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Anti-inflammatory activity of probiotic Bifidobacterium: Enhancement of IL-10 production in peripheral blood mononuclear cells from ulcerative colitis patients and inhibition of IL-8 secretion in HT-29 cells

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World Journal of Gastroenterology 2008年第16期14卷 2511-2516页

作者： Akemi Imaoka Tatsuichiro Shima Kimitoshi Kato shigeaki mizuno Toshiki Uehara Satoshi Matsumoto Hiromi Setoyama Taeko Hara Yoshinori Umesaki Yakult Central Institute for Microbiological Research Yaho Kunitachi Department of Gastroenterology and Hepatology Nihon University School of Medicine

AIM: To determine the anti-inflammatory activity of probiotic Bifidobacteria in Bifidobacteria-fermented milk (BFM) which is effective against active ulcerative colitis (UC) and exacerbations of UC, and to explore the immunoregulatory mechanisms. METHODS: Peripheral blood mononuclear cells (PBMNC) from UC patients or HT-29 cells were co-cultured with heat-killed probiotic bacteria or culture supernatant of Bifidobacterium breve strain Yakult (BbrY) or Bifidobacterium bifidum strain Yakult (BbiY) to estimate the amount of IL-10 or IL-8 secreted. RESULTS: Both strains of probiotic Bifidobacteria contained in the BFM induced IL-10 production in PBMNC from UC patients, though BbrY was more effective than BbiY. Conditioned medium (CM) and DNA of both strains inhibited IL-8 secretion in HT-29 cells stimulated with TNF-α, whereas no such effect was observed with heat- killed bacteria. The inhibitory effect of CM derived from BbiY was greater than that of CM derived from BbrY. DNAs of the two strains had a comparable inhibitory activity against the secretion of IL-8. CM of BbiY induced a repression of IL-8 gene expression with a higher expression of IκB-ζ mRNA 4 h after culture of HT-29 cells compared to that in the absence of ***: Probiotic Bifidobacterium strains in BFM enhance IL-10 production in PBMNC and inhibit IL-8 secretion in intestinal epithelial cells, suggesting that BFM has anti-inflammatory effects against ulcerative colitis.

关键词： Bifidobacterium Ulcerative colitis Anti-inflammatory Intedeukin-10 Interleukin-8

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Pedestrian trajectory prediction method based on the Social-LSTM model for vehicle collision

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Transportation Safety and Environment 2024年第3期6卷 140-151页

作者： Yong Han Xujie Lin Di Pan Yanting Li Liang Su Robert Thomson Koji mizuno School of Mechanical and Automotive Engineering Xiamen University of TechnologyXiamen 361024China Fujian Province Key Laboratory of Advanced Design and Manufacturing of Buses Xiamen 361024China Engineering Research Institute of Xiamen Kinglong United Automobile Industry Co. Ltd.Xiamen 361000China Chalmers University of Technology Gothenburg 41296Sweden Department of Mechanical Systems Engineering Nagoya UniversityNagoya 464-8603Japan

Techniques for predicting the trajectory of vulnerable road users are important to the development of perception systems for autonomous vehicles to avoid *** most effective trajectory prediction methods,such as Social-LSTM,are often used to predict pedestrian trajectories in normal passage ***,they can produce unsatisfactory prediction results and data redundancy,as well as difficulties in predicting trajectories using pixel-based coordinate systems in collision avoidance *** is also a lack of validations using real vehicle-to-pedestrian *** address these issues,some insightful approaches to improve the trajectory prediction scheme of Social-LSTM were proposed,such methods included transforming pedestrian trajectory coordinates and converting image coordinates to world *** YOLOv5 detection model was introduced to reduce target loss and improve prediction *** DeepSORT algorithm was employed to reduce the number of target transformations in the tracking *** Perspective Transformation(IPT)and Direct Linear Transformation(DLT)theories were combined to transform the coordinates to world coordinates,identifying the collision location where the accident could *** performance of the proposed method was validated by training tests using MS COCO(Microsoft Common Objects in Context)and ETH/UCY *** results showed that the target detection accuracy was more than 90%and the prediction loss tends to decrease with increasing training steps,with the final loss value less than 1%.The reliability and effectiveness of the improved method were demonstrated by benchmarking system performance to two video recordings of real pedestrian accidents with different lighting conditions.

