检索结果-南通市图书馆

Overcoming adaptive resistance in AML by synergistically targeting FOXO3A-GNG7-mTOR axis with FOXO3A inhibitor Gardenoside and rapamycin

引用

Genes & Diseases 2024年第1期11卷 397-412页

作者： Zhe Chen Qian Guo shichen Huang Lei Li Feng Wu Zhilong Liu Zhigang Li tao Chen Guanbin Song Shuangnian Xu Jieping Chen Yu Hou Department of Hematology Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China Institute of Life Sciences Chongqing Medical UniversityChongqing 400016China Key Laboratory of Biorheological Science and Technology Ministry of EducationCollege of BioengineeringChongqing UniversityChongqing 400044China Chongqing Foreign Language School Chongqing 400039China

Therapeutic targeting FOxO3A(a forkhead transcription factor)represents a prom-ising strategy to suppress acute myeloid leukemia(AML).However,the effective inhibitors that target FOXO3A are lacking and the adaptive response signaling weakens the cytotoxic effect of FOxO3A depletion on AML cells.Here,we show that FOxO3A deficiency induces a compensa-tory response involved in the reactive activation of mTOR that leads to signaling rebound and adaptive resistance.Mitochondrial metabolism acts downstream of mTOR to provoke activa-tion of JNK/c-JUN via reactive oxygen species(ROS).At the molecular level,FOXO3A directly binds to the promoter of G protein gamma subunit 7(GNG7)and preserves its expression,while GNG7 interacts with mTOR and restricts phosphorylated activation of mTOR.Consequently,combinatorial inhibition of FOXO3A and mTOR show a synergistic cytotoxic effect on AML cells and prolongs survival in a mouse model of AML.Through a structure-based virtual screening,we report one potent small-molecule FOxO3A inhibitor(Gardenoside)that exhibits a strong effect of anti-FOXO3A DNA binding.Gardenoside synergizes with rapamycin to substantially reduce tumor burden and extend survival in AML patient-derived xenograft model.These results demonstrate that mTOR can mediate adaptive resistance to FOxO3A inhibition and validate a combinatorial approach for treating AML.

关键词： AML Combinatorial inhibition FOXO3A GNG7 mTOR

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

New insights into developmental biology of Eimeria tenella revealed by comparative analysis of mRNA N6-methyladenosine modification between unsporulated oocysts and sporulated oocysts

引用

Journal of Integrative Agriculture 2024年第1期23卷 239-250页

作者： Qing Liu Bingjin Mu Yijing Meng Linmei Yu Zirui Wang tao Jia Wenbin Zheng Wenwei Gao shichen Xie Xingquan Zhu Laboratory of Parasitic Diseases College of Veterinary MedicineShanxi Agricultural UniversityTaigu 030801China Research Center for Parasites&Vectors College of Veterinary MedicineHunan Agricultural UniversityChangsha 410128China

Evidence showed that N6-methyladenosine(m^(6)A)modification plays a pivotal role in influencing RNA fate and is strongly associated with cell growth and developmental processes in many species.However,no information regarding m^(6)A modification in Eimeria tenella is currently available.In the present study,we surveyed the transcriptome-wide prevalence of m^(6)A in sporulated oocysts and unsporulated oocysts of E.tenella.Methylated RNA immunoprecipitation sequencing(MeRIP-seq)analysis showed that m^(6)A modification was most abundant in the coding sequences,followed by stop codon.There were 3,903 hypermethylated and 3,178 hypomethylated mRNAs in sporulated oocysts compared with unsporulated oocysts.Further joint analysis suggested that m^(6)A modification of the majority of genes was positively correlated with mRNA expression.The mRNA relative expression and m^(6)A level of the selected genes were confirmed by quantitative reverse transcription PCR(RT-qPCR)and MeRIP-qPCR.GO and KEGG analysis indicated that differentially m^(6)A methylated genes(DMMGs)with significant differences in mRNA expression were closely related to processes such as regulation of gene expression,epigenetic,microtubule,autophagy-other and TOR signaling.Moreover,a total of 96 DMMGs without significant differences in mRNA expression showed significant differences at protein level.GO and pathway enrichment analysis of the 96 genes showed that RNA methylation may be involved in cell biosynthesis and metabolism of E.tenella.We firstly present a map of RNA m^(6)A modification in E.tenella,which provides significant insights into developmental biology of E.tenella.

