检索结果-南通市图书馆

Effect of droplet characteristics on liquid-phase distribution in spray zone of internal mixing air-mist nozzle

在线全文

学校读者我要写书评

暂无评论

China Foundry 2024年第2期21卷 185-196页

作者： Wei-li Wu Chang-gui Cheng Yang li shi-fa Wei De-li Chen The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081China Hubei Provincial Key Laboratory for New Processes of Ironmaking and Steelmaking Wuhan University of Science and TechnologyWuhan 430081China Technology Center Fushun Special Steel Co.Ltd.Fushun 113001LiaoningChina

In continuous casting production,droplet characteristics are important parameters for evaluating the nozzle atomization quality,and have a significant impact on the secondary cooling effect and the slab *** order to study the behavior of atomized droplets after reaching the slab surface and to optimize the spray cooling effect,the influence of droplet diameter and droplet velocity on the migration behavior of droplets in the secondary cooling zone was analyzed by FLUENT *** show that the droplets in the spray zone and on the slab surface are mainly concentrated in the center,thus,the liquid volume fraction in the center is higher than that of either *** the droplet diameter increases,the region of high liquid volume fraction on the slab surface becomes wider,and the liquid phase distribution in the slab width direction becomes *** increasing the droplet velocity at the nozzle exit has little effect on droplet diffusion in the spray zone,the distribution becomes more uneven due to more liquid reaches the slab surface per unit time.A prediction formula of the maximum water flow rate on the slab surface for specific droplet characteristics was proposed based on dimensionless analysis and validated by simulated data.A nozzle spacing of 210 mm was recommended under the working conditions in this study,which ensures effective coverage of the spray water over the slab surface and enhances the distribution uniformity of water flow rate in the transverse direction.

关键词： continuous casting secondary cooling zone internal mixing air-mist nozzle droplet characteristics liquid phase distribution water flow rate

Influence of rare earth oxides on microstructure and mechanical properties of nickel-based superalloys fabricated by high energy beam processing:A review

在线全文

学校读者我要写书评

暂无评论

Journal of Rare Earths 2024年第9期42卷 1629-1645,I0001页

作者： lianjie Bi Hua Yan Peilei Zhang Haichuan shi Zhiyuan li Ruidi li School of Materials Science and Engineering Shanghai University of Engineering ScienceShanghai201620China College of Agricultural Science and Engineering Hohai UniversityNanjing211100China Department of Mechanics and Maritime Science Chalmers University of TechnologyGothenburSE41296Sweden State Key Laboratory of Powder Metallurgy Central South UniversityChangsha410083China

In this paper,the effects of rare earth oxides on the micro structure and mechanical properties of nickelbased superalloys prepared by high-energy beam processing technology were critically *** focus is on the optimal amount of rare earth oxides that can produce ideal *** attention was paid to their main strengthening mechanisms,including solid solution strengthening mainly in the form of solid solution dissolved in the nickel-based alloy and improving the microstructure of the alloy by grain refinement or fine grain strengthening produced by homogenizing the distribution phase.Y_(2)O_(3),La_(2)O_(3) and CeO_(2) rare earth oxides can also improve the fluidity of the alloy molten pool and reduce the segregation of alloying *** advantages can significantly improve the mechanical properties of the ***,this paper outlines the future research directions of rare earth oxides,aiming to expand their application potential.

关键词： Rare earths High energy beam Nickel-based superalloys Microstructure Mechanical properties

Potassium dehydroandrographolide succinate regulates the MyD88/CDH13 signaling pathway to enhance vascular injuryinduced pathological vascular remodeling

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Natural Medicines 2024年第1期22卷 62-74页

作者： GUO Qiru li Jiali WANG Zheng WU Xiao JIN Zhong ZHU Song li Hongfei ZHANG Delai HU Wangming XU Huan YANG Lan shi liangqin WANG yong College of Basic Medicine Chengdu University of Traditional Chinese MedicineChengdu 610000China Chengdu University of Traditional Chinese Medicine Hospital of Chengdu University of Traditional Chinese MedicineChengdu 610000China

