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Acta Metallurgica Sinica(English Letters) 2022年第11期35卷 1882-1894页

作者： shi-yong li Ruo-Han Shen Yu-Tao He Cui-Lan Wu Jiang-Hua Chen Centre for High Resolution Electron Microscopy College of Materials Science and EngineeringHunan UniversityChangsha 410082China College of Materials Science and Engineering Hainan UniversityHaikou 570228China

Mechanical theories show that properties of alloys are strongly dependent on the morphological parameters oftheir strengthening ***,accurate measurement of precipitates microstructure parameters is still a challenging *** this article,we develop a quantitative electron tomography method by combining computer vision technology to accurately characterize the three-dimensional microstructure parameters,such as volume fractions,sizes and distributions,of the T_(1) and δ’/θ’/δ’ precipitates in Al-Cu-li(-Mg) *** they have extremely large aspect-ratios in shape and large numbers in density upon formation in the Al matrix,these thin plate-like precipitates are difficult to be characterized quantitatively without the assistance of computer vision *** is shown that the property difference between two peak-aged states of the alloy can be well explained with the quantitative precipitate parameters correctly *** these correct precipitate data,we also tested the validity of current mechanical models for projecting the contribution of precipitates to the strengths of the alloy,demonstrating that quantitative relations between strength and micro structure parameters still need to be refined.

关键词： Al–Cu–li–Mg alloy T1 precipitate δ′/θ′/δ′composite precipitate Morphological parameters Electron tomography Computer vision

全膝关节置换术后康复基础上有无针刺对改善膝关节功能的影响:一项系统评价和meta分析

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World Journal of Acupuncture-Moxibustion 2024年第2期34卷 95-102页

作者：褚文明曹原李世永吴琼高希言河南中医药大学郑州450008 河南中医药大学第三附属医院郑州450003

Objective:To assess the effect and safety of acupuncture on the base of rehabilitation for knee function after total knee ***:Relevant articles were collected from CNKI,Sinomed,Wanfang,VIP,Cochrane library,Medline and *** search was conducted by using a combination of subject terms and free *** data were analyzed by Revman 5.4 software,and the included studies were evaluated in compliance with the Cochrane Collaboration's tool for assessing risk of bias in randomized ***:A total of 10 studies of randomized controlled trial(RCT) were included,with 785 participants involved,of which,393 cases in experiment group and 392 cases in control *** interventions were electroacupuncture in 4 RCTs,filiform needling in 4 RCTs and transcutaneous electrical acupoint stimulation in 2 ***-analysis results showed that,compared with rehabilitation alone,acupuncture combined with rehabilitation improved the score of Hospital for Special Surgery(HSS)(MD=4.27,95%CI=[2.77,5.78],Z=5.58,Plinical *** sensitivity analysis showed the results were *** subgroup analysis,the stability of VAS score was relatively poorer in electroacupuncture group and filiform needle group,which may be associated with the differences in waveform of electroacupuncture and trial ***:Compared with rehabilitation alone,acupuncture in combination with rehabilitation could effectively improve the knee function for the patients after total knee arthroplasty.

关键词： Acupuncture Rehabilitation Total knee arthroplasty Systematic review Meta-analysis

Polyimide covalent organic frameworks as efficient solid-state li^(+) electrolytes

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Science China Chemistry 2024年第5期67卷 1647-1652页

作者： Xu liu shi Wang Siqi liu Chengfang liu Xiangchun li Jian Wu Dazhi li shihao Xu Chongyang liu Wen-yong Lai State Key Laboratory of Organic Electronics and Information Displays(SKLOEID) Institute of Advanced Materials(IAM)School of Chemistry and Life SciencesNanjing University of Posts&TelecommunicationsNanjing 210023China

Covalent organic frameworks(COFs) are attractive porous crystalline materials with extremely high stability, easy functionalization, and open channels, which are expected to be unique ion conductors/transporters in lithium ion batteries(liBs). Despite recent advances, low ion conductivity and low transference number, resulting in low charging/discharging rate, low energy density, and short battery life, are the main issues that limit their direct application as solid electrolytes in liBs. Here, we designed and synthesized a novel polyimide COF, namely, TAPA-PDI-COF, with abundant C=O groups, which has been successfully employed as high-performance solid electrolytes by doping TAPA-PDI-COF and succinonitrile(SN). Both the well-defined nanochannels of COFs and SN confined in the well-aligned channels restricted the free migration of anions, while C=O on COFs and CN groups of SN enhanced li^(+) transport, thus achieving a high ion conductivity of 0.102 m S cm^(-1)at 80 °C and a high lithium-ion transference number of 0.855 at room temperature. According to density functional theory(DFT)calculations, li-ion migration mainly adopted in-plane transport rather than the axial pathway, which may be due to the shorter hopping distances in the planar pathway. The results suggest an effective strategy for the design and development of all-solidstate ionic conductors for achieving high-performance liBs.

