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A Mechanism Study of a Novel Acid-Activatable Michael-Type Fluorescent Probe for Thiols

Chinese Journal of Chemical Physics 2015年第3期28卷 277-287,I0001页

作者： Yao Tong Chun-guang Dai Yi Ren shi-wei luo Department of Chemistry University of Science and Technology of China Hefei 230026 China College of Chemistry and State Key Laboratory of Biotherapy Sichuan University Chengdu 610064 China

A Michael addition is usually taken as a base-catalysed reaction. However, our synthesized 2-（quinolin-2-ylmethylene） malonic acid （QMA） as a Michael-type thiol fluorescent probe is acid-active in its sensing reaction. In this work, based on theoretic calculation and experimental study on 7-hydroxy-2-（quinolin-2-ylmethylene） malonic acid, we demonstrated that QMA as a Michael acceptor is acid-activatable, i.e., it works only in solutions at pH〈7, and the lower the pH of solutions is, the higher reactivity QMA has. In alkaline solution, the malonate QMA[-2H＋]2- cannot react with both RSand RSH. In contrast, 2-（quinolin-2- ylmethylene） malonic ester （QME）, the ester of QMA, reveal a contrary pH effect on its sensing reaction, that is, it can sense thiols in alkaline solutions but not in acidic solutions, like a normal base-catalysed Michael addition. The values of activation enthalpies from theoretic calculation support the above sensing behavior of two probes under different pH conditions. In acidic solutions, the protonated QMA is more highly reactive towards electrophilic attack over its other ionized states in neutral and alkaline solutions, and so can react with lowly reactive RSH. In contrast, there is a big energy barrier in the interaction of QME with RSH （acidic solutions）, and the reaction of QME with the highly reactive nucleophile RS- is a low activation energy process （in alkaline solutions）. Theoretic calculation reveals that the sensing reaction of QMA undergoes a 1,4-addition process with neutral thiols （RSH）, and a 1,2-addition pathway for the sensing reaction of QME with RS-. Therefore, the sensing reaction of QMA is an acid-catalysed Michael addition via a 1,4-addition, and a normal base-catalysed Michael addition via a 1,2-addition.

关键词： Fluorescent probe Thiols Michael addition DFT calculation Transitionstate Activation enthalpy

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Finite element analysis of high-pressure hose for radial horizontal wells in coalbed methane extraction

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Journal of Coal Science & Engineering(China) 2013年第2期19卷 182-186页

作者： wei-Dong ZHOU wei shi luo-Peng LI Jing-Shuang WANG Jun SUN College of Petroleum Engineering China University of Petroleum (East China) Dongying 257061 China

Based on the serial-parallel model of single-layer board and the lamination theory, the forces exerted on different layers of the high-pressure hose and the resulting deformations were analyzed when the hose was radially stretched. An equation was proposed to calculate the anisotropic elastic constant of the composite layer with the wound steel wires. Furthermore, the finite element analysis （FEA） model of the high-pressure hose was established, followed by a simulation of the forces that act on different layers, and their deformations. The simulation results show that the stress imposed on the inner reinforced layer and external reinforced layer of the high-pressure hose are approximately 150 MPa and 115 MPa, respectively, in the presence of inner pressure. The stress of the rubber coating and polyethylene coating is lower. The lowest stress occurs on the inner surface of the high-pressure hose and the rubber coating between the two composite layers. The deformation of the rubber layer in the inner surface of the high-pressure hose decreases gradually along the radial direction from the inner surface to the external surface. The deformation of the reinforced composite layer is less than that of the external surface of the rubber coating. The equivalent stress of the reinforced composite layer is higher than that caused by the inner pressure, due to the presence of both inner pressure and axial tension.

关键词： coalbed methane radial horizontal well high-pressure hose finite element analysis

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基于OSG的铁路站场三维场景层次细节建模研究

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铁道工程学报 2017年第3期34卷 63-67页

作者：蒲浩罗诗潇李伟罗宏伟中南大学长沙410000 中南大学高速铁路建造技术国家工程实验室长沙410000 中铁第四勘察设计院线站处武汉430063

研究目的:BIM建模的重要环节是实现三维可视化模型的创建。在铁路站场的设计工作中,实时生成的三维场景模型可为设计成果提供参照,增加设计的准确性。但站场设备众多且庞杂,如何组织数据,快速生成适应站场设计阶段方案修改要求、调度流... 详细信息

