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Bifidobacterium breve CCFM1078 regulates bone development in growing BALB/c mice via gut microbiota and metabolites to balance bone formation and resorption

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Food Science and Human Wellness 2024年

作者： Bowen li Mengfan Ding Xiaoming liu Haiqin Chen Jianxin Zhao R.Paul Ross Catherine Stanton shilong Jiang wei Chen Bo Yang Nutrition and Metabolism Research Division， Innovation Center， Heilongjiang Feihe Dairy Co.， Ltd. National Engineering Research Center for Functional Food， Jiangnan University State Key Laboratory of Food Science and Technology， Jiangnan University PKUHSC-China Feihe Joint Research Institute of Nutrition and Healthy lifespan Development APC Microbiome Ireland， University College Cork School of Food Science and Technology， Jiangnan University International Joint Research Center for Probiotics & Gut Health， Jiangnan University Teagasc Food Research Centre

This study endeavors to investigate the effects of Bifidobacterium breve CCFM1078 on bone formation and resorption balance in growing BALB/c mice. Newborn BALB/c mice were assigned to the control group (administration saline) and the CCFM1078 group (administration B. breve CCFM1078， 3 × 109CFU/day) in 3-， 4-， and 5-week tests. All the groups have male and female distinctions. Our findings demonstrate that B. breve CCFM1078 exerts on the dynamic equilibrium between bone formation and resorption during the critical period of growth in mice by modulating the composition of gut microbiota and metabolites (hexadecanamide， linoleoyl ethanolamide， and palmitoyl ethanolamide)， the genes and proteins expression related to the GH/IGF-1 axis and Gs/PKA/CREB signaling pathways， as well as downstream osteogenic and osteoclastic differentiation factors. The effects of B. breve CCFM1078 were different with age and gender dependent. This finding suggests B. breve CCFM1078 may have potential applications in regulating bone metabolism in the growth period population.

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Quafu-Qcover:Explore combinatorial optimization problems on cloud-based quantum computers

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Chinese Physics B 2024年第5期33卷 104-115页

作者：许宏泽庄伟峰王正安黄凯旋时运豪马卫国李天铭陈驰通许凯冯玉龙刘培陈墨李尚书杨智鹏钱辰靳羽欣马运恒肖骁钱鹏顾炎武柴绪丹普亚南张翼鹏魏世杰增进峰李行龙桂鲁金贻荣于海峰范桁刘东胡孟军 Beijing Academy of Quantum Information Sciences Beijing 100193China State Key Laboratory of Low Dimensional Quantum Physics Department of PhysicsTsinghua UniversityBeijing 100084China Institute of Physics Chinese Academy of SciencesBeijing 100190China Frontier Science Center for Quantum Information Beijing 100184China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100190China CAS Center for Excellence in Topological Quantum Computation UCASBeijing 100190China

We introduce Quafu-Qcover,an open-source cloud-based software package developed for solving combinatorial optimization problems using quantum simulators and hardware ***-Qcover provides a standardized and comprehensive workflow that utilizes the quantum approximate optimization algorithm(QAOA).It facilitates the automatic conversion of the original problem into a quadratic unconstrained binary optimization(QUBO)model and its corresponding Ising model,which can be subsequently transformed into a weight *** core of Qcover relies on a graph decomposition-based classical algorithm,which efficiently derives the optimal parameters for the shallow QAOA ***-Qcover incorporates a dedicated compiler capable of translating QAOA circuits into physical quantum circuits that can be executed on Quafu cloud quantum *** to a general-purpose compiler,our compiler demonstrates the ability to generate shorter circuit depths,while also exhibiting superior speed ***,the Qcover compiler has the capability to dynamically create a library of qubits coupling substructures in real-time,utilizing the most recent calibration data from the superconducting quantum *** ensures that computational tasks can be assigned to connected physical qubits with the highest *** Quafu-Qcover allows us to retrieve quantum computing sampling results using a task ID at any time,enabling asynchronous ***,it incorporates modules for results preprocessing and visualization,facilitating an intuitive display of solutions for combinatorial optimization *** hope that Quafu-Qcover can serve as an instructive illustration for how to explore application problems on the Quafu cloud quantum computers.

