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Regenerative Biomaterials 2022年第1期9卷 314-324页

作者： Xiuli Ren Yanan Hu Linna Chang shibo xu Xifan Mei Zhenhua Chen Jinzhou Medical University Jinzhou 121001China

Bacterial infection and excessive inflammation are still the main obstacles to wound ***,antibacterial and antiinflammation nanomaterials are always attracting for infected wound *** this work,ultra-uniform(-20 nm)and colloidally stable Ag nanoparticles(Ag-Hes NPs)with core-shell structure were prepared by using hesperidin as reducing and capping *** obtained Ag-Hes NPs present effective antibacterial properties on both Staphylococcus aureus and Escherichia ***-Hes NPs also got high 1,1-diphenyl-1-picrylhydrazyl scavenging capability of 69%.Under the package of polyvinyl alcohol and sodium alginate,Ag-Hes NPs were encapsulated into electro spun nanofibers to form hydrogel(Ag-Hes@H).This strategy provides a moisture environment which could enrich and release Ag-Hes NPs *** experiments and animal wound healing investigation proved that Ag-Hes@H could promote the proliferation and migration of human umbilical vein endothelial cells and accelerate infected wound ***,Ag-Hes@H significantly reduced the expression of inflammatory cytokines,including IL-6,MMP9 and TNF-α.Immunohistochemistry data further suggested that Ag-Hes@H accelerated wound closure by promoting collagen deposition and skin cell *** designed antibacterial and anti-inflammatory Ag-Hes@H has great potential for promoting infected wound healing.

关键词： antibacterial hydrogel Ag nanospheres wound healing anti-inflammation

Preparation of EGCG decorated,injectable extracellular vesicles for cartilage repair in rat arthritis

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Regenerative Biomaterials 2021年第6期8卷 209-217页

作者： Changwei Song shibo xu Linna Chang Xingjun Zhao Xifan Mei Xiuli Ren Zhenhua Chen First Affiliated Hospital of Jinzhou Medical University Jinzhou 121001China Jinzhou Medical University JinzhouLiaoning 121001China

Arthritis is a kind of chronic inflammatory autoimmune disease,which can destroy joint cartilage and bone,leading to joint pain,joint swelling,and limited *** therapies have many side effects or focus too much on anti-inflammation while neglecting joint *** this experiment,we combined Epigallocatechin gallate(EGCG)with extracellular vesicles derived from macrophages to treat rheumatoid ***-release resulted in a significant decrease in chondrocyte expression of hypoxia-inducible factor 1-alpha,a decrease in apoptosis-related proteins Cytochrome C,Caspase-3,Caspase-9,and *** biological analysis showed that extracellular vesicles-encapsulated EGCG(EVs-EGCG)more significantly upregulated type II collagen expression by about 1.8-fold than EGCG alone,which was more beneficial for arthritis *** experiments revealed that these EGCG-coated extracellular vesicles significantly reduced swelling,decreased synovial hyperplasia,repaired cartilage,and attenuated arthritis-related pathology scores in arthritic *** data showed that EVs-EGCG treatment reduced joint swelling by approximately 39.5%in rheumatoid *** vitro studies have shown that this EVs-EGCG can increase the expression of cartilage type II collagen and reduce apoptosis of ***,it was demonstrated in vivo experiments to reduce cartilage destruction in rheumatoid arthritis rats,providing a solution for the treatment of rheumatoid arthritis.

关键词： cartilage repair arthritis tea polyphenol extracellular vesicles

Integrated spatial-temporal random speckle spectrometer with high resolution in the C-band

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Photonics Research 2024年第7期12卷 1556-1563页

作者： shibo xu JIAHUI ZHANG JUNWEI CHENG JIANJI DONG Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan 430074China Optics Valley Laboratory Wuhan 430074China

The increasing demand for diverse portable high-precision spectral analysis applications has driven the rapid development of spectrometer miniaturization. However, the resolutions of existing miniaturized spectrometers mostly remain at the nanometer level, posing a challenge for further enhancement towards achieving picometerlevel precision. Here, we propose an integrated reconstructive spectrometer that utilizes Mach–Zehnder interferometers and a tunable diffraction network. Through random tuning in the time domain and disordered diffraction in the space domain, the random speckle patterns closely related to wavelength information are obtained to construct the transmission matrix. Experimentally, we achieve a high resolution of 100 pm and precisely reconstruct multiple narrowband and broadband spectra. Moreover, the proposed spectrometer features a simple structure, strong portability, and fast sampling speed, which has great potential in the practical application of high-precision portable spectral analysis.

