learning,and a decrease in hippocampal volume is reportedly associated with an insulin-resistant phenotype in T2DM patients without *** To investigate the relationship between Akt phosphorylation in unstimulated platelets and the hippocampal volume in T2DM *** Platelet-rich plasma(PRP)was prepared from the venous blood of patients with T2DM or age-matched *** pellet lysate of the centrifuged PRP was subjected to western blotting to analyse the phosphorylation of Akt,p38 mitogen-activated protein(MAP)kinase and glyceraldehyde 3-phosphate dehydrogenase(GAPDH).Phosphorylation levels were quantified by densitometric *** volume was analysed using a voxel-based specific regional analysis system for Alzheimer’s disease on magnetic resonance imaging,which proposes the Z-score as a parameter that reflects hippocampal *** The levels of phosphorylated Akt corrected with phosphorylated p38 MAP kinase were inversely correlated with the Z-scores in the T2DM subjects,whereas the levels of phosphorylated Akt corrected with GAPDH were ***,this relationship was not observed in the control *** These results suggest that an inverse relationship may exist between platelet Akt activation and hippocampal atrophy in T2DM *** findings provide insight into the molecular mechanisms underlying T2DM hippocampal atrophy.

关键词： Akt Platelet Hippocampal atrophy Magnetic resonance imaging Diabetes mellitus

Long-term survival of the Sister Mary Joseph nodule originating from breast cancer:A case report

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World Journal of Clinical Cases 2023年第34期11卷 8205-8211页

作者： Koji Kanayama Maki Tanioka Yoshitsugu Hattori Takuya iida Mutsumi Okazaki Department of Plastic and Reconstructive Surgery The University of TokyoTokyo 113-8655Japan Department of Medical Oncology National Cancer Center HospitalTokyo 104-0045Japan

BACKGROUND A Sister Mary Joseph nodule(SMJN)is an uncommon cutaneous metastasis found in the umbilicus,indicating an advanced *** typically originate from intra-abdominal sources,rarely from breast *** suggests a poor prognosis with a median survival of approximately 8 mo after *** patients with SMJNs is challenging,as most receive limited palliative care *** optimal strategy for long-term survival of these patients remains *** SUMMARY A 58-year-old female,previously diagnosed with right breast cancer 17 years ago and underwent breast-conserving surgery,adjuvant radiotherapy,and endocrine therapy,presented with a 2-cm umbilical *** years previously,metastases were detected in the right supraclavicular,infraclavicular,hilar,and mediastinal lymph *** umbilical nodule emerged four years before the date of presentation,confirmed as a skin metastasis of primary breast cancer upon excisional *** initial removal,the nodule recurred and grew,leading to her referral to our *** patient underwent extensive excision of the umbilical tumor and immediate abdominal wall *** therapy was continued *** years later,no local recurrence was observed,and the patient continued to work full-time,achieving over 9 years of survival following SMJN *** This case study aimed to identify the optimal strategy for achieving extended survival outcomes in patients with SMJN through comprehensive *** presented a case of the longest survival in a patient after undergoing a multidisciplinary treatment *** findings underscore the significance of adopting a multimodal treatment approach comprising timely and wide excision along with adjunctive *** approach can control the disease,prolong survival,and improve the quality of life in patients with SMJN.

关键词： Sister Mary Joseph nodule Breast cancer Cutaneous metastasis Long-term survival Abdominal wall reconstruction Case report

Negative refraction of deep water waves through water channel network

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Journal of Hydrodynamics 2019年第4期31卷 840-847页

作者： Takahito iida Masashi Kashiwagi Department of Naval Architecture and Ocean Engineering Osaka University Suita Osaka 5650871 Japan Research Fellow of Japan Society for the Promotion of Science Chiyoda-ku Tokyo 1020083 Japan

A design method of a negative refractive index for free surface water waves in deep water is presented. To obtain a condition of a negative index, an analogy between water waves in a water channel and electric waves in an electric circuit is employed. An analytical solution of waves around a periodic array of rectangular columns is obtained by a circuit analysis. Attention is not focused on columns but a space among columns, and then the space is regarded as the water channel. Therefore, the circuit analysis can be applied to water waves. One channel is treated as a unit structure and a number of channels are periodically cascaded as a network. The negative refraction and backward waves by a network of the water channels are shown. Since the negative refraction might occur even around simple periodic structures, it is meaningful to understand wave phenomenon around offshore structures and develop innovative technology.

