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江西相山火山岩型铀矿床构造‒流体动力学数值模拟研究

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大地构造与成矿学 2024年第2期48卷 338-351页

作者：黄沁怡李增华许德如郭福生邓腾吴志春周万蓬韦晓艳郭世超张衡中国科学院广州地球化学研究所矿物学与成矿学重点实验室广东广州510640 中国科学院大学北京100049 东华理工大学核资源与环境国家重点实验室江西南昌330013 东华理工大学地球科学学院江西南昌330013

相山铀矿床是中国最大的火山岩型铀矿床,矿体的空间分布主要受断裂构造控制,但构造对流体运移的具体影响,以及对成矿的控制机制尚未明确。本文基于FLAC3D软件,运用数值模拟方法对相山地区的构造‒流体‒成矿系统进行研究。首先通过总结分... 详细信息

相山铀矿床是中国最大的火山岩型铀矿床,矿体的空间分布主要受断裂构造控制,但构造对流体运移的具体影响,以及对成矿的控制机制尚未明确。本文基于FLAC3D软件,运用数值模拟方法对相山地区的构造‒流体‒成矿系统进行研究。首先通过总结分析前人研究资料得到模拟所需的地质模型,然后设置模型中的物性参数、边界条件和初始条件,并在此基础上进行相山铀矿床成矿过程数值模拟中应力场和流体场的耦合模拟计算,最后得到了不同构造背景下的体积应变率、流体流速和流动模式等。模拟结果显示,坡度的存在为浅部流体下渗提供了一定的驱动力,在挤压构造环境下,流体趋向于通过断层向上流入红层,体积应变率最大的区域位于红层中;在拉张构造环境下,流体趋向于通过断层向下流入基底,体积应变率最大的区域位于火山岩层中的断层内。因此,构造拉张作用有利于浅部氧化性流体的下渗,并且构造拉张环境下的断层活化能够形成有利于成矿的空间。

关键词：数值模拟构造作用流体运移机制

冠状动脉支架植入术后Stanford A型主动脉夹层的外科治疗

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中国胸心血管外科临床杂志 2024年第1期31卷 111-115页

作者：郭世超乔志钰里程楠孙立忠朱俊明北京市心肺血管疾病研究所、首都医科大学附属北京安贞医院、北京市主动脉疾病诊疗中心北京100029

目的分析冠状动脉支架植入术后Stanford A型主动脉夹层患者的外科治疗方式,探讨其手术技术及手术时机。方法回顾性分析2016年4月—2019年7月首都医科大学附属北京安贞医院连续收治的1246例Stanford A型主动脉夹层患者的临床资料。纳入... 详细信息

目的分析冠状动脉支架植入术后Stanford A型主动脉夹层患者的外科治疗方式,探讨其手术技术及手术时机。方法回顾性分析2016年4月—2019年7月首都医科大学附属北京安贞医院连续收治的1246例Stanford A型主动脉夹层患者的临床资料。纳入冠状动脉支架植入术后Stanford A型主动脉夹层患者。结果最终纳入患者19例,其中男16例、女3例,年龄35~66(54±7)岁。19例患者中急性主动脉夹层11例。AC型(DeBakeyⅠ型)主动脉夹层15例,AS型(DeBakeyⅡ型)4例。AC型患者中行孙氏手术(全弓置换+支架象鼻手术)10例,部分弓置换5例;19例患者中同期行冠状动脉旁路移植术7例,二尖瓣置换术1例;4例患者术中取出位于右冠开口的支架。本组住院死亡1例,主因术前合并脏器灌注不良,术后死于多脏器功能衰竭。18例患者经治疗后痊愈出院,平均随访30(18~56)个月,其中1例因冠状动脉吻合口漏行二次漏修补术,1例因远端夹层新发破口行胸主动脉腔内修复,1例因左主干支架闭塞急诊行经皮冠状动脉介入治疗,1例因髂动脉闭塞行股股转流。结论冠状动脉支架植入术后Stanford A型主动脉夹层的患者中,医源性主动脉夹层同期行冠状动脉旁路移植的比例高,对于广泛受累的Stanford A型主动脉夹层应当积极手术治疗。