关键词： lithium ion batteries(liBs) covalent organic frameworks(COFs) solid-state ion conductors solid-state electrolytes ion conductivity

2012-2020年某院Ⅰ类切口手术围手术期预防用抗菌药物持续性综合规范管理实践及其效果

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中华医院感染学杂志 2024年第14期34卷 2149-2153页

作者：袁可欣孙薇翟秀伟刘净耿志伟石永丽张玉玺李杨大庆油田总医院感染管理科黑龙江大庆163001 大庆油田总医院院长办公室黑龙江大庆163001 大庆油田总医院医务部黑龙江大庆163001 大庆油田总医院药学部黑龙江大庆163001

目的评价2012-2020年某院Ⅰ类切口手术围手术期预防使用抗菌药物持续性综合规范管理实践及其效果.方法采取持续性综合规范管理措施,对Ⅰ类切口手术围手术期预防使用抗菌药物进行干预管理.对2011年1月1日-2020年12月31日大庆油田总医... 详细信息

目的评价2012-2020年某院Ⅰ类切口手术围手术期预防使用抗菌药物持续性综合规范管理实践及其效果.方法采取持续性综合规范管理措施,对Ⅰ类切口手术围手术期预防使用抗菌药物进行干预管理.对2011年1月1日-2020年12月31日大庆油田总医院Ⅰ类切口手术病例抗菌药物预防使用情况进行描述性分析.将对照组(2011年1月1日-12月31日)、1阶段干预组(2015年1月1日-12月31日)和2阶段干预组(2020年1月1日-12月31日)预防使用抗菌药物合理性及患者住院总费用及抗菌药物使用费用进行回顾性对比研究.结果医院2011-2020年Ⅰ类切口手术预防用药使用率呈逐年下降趋势,下降了 34.13%(P<0.05).经过两阶段干预,术前给药时间在0.5~1 h的比例、药品选择合理性及溶媒选择合理性均不同程度提高(P<0.05),术后用药时间也趋于规范化.患者人均预防性使用抗菌药物费用呈下降趋势,人均预防性使用抗菌药物费用占患者人均住院总费用的比例也在逐渐减小(P<0.05).结论通过医院顶层设计及指标制定到职能科室专项管理及反馈,再到临床科室执行及整改的闭环管理模式,运行临床抗菌药物预防应用的长效管理工作机制,使Ⅰ类切口手术抗菌药物预防使用向规范化、合理化逐渐转变,临床抗菌药物合理使用水平逐渐提升,同时减少了患者的住院费用.

关键词： Ⅰ类切口手术抗菌药物围手术期持续性综合管理措施效果

Synthesis and Crystal Structure of N-[(3aR,4R,4aR,5aS,6S,6aS)-1,3-Dioxo-octahydro-4,6-ethenocyclopropa[f]isoindol-2(1H)-yl]-4-(trifluoromethyl)phenylmethanimine Monohydrate

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Chinese Journal of Structural Chemistry 2010年第7期29卷 1043-1046页

作者： ZHOU Xin-Bo XIE Yun-De ZHONG Wu FAN shi-yong li Song Institute of Pharmacology and Toxicology Academy of Military Medical Sciences Beijing 100850 China

The crystal structure of the title compound （C19H17F3N2O4, Mr = 394.35） was determined by single-crystal X-ray diffraction. The crystal belongs to monoclinic, space group C2/c with a = 28.383（6）, b = 10.355（2）, c = 12.799（3） A, β = 111.74（3）°, V= 3493.8（12） A3, Z = 8, De = 1.499 g,/cm3, λ（MoKα） = 0.71073, F（000） = 1632,μ = 0.127 mm^-1, R = 0.0412 and wR = 0.1019. In the title compound, there exist three intermolecular hydrogen interactions （O（4）...O（1）, 0（4）...0（3） and O（4）...N（1）） between water. The neighboring molecules are linked to each other generating a two-dimensional network structure via the three intermolecular hydrogen bonds and π-π interactions shaped by phen-phen with centroid distance of 4.049 A.