关键词： Negative refractive index backward wave water channel network equivalent circuit deep water

Electron transfer governed by light-matter interaction at metal-semiconductor interface

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npj Computational Materials 2020年第1期6卷 1628-1635页

作者： Kenji iida Masashi Noda Department of Theoretical and Computational Molecular Science Institute for Molecular ScienceMyodaijiOkazaki 444-8585Japan Center for Computational Sciences University of Tsukuba1-1-1 TennodaiTsukuba 305-8577Japan

The photoexcitation of heterostructures consisting of metallic nanoclusters and a semiconductor has been extensively investigated in relation to interests in photocatalysis and optical *** optoelectronic functions of the heterostructures originate from localized surface plasmon resonance,which can induce electron and resonance energy *** it is well known that photoinduced electronic interaction between a metallic nanocluster and a semiconductor is responsible for the resonance energy transfer,the electron transfer associated with the photoinduced electronic interaction has not been *** this paper,we elucidate the photoexcitation dynamics of a silver nanocluster/TiO_(2) heterostructure using an original first-principles computational approach that explicitly deals with light–matter *** is shown that the photoinduced silver–TiO_(2) electronic interaction causes excited electrons to be directly transferred from the silver nanocluster to the TiO2 layer without passing through the conduction band of the silver nanocluster.

关键词： silver interaction transfer

Ultrasmall and ultradense InGaN-based RGB monochromatic micro-light-emitting diode arrays by pixilation of conductive p-GaN

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Photonics Research 2021年第12期9卷 2429-2434页

作者： ZHE ZHUANG DAISUKE iida KAZUHIRO OHKAWA Computer Electrical and Mathematical Sciences and Engineering(CEMSE)DivisionKing Abdullah University of Science and Technology(KAUST)Thuwal 23955-6900Saudi Arabia

We describe 5μm squircle InGaN-based red,green,and blue(RGB)monochromatic micro-light-emitting diodes(μLEDs)with an interpitch of 4μm by pixilation of conductive p-GaN using a H2-plasma *** p-GaN was passivated by H2 plasma and prevented the current’s injection into the InGaN quantum wells *** observed that InGaN-based redμLEDs exhibited a broader full width at half-maximum and larger peak wavelength blueshift at 11.5-115 A/cm^(2) than the green/blueμ*** on-wafer light output power density of the redμLEDs at a wavelength of 632 nm at 115 A/cm^(2) was approximately 936 mW/cm^(2),the highest value reported thus far for InGaN-based redμ*** value was comparable with that of the green/blueμLEDs at 11.5 A/cm^(2),indicating that the redμLEDs can satisfy the requirement of high brightness levels for specific *** color gamut based on InGaN RGBμLEDs covered 83.7%to 75.9%of the Rec.2020 color space in the CIE 1931 diagram at 11.5 to 115 A/cm^(2).

关键词： diode conductive light

630-nm red InGaN micro-light-emitting diodes(<20μm×20μm)exceeding 1 mW/mm~2 for full-color micro-displays

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Photonics Research 2021年第9期9卷 1796-1802页

作者： ZHE ZHUANG DAISUKE iida MARTIN VELAZQUEZ-RIZO KAZUHIRO OHKAWA Computer Electrical and Mathematical Sciences and Engineering(CEMSE)DivisionKing Abdullah University of Science and Technology(KAUST)Thuwal 23955-6900Saudi Arabia

We demonstrated 10×10 arrays of In Ga N 17μm×17μm micro-light-emitting diodes(μLEDs)with a peak wavelength from 662 to 630 nm at 10–50 A∕cm^(2).The on-wafer external quantum efficiency reached 0.18%at 50 A∕cm^(2).The output power density of the redμLEDs was obtained as 1.76 m W∕mm^(2),which was estimated to be higher than that of 20μm×20μm Al In Ga P redμLEDs(~630 nm).Finally,we demonstrate that In Ga N red/green/blueμLEDs could exhibit a wide color gamut covering 81.3%and 79.1%of the Rec.2020 color space in CIE 1931 and 1976 diagrams,respectively.