关键词：主动脉夹层误诊医源性经皮冠状动脉介入治疗孙氏手术

Deregulated expression and subcellular localization of CPSF6,a circRNA-binding protein,promote malignant development of esophageal squamous cell carcinoma

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Chinese Journal of Cancer Research 2022年第1期34卷 11-27页

作者： shichao guo Guangchao Wang Zitong Zhao Dan Li Yongmei Song Qimin Zhan State Key Laboratory of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Laboratory of Molecular OncologyPeking University Cancer Hospital&InstituteBeijing 100142China

Objective:Cleavage and polyadenylation specific factor 6(CPSF6)has been documented as an oncoprotein in different types of ***,functions of CPSF6 have not been investigated yet in esophageal squamous cell carcinoma(ESCC).Here,we aimed to investigate the potential clinical values and biological functions of CPSF6 in ***:For determining the expression level of CPSF6 in ESCC patients,we analyzed published data,performed quantitative real-time polymerase chain reaction(RT-qPCR)and immunohistochemistry ***-Meier curves and log-rank tests were used for survival *** and KEGG analyses were done for CPSF6-related *** proliferation,colony formation and xenograft assays were conducted to verify the effects of CPSF6 on *** addition,cell cycle and apoptosis assays were also performed to manifest the functions of CPSF6 and *** pulldown and radioimmunoprecipitation(RIP)assays were used for confirming the interaction between circCPSF6(hsa_circ_0000417)and CPSF6 *** regulatory relationship between CPSF6 protein and circCPSF6 was determined by ***:We found that CPSF6 was upregulated in ESCC tissues and overexpression of cytoplasmic CPSF6 was associated with poor *** and KEGG analyses suggested that CPSF6 could mainly affect cell division in *** experiments manifested that CPSF6 promoted cell proliferation and colony formation in *** assay showed that knockdown of CPSF6 significantly decreased tumor growth rate in ***,we verified that depletion of CPSF6 led to cell cycle arrest and ***,we validated that CPSF6,as a circRNA-binding protein,interacted with and regulated its circular isoform circCPSF6(hsa_circ_0000417),of which depletion also resulted in cell cycle arrest and cell apoptosis in ***:These findings gave us insight that overexpression of cytoplasmic CPSF6 protein is associated with poor prognosis in ESCC and CPSF6 may function a

关键词： CPSF6 esophageal squamous cell carcinoma prognosis cell proliferation circRNA-binding protein circCPSF6

FISH及RNA测序在高级别子宫内膜间质肉瘤中的诊断价值探索

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中国妇产科临床杂志 2024年第4期25卷 322-326页

作者：康南刘丽丽郭世超张银丽张晓波孔方舟沈丹华王建六北京大学人民医院病理科北京100044 中国医学科学院北京协和医学院国家癌症中心/国家肿瘤临床医学研究中心/肿瘤医院分子肿瘤学国家重点实验室北京100021 北京大学人民医院妇产科北京100044

目的探讨高级别子宫内膜间质肉瘤(HG-ESS)分子异常的致癌机制。方法回顾性分析21例HG-ESS患者的临床病理资料,使用YWHAE单融合易位探针对肿瘤组织样本进行荧光原位杂交(FISH)。对于肿瘤组织可及的5例样本进行RNA测序以验证融合状态,对... 详细信息