研究目的:BIM建模的重要环节是实现三维可视化模型的创建。在铁路站场的设计工作中,实时生成的三维场景模型可为设计成果提供参照,增加设计的准确性。但站场设备众多且庞杂,如何组织数据,快速生成适应站场设计阶段方案修改要求、调度流畅的实时三维可视化模型是创建三维场景模型的难点。研究结论:(1)提出层次细节三维站场模型构建方法,解决了大数据量模型加载时间长、硬件要求高的问题;(2)提出合理的数据管理结构,创建设计数据独立于建模过程的建模方法;(3)基于本文方法完成站场三维场景平台搭建,可实现站场三维快速建模、动态加载和交互式浏览,显著提高工作效率;(4)该研究成果可广泛应用于公路、隧道、水利等其他工程领域的三维层次细节建模及三维场景管理中。

关键词：铁路站场三维可视化层次细节模型

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The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons

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Neural Regeneration Research 2025年第1期20卷 209-223页

作者： shi-Yan Sun Lingyun Nie Jing Zhang Xue Fang Hongmei luo Chuanhai Fu Zhiyi wei Ai-Hui Tang Hefei National Research Center for Physical Sciences at the Microscale CAS Key Laboratory of Brain Function and DiseaseMinistry of Education Key Laboratory for Membrane-less Organelles and Cellular DynamicsDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina CAS Center for Excellence in Molecular Cell Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Neurobiology School of Life SciencesSouthern University of Science and TechnologyShenzhenGuangdong ProvinceChina Brain Research Center Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina

Morphological alterations in dendritic spines have been linked to changes in functional communication between neurons that affect learning and ***-4 KIF21A helps organize the microtubule-actin network at the cell cortex by interacting with KANK1;however,whether KIF21A modulates dendritic structure and function in neurons remains *** this study,we found that KIF21A was distributed in a subset of dendritic spines,and that these KIF21A-positive spines were larger and more structurally plastic than KIF21A-negative ***,the interaction between KIF21A and KANK1 was found to be critical for dendritic spine morphogenesis and synaptic *** of either KIF21A or KANK1 inhibited dendritic spine morphogenesis and dendritic branching,and these deficits were fully rescued by coexpressing full-length KIF21A or KANK1,but not by proteins with mutations disrupting direct binding between KIF21A and KANK1 or binding between KANK1 and *** down KIF21A in the hippocampus of rats inhibited the amplitudes of long-term potentiation induced by high-frequency stimulation and negatively impacted the animals’cognitive *** together,our findings demonstrate the function of KIF21A in modulating spine morphology and provide insight into its role in synaptic function.

关键词： actin cytoskeleton dendrite KANK1 KIF21A microtubule spine morphology spine synaptic plasticity talin1

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MSP430-based single-phase sine wave inverter

MSP430-based single-phase sine wave inverter

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教育部中南地区高等学校电子电气基础课教学研究会第二十届学术年会

作者： Liu Zi-xi,shi wei,luo Jin-wei (School of Information Engineering,Wuhan University of Technology,Wuhan 430070,China)

This paper describes a MSP430 microcontroller based SPWM inverter *** the boost section and the SPWM inverter section,it can give high-quality AC whose frequency and voltage has been *** design is based on Boost topology principle and uses high-performance voltage PWM control chip TL494 to drive the MOS tube in main ***430 microcontroller is the center of the whole *** cooperates with the 12-bit high-precision D/A module to control the output voltage *** system has a good over-current protection and can detect load conditions *** SCM technology to control this power makes the whole system more simple and achieves digital *** provides a kind of high-quality AC power for equipments with high performance requirements.

关键词： Inverters MSP430 single chip sinusoidal pulse width modulation voltage negative feedback

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Boosting Oxygen Evolution Reaction Performance on NiFe‑Based Catalysts Through d‑Orbital Hybridization

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Nano-Micro Letters 2025年第1期17卷 281-292页

作者： Xing Wang wei Pi Sheng Hu Haifeng Bao Na Yao wei luo State Key Laboratory of New Textile Materials and Advanced Processing Technology Key Laboratory of New Textile Materials and Applications of Hubei ProvinceSchool of Materials Science and EngineeringWuhan Textile UniversityWuhan 430200People’s Republic of China College of Chemistry and Molecular Sciences Wuhan UniversityWuhan 430072People’s Republic of China

Anion-exchange membrane water electrolyzers(AEMWEs)for green hydrogen production have received intensive attention due to their feasibility of using earth-abundant NiFe-based *** introducing a third metal into NiFe-based catalysts to construct asymmetrical M-NiFe units,the d-orbital and electronic structures can be adjusted,which is an important strategy to achieve sufficient oxygen evolution reaction(OER)performance in ***,the ternary NiFeM(M:La,Mo)catalysts featured with distinct M-NiFe units and varying d-orbitals are reported in this *** and theoretical calculation results reveal that the doping of La leads to optimized hybridization between d orbital in NiFeM and 2p in oxygen,resulting in enhanced adsorption strength of oxygen intermediates,and reduced rate-determining step energy barrier,which is responsible for the enhanced OER *** critically,the obtained NiFeLa catalyst only requires 1.58 V to reach 1 A cm^(−2) in an anion exchange membrane electrolyzer and demonstrates excellent long-term stability of up to 600 h.

