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The Arabidopsis in vivo POLLEN TUBE DEFFECT 1 Gene Encodes a Putative Alkaline Phytoceramidase that is Important for Pollen Tube and Female Gametophyte Interaction

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The Arabidopsis in vivo POLLEN TUBE DEFFECT 1 Gene Encodes a...

Finite element simulation of wireless structural vibration and Shape control with photostrictive actuators

中国遗传学会植物遗传和基因组学专业委员会2009年学术研讨会

作者： Liyu Chen,Wenjuan Zhang,Dongqiao shi,jie Liu,and Weicai yang~* Key Laboratory of Molecular and Developmental Biology,Institute of Genetics and Developmental Biology,Chinese Academy of Sciences,Beijing 100101,China

In flowering plants,the interaction between pollen tube and female gametophyte plays a critical role for the successful ***,we identified an Arabidopsis mutant,in vivo pollen tube defect 1(ipod1),from Ds transposon in... 详细信息

关键词： alkaline phytoceramidase Arabidopsis iPOD male sterility pollen tube

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Finite element simulation of wireless structural vibration a...

AAV mediated carboxyl terminus of Hsp70 interacting protein overexpression mitigates the cognitive and pathological phenotypes of APP/PS1 mice

2011年全国压电和声波理论及器件应用研讨会

作者： shi-jie ZHENG*Shu-yang LI Jing-jing LIAN Institute of Smart materials and Structures,State Key Laboratory of Mechanics and Control of Mechanical Structures, Nanjing University of Aeronautics and Astronautics,Nanjing 210016

＜正＞This paper focuses on the investigation of non-contact control of structural shape and vibration via surface bonded photostrictive *** recently emerging family of smart materials,photostrictive materials exhibit... 详细信息

关键词： PLZT Photostrictive actuators Non-contact shape control wireless vibration control Finite element method Genetic algorithm

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Neural Regeneration Research 2025年第1期20卷 253-264页

作者： Zhengwei Hu Jing yang Shuo Zhang Mengjie Li Chunyan Zuo Chengyuan Mao Zhongxian Zhang Mibo Tang Changhe shi Yuming Xu Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Academy of Medical Sciences of Zhengzhou University ZhengzhouHenan ProvinceChina NHC Key Laboratory of Prevention and treatment of Cerebrovascular Diseases The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Henan Key Laboratory of Cerebrovascular Diseases The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Institute of Neuroscience Zhengzhou UniversityZhengzhouHenan ProvinceChina Sino-British Research Centre for Molecular Oncology National Centre for International Research in Cell and Gene TherapySchool of Basic Medical SciencesAcademy of Medical SciencesZhengzhou UniversityZhengzhouHenan ProvinceChina Department of Gerontology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina

The E3 ubiquitin ligase,carboxyl terminus of heat shock protein 70(Hsp70)interacting protein(CHIP),also functions as a co-chaperone and plays a crucial role in the protein quality control *** this study,we aimed to investigate the neuroprotective effect of overexpressed CHIP on Alzheimer’s *** used an adeno-associated virus vector that can cross the blood-brain barrier to mediate CHIP overexpression in APP/PS1 mouse *** overexpression significantly ameliorated the performance of APP/PS1 mice in the Morris water maze and nest building tests,reduced amyloid-βplaques,and decreased the expression of both amyloid-βand phosphorylated *** also alleviated the concentration of microglia and astrocytes around *** APP/PS1 mice of a younger age,CHIP overexpression promoted an increase in ADAM10 expression and inhibitedβ-site APP cleaving enzyme 1,insulin degrading enzyme,and neprilysin *** of HSP70 and HSP40,which have functional relevance to CHIP,were also *** nuclei transcriptome sequencing in the hippocampus of CHIP overexpressed mice showed that the lysosomal pathway and oligodendrocyte-related biological processes were up-regulated,which may also reflect a potential mechanism for the neuroprotective effect of *** research shows that CHIP effectively reduces the behavior and pathological manifestations of APP/PS1 ***,overexpression of CHIP could be a beneficial approach for the treatment of Alzheimer’s disease.