目的探讨高级别子宫内膜间质肉瘤(HG-ESS)分子异常的致癌机制。方法回顾性分析21例HG-ESS患者的临床病理资料,使用YWHAE单融合易位探针对肿瘤组织样本进行荧光原位杂交(FISH)。对于肿瘤组织可及的5例样本进行RNA测序以验证融合状态,对其中检出YWHAE-NUTM2B融合的样本进行免疫组织化学(IHC)和免疫荧光(IF)检测以验证是否为功能性融合,并基于Kaplan-Meier法和log-rank检验对YWHAE融合阳性与阴性亚组进行生存分析。结果21例HG-ESS患者平均确诊年龄(46.1±12.6)岁,均出现阴道异常流血症状。FISH检测结果为阴性11例,阳性7例,不典型3例。组织可及的5例样本RNA测序结果提示在1例FISH阳性和1例FISH不典型患者中检出YWHAE-NUTM2B融合,3例FISH阴性样本未检出融合。经IHC和IF检测确认2例RNA测序阳性患者中该融合基因产物(14-3-3ε)核表达。Kaplan-Meier生存曲线提示YWHAE融合阳性组生存略优于阴性组,但两组差异无统计学意义(P>0.05)。结论FISH和RNA测序是辅助诊断HG-ESS的有效技术,对于YWHAE融合检测FISH结果为阴性或不典型的HG-ESS患者,应进行RNA测序进一步确认YWHAE融合或其他特异性结构变异。

关键词：高级别子宫内膜间质肉瘤 YWHAE-NUTM2B融合荧光原位杂交 RNA测序

Analysis and optimization of stamping and forming process of bearing outer ring

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Theoretical & Applied Mechanics Letters 2024年第3期14卷 227-237页

作者： shichao Zhu Yulu Ding Bing Long Hun guo Linhan Ouyang Wengang Chen Zhengyi Jiang College of Aeronautics and Mechanical Engineering Changzhou Institute of TechnologyChangzhou 213002China College of Economics and Management Nanjing University of Aeronautics and AstronauticsNanjing 211106China eering University of WollongongWollongong NSW 2522Australia

To address the common issues of wrinkling,tearing,and uneven wall thickness in the actual sheet metal stamp-ing process of the outer ring of needle roller bearings,this study analyzes critical technical indicators such asforming limits,thickness distribution,and principal strains in the forming process in ***-dimensionalmodels of the concave and convex dies were *** effects of different process parameters,includingstamping speed,edge pressure,sheet metal thickness,and friction coefficient,on the quality of the forming partswere investigated by varying these ***,the orthogonal experimental method was used todetermine an optimal experimental group from multiple sets of *** was found that under the processparameters of a stamping speed of 3000 mm/s,edge pressure of 2000 N,sheet metal thickness of 0.9 mm,andfriction coefficient of 0.125,the forming quality of the outer ring of the bearing is ideal.

关键词： Plate stamping Bearing outer ring Mold design Optimization

Melatonin improves the first cleavage of parthenogenetic embryos from vitrified-warmed mouse oocytes potentially by promoting cell cycle progression

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Journal of Animal Science and Biotechnology 2022年第1期13卷 106-122页

作者： Bo Pan Izhar Hyder Qazi shichao guo Jingyu Yang Jianpeng Qin Tianyi Lv Shengqin Zang Yan Zhang Changjun Zeng Qingyong Meng Hongbing Han Guangbin Zhou Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province College of Animal Science and TechnologySichuan Agricultural UniversityChengdu 611130China Department of Veterinary Anatomy and Histology Shaheed Benazir Bhutto University of Veterinary and Animal SciencesSakrandSindh 67210Pakistan State Key Laboratory of AgroBiotechnology China Agricultural UniversityBeijing 100193China National Engineering Laboratory for Animal Breeding Key Laboratory of Animal Genetics and Breeding of the Ministry of AgricultureBeijing Key Laboratory for Animal Genetic ImprovementCollege of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China