关键词： vehicle-to-pedestrian collisions pedestrian trajectory prediction YOLOvB DeepSORT Social-LSTM

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Current perspectives of viral hepatitis

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World Journal of Gastroenterology 2024年第18期30卷 2402-2417页

作者： Daisuke Usuda Yuki Kaneoka Rikuo Ono Masashi Kato Yuto Sugawara Runa Shimizu Tomotari Inami Eri Nakajima Shiho Tsuge Riki Sakurai Kenji Kawai Shun Matsubara Risa Tanaka Makoto Suzuki Shintaro Shimozawa Yuta Hotchi Ippei Osugi Risa Katou Sakurako Ito Kentaro Mishima Akihiko Kondo Keiko mizuno Hiroki Takami Takayuki Komatsu Tomohisa Nomura Manabu Sugita Department of Emergency and Critical Care Medicine Juntendo University Nerima HospitalNerima 177-8521TokyoJapan Department of Sports Medicine Faculty of MedicineJuntendo UniversityBunkyo 113-8421TokyoJapan

Viral hepatitis represents a major danger to public health,and is a globally leading cause of *** five liver-specific viruses:Hepatitis A virus,hepatitis B virus,hepatitis C virus,hepatitis D virus,and hepatitis E virus,each have their own unique epidemiology,structural biology,transmission,endemic patterns,risk of liver complications,and response to antiviral *** remain few options for treatment,in spite of the increasing prevalence of viral-hepatitiscaused liver ***,chronic viral hepatitis is a leading worldwide cause of both liver-related morbidity and mortality,even though effective treatments are available that could reduce or prevent most patients’*** 2016,the World Health Organization released its plan to eliminate viral hepatitis as a public health threat by the year 2030,along with a discussion of current gaps and prospects for both regional and global eradication of viral ***,treatment is sufficiently able to prevent the disease from reaching advanced ***,future therapies must be extremely safe,and should ideally limit the period of treatment necessary.A better understanding of pathogenesis will prove beneficial in the development of potential treatment strategies targeting infections by viral *** review aims to summarize the current state of knowledge on each type of viral hepatitis,together with major innovations.

关键词： Hepatitis A virus Hepatitis B virus Hepatitis C virus Hepatitis D virus Hepatitis E virus Current perspectives

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Identification of CO_2 disposal locations in an ocean general circulation model of the North Pacific

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Acta Oceanologica Sinica 2009年第1期28卷 15-24页

作者： XU Yongfu AOKI shigeaki HARADA Koh State Key Laboratory of Atmospheric Boundal7 Layer Physics and Atmospheric Chemistl＇y Institute of Atmos- pheric Physics Chinese Academy of Sciences Beijing 100029 China Institute for Environmental Management Technology National Institute for kdvanced Industrial Science and Technology Tsukuha lbaraki 305-8569 Japan

A basin-wide ocean general circulation model of the North Pacific is used to identify which location is more efficient for ocean CO2 sequestration in the North *** injection depths at each one of fifteen locations are *** terms of effectiveness index（EI） and escape factor（EF）,it is clear that the effectiveness increases with increasing latitude at the end of the 50 a injection ***-by-site differences in the EI can be over 9% for the 1 000 m injection depth in the western North Pacific at the end of 50 a of continuous *** difference is much larger for the 500 m *** difference decreases with increasing injection ***,the site-by-site difference is small for the injection in the eastern North *** sequestration is more efficient for the injection in the east than in the *** the 500 m injection depth,the difference in effectiveness between the west and the east is over 10% at the end of 50 a injection *** largest concentration of sequestered CO2 increases with increasing injection *** the injection in both the western and central North Pacific,the largest exchange flux always appears to be at about 42°N,150°E,whereas for the injection in the eastern area the large flux appears to be in the equatorial region（120°W）.