关键词： quantum cloud platform combinatorial optimization problems quantum software

DTD1 modulates synaptic efficacy by maintaining D-serine and D-aspartate homeostasis

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Science China life Sciences 2024年

作者： Xiao liu Chaojuan Yang Zhuoran lin Jianing li Bin Yin Xuepei Lei wei Han Boqin Qiang Pengcheng Shu Chen Zhang Xiaozhong Peng State Key Laboratory of Common Mechanism Research for Major Diseases Department of Biochemistry & Molecular Biology Medical Primate Research Center Neuroscience Center Institute of Basic Medical Sciences Chinese Academy of Medical Sciences School of Basic Medicine Peking Union Medical College School of Basic Medical Sciences Beijing Key Laboratory of Neural Regeneration and Repair Capital Medical University Key Laboratory of Biomechanics and Mechanobiology (Beihang University) Ministry of Education Beijing Advanced Innovation Center for Biomedical Engineering School of Engineering Medicine Beihang University Institute of Laboratory Animal Sciences Chinese Academy of Medical Sciences & Peking Union Medical College Chinese Institute for Brain Research State Key Laboratory of Respiratory Health and Multimorbidity

D-serine and D-aspartate are involved in N-methyl-D-aspartate receptor(NMDAR)-related physiological and pathological processes. Daminoacyl-tRNA deacylase 1(DTD1) may biochemically contribute to D-serine or D-aspartate production. However, it is unclear thus far whether DTD1 regulates D-serine or D-aspartate content in neurobiological processes. In the present research, we found that DTD1 was essential to maintain the D-serine or D-aspartate homeostasis, which was consistent with the phenomenon that DTD1-deficiency resulted in changes in the quantity changes of functional NMDAR subunits in postsynaptic compartments. Moreover, DTD1 played a considerable role in regulating dendritic morphology and synaptic structure. As a consequence, DTD1 affected neurobiological events, including the synaptic strength of the CA3-to-CA1 circuit, dendritic spine density of hippocampal pyramidal neurons, and behavioral performance of mice in the Morris water maze. These findings highlight the important role of DTD1 in synaptic transmission, neuronal morphology, and spatial learning and memory and suggest an undisclosed mechanism of DTD1 that participates the regulation of D-serine or D-aspartate homeostasis in hippocampal neurons.

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1979-2021年中国南海海表风速和大风事件的变化特征

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高原气象 2024年第3期43卷 696-710页

作者：李晨轩韦志刚北京师范大学地表过程与资源生态国家重点实验室北京100875 北京师范大学环境演变与自然灾害教育部重点实验室北京100875 北京师范大学地理科学学部北京100875

利用欧洲中期天气预报中心European Centre for Medium-Range Weather Forecasts(ECMWF)最新的第五代再分析资料ECMWF Reanalysis v5(ERA5),定义了大风事件,使用经验正交分解等方法分析了1979-2021年中国南海海表风速和大风事件的变化特... 详细信息

利用欧洲中期天气预报中心European Centre for Medium-Range Weather Forecasts(ECMWF)最新的第五代再分析资料ECMWF Reanalysis v5(ERA5),定义了大风事件,使用经验正交分解等方法分析了1979-2021年中国南海海表风速和大风事件的变化特征,并对是否受热带气旋的影响进行了区分。结果发现,南海风速分布呈现出十分明显的季节特征,冬季主要为东北风,夏季为西南风;春、夏季南海东北部与其他地区风速变化存在反向关系,除东北部沿海地区外,春季平均风速变化经历了减小-增大-减小的变化,总体呈较弱的增加趋势;而夏季则是增大-减少-增大,总体呈减小趋势。秋季南海风速呈全区一致的变化,呈减小趋势。冬季变为东南与其余部分反向,除西南部外,风速呈显著增强趋势。大风事件发生在风速较大的区域和时间内,冬季和秋季发生大风事件的频次要高于春季和秋季,冬半年要高于夏半年;在冬季和冬半年,大风事件的发生频次在南海中部长山山脉东侧直到南海东北部台湾海峡附近有显著上升趋势;大风事件频次变化趋势随季节改变有很大的差异,冬季和春季大风事件频次变化趋势与夏季和秋季相反。夏半年大风事件频次变化融合了夏季和秋季的变化趋势特点;类似的冬半年大风事件频次融合了冬季和春季的变化趋势特点。在夏季,秋季和夏半年这些受到南海夏季季风影响的季节内,热带气旋对发生的大风事件频次影响更大;对在冬季,春季和冬半年发生的大风事件则影响较小。