Background:This study investigated the effect of melatonin(MT)on cell cycle(G1/S/G2/M)of parthenogenetic zygotes developed from vitrified-warmed mouse metaphase II(MII)oocytes and elucidated the potential mechanism of MT action in the first cleavage of ***:After vitrification and warming,oocytes were parthenogenetically activated(PA)and in vitro cultured(IVC).Then the spindle morphology and chromosome segregation in oocytes,the maternal mRNA levels of genes including Miss,Doc1r,Setd2 and Ythdf2 in activated oocytes,pronuclear formation,the S phase duration in zygotes,mitochondrial function at G1 phase,reactive oxygen species(ROS)level at S phase,DNA damage at G2 phase,early apoptosis in 2-cell embryos,cleavage and blastocyst formation rates were *** results indicated that the vitrification/warming procedures led to following perturbations 1)spindle abnormalities and chromosome misalignment,alteration of maternal mRNAs and delay in pronucleus formation,2)decreased mitochondrial membrane potential(MMP)and lower adenosine triphosphate(ATP)levels,increased ROS production and DNA damage,G1/S and S/G2 phase transition delay,and delayed first cleavage,and 3)increased early apoptosis and lower levels of cleavage and blastocyst *** results further revealed that such negative impacts of oocyte cryopreservation could be alleviated by supplementation of warming,recovery,PA and IVC media with 10^(−9) mol/L MT before the embryos moved into the 2-cell stage of ***:MT might promote cell cycle progression via regulation of MMP,ATP,ROS and maternal mRNA levels,potentially increasing the first cleavage of parthenogenetic zygotes developed from vitrified-warmed mouse oocytes and their subsequent development.

关键词： Cell cycle Cleavage rate Melatonin MetaphaseⅡoocyte Parthenogenetic activation Vitrification

Geochronology and zircon geochemistry of auriferous intrusions in the Bumo deposit,Hainan Province,China

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Acta Geochimica 2022年第2期41卷 208-225页

作者： Yan Hai Bingtao Li Teng Deng Deru Xu Li Wang Youzhong Xiong Xiaowen Zhang Zhiling Wang Shaohao Zou Zhengpeng Ding Qian Qian shichao guo School of Earth Sciences East China University of TechnologyNanchang 330013China State Key Laboratory of Nuclear Resources and Environment East China University of TechnologyNanchang 330013China Zhaojin Group Co. LtdDongfang 572600HainanChina Jiangxi Engineering Laboratory on Radioactive Geoscience and Big Data Technology East China University of TechnologyNanchang 330013JiangxiChina Resource and Environment Survey Institute of Hainan Province Haikou 570206China School of Geosciences and Info-Physics Central South UniversityChangsha 410083China

Intrusion-related gold deposits(IRGS)are a lowgrade,large-tonnage exploration ***,auriferous magmatic rocks were found in the Bumo deposit of the Gezhen shear zone in Hainan Province,***,the geochronology and geochemical characteristics of the intrusions,as well as the mineralization potential,are still *** and petrographic work show that the sulfidebearing intrusions can be divided into diorite porphyrites,quartz monzodiorites and *** LA–ICP–MS U–Pb dating demonstrates that diorite porphyrites,quartz monzodiorites and monzodiorites were formed at104±1,114±1,114±1 Ma,*** addition,sulfides in Yanshanian intrusion-related gold mineralization haveδ;S values of 0.2–4.4%,lower than those in Hercynian-Indosinian(1.9–9.8%)orogenic deposits(ca.219–378 Ma)in the Gezhen shear *** addition,all these intrusions display close correlations between Eu/EuN*with Th/U,consistent with the differentiation of amphibole,apatite and titanite from a hydrous ***,zircon Eu/EuN*in the intrusions are higher than0.4,demonstrating that the magmatic rocks have high water contents and oxygen fugacity values,favorable for gold ***,the Yanshanian magmatic rocks can be a new potential gold exploration target in the Gezhen shear zone.

关键词： Hainan Bumo Intrusion-related mineralization Zircon trace elements Gold mineralization

Solar-powered miniature robot for on-site oil spill treatment under magnetic steering

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Science China(Technological Sciences) 2024年第7期67卷 2164-2175页