Pathological vascular remodeling is a hallmark of various vascular *** research has established the significance of andrographolide in maintaining gastric vascular homeostasis and its pivotal role in modulating endothelial barrier dysfunction,which leads to pathological vascular *** dehydroandrographolide succinate(PDA),a derivative of andrographolide,has been clinically utilized in the treatment of inflammatory diseases precipitated by viral *** study investigates the potential of PDA in regulating pathological vascular *** effect of PDA on vascular remodeling was assessed through the complete ligation of the carotid artery in C57BL/6 *** approaches,including rat aortic primary smooth muscle cell culture,flow cytometry,bromodeoxyuridine(BrdU)incorporation assay,Boyden chamber cell migration assay,spheroid sprouting assay,and Matrigel-based tube formation assay,were employed to evaluate the influence of PDA on the proliferation and motility of smooth muscle cells(SMCs).Molecular docking simulations and co-immunoprecipitation assays were conducted to examine protein *** results revealed that PDA exacerbates vascular injury-induced pathological remodeling,as evidenced by enhanced neointima *** treatment significantly increased the proliferation and migration of *** mechanistic studies disclosed that PDA upregulated myeloid differentiation factor 88(MyD88)expression in SMCs and interacted with T-cadherin(CDH13).This interaction augmented proliferation,migration,and extracellular matrix deposition,culminating in pathological vascular *** findings underscore the critical role of PDA in the regulation of pathological vascular remodeling,mediated through the MyD88/CDH13 signaling pathway.

关键词： Potassium dehydroandrographolide succinate Smooth muscle cell Myeloid differentiation factor 88 T-cadherin Pathological vascular remodeling

Development of a Mengla virus minigenome and comparison of its polymerase complexes with those of other filoviruses

在线全文

学校读者我要写书评

暂无评论

Virologica Sinica 2024年第3期39卷 459-468页

作者： shi-Zhe Xie Ke Yao Bei li Cheng Peng Xing-Lou Yang Zheng-li shi State Laboratory of Virology Wuhan Institute of VirologyChinese Academy of SciencesWuhan430071China University of Chinese Academy of Sciences Beijing100049China Yunnan Key Laboratory of Biodiversity Information Kunming Institute of ZoologyChinese Academy of SciencesKunming650201China Hubei Jiangxia Laboratory Wuhan430200China

Ebola virus(EBOV)and Marburg virus(MARV),members of the Filoviridae family,are highly pathogenic and can cause hemorrhagic fevers,significantly impacting human *** are considered reservoirs of these viruses because related filoviruses have been discovered in ***,due to the requirement for maximum containment laboratories when studying infectious viruses,the characterization of bat filoviruses often relies on pseudoviruses and minigenome *** this study,we used RACE technology to sequence the 30-leader and 50-trailer of Mengla virus(MLAV)and constructed a *** to MARV,the transcription activities of the MLAV minigenome are independent of *** further assessed the effects of polymorphisms at the 50 end on MLAV minigenome activity and identified certain mutations that decrease minigenome reporter efficiency,probably due to alterations in the RNA secondary *** reporter activity upon recombination of the 30-leaders and 50-trailers of MLAV,MARV,and EBOV with those of the homologous or heterologous minigenomes was compared and it was found that the polymerase complex and leader and trailer sequences exhibit intrinsic ***,we investigated whether the polymerase complex proteins from EBOV and MARV support MLAV minigenome RNA synthesis and found that the homologous system is more efficient than the heterologous *** efficiently inhibited MLAV as well as EBOV *** summary,this study provides new information on bat filoviruses and the minigenome will be a useful tool for high-throughput antiviral drug screening.

关键词： Bat filovirus Mengla virus(MLAV) Minigenome Replication Antiviral drug screening

Effects of Potassium-Solubilizing Bacteria on Growth, Antioxidant Activity and Expression of Related Genes in Fritillaria taipaiensis P. Y. li

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Phyton-International Journal of Experimental Botany 2024年第4期93卷 789-806页

作者： Jiaqi Lang Mingyan Ye Ya Luo Yueheng Wang Zhifen shi Xiaotian Kong Xuan li Nong Zhou Chongqing Engineering Laboratory of Green Planting and Deep Processing of Famous-Region Drug in the Three Gorges Reservoir Region College of Biology and Food EngineeringChongqing Three Gorges UniversityChongqing404120China College of Modern Chinese Medicine Industry Chengdu University of Traditional Chinese MedicineChengdu611130China College of Pharmacy Dali UniversityDali671000China