关键词： Eimeria tenella m^(6)A RNA methylation MeRIP-seq RNA-seq proteomic analysis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

El Ni?o/Southern Oscillation during the 4.2 ka event recorded by growth rates of corals from the North South China Sea

引用

Acta Oceanologica Sinica 2020年第1期39卷 110-117页

作者： Shaohua Dang Kefu Yu shichen tao tao Han Huiling Zhang Wei Jiang Guangxi Laboratory on the Study of Coral Reefs in the South China Sea Guangxi UniversityNanning 530004China Coral Reef Research Center of China Guangxi UniversityNanning 530004China School of Marine Sciences Guangxi UniversityNanning 530004China South China Sea Institute of Oceanology Chinese Academy of SciencesGuangzhou 510301China College of Ocean Engineering Guangdong Ocean UniversityZhanjiang 524088China

The 4.2 ka event that occurred during the period from 4 500–3 900 a BP was characterized by cold and dry climates and resulted in the collapse of civilizations around the world. The cause of this climatic event, however, has been under debate. We collected four corals(Porites lutea) from Yongxing Island, Xisha Islands, South China Sea, dated them with the U-series method, and measured the annual coral growth rates using X-ray technology. The dating results showed that the coral growth ages were from 4 500–3 900 a BP, which coincide well with the period of the4.2 ka event. We then reconstructed annual sea surface temperature anomaly(SSTA) variations based on the coral growth rates. The growth rate-based SSTA results showed that the interdecadal SSTA from 4 500–3 900 a BP was lower than that during modern times(1961–2008 AD). A spectral analysis showed that the SSTA variations from4 500–3 900 a BP were under the influence of El Nino-Southern Oscillation(ENSO) activities. From 4 500–4 100 a BP, the climate exhibited La Nina-like conditions with weak ENSO intensity and relatively stable and lower SSTA amplitudes. From 4 100–3 900 a BP, the climate underwent a complicated period of ENSO variability and showed alternating El Nino-or La Nina-like conditions at interdecadal time scales and large SSTA amplitudes. We speculate that during the early and middle stages of the 4.2 ka event, the cold climate caused by weak ENSO activities largely weakened social productivity. Then, during the end stages of the 4.2 ka event, the repeated fluctuations in the ENSO intensity caused frequent extreme weather events, resulting in the collapse of civilizations worldwide. Thus, the new evidence obtained from our coral records suggests that the 4.2 ka event as well as the related collapse of civilizations were very likely driven by ENSO variability.

关键词： 4.2 ka event ENSO variability SSTA coral growth rate Xisha Islands

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Influence of Aspect Ratio on Rolling Shear Properties of Fast-Grown Small Diameter Eucalyptus Lumber

引用

Journal of Renewable Materials 2020年第9期8卷 1053-1066页

作者： tao Gui shichen Cai Zhiqiang Wang Jianhui Zhou College of Materials Science and Engineering Nanjing Forestry UniversityNanjing210037China Integrated Wood Engineering University of Northern British ColumbiaPrince GeorgeV2L 1R7Canada

Eucalyptus is a major fast-grown species in South China,which has the potential for producing structural wood products such as cross-laminated timber(CLT).Aspect ratio(board width vs.board thickness)of eucalyptus lumbers is small due to the small diameter of fast-grown eucalyptus wood.To evaluate its rolling shear modulus and strength for potential CLT applications,three-layer hybrid CLT shear block specimens with different aspect ratios(2,4,6),were tested by planar shear test method.Digital image correlation(DIC)was employed to measure the rolling shear strain distribution and development during the planar shear tests.The mean values of rolling shear modulus and strength of eucalyptus lamination were 260.3%and 88.2%higher than those of SPF(Spruce-pine-fir)lamination with the same aspect ratio of 4,respectively.The rolling shear properties of eucalyptus laminations increased as the aspect ratio increased.Aspect ratio had a significant influence on rolling shear modulus compared to rolling shear strength.The high shear strain regions were primarily found around the gaps between segments of cross layer.The quantity of high shear strain regions increased as the aspect ratio of lamination decreased.Other high shear strain regions also occurred around the pith and along the glue line.The sudden failure of specimen occurred in the high strain region.In conclusion,the rolling shear strength and modulus of fast-grown eucalyptus laminations exceed the respective characteristic values for softwoods in the current standard by roughly factors of 3 and 8,indicating great potential for fast-grown eucalyptus wood cross-layers in CLT.