关键词：南海气候变暖 ERA5再分析资料大风事件极端事件

应用双弹光级联差频调制的红外材料应力缺陷检测

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红外与毫米波学报 2024年第1期43卷 126-133页

作者：李克武王爽李孟委王志斌中北大学电气与控制工程学院山西太原030051 中北大学前沿交叉科学研究院山西太原030051 山西省光电信息与仪器工程技术研究中心山西太原030051

为了实现对Si、Ge、GaAs等红外材料应力缺陷检测,采用两个工作在不同频率的光弹性调制器级联,构成偏振测量系统。应力缺陷引入的双折射延迟量和快轴方位角两个参数,被加载到偏振测量系统调制信号中;利用数字锁相技术同时获取调制信号的... 详细信息

为了实现对Si、Ge、GaAs等红外材料应力缺陷检测,采用两个工作在不同频率的光弹性调制器级联,构成偏振测量系统。应力缺陷引入的双折射延迟量和快轴方位角两个参数,被加载到偏振测量系统调制信号中;利用数字锁相技术同时获取调制信号的基频项和差频项幅值,然后完成两个应力参数求解。详细分析了检测原理,并搭建了实验系统进行验证。实验结果表明,该检测方法及实验系统实现了应力方向角标准偏差为0.31°,应力双折射延迟量标准偏差为0.72 nm,高速、高精度和高重复度的应力缺陷检测,并且实现了Ge样品的应力缺陷方向和值大小分布测量,可为红外材料质量测试分析和评估提供有效手段。

关键词：应力缺陷弹光调制快轴方位角延迟量

以创新力为导向的“土壤微生物学”教学改革与实践

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微生物学通报 2024年第4期51卷 1175-1189页

作者：宋文琛李崴中央民族大学生命与环境科学学院北京100081

在新时代亟需创新型人才的背景下,现行“土壤微生物”课程教学中存在教学内容相对滞后、缺乏提升学生自主学习和分析能力的培养机制、重分数轻能力等3个主要问题,影响对学生创新能力的培养。为此,根据教学实际情况尝试了4项改革措施:修... 详细信息

在新时代亟需创新型人才的背景下,现行“土壤微生物”课程教学中存在教学内容相对滞后、缺乏提升学生自主学习和分析能力的培养机制、重分数轻能力等3个主要问题,影响对学生创新能力的培养。为此,根据教学实际情况尝试了4项改革措施:修改过时教学内容并紧跟前沿、采取开放引导式教学方法、设计布置“看图说话”或话题讨论模式作业任务,以及期末考核采用试验设计或者观点论文方式。实践表明,这些教学改革获得了绝大多数学生的正面评价,有效提高了学生的创新积极性和创新能力。

关键词：土壤微生物学教学改革创新能力开放引导式教学考核评价方式

Operation Strategy and Matching of Supply and Demand of CCHP System with Various Building Types

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Journal of Thermal Science 2024年第06期33卷 2203-2220页

作者： li Yaohong WANG Pengxiang PENG Bin BIAN Xiaoyang School of Mechanical and Electrical Engineering Lanzhou University of Technology

The important indications for assessing CCHP(combined cooling,heating and power) systems are their supply-demand matching characteristics between the user demand side and the energy supply *** characteristics are primarily influenced by different building types and operating *** view of the energy redundancy of the following electric load(FEL) and following thermal load(FTL) operation strategies and the energy deficiency of the following hybrid electric-heating load(FHL) operation strategy,this paper proposes an improved following balanced heat-electrical load(IFBL) operation strategy based on the following balanced heat-electrical load(FBL) operation *** on the energy utilization rate as the objective function,this paper optimizes the installed capacity of CCHP systems in different buildings and proposes an energy factor for evaluating the supply-demand matching characteristics of the *** results show that the energy utilization rate and energy factor of the system under IFBL are optimal relative to the other operation ***,the hotel building has the highest energy utilization rate and the lowest energy factor;on the contrary,the office building has the lowest energy utilization rate and the highest energy ***,the analysis of supply-demand matching for different building types under multiple operating strategies shows that the hospital and hotel systems exhibit optimal supply-demand matching performance under the IFBL strategy,with values of0.945 and 0.938,respectively;on the contrary,the office system has an optimal supply-demand matching of 0.935under the FEL *** the FTL strategy,the systems of all three buildings exhibit poor matching performance.