This study aimed to examine the effects of inoculating Fritillaria taipaiensis *** leaves with different strains ofpotassium-solubilizing bacteria (KSB), or combinations thereof, focusing on aspects of photosynthesis and physiologicaland biochemical characteristics. At present, some studies have only studied the rhizosphere microbialcommunity characteristics of F. taipaiensis and have not discussed the effects of different microbial species on thegrowth promotion of F. taipaiensis. This paper will start from the perspective of potassium-solubilizing bacteria toconduct an in-depth study. Seed cultivation commenced at the base with three different KSBs in early October2022. The growth of F. taipaiensis leaves was observed after different treatments. Both single-plant and compoundinoculations were executed. A total of eight treatment groups were established, with aseptic fertilizer and sterilizedsoil functioning as the control group. The results reveal that intercellular CO_(2) concentration (Ci), stomatal conductance(Gs), and transpiration rate (Tr) were at their apex in the S7 group. Most treatment groups exhibited anincrease in leaf area, photosynthetic pigment content, soluble sugar, soluble protein, Superoxide Dismutase(SOD), Peroxidase (POD), Catalase (CAT) activities, and proline content. The expression levels of POD, SOD,and CAT genes were evaluated, following inoculation with different KSB. The highest was the S7 group. Theinoculation with various KSB, or combinations thereof, appears to bolster the growth and development of F. *** composite inoculation group S7, comprising Bacillus cereus, Burkholderia cepacia, and Bacillus subtilis,manifested the most favorable impact on the diverse indices of F. taipaiensis, thereby furnishing valuableinsights for the selection of bacterial fertilizer in the artificial cultivation of F. taipaiensis.

关键词： Fritillaria taipaiensis bacteria antioxidant enzyme genes leaf physiology and biochemistry photosynthetic characteristics

Metarelation2vec:A Metapath-Free Scalable Representation Learning Model for Heterogeneous Networks

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Tsinghua Science and Technology 2024年第2期29卷 553-575页

作者： Lei Chen Yuan li yong Lei Xingye Deng School of Information and Electrical Engineering Hunan University of Science and TechnologyXiangtan 411201China School of Computer Science and Engineering Hunan University of Science and TechnologyXiangtan 411201China

Metapaths with specific complex semantics are critical to learning diverse semantic and structural information of heterogeneous networks(HNs)for most of the existing representation learning ***,any metapaths consisting of multiple,simple metarelations must be driven by domain *** sensitive,expensive,and limited metapaths severely reduce the flexibility and scalability of the existing models.A metapath-free,scalable representation learning model,called Metarelation2vec,is proposed for HNs with biased joint learning of all metarelations in a bid to address this ***,a metarelation-aware,biased walk strategy is first designed to obtain better training samples by using autogenerating cooperation probabilities for all metarelations rather than using expert-given ***,grouped nodes by the type,a common and shallow skip-gram model is used to separately learn structural proximity for each node ***,grouped links by the type,a novel and shallow model is used to separately learn the semantic proximity for each link ***,supervised by the cooperation probabilities of all meta-words,the biased training samples are thrown into the shallow models to jointly learn the structural and semantic information in the HNs,ensuring the accuracy and scalability of the *** experimental results on three tasks and four open datasets demonstrate the advantages of our proposed model.

关键词： metarelation random walk heterogeneous network metapath representation learning

Serum tumor markers expression(CA199,CA242,and CEA)and its clinical implications in type 2 diabetes mellitus

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Diabetes 2024年第2期15卷 232-239页

作者： Mei Meng li-li shi Department of Endocrinology Hefei BOE HospitalHefei 230013Anhui ProvinceChina Department of Cadre Ward The First Affiliated Hospital of Harbin Medical UniversityHarbin 150001Heilongjiang ProvinceChina