关键词： speckle random resolution

Acoustic numerical simulation for VTI media

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Global Geology 2013年第4期16卷 226-232页

作者： xu shibo WANG Deli College of Geo-Exploration Science and Technology Jilin University

The generality to anisotropy of the earth media can be proved by a lot of research and observation, which is shown by the elastic parameters of the seismic wave changes with the direction of propagation. Actually, computational efficiency is very low, when simulating on the elastic anisotropie media, for the complicated and multi-parameters computation, which becomes a disadvantage to the succeeding migration and imaging pro-cedure. Using acoustic approximation in the VT[ media is an advisable simplification for the elastic wave simu-lation in that setting S-velocity into zero can greatly reduce the computational amount as well as get the same simulation effect. The authors get an acoustic approximation formula, then gain an anisotropic wave equation with 2-order in time and 4-order in space by inverse Fourier transformation, and dispel with the dispersion by adopting the high order finite difference operator in space and remove the edge reflection using the absorption attenuation boundary. Finally, the feasibility and effectiveness of this algorithm can be proved by the snaps and synthetic records.

关键词： VTI media acoustic approximation anisotropy simulation attenuation boundary

AlCl3-mediated synthesis of spirocyclic oxindole by using allenoate as C4 building blocks

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AlCl3-mediated synthesis of spirocyclic oxindole by using al...

中国化学会全国第十一届有机合成化学学术研讨会

作者： shibo xu Jian Li xueshun Jia 上海大学理学院化学系

Spirocyclic oxindole is a privileged synthetic motif that constitutes a large family of natural products and clinical pharmaceuticals. These compounds have been shown to exhibit a broad range of biological activities,including insecticidal,antitumor,anthelmintic,and antibacterial properties. Owing to their increased structural complexity and significant biological activities,the past decades have witnessed a rapid progress in the efficient and selecitve construction of these spirocyclic oxindole *** spite of these considerable advances,new strategies to effciently construct these core structures in chemo-,regio- and stereocontrolled manners are still of high *** the past several years,we have spent much time working on the syntheses of functionahzed carbocycles and heterocycles. As a continuation,herein we wish to report AlCl-mediated synthesis of spirocyclic oxindole by using allenoate as building blocks(Scheme 1).

关键词：联烯酸酯氧化吲哚螺环环加成

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清代贡院号舍添建活动考论

近代史研究 2021年第6期 61-74,F0003页

作者：徐世博暨南大学历史系

清末科举之改制停罢,与科举制度的内部危机关联密切。道光以来,各省乡试人数不断攀升,清廷不但无力限制,更放任地方大肆添建贡院号舍,对科举考试的严肃性乃至士习文风造成消极影响。这类工程多因增广学额、举额而起,实则与清廷管控乡试... 详细信息

清末科举之改制停罢,与科举制度的内部危机关联密切。道光以来,各省乡试人数不断攀升,清廷不但无力限制,更放任地方大肆添建贡院号舍,对科举考试的严肃性乃至士习文风造成消极影响。这类工程多因增广学额、举额而起,实则与清廷管控乡试规模的态度和能力有关,而清末添建贡院号舍的新高潮与乡试规模失控亦是乾隆科举改革"崇尚实学"的指导思想及其政策遭到废置的表现。至此,科举既无裨于实学,不得不让位于学校。

关键词：清代科举制度贡院乡试

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清末科舉停罷前的上海“書局”考論

文史 2019年第2期 223-232,I0001,233-256页

作者：徐世博暨南大學歷史系

"書局"這一近代形成的概念,在同治初年各省創建地方官立書局的潮流之下開始得到廣泛使用。十九世紀七八十年代以來,隨着鉛印、石印、雕刻銅版等新式印刷技術的商業化應用,"書局"開始進入民間,被普遍用作民營書業機構的牌號,甚至成爲了"... 详细信息