关键词： ocean carbon disposal north Pacific Ocean numerical modelling sequestration

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A virtual globe-based visualization and interactive framework for a small craft navigation assistance system in the near sea

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Journal of Traffic and Transportation Engineering(English Edition) 2017年第6期4卷 564-575页

作者： xinzhu liu shigeaki shiotani faculty of international economics and trade jilin huaqiao university of foreign languagesChangchun 130217China graduate school of maritime sciences kobe universityKobe 658-0022Japan organization of advanced science and technology faculty of maritime scienceskobe universityKobe 658-0022Japa

With the growing popularization of small crafts, the accidents that happen among such crafts are also drawing increasing attention, according to the marine accident data released by the Japan Coast Guard. In order to prevent possible navigation accidents, the authors considered that besides sharing information from land by the coast office broadly, man- agers on land can also watch out and give appropriate advice for operators in crafts one-to- one. This paper discusses the technical issues of developing virtual globe-based （Google Maps/Earth geographic information system （GIS）） 3D visualization stand-alone software for small craft navigation assistance in the aim to facilitate the safety and sufficiency of small crafts in the near sea. The system was developed using web services and object-oriented programming disciplines to support the integration of a virtual global framework, GPS, and real-time imaging data. The authors have also developed data processing programs that are glued together with C# language, JavaScript language, National Marine Electronics Association （NMEA） instance data, and keyhole markup language （KML） data. Experiments for evaluating the framework have been made around the near coastal area. The perfor- mances and deficiencies are discussed in this paper. In order to evaluate the validity of the performance and the functionality of the system, authors conducted a questionnairesurvey among third year students of the Voyage Course at Kobe University. The evaluation of the system suggests valuable potential for the small craft navigation assistance system.

关键词： Small craftNavigation assistanceGISVirtual globe-basedKeyhole markup language

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A Novel Sterilization Method Using Pulsed Discharge Plasma

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Chinese Physics Letters 1998年第1期15卷 41-42页

作者： WANG Xi-lu Akira mizuno Shijin Katsura Department of Ecological Engineering Toyohashi University of TechnologyTempaku-choToyohashi441Japan Institute of Electrostatics Northeast Normal UniversityChangchun 130024

Pulsed discharge plasma(PDP)has been used to kill bacteria and the curves of the survival rate of bacteria against treatment time are *** structural change in the cell membrane is caused by PDP and the cell is thus **... 详细信息

关键词： PDP Plasma treatment

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A Novel Estimating Method for Steering Efficiency of the Driver with Electromyography Signals

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Chinese Journal of Mechanical Engineering 2014年第3期27卷 460-467页

作者： LIU Yahui JI Xuewu HAYAMA Ryouhei mizuno Takahiro State Key Laboratory of Automotive Safety and Energy Tsinghua University Research and Development Center jtekt co.ltd.

The existing research of steering efficiency mainly focuses on the mechanism efficiency of steering system, aiming at designing and optimizing the mechanism of steering system. In the development of assist steering system especially the evaluation of its comfort, the steering efficiency of driver physiological output usually are not considered, because this physiological output is difficult to measure or to estimate, and the objective evaluation of steering comfort therefore cannot be conducted with movement efficiency perspective. In order to take a further step to the objective evaluation of steering comfort, an estimating method for the steering efficiency of the driver was developed based on the research of the relationship between the steering force and muscle activity. First, the steering forces in the steering wheel plane and the electromyography （EMG） signals of the primary muscles were measured. These primary muscles are the muscles in shoulder and upper ann which mainly produced the steering torque, and their functions in steering maneuver were identified previously. Next, based on the multiple regressions of the steering force and EMG signals, both the effective steering force and the total force capacity of driver in steering maneuver were calculated. Finally, the steering efficiency of driver was estimated by means of the estimated effective force and the total force capacity, which represented the information of driver physiological output of the primary muscles. This research develops a novel estimating method for driver steering efficiency of driver physiological output, including the estimation of both steering force and the force capacity of primary muscles with EMG signals, and will benefit to evaluate the steering comfort with an objective perspective.

关键词： electromyography muscle activity steering efficiency estimating

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Optimization of causative factors using logistic regression and artificial neural network models for landslide susceptibility assessment in Ujung Loe Watershed, South Sulawesi Indonesia

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Journal of Mountain Science 2019年第2期16卷 383-401页

作者： Andang Suryana SOMA Tetsuya KUBOTA Hideaki mizuno Faculty of Forestry Hasanuddin University Faculty of Agriculture Kyushu University