BACKGROUND Glucose and lipid metabolic disorder in patients with type 2 diabetes mellitus(T2DM)is associated with the levels of serum tumor markers of the digestive tract,such as cancer antigen(CA)***,tumor markers in T2DM are *** To evaluate the expression of serum tumor markers[CA199,CA242,and carcinoembryonic antigen(CEA)]and the clinical implications of the expression in *** For this observational study conducted at Hefei BOE Hospital,China,we enrolled 82 patients with first-onset T2DM and 51 controls between April 2019 and December *** of fasting blood glucose(FBG),tumor markers(CA199,CEA,and CA242),glycosylated hemoglobin(HbA1c),*** measured and group index levels were ***,FBG and HbA1c levels were correlated with tumor marker *** markers were tested for diagnostic accuracy in patients with>9%HbA1c using the receiver operating curve(ROC)*** The T2DM group had high serum FBG,HbA1c,CA199,and CEA levels(P9%)revealed significant differences in CEA and CA199 levels(P<0.05).The areas under the ROC curve for CEA and CA199 were 0.853 and 0.809,***199,CEA,and CA242 levels positively correlated with HbA1c(r=0.308,0.426,and 0.551,respectively)and FBG levels(r=0.236,0.231,and 0.298,respectively).CONCLUSION As compared to controls,serum CEA and CA199 levels were higher in patients with ***1c and FBG levels correlated with CA199,CEA,and CA242 *** with poorly controlled blood sugar must be screened for tumor markers.

关键词： Type 2 diabetes mellitus Carcinoembryonic antigen Cancer antigen 199 Cancer antigen 242 Glycosylated hemoglobin

A rare missense PAX6 mutation causes atypical aniridia in a three-generation Chinese family

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2024年第3期17卷 466-472页

作者： Zhi-Bo lin Chun-Yun Feng Jin li An-Peng Pan Hai-Sen Sun A-yong Yu shi-Hao Chen National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina Department of Ophthalmology the Quzhou Affiliated Hospital of Wenzhou Medical UniversityQuzhou People’s HospitalQuzhou 324000Zhejiang ProvinceChina

●AIM:To investigate the molecular diagnosis of a threegeneration Chinese family affected with aniridia,and further to identify clinically a PAX6 missense mutation in members with atypical aniridia.●METHODS:Eleven family members with and without atypical aniridia were *** family members underwent comprehensive ophthalmic examinations.A combination of whole exome sequencing(WES)and direct Sanger sequencing were performed to uncover the causative mutation.●RESULTS:Among the 11 family members,8 were clinically diagnosed with congenital aniridia(atypical aniridia phenotype).A rare heterozygous mutation c.622C>T(***208Trp)in exon 8 of PAX6 was identified in all affected family members but not in the unaffected members or in healthy control subjects.●CONCLUSION:A rare missense mutation in the PAX6 gene is found in members of a three-generation Chinese family with congenital atypical *** result contributes to an increase in the phenotypic spectrum caused by PAX6 missense heterozygous variants and provides useful information for the clinical diagnosis of atypical aniridia,which may also contribute to genetic counselling and family planning.

关键词： PAX6 gene atypical aniridia missense mutation mutation

Molecular analyses display the increasing diversity of Podostemaceae in China

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Plant Diversity 2024年第3期46卷 421-424页

作者： Zhi-Zhong li Zhun Xu Shuang Wu Lang-Xing Yuan Chun-Yu Zou Yan liu Jian-yong lin shi-Chu liang Key Laboratory of Ecology of Rare and Endangered Species and Environmental Protection(Guangxi Normal University) Ministry of EducationGuilin 541006China Wuhan Botanical Garden Chinese Academy of SciencesWuhan 430074China Sino-Africa Joint Research Center Chinese Academy of SciencesWuhan 430074China Guangxi Association for Science and Technology Nanning 530023China Tropical Crops Genetic Resources Institute Chinese Academy of Tropical Agricultural SciencesHaikou 571101China Guangxi Institute of Botany Chinese Academy of SciencesGuilin 541006China Guangxi Forestry Research Institute Nanning 530028China

Podostemaceae(riverweed family),one of the largest aquatic plant families in the world,comprises about 350 species in 51 genera placed in three subfamilies,Podostemoideae,Weddellinoideae,and Tristichoideae(Koi et al.,2022).Most Podostemaceae genera(~38)are monotypic or oligotypic,with a high level of endemism(Koi et al.,2018,2022).Members of Podostemaceae adhere to rocks in fast-flowing rivers,streams,or waterfalls in the subtropics and tropics(Koi et al.,2018).As an adaptation to fastrunning currents,the morphological structure of river-weeds tends to be extremely reduced,including a loss or reduction of primary shoots or roots(Koi and Kato,2007).The vegetative mass of these plants resembles lichens or bryophytes,and are thus known commonly as“dream bryophytes”(Philbrick and Retana,1998).Podostemaceae plants flower when the water level drops during the dry *** recent years,anthropogenic factors and climate change have severely affected river weed habitats,decreasing populations of these plants.

关键词： roots season habitat