"書局"這一近代形成的概念,在同治初年各省創建地方官立書局的潮流之下開始得到廣泛使用。十九世紀七八十年代以來,隨着鉛印、石印、雕刻銅版等新式印刷技術的商業化應用,"書局"開始進入民間,被普遍用作民營書業機構的牌號,甚至成爲了"利用西法進行書籍生産"的一類新式書業機構的統稱。本文首先對清末科舉停罷前的"書局"意涵及其衍變進行考訂,繼而將書局的産生、石印書局的"黄金時代"作爲清末上海書業興起過程中的重要歷史現象進行解讀。本文認爲,必須從制度性動力、市場特點、生産組織模式、産銷關係等多方面入手,才能從根本上理解清末上海"書局"乃至書業的相關問題。

关键词：書局書坊科舉石印黄金時代

Integrated Enhanced Feature Fusion Module For Photovoltaic Defect Detection Network

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Integrated Enhanced Feature Fusion Module For Photovoltaic D...

第43届中国控制会议

作者： Ying Zhou shibo xu Haiyong Chen Kun Liu School of Artificial Intelligence Hebei University of Technology Hebei Control Engineering Research Center

To address the challenges of high similarity between surface defect features and background features, as well as the variability in geometric shapes in solar cell surface defects, a solar cell surface defect detection network model called EMFAnet is proposed, which combines multi-scale features and attention mechanisms. Firstly, a Three-path Coordinate Attention(TCA) is designed to enhance the detection capability in the interested regions;secondly, to improve the accuracy and precision of defect localization and description, TCA is fused with deformable convolutions to form a Multi-Path Coordinate-Deformable Conv Module(MCD);lastly, to adapt to complex backgrounds and effectively detect defects at various scales, an enhanced multi-scale feature fusion method is designed. Experimental results demonstrate that the proposed approach achieves significantly higher accuracy in identifying solar cell EL defects compared to existing state-of-the-art detection algorithms.

关键词： feature fusion Three-path coordinate attention receptive field deformable convolution

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基于政策工具视角下众创空间发展政策研究

中国科技论坛 2019年第6期 29-39页

作者：徐示波科学技术部火炬高技术产业开发中心

本文对2015年以来的159项众创空间政策文本进行量化研究,将众创空间政策划分为自由放任型、部分参与型、策略引导型、政府主导型4种政策类型和17种具体政策工具,并分析政策工具的时间和区域特点,逐步剖析众创空间政策的规律,结果发现:... 详细信息

本文对2015年以来的159项众创空间政策文本进行量化研究,将众创空间政策划分为自由放任型、部分参与型、策略引导型、政府主导型4种政策类型和17种具体政策工具,并分析政策工具的时间和区域特点,逐步剖析众创空间政策的规律,结果发现:众创空间政策呈现一定时间和区域分布规律,政策工具覆盖面较广,但缺乏系统性,政府介入力度较强的政策工具偏多,部分有效的政策工具使用不足。最后提出在打造“双创”升级版中,众创空间政策工具的使用建议。

关键词：众创空间量化研究政策工具 “双创”升级版

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西藏山南藏语方言的清鼻音和清边音

民族语文 2023年第5期 10-18页

作者：许仕波上海师范大学人文学院上海200234

西藏山南部分藏语方言中存在书面藏语r N-声类词今读清鼻音、rl-声类词今读清边音的现象。本文结合藏语方言、文献材料以及音变的一般规律对清鼻音和清边音的来源以及演变进行探讨,认为该类清鼻音和清边音分别来源于早期的语音形式^(*)... 详细信息

西藏山南部分藏语方言中存在书面藏语r N-声类词今读清鼻音、rl-声类词今读清边音的现象。本文结合藏语方言、文献材料以及音变的一般规律对清鼻音和清边音的来源以及演变进行探讨,认为该类清鼻音和清边音分别来源于早期的语音形式^(*)SN-和^(*)rl-,在演变上除浊化外,还存在向清喉擦音(N->h-、l->h-)发展的趋势。

关键词：藏语方言清鼻音清边音历史来源语音演变