Landslide susceptibility maps(LSMs) play a vital role in assisting land use planning and risk mitigation. This study aims to optimize causative factors using logistic regression(LR) and an artificial neural network(ANN) to produce a LSM. The LSM is produced with 11 causative factors and then optimized using forward-stepwise LR(FSLR), ANN, and their combination(FSLR-ANN) until eight causative factors were found for each method. The ANN method produced superior validation results compared with LR. The ROC values for the training data set ranges between 0.8 and 0.9. On the other hand, validation with the percentage of landslide fall into LSM class high and very high, ANN method was higher(92.59%) than LR(82.12%). FSLR-ANN with nine causative factors gave the best validation results with respect to area under curve(AUC) values, and validation with the percentage of landslide fall into LSM class high and very high. In conclusion, ANN was found to be better than LR when producing LSMs. The best Optimization was combination of FSLR-ANN with nine causative factors and AUC success rate 0.847, predictive rate 0.844 and validation with landslide fall into high and very high class with 91.30%. It is an encouraging preliminary model towards a systematic introduction of FSLR-ANN model for optimization causative factors in landslide susceptibility assessment in the mountainous area of Ujung Loe Watershed.

关键词： Optimized causative factor Landslide, Logistic Regression Artificial neural network Indonesia

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Effect of Different Titanium Surface Treatments on the Adhesion Test Result:Dental Application

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Journal of Wuhan University of Technology(Materials Science) 2023年第1期38卷 255-259页

作者： Alireza Valanezhad Masayoshi Suzue Sirus Safaee Mahdis Nesabi Mohammad Khodaei shigeaki Abe Ikuya Watanabe Department of Dental and Biomedical Materials Science Nagasaki UniversityNagasakiJapan Medical Education Development Center Nagasaki University HospitalNagasakiJapan Materials Engineering Group Golpayegan College of EngineeringIsfahan University of TechnologyGolpayegan 87717-67498Iran

The aim of the study was to investigate the effect of different surface treatment of titanium(Ti)on the adhesion test results for dental *** substrates roughened by 400 to 1500-grit SiC polish papers and alumina blasting,alkali treated by 5 molar(M)NaOH and KOH solutions and heat treated at the temperature range of 400-800℃were used in this *** treated samples were subjected to the adhesion *** to the results of the adhesion test,the adhesive strength showed the highest value for the blasted titanium among all polished and blasted *** Ti samples heated at 650℃showed the highest adhesive strength among all heat-treated ***,the adhesion test results indicated the higher adhesive strength of chemically treated samples treated by NaOH rather than that by *** polished and heated Ti samples showed the highest adhesive strength among all samples.

关键词： titanium implant surface treatment bonding strength anatase rutile

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Semisupervised Deep State-Space Model for Plant Growth Modeling

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Plant Phenomics 2020年第1期2卷 122-137页

作者： S.Shibata R.mizuno H.Mineno Graduate School of Integrated Science and Technology Shizuoka University3-5-1 JohokuNaka-kuHamamatsuShizuoka 432-8011Japan College of Informatics Academic InstituteShizuoka University3-5-1 JohokuNaka-kuHamamatsuShizuoka 432-8011Japan JST PRESTO4-1-8 HonchoKawaguchiSaitama 332-0012Japan

The optimal control of sugar content and its associated technology is important for producing high-quality crops more stably and ***-based reinforcement learning(RL)indicates a desirable action depending on the type of situation based on trialand-error calculations conducted by an environmental *** this paper,we address plant growth modeling as an environmental model for the optimal control of sugar *** the growth process,fruiting plants generate sugar depending on their state and evolve via various external stimuli;however,sugar content data are sparse because appropriate remote sensing technology is yet to be developed,and thus,sugar content is measured *** propose a semisupervised deep state-space model(SDSSM)where semisupervised learning is introduced into a sequential deep generative *** achieves a high generalization performance by optimizing the parameters while inferring unobserved data and using training data efficiently,even if some categories of training data are *** designed an appropriate model combined with model-based RL for the optimal control of sugar content using SDSSM for plant growth *** evaluated the performance of SDSSM using tomato greenhouse cultivation data and applied cross-validation to the comparative evaluation *** SDSSM was trained using approximately 500 sugar content data of appropriately inferred plant states and reduced the mean absolute error by approximately 38%compared with other supervised learning *** results demonstrate that SDSSM has good potential to estimate time-series sugar content variation and validate uncertainty for the optimal control of high-quality fruit cultivation using model-based RL.

关键词： Deep sugar optimal

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