关键词： Fast-grown eucalyptus cross-laminated timber rolling shear aspect ratio digital image correlation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Recent advances and prospects toward blue perovskite materials and light-emitting diodes

引用

InfoMat 2019年第2期1卷 211-233页

作者： tao Fang Fengjuan Zhang shichen Yuan Haibo Zeng Jizhong Song School of Materials Science and Engineering Nanjing University of Science and TechnologyNanjingChina MIIT Key Laboratory of Advanced Display Materials and Devices Institute of Optoelectronics and NanomaterialsNanjingChina

Perovskite based light-emitting diodes(PeLEDs)have become a powerful candidate for next-generation solid-state lightings and high-definition displays due to their high photoluminescence quantum yield(PLQY),tunable emission wavelength over the visible spectrum,and narrow emission linewidths.Over the past few years,the development of red-and green-emissive PeLEDs has rapidly increased,and the corresponding external quantum efficiencies(EQE)have exceeded 20%.However,the research progress of blue-emitting PeLEDs is limited by its poor material quality and inappropriate device structure.Currently,the maximum EQE of blue PeLED is only 6.2%,which is far from the industrialization requirements.In order to promote the development of blue PeLEDs,we summarize the recent research progress of blue perovskite materials and LEDs and discuss several fatal challenges,mainly embodied in low efficiency and poor stability.In order to overcome these challenges,detailed analysis and strategies are put forward in terms of the materials and devices.For the former,we summarize the feasible strategy for the preparation of efficient and stable blue-emissive perovskites using component engineering.For the latter,we analyze the advantages and limitations of the different strategies for blue-emissive perovskite in LEDs.At the end of the review,a comprehensive outlook is detailed,including future development directions and several technical problems to be solved.Thus,we aim to highlight the significance and promote the industrialization of PeLEDs.

关键词： blue emission component engineering efficiency light-emitting diodes perovskites stability

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A novel protein domain is important for photosystem Ⅱ complex assembly and photoautotrophic growth in angiosperms

引用

Molecular Plant 2023年第2期16卷 374-392页

作者： Wei Li Jiangfan Guo Xue Han Xiaowen Da Kai Wang Hongfei Zhao Shi-Tang Huange Bosheng Li Hang He Ruirui Jiang shichen Zhou Peng Yan tao Chen Yi He Jiming Xu Yu Liu Yunrong Wu Huixia Shou Zhongchang Wu Chuanzao Mao Xiaorong Mo State Key Laboratory of Plant Environmental Resilience College of Life ScienceZhejang UniversityHangzhou 310058PR China College of Life Science Shaanxi Normal UniversityXi'anShaanxi Province 710062PR China School of Advanced Agricultural Sciences and School of Life Sciences State Key Laboratory of Protein and Plant Gene ResearchPeking UniversityBeijing 100871China Peking University Institute of Advanced Agricultural Sciences Shandong Laboratory of Advanced Agricultural Sciences at WeifangWeifangShandong 261000China College of Urban Construction Zhejiang Shuren UniversityHangzhou 310015PR China School of Life Sciences Peking UniversityBeijing 100871PR China State Key Laboratory of Subtropical Silviculture Zhejiang A&F UniversityLin'anHangzhou 311300PR China

Photosystem Ⅱ(PSⅡ)is a multi-subunit protein complex of the photosynthetic electron transport chain that is vital to photosynthesis.Although the structure,composition,and function of PSⅡ have been extensively studied,its biogenesis mechanism remains less understood.Thylakoid rhodanese-like(TROL)provides an anchor for leaf-type ferredoxin:NADP^(+)oxidoreductase.Here,we report the chacterizaton of a second type of TROL protein,TROL2,encoded by seed plant genomes whose function has not previously been reported.We show that TROL2 is a PSⅡ assembly cofactor with essential roles in the establishment of photoautotrophy.TROL2 contains a 45-amino-acid domain,termed the chlorotic lethal seedling(CLS)domain,that is both necessary and sufficient for TROL2 function in PSⅡ assembly and photoautotrophic growth.Phylogenetic analyses suggest that TROL2 may have arisen from ancestral TROL1 via gene duplication before the emergence of seed plants and acquired the CLS domain via evolution of the sequence encoding its N-terminal portion.We further reveal that TROL2(or CLS)forms an assembly cofactor complex with the intrinsic thylakoid membrane protein LOW PSⅡ ACCUMULATION2 and interacts with small PSⅡ subunits to facilitate PSⅡ complex assembly.Collectively,our study not only shows that TROL2(CLS)is essential for photoautotrophy in angiosperms but also reveals its mechanistic role in PSⅡ complex assembly,shedding light on the molecular and evolutionary mechanisms of photosynthetic complex assemblyin angiosperms.