关键词： ST246 monohydrate crystal structure synthesis

Interplay between geometric and electronic structures of Pt entities over TiO_(2) for CO oxidation

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Science China Chemistry 2024年第2期67卷 705-714页

作者： Xixiong Zhang Wen shi Shaobo Han yong li Wenjie Shen School of Chemistry Dalian University of TechnologyDalian116024China State Key Laboratory of Catalysis Dalian Institution of Chemical PhysicsChinese Academy of SciencesDalian116023China

Monodispersed Pt colloids with a mean size of 2 nm were deposited uniformly on the {110} facets of a rod-shaped rutile TiO_(2),forming a well-defined Pt/TiO_(2) *** treatment of this precursor at elevated temperatures re-dispersed the Pt particles into clusters and ***-calcination at 673 K partially oxidized the Pt particle surface,while calcination at 773 K yielded Pt Oxclusters of 1.6 nm in 7–8 atomic *** calcination at 873 K formed a mixture of raft-like PtO_(x) clusters(1.6 nm,1–2 atomic layers) and cationic *** tested for CO oxidation at 373 K,the Pt particles showed a higher activity than the Pt Oxclusters,whereas the cationic single-atoms were much less *** H_(2)-reduction at 473 K converted the partially oxidized Pt particles into the metallic species,but they were encapsulated by TiO_(2)–xoverlayers because of the strong metal–support interactions,which decreased the activity dramatically.H_(2)-reduction of the PtO_(x) clusters at473 K enhanced the fraction of metallic Pt species without changing the size and geometry,and promoted the activity substantially.H_(2)-treatment of Pt single-atoms at 473 K increased the activity only moderately because most Pt species still kept at cationic *** results straightforwardly differentiated the catalytic behavior of Pt particles,clusters and single-atoms at the same metal loading and over the same TiO_(2) support,and further demonstrated that the electronic structures of Pt entities played a decisive role in the catalytic oxidation,in addition to the specified sizes.

关键词： Pt/TiO_(2)catalyst size effect Pt clusters active sites electronic structures CO oxidation

Digestive system involvement of infections with SARS-CoV-2 and other coronaviruses:Clinical manifestations and potential mechanisms

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World Journal of Gastroenterology 2021年第7期27卷 561-575页

作者： Gao-Feng Zhan Yue Wang Ning Yang Ai-lin Luo shi-yong li Department of Anesthesiology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030Hubei ProvinceChina Department of Anesthesiology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030Hubei ProvinceChina

Although coronavirus(CoV)infection is often characterized by respiratory symptoms,the virus can also result in extrapulmonary symptoms,especially the symptoms related to the digestive *** outbreak of coronavirus disease 2019(COVID-19)is currently the world’s most pressing public health threat and has a significant impact on civil societies and the global *** occurrence of digestive symptoms in patients with COVID-19 is closely related to the development and prognosis of the ***,thus far,there are no specific antiviral drug or vaccine approved for the treatment or prevention of ***,we elaborate on the effects of CoVs on the digestive system and the potential underlying mechanisms.

关键词： SARS-CoV-2 Gastrointestinal diseases liver dysfunction COVID-19 Coronavirus Mechanisms

A highly sensitive multiple-mode optical thermometer designed in Eu^(2+/3+)and li^(+)co-doped polymorphism compound LaSc_(3)(BO_(3))_(4)

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Journal of Advanced Ceramics 2024年第6期13卷 821-833页

作者： Nan Yang Zhuo li Tingxia Zhou Ziwang Zhang Wen shi Yexiang Tong Jianxin shi School of Chemistry IGCMESun Yat-sen UniversityGuangzhou 510006China MOE of the Key Laboratory of Bioinorganic and Synthetic Chemistry IGCMEThe Key Lab of Low-Carbon Chemistry&Energy Conservation of Guangdong ProvinceSun Yat-sen UniversityGuangzhou 510006China

Noncontact optical thermometers have attracted widespread attention,but existing problems such as single-mode and low-sensitivity thermometers still urgently need to be ***,a novel multiple-mode thermometer was designed for the polymorphism LaSc_(3)(BO_(3))_(4):Eu^(2+/3+),li^(+).X-ray diffraction(XRD)patterns revealed a slight transition betweenα-andβ-phases with the concentrations of the dopants,which is further proved by structure refinements and first-principles *** coexistence of Eu^(2+)and Eu^(3+)in the phosphors and their relative percentages were confirmed by X-ray absorption near-edge structure(XANES)*** from appropriate emissions from Eu^(2+)and Eu^(3+)without obvious energy transfer and their opposite changing trends with temperatures under 307 nm excitation,a triple-mode optical thermometer is obtained for this material within the temperature range of 150–450 *** highest sensitivities of 27.65,14.05,and 7.68%·K^(−1)are achieved based on two fluorescence intensity ratio(FIR)modes of Eu^(2+)and Eu^(3+)(5d–4f/^(5)D_(0)–^(7)F_(2,4))and the fluorescence lifetime(FL)mode of Eu^(2+),*** the best of our knowledge,the former is almost the highest in Eu^(2+)and Eu^(3+)co-doped *** results indicate that this material may be used as an excellent multiple-mode optical thermometer.