关键词： adeno-associated virus Alzheimer’s disease APP/PS1 mice carboxyl terminus of Hsp70 interacting protein gene therapy

Tranylcypromine upregulates Sestrin 2 expression to ameliorate NLRP3-related noise-induced hearing loss

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Neural Regeneration Research 2025年第5期20卷 1483-1494页

作者： Xihang Chen Zhifeng Chen Menghua Li Weiwei Guo Shuolong Yuan Liangwei Xu Chang Lin Xi shi Wei Chen shiming yang Senior Department of Otolaryngology Head and Neck Surgery Chinese PLA General HospitalChinese PLA Medical SchoolBeijingChina State Key Laboratory of Hearing and Balance Science BeijingChina National Clinical Research Center for Otolaryngologic Diseases BeijingChina Key Laboratory of Hearing Science Ministry of EducationBeijingChina Beijing Key Laboratory of Hearing Impairment Prevention and Treatment BeijingChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Otolaryngology Head and Neck Surgery The 940th Hospital of Joint Logistics Support Force of Chinese PLALanzhouGansu ProvinceChina Key Laboratory of Tropical Biological Resources of Ministry of Education School of Pharmaceutical SciencesHainan UniversityHaikouHainan ProvinceChina Academician Workstation of Hainan University School of Pharmaceutical SciencesYazhou BaySanyaHainan ProvinceChina

Noise-induced hearing loss is the primary non-genetic factor contributing to auditory ***,there are currently no effective pharmacological interventions for patients with noise-induced hearing ***,we present evidence suggesting that the lysine-specific demethylase 1 inhibitor–tranylcypromine is an otoprotective agent that could be used to treat noise-induced hearing loss,and elucidate its underlying regulatory *** established a mouse model of permanent threshold shift hearing loss by exposing the mice to white broadband noise at a sound pressure level of 120 d B for 4 *** found that tranylcypromine treatment led to the upregulation of Sestrin2(SESN2)and activation of the autophagy markers light chain 3B and lysosome-associated membrane glycoprotein 1 in the cochleae of mice treated with *** noise exposure group treated with tranylcypromine showed significantly lower average auditory brainstem response hearing thresholds at click,4,8,and 16 k Hz frequencies compared with the noise exposure group treated with *** findings indicate that tranylcypromine treatment resulted in increased SESN2,light chain 3B,and lysosome-associated membrane glycoprotein 1 expression after noise exposure,leading to a reduction in levels of 4-hydroxynonenal and cleaved caspase-3,thereby reducing noise-induced hair cell ***,immunoblot analysis demonstrated that treatment with tranylcypromine upregulated SESN2 expression via the autophagy *** treatment also reduced the production of NOD-like receptor family pyrin domaincontaining 3(NLRP3)*** conclusion,our results showed that tranylcypromine treatment ameliorated cochlear inflammation by promoting the expression of SESN2,which induced autophagy,thereby restricting NLRP3-related inflammasome signaling,alleviating cochlear hair cell loss,and protecting hearing *** findings suggest that inhibiting lysine-specific demethylase 1 is a

关键词： 4-hydroxynonenal apoptosis autophagy cleaved caspase-3 inflammation NOD-like receptor family pyrin domain-containing 3(NLRP3) noise-induced hearing loss oxidative stress Sestrin2 tranylcypromine

急性高原暴露及短期习服对青年男性血小板相关参数的影响

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解放军医学杂志 2018年第3期43卷 251-256页

作者：柯景彬李佳蓓张继航卞士柱杨杰刘川陈灿张辰余洁晋军黄岚陆军军医大学新桥医院心血管内科、全军心血管病研究所重庆400037

目的探讨急性高原暴露及短期习服对健康青年男性血小板的影响。方法依据纳入和排除标准于2012年6月-2013年8月在成都分别纳入世居成都(海拔500m,平原组,n=193)、由成都(海拔500m)乘飞机2h内进驻拉萨(海拔3700m)后暴露1d(急性高原暴露组,... 详细信息

目的探讨急性高原暴露及短期习服对健康青年男性血小板的影响。方法依据纳入和排除标准于2012年6月-2013年8月在成都分别纳入世居成都(海拔500m,平原组,n=193)、由成都(海拔500m)乘飞机2h内进驻拉萨(海拔3700m)后暴露1d(急性高原暴露组,n=147)和7d(短期习服组,n=122)的健康青年男性志愿者。收集志愿者的人口学资料和生理参数,采集血常规及血清学中血小板相关参数,比较3组间血小板相关参数的差异。结果与平原组比较,急性高原暴露组血小板计数(PLT)、血小板分布宽度(PDW)、血小板压积(PCT)降低,平均血小板体积(MPV)升高(P0.05)。Pearson相关性分析结果提示PLT与外周血氧饱和度(SpO_2)呈正相关(P<0.05)。结论急性高原暴露后PLT、PDW、PCT的改变可能与SpO_2降低有关;短期习服后,机体能够逐渐代偿急性高原暴露导致的血小板改变。