关键词： combined cooling energy factor energy utilization rate heating and power system (CCHP) matching supply and demand operation strategy

基于多项Logistic的危化品槽罐车火灾类型判别

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中国安全科学学报 2024年第1期34卷 231-237页

作者：刘勇李肖施式亮鲁义王正武施星宇湖南科技大学资源环境与安全工程学院湖南湘潭411201 湖南科技大学公共安全与应急管理研究院湖南湘潭411201 长沙理工大学交通运输工程学院湖南长沙410114 长沙理工大学电气与信息工程学院湖南长沙410114

为有效防控危化品槽罐车火灾事故,准确判别槽罐车火灾类型,运用Python统计我国2013—2020年危化品槽罐车道路火灾案例;在确定火灾事故特征的基础上,将3种危化品槽罐车火灾类型(喷射火灾、池火灾与沸腾液体膨胀蒸气爆炸火灾(BLEVE))作为... 详细信息

为有效防控危化品槽罐车火灾事故,准确判别槽罐车火灾类型,运用Python统计我国2013—2020年危化品槽罐车道路火灾案例;在确定火灾事故特征的基础上,将3种危化品槽罐车火灾类型(喷射火灾、池火灾与沸腾液体膨胀蒸气爆炸火灾(BLEVE))作为被解释变量类别,确定空间与道路特征、时间与气象特征、人员因素、车辆及设备因素以及危化品因素5个方面共15项火灾因子;构建基于多项Logistic危化品槽罐车火灾类型判别模型;开展准确性检验和显著性检验以及实例应用,获得3种火灾类型的发生概率,并提出相应的火灾防治措施。结果表明:实例中液化天然气(LNG)罐车最有可能发生池火灾,其概率为0.55;其次为喷射火灾,BLEVE火灾的概率最小。采取提高危化品容器机械强度、减小碰撞强度等措施,可避免容器出现较大尺寸的泄漏孔,减少池火灾发生概率;采取减缓泄漏速度、控制泄漏范围、迅速合理灭火等应急措施可以减少LNG池火灾危害后果。

关键词：多项Logistic 危化品槽罐车火灾类型判别道路运输

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多操作系统智能手机的定位导航能力分析

导航定位学报 2024年第4期12卷 99-105,173页

作者：施星宇陈明剑李广云李万里蔡巍吕葳信息工程大学地理空间信息学院郑州450001

针对智能手机全球导航卫星系统(GNSS)在城市峡谷条件下、多路径条件下的定位导航能力不足的问题,分析GNSS观测数据质量,对比定位结果,安卓手机采用伪距单点定位和伪距差分定位的方式进行数据处理,苹果手机采用融合数据进行定位解算。结... 详细信息

针对智能手机全球导航卫星系统(GNSS)在城市峡谷条件下、多路径条件下的定位导航能力不足的问题,分析GNSS观测数据质量,对比定位结果,安卓手机采用伪距单点定位和伪距差分定位的方式进行数据处理,苹果手机采用融合数据进行定位解算。结果表明:苹果手机的载噪比明显高于安卓手机;环境良好的路段下,融合定位数据的结果相比于伪距差分定位准确度提升38 m左右,精度提升4 m左右,比单点定位结果准确度提升41 m左右,精度提升4 m左右;在多路径条件下,融合定位数据的结果相比于伪距差分定位准确度提升39 m左右,精度提升4 m左右,比单点定位结果准确度提升48 m左右,精度提升17 m左右;在城市峡谷环境下发现智能手机仅依靠GNSS导航的能力不足以满足日常定位需求,目前仍需要依靠融合定位来保障日常生活中导航的需求。

关键词：智能手机导航精度数据分析城市峡谷差分定位