作者： WANG Ben CHEN YunRui WANG Yun JI FengTong LI HongYuan NIU shichao HAN ZhiWu ZHANG YaBin guo ZhiGuang College of Chemistry and Environmental Engineering Shenzhen UniversityShenzhen 518060China State Key Laboratory of Featured Metal Materials and Life-cycle Safety for Composite Structures Ministry of Education Key Laboratory of New Processing Technology for Nonferrous Metals and Materialsand School of ResourcesEnvironment and MaterialsGuangxi UniversityNanning 530004China Key Laboratory for Bionic Engineering Ministry of Education Jilin UniversityChangchun 130022China Hubei Collaborative Innovation Centre for Advanced Organic Chemical Materials Ministry of Education Key Laboratory for the Green Preparation and Application of Functional MaterialsHubei UniversityWuhan 430062China Wellcome Trust/Cancer Research UK Gurdon Institute University of CambridgeCambridge CB21QNUK Department of Physiology Development and NeuroscienceUniversity of CambridgeCambridge CB21QNUK State Key Laboratory for Turbulence and Complex Systems Department of Mechanics and Engineering ScienceBeijing Innovation Center for Engineering Science and Advanced TechnologyCollege of EngineeringPeking UniversityBeijing 100871China

Walking on the water surface is an effective method for miniature robots to transport payloads with dramatically decreased interfacial drag. Current aquatic robots reported are generally actuated by a beam of focused light that can trigger asymmetrical deformation, enabling the directional movement through horizontal momentum transfer of photoinduced actuation force to the water. However, the operations are heavily dependent on manual manipulation of the focused light, making the long-term actuation and application of the aquatic robots in vast scenarios challenging. Herein, we developed a kind of water striderinspired robot that can autonomously manage the motion on the water surface under solar irradiation, with their direction steerable by a magnetic field. The motion of this bioinspired robot on the water surface was achieved by the use of a solar cell panel as a driving module to enable propulsive motion based on the conversion of light-electric-mechanical energies. The superhydrophobic design of its leg surfaces enables the aquatic robots with weight-bearing and drag-reducing abilities. With the assistance of magnetic navigation, the bioinspired robot can continuously and controllably locomote to the oily spill floating on the water body and collect them with high efficiency. For further demonstration, the treatment of oil spills in a campus pool with high efficiency has also been achieved. This on-site oil-spill treating strategy, taking advantage of a home-made bioinspired robot actuated by natural sunlight under magnetic steering, shows great potential applications in water-body remediation.

关键词： miniature robot superhydrophobic water strider interfacial friction magnetic actuation

How Emotion Nurtures Mentality:The Influencing Mechanism of Social-Emotional Competency on the Mental Health of University Students

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International Journal of Mental Health Promotion 2024年第4期26卷 303-315页

作者： Yulei Chen Zhaojun Chen shichao Wang Yang Hang Jianpeng guo Institute of Education Xiamen UniversityXiamen361005China Shandong Social Science Education Base Yantai Nanshan UniversityLongkou265706China

Social-Emotional Competency(SEC),regarded as a critical psychological resource for individuals to adapt to social environments,is an effective protective factor for students’mental health,impacting their future success and *** the impact of SEC on university students’mental health can offer valuable insights for nurturing talents with healthy psychological and physical *** on data from two large-scale surveys of Chinese university students,this study designed two comprehensive Multiple Mediation Models involving SEC,stress,coping strategies,and stress reaction to explore the pathway of emotion nurturing *** 1 utilized a parallel mediation model to examine the relationships between SEC,academic stress,interpersonal stress,and stress *** results indicated that SEC negatively predicted academic stress,interpersonal stress,and stress ***,academic and interpersonal stress mediated the relationships between SEC and stress reactions in *** these findings,Study 2 further investigated the role of coping *** constructing a multiple-chain mediation model,it examined the predictive relationships among SEC,academic stress,interpersonal stress,three types of coping strategies,and stress *** findings indicated that SEC negatively predicted stress,problemavoiding strategy,and stress reactions,while positively predicting problem-solving and assistant-seeking ***,the two stress types and three coping strategies significantly mediated the relationship between SEC and stress *** indicated that higher SEC was associated with reduced stress and more adaptive coping strategies and subsequently contributed to more favorable stress *** research explored the impact of university students’SEC on mental health and its relational mechanisms,aiming to provide theoretical reference and practical insights for future efforts in cultivating SEC among uni

关键词： Social-Emotional Competency academic stress interpersonal stress stress reaction coping strategies Multiple Mediation Model