关键词： NiFe-based catalysts d-orbital coupling Oxygen evolution reaction Anion exchange membrane electrolyzer

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Stiffness-tunable biomaterials provide a good extracellular matrix environment for axon growth and regeneration

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Neural Regeneration Research 2025年第5期20卷 1364-1376页

作者： Ronglin Han Lanxin luo Caiyan wei Yaru Qiao Jiming Xie Xianchao Pan Juan Xing Department of Pathophysiology School of Basic Medical SciencesSouthwest Medical UniversityLuzhouSichuan ProvinceChina Department of Medicinal Chemistry School of PharmacySouthwest Medical UniversityLuzhouSichuan ProvinceChina

Neuronal growth, extension, branching, and formation of neural networks are markedly influenced by the extracellular matrix—a complex network composed of proteins and carbohydrates secreted by cells. In addition to providing physical support for cells, the extracellular matrix also conveys critical mechanical stiffness cues. During the development of the nervous system, extracellular matrix stiffness plays a central role in guiding neuronal growth, particularly in the context of axonal extension, which is crucial for the formation of neural networks. In neural tissue engineering, manipulation of biomaterial stiffness is a promising strategy to provide a permissive environment for the repair and regeneration of injured nervous tissue. Recent research has fine-tuned synthetic biomaterials to fabricate scaffolds that closely replicate the stiffness profiles observed in the nervous system. In this review, we highlight the molecular mechanisms by which extracellular matrix stiffness regulates axonal growth and regeneration. We highlight the progress made in the development of stiffness-tunable biomaterials to emulate in vivo extracellular matrix environments, with an emphasis on their application in neural repair and regeneration, along with a discussion of the current limitations and future prospects. The exploration and optimization of the stiffness-tunable biomaterials has the potential to markedly advance the development of neural tissue engineering.

关键词： alginate axon growth biomaterials extracellular matrix neural repair neurons neuroregeneration polyacrylamide polydimethylsiloxane stiffness

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某核电厂热检修厂房暖通系统调试研究与分析

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发电与空调 2017年第2期38卷 50-54,64页

作者：刘世昊罗伟涛上海核工程研究设计院上海200233

介绍了某核电厂热检修厂房的空调与通风系统及其控制方案;通过对该厂房空调与通风系统的调试,发现部分房间排风量不足,冬季室温达不到设计温度等问题,并对引起这些问题的原因进行了分析;根据分析,总结了热检修厂房空调通风系统设计、调... 详细信息

介绍了某核电厂热检修厂房的空调与通风系统及其控制方案;通过对该厂房空调与通风系统的调试,发现部分房间排风量不足,冬季室温达不到设计温度等问题,并对引起这些问题的原因进行了分析;根据分析,总结了热检修厂房空调通风系统设计、调试、运行维护等需要注意的问题,强调了系统调试对保证热检修厂空调通风系统正常运行的重要性。

关键词：热检修厂房空调通风调试

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Exploring practical methods for detecting k-nonseparability in multipartite quantum states

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 255-256页

作者： Shunlong luo Academy of Mathematics and Systems Science Chinese Academy of Sciences

Quantum entanglement, referred to as “spooky action at a distance” by Einstein, is not only an intriguing and fascinating feature of quantum theory challenging our classical intuitions about locality and correlations, but also has practical and profound implications for quantum technologies. Initially described by Einstein, Podolsky and Rosen, as well as by Schro¨dinger, entanglement now has become a basic and crucial ingredient for both foundational and experimental investigations of the quantum world.

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基于修正相干态光源的MDI-QKD全局估计性能分析

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量子电子学报 2017年第4期34卷 446-450页

作者：薛阳马丽华石磊魏家华罗均文空军工程大学信息与导航学院陕西西安710077

为了提高测量设备无关量子密钥分发(MDI-QKD)系统的整体性能,利用修正相干态光源(MCS)可以优化光子数分布率的性质,设计了一种基于MCS的MDI-QKD系统。基于全局估计的计算方法推导了密钥生成率与传输距离的关系,保证了在密性放大计算过... 详细信息

为了提高测量设备无关量子密钥分发(MDI-QKD)系统的整体性能,利用修正相干态光源(MCS)可以优化光子数分布率的性质,设计了一种基于MCS的MDI-QKD系统。基于全局估计的计算方法推导了密钥生成率与传输距离的关系,保证了在密性放大计算过程中单光子信息的充分利用,得到较为精确的密钥率下限值。通过仿真分析将所提出的系统与基于预报单光子源(HSPS)的MDI-QKD系统性能进行对比,结果表明MCS光源比HSPS光源的传输距离提高了9%,有效改善了系统性能。

关键词：量子光学测量设备无关全局估计修正相干态光源

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