关键词： PSⅡassembly TROL2 assembly factors angiosperms evolution

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pollen-inferred vegetation and environmental changes since 16.7 ka BP at Balikun Lake, Xinjiang

引用

Chinese Science Bulletin 2010年第22期55卷 2449-2457页

作者： tao shichen AN ChenBang CHEN FaHu TANG LingYu WANG ZongLi LU YanBin LI ZhiFei ZHENG TongMing ZHAO JiaJu MOR Key Laboratory of West China's Environmental System Lanzhou University Lanzhou 730000 China Nanjing Institute of Geology and Paleontology Chinese Academy of Sciences Nanjing 210008 China

A high-resolution fossil pollen record from the sedimentary cores of Balikun Lake, northwestern China, combined with modern surface pollen data, is used to reconstruct the history of vegetation and climatic change since 16.7 cal. ka BP. Fossil pollen assem-blages and lithology indicate that the study area was dominated by desert. The desert had extremely arid climate and lower effec-tive moisture during 16.7–7.9 cal. ka BP, especially from 16.7 to 8.9 cal. ka BP when the lake maybe dried up. During 8.9–7.9 cal. ka BP, the environment gradually recovered in this area. It was then followed by the optimum period from 7.9 to 4.3 cal. Ka BP, when the effective moisture obviously increased. It was characterized by the typical desert-steppe/steppe vegetation and was ac-companied with several patch-birch woodlands around the lake. After that, a short but extremely arid climatic event occurred during 4.3–3.8 cal. ka BP, and the vegetation quickly changed from desert-steppe/steppe to desert. It was a relatively optimum period from 3.8 to 0.53 cal. ka BP showing typical desert-steppe/meadow-steppe landscape. Since 0.53 cal. ka BP, the climate has shown signs of deteriorating again. Furthermore, regional comparison shows that the characteristics of climatic and environmental evolution in this area were clearly different from East Asia monsoonal area during the last 16.7 cal. ka BP. It was characterized by the arid climate during the late-glacial and early Holocene, and relatively wet during the mid-late Holocene.

关键词：环境变化巴里坤湖花粉记录 BP 植被中晚全新世新疆气候变化

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

双向地震波作用下巨子型有控结构建筑的隔震设计

引用

地震工程学报 2020年第1期42卷 44-51页

作者：温世臣杨涛广西建设职业技术学院土木工程系广西南宁530007 广西大学土木建筑工程学院广西南宁530004

为了增强巨子型有控结构建筑的动力特性,提升其稳定性,设计双向地震波作用下建筑有控结构。采用3种磁流变阻尼器(MRD)与滑移隔震混合控制结构构成单体建筑有控结构,其包括巨结构和子结构,并建立该有控结构的动力分析模型。在动力分析模... 详细信息

为了增强巨子型有控结构建筑的动力特性,提升其稳定性,设计双向地震波作用下建筑有控结构。采用3种磁流变阻尼器(MRD)与滑移隔震混合控制结构构成单体建筑有控结构,其包括巨结构和子结构,并建立该有控结构的动力分析模型。在动力分析模型中输入水平和竖向地震,得到模型的竖向和水平滑动状态运动微分方程,依据这两个方程采用自适应模糊神经网络优化动力分析模型,构建优化模型。从优化模型出发,通过实例实验分析得出,优化设计双向地震波作用下建筑有控结构时,在其上部结构层间和隔离层各安装一个MRD,可确保优化设计后的有控结构在不同双向地震工况下的地震反应控制效果最佳,且有控结构在双向地震工况2下,结构第一层、中间三层以及顶层的加速度和位移的时程曲线走向一致,且差距微小;同时有控结构的巨结构顶层侧移响应随着子结构刚度增加而提高,动力特性没有明显的变化,子结构随着其自身刚度增加顶层侧移响应表现稳定,子结构动力特性增强。