关键词： diodes emitting arrays

Multilinear Fractional Integrals on Morrey Spaces

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Acta Mathematica Sinica,English Series 2012年第7期28卷 1375-1384页

作者： Takeshi iida Enji SATO Yoshihiro SAWANO Hitoshi TANAKA Department of Mathematical Sciences Faculty of ScienceYamagata University Department of Mathematics Kyoto University Graduate School of Mathematical Sciences The University of Tokyo

In the present paper we obtain and extend the boundedness property of the Adams type for multilinear fractional integral operators. Also, we deal with the Olsen type inequality.

关键词： Multilinear fractional integral operators Morrey spaces

Role of autophagy in the pathogenesis of inflammatory bowel disease

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World Journal of Gastroenterology 2017年第11期23卷 1944-1953页

作者： Tomoya iida Kei Onodera Hiroshi Nakase Department of Gastroenterology and Hepatology Sapporo Medical University School of MedicineHokkaido 060-8556Japan

Inflammatory bowel disease(IBD) results from a complex series of interactions between susceptibility genes, the environment, and the immune ***, some studies provided strong evidence that the process of autophagy affects several aspects of mucosal immune responses. Autophagy is a cellular stress response that plays key roles in physiological processes, such as innate and adaptive immunity, adaptation to starvation, degradation of aberrant proteins or organelles, antimicrobial defense, and protein secretion. Dysfunctional autophagy is recognized as a contributing factor in many chronic inflammatory diseases, including IBD. Autophagy plays multiple roles in IBD pathogenesis by altering processes that include intracellular bacterial killing, antimicrobial peptide secretion by Paneth cells, goblet cell function, proinflammatory cytokine production by macrophages, antigen presentation by dendritic cells, and the endoplasmic reticulum stress response in enterocytes. Recent studies have identified susceptibility genes involved in autophagy, such as NOD2, ATG16L1, and IRGM, and active research is ongoing all over the world. The aim of this review is a systematic appraisal of the current literature to provide a better understanding of the role of autophagy in the pathogenesis of IBD. Understanding these mechanisms will bring about new strategies for the treatment and prevention of IBD.

关键词： Autophagy Inflammatory bowel disease Genome-wide association study Ulcerative colitis Crohn’s disease

Effectiveness of impedance monitoring during radiofrequency ablation for predicting popping

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World Journal of Gastroenterology 2012年第41期18卷 5870-5878页

作者： Hiroya iida Tsukasa Aihara Shinichi Ikuta Naoki Yamanaka Department of Surgery Meiwa Hospital4-31 Agenaruo-choNishinomiyaHyogo 663-8186Japan

AIM:To retrospectively evaluate the effectiveness of impedance monitoring for predicting popping during radiofrequency ablation(RFA) using internally cooled ***:We reviewed 140 patients(94 males,46 females;age range 73.0 ± 11.1 year) who underwent RFA between February 2006 and November 2008 with a modified protocol using a limited power delivery rather than a conventional one to avoid *** the patients provided their written informed consent,and the study was approved by the institutional review *** impedances were measured for the study subjects,and the tumors were classified into three types according to the characteristics of their impedance curves:increasing,flat,or *** tumors were further sorted into seven subtypes(A-G) depending on the curvature of the impedance curve' s increase or *** popping rates were determined for the three types and seven subtypes.A chi-square test was performed to estimate statistical ***:A total of 148 nodules treated by RFA were *** study samples included 132 nodules of hepatocellular carcinoma,14 nodules of metastatic liver cancer,and two nodules of intrahepatic *** numbers of nodules with each impedance curve type were as follows:37 increasing-type nodules,43 flat-type nodules,and 68 decreasing-type *** occurrence rates were 24.3%,46.5% and 64.7%,***-type nodules exhibited a significantly higher rate of popping compared to increasing-type nodules(P = 0.039).Decreasing-type nodules exhibited a significantly higher rate of popping compared to increasing-type nodules(P < 0.0001).Notably,nodules that showed a sharp decrease in impedance in the latter ablation period(subtype E) exhibited a significantly higher rate of popping compared to other ***:Intraprocedural impedance monitoring can be a useful tool to predict the occurrence of popping during liver tumor RFA performed with internall

关键词：阻抗曲线射频消融监测预测治疗内部冷却 RFA 增长型