关键词： phase transition europium(Eu)ions multiple-mode optical thermometer thermal quenching properties fluorescence intensity ratio(FIR) fluorescence lifetime(FL)

Triclosan-conjugated,lipase-responsive Polymeric Micelles for Eradication of Staphylococcal Biofilms

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Chinese Journal of Polymer Science 2024年第6期42卷 718-728页

作者： Yan-Qiang Huang Yuan-Feng li yong liu lin-Qi shi Guangxi Technology Innovation Cooperation Base of Prevention and Control Pathogenic Microbes with Drug Resistance Youjiang Medical University for NationalitiesBaise533000China Translational Medicine Laboratory the First Affiliated Hospital of Wenzhou Medical UniversityWenzhou325035China Wenzhou Institute University of Chinese Academy of SciencesWenzhou325001China State Key Laboratory of Medicinal Chemical Biology Key Laboratory of Functional Polymer Materials of Ministry of Educationand Institute of Polymer ChemistryCollege of ChemistryNankai UniversityTianjin300071China

Bacterial biofilms present a significant challenge in treating drug-resistant infections,necessitating the development of innovative *** this study,we introduce triclosan-conjugated,lipase-responsive polymeric micelles designed to exploit biofilm properties and serve as a responsive drug delivery *** micelles were created using an amphiphilic block polymer synthesized via ring-opening polymerization ofε-caprolactone(CL)and triclosan-containing cyclic trimethylene carbonate(MTC-Tri).Poly(ethylene glycol)(PEG-OH)acted as the macro-initiator,resulting in micelles with a PEG shell that facilitated their penetration into bacterial *** important advantage of our micelles lies in their interaction with local bacterial lipases within *** lipases triggered rapid micelle degradation,releasing triclosan in a controlled *** liberated triclosan effectively eliminated bacteria embedded in the ***,the triclosan-conjugated micelles displayed minimal toxicity to murine fibroblasts,indicating their biocompatibility and *** finding emphasizes the potential application of these micelles in combatting drug resistance observed in bacterial *** triclosan-conjugated,lipase-responsive polymeric micelles exhibit promising characteristics for addressing drug resistance in bacterial *** harnessing biofilm properties and implementing a responsive drug delivery system,we seek to provide an effective solution in the fight against drug-resistant bacteria.

关键词： Self-assembly Polymer prodrug Ring-opening polymerization Biofilm eradication Cytotoxicity

Role of Prosurvival Molecules in the Action of lidamycin toward Human Tumor Cells

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Biomedical and Environmental Sciences 2009年第3期22卷 244-252页

作者： A-JING YANG WEI-WEI shi yong li ZHEN WANG RONG-GUANG SHAO DIAN-DONG li QI-YANG HE Institute of Medicinal Biotechnology Peking Union Medical College and Chinese Academy of Medical Sciences Beijing 100050 China

Objective lidamycin, an enediyne antibiotic, leads to apoptosis and mitotic cell death of human tumor cells at high and low concentrations. The reason why tumor cells have distinct responses to lidamycin remains elusive. This study was to elucidate if cellular prosurvival molecules are involved in these responses. Methods Cleavage of chromatin and DNA was observed by chromatin condensation and agarose gel electrophoresis. Accumulation of rhodamine 123 in lidamycin-treated cells was assayed by flow cytometry. Cell multinucleation was detected by staining with Hoechst 33342. Western blot and senescence-associated β-galactosidase （SA-β-gal） staining were used to analyze protein expression and senescence-like phenotype, respectively. Results SIRT1 deacetylase remained unchanged in 0.5 nmol/L lidamycin whereas cleavage occurred when apoptosis was induced by lidamycin. Increased FOXO3a, SOD-1 and SOD-2 expression and transient phosphorylation of ERK were detected after exposure of human hepatoma BEL-7402 cells to 0.5 nmol/L lidamycin. High expressions of SIRT1 and Akt were found in colon carcinoma HCT116 p53 knock-out cells exposed to lidamycin. Degradation of PARP and p53 by lidamycin as a substitute for SIRT1 and Akt was confirmed with caspase inhibitor Q-VD-OPh and proteasome inhibitor MG132. Resistance to lidamycin-induced DNA cleavage was observed in breast cancer doxorubicin-resistant MCF-7 cells. This was not induced by P-glycoprotein as no accumulation of rhodamine 123 was detected in the resistant cells following exposure to lidamycin. In contrast to sensitive MCF-7 cells, a lower multinucleation rate for the resistant cells was measured following exposure to equal concentrations of lidamycin. Conclusions Cellular prosurvival molecules, such as SIRTI, Akt, SOD-1, SOD-2 and other unknown factors can influence the action of lidamycin on human tumor cells.

关键词： lidamycin Prosurvival molecules SIRTI deacetylase Apoptosis Mitotic cell death Multidrug resistance