关键词：单体建筑有控结构阻尼器动力分析模糊神经网络

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

南沙群岛现代滨珊瑚骨骼Sr/Ca、δ^(18)O和δ^(13)C对极端高温事件响应

引用

热带地理 2022年第11期42卷 1771-1782页

作者：徐潇峰余克服陈天然陶士臣严宏强陈特固中国科学院边缘海与大洋地质重点实验室南海海洋研究所广州510301 中国科学院大学北京100049 广西大学珊瑚礁研究中心广西南海珊瑚礁研究重点实验室广西大学海洋学院南宁530004 南方海洋科学与工程实验室广东珠海519080

以南沙群岛永暑礁的现代滨珊瑚YSL24(生长时间为1985-1999年)与YSL2A(生长时间为1971-1999年)为材料,通过对其骨骼开展高分辨率的Sr/Ca、^(18)δO和^(13)δC分析,探讨其对极端高温事件的响应特征。有记录表明,1971-1999年,南海南部在197... 详细信息

以南沙群岛永暑礁的现代滨珊瑚YSL24(生长时间为1985-1999年)与YSL2A(生长时间为1971-1999年)为材料,通过对其骨骼开展高分辨率的Sr/Ca、^(18)δO和^(13)δC分析,探讨其对极端高温事件的响应特征。有记录表明,1971-1999年,南海南部在1973、1983和1998年发生了极端高温事件,滨珊瑚骨骼Sr/Ca序列清楚地记录了这3次高温事件,其相应条带Sr/Ca周期数值显著低于序列其他年份。而^(18)δO对高温事件的响应不太明显,其原因可能与^(18)δO序列同时受温度和盐度变化的影响有关。^(13)δC在这3个高温年份均在夏季发生了异常负偏,应该是由高温胁迫下共生藻光合作用强度下降所致。因此,珊瑚骨骼的Sr/Ca和^(13)δC对南沙群岛高温胁迫具有明显的响应,可作为记录过去白化事件的可靠指标。

关键词：滨珊瑚骨骼地化指标珊瑚白化高温事件 δ^(13)C负偏南沙群岛

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

环礁潟湖沉积物重建南沙群岛小冰期以来的热带气旋活动

引用

热带海洋学报 2022年第6期41卷 171-182页

作者：杨红强谭飞徐辉龙张喜洋施祺陶士臣中国科学院边缘海与大洋地质重点实验室中国科学院南海海洋研究所中国科学院南海生态环境工程创新研究院广东广州510301 南方海洋科学与工程广东省实验室(广州) 广东广州511458 中国科学院南沙海洋生态环境实验站海南三沙573199 中国科学院大学北京100049

热带气旋活动以及由此产生的风暴潮和强降雨对南海及周边沿海地区社会经济构成巨大威胁。对器测记录之前全新世热带气旋的研究有助于准确预测全球变暖背景下热带气旋活动的变化趋势。本文利用南沙群岛安乐礁潟湖沉积物重建了小冰期以来... 详细信息

热带气旋活动以及由此产生的风暴潮和强降雨对南海及周边沿海地区社会经济构成巨大威胁。对器测记录之前全新世热带气旋的研究有助于准确预测全球变暖背景下热带气旋活动的变化趋势。本文利用南沙群岛安乐礁潟湖沉积物重建了小冰期以来准年分辨率的热带气旋活动,共识别28个风暴事件层。研究表明,小冰期以来,南沙群岛安乐礁热带气旋活动在年代际到百年尺度上频繁变化,发育两个主要的风暴活跃期。在小冰期早期(AD1471—1620)经历了最为强烈的风暴活跃期,另一个风暴活跃期位于现代暖期的AD 1930—1960,风暴活动虽有所加强,但明显低于小冰期早期。与同期永暑礁重建结果的对比表明,热带气旋活动存在明显的时空差异性,更多来自相近区域的高分辨率风暴记录可有效降低古风暴活动重建的不确定性,提高重建记录的准确度。

关键词：热带气旋小冰期潟湖沉积古风暴南沙群岛南海

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：