关键词：高原习服血小板血小板活性

疤痕子宫患者再次剖宫产术后产褥感染的危险因素与病原学和耐药性分析

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中华医院感染学杂志 2017年第7期27卷 1608-1611页

作者：蒋凤芳李怡澄赵赛婉施洁朱伟央缙云县妇幼保健院保健科浙江缙云县321400 缙云县人民医院妇产科浙江缙云县321400 缙云县妇幼保健院围产保健科浙江缙云县321400

目的探讨疤痕子宫患者再次剖宫产术后产褥感染的危险因素、病原学和耐药性,为临床治疗提供参考依据。方法自2015年1月-2016年6月前瞻性收集医院收治的疤痕子宫再次行剖宫产术的孕产妇382例,分析疤痕子宫患者再次剖宫产术后产褥感染的发... 详细信息

目的探讨疤痕子宫患者再次剖宫产术后产褥感染的危险因素、病原学和耐药性,为临床治疗提供参考依据。方法自2015年1月-2016年6月前瞻性收集医院收治的疤痕子宫再次行剖宫产术的孕产妇382例,分析疤痕子宫患者再次剖宫产术后产褥感染的发生率、危险因素、病原学和耐药性。结果 382例孕产妇,共31例发生产褥感染,感染率为8.12%;多因素回归分析显示,凶险型前置胎盘、凶险型前置胎盘合并胎盘植入、产后出血和孕产妇阴道炎是疤痕子宫患者再次剖宫产术后产褥感染的独立危险因素(P<0.05);共培养出26株病原菌,以革兰阴性菌为主,占65.38%,革兰阴性菌耐药率最高的是头孢他啶,为41.18%。结论疤痕子宫患者再次剖宫产术后产褥感染率较高,凶险型前置胎盘、凶险型前置胎盘合并胎盘植入、产后出血和孕产妇阴道炎是高危因素,革兰阴性菌较为常见,对青霉素和头孢他啶耐药率较高。

关键词：疤痕子宫剖宫产产褥感染危险因素病原学耐药性

Direct Photolithography of WO_x Nanoparticles for High-Resolution Non-Emissive Displays

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NANO-MICRO LETTERS 2025年第1期17卷 1-13页

作者： Gu, Chang yang, Guojian Wang, Wenxuan shi, Aiyan Fang, Wenjuan Qian, Lei Hu, Xiaofei Zhang, Ting Xiang, Chaoyu Zhang, Yu-Mo Chinese Acad Sci Ningbo Inst Mat Technol & Engn Lab Optoelect Informat Technol & Devices Ningbo 315201 Peoples R China Qianwan Inst CNITECH Hangzhou Bay Lab Adv Nanooptoelectron Mat & Device Ningbo 315336 Peoples R China Zhejiang Univ Innovat Ctr Yangtze River Delta Smart Mat Architecture Res Lab Jiaxing 314100 Peoples R China Univ Sci & Technol China Hefei 230026 Peoples R China Jilin Univ Coll Chem State Key Lab Supramol Struct & Mat Changchun 130012 Peoples R China

High-resolution non-emissive displays based on electrochromic tungsten oxides (WOx) are crucial for future near-eye virtual/augmented reality interactions, given their impressive attributes such as high environmental stability, ideal outdoor readability, and low energy consumption. However, the limited intrinsic structure of inorganic materials has presented a significant challenge in achieving precise patterning/pixelation at the micron scale. Here, we successfully developed the direct photolithography for WOx nanoparticles based on in situ photo-induced ligand exchange. This strategy enabled us to achieve ultra-high resolution efficiently (line width m, the best resolution for reported inorganic electrochromic materials). Additionally, the resulting device exhibited impressive electrochromic performance, such as fast response ( 3600 cycles), as well as promising applications in electronic logos, pixelated displays, flexible electronics, etc. The success and advancements presented here are expected to inspire and accelerate research and development (R&D) in high-resolution non-emissive displays and other ultra-fine micro-electronics.

关键词： Electrochromic Direct photolithography WOx nanoparticles In situ photo-induced ligand exchange High-resolution displays

H_(XXZ)模型与量子SUq(2)群的表示

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物理学报 1992年第2期41卷 201-212页

作者：侯伯宇石康杰杨仲侠岳瑞宏西北大学现代物理研究所西安710069

本文利用Bethe Ansatz方法讨论具有特定的边界条件的H_(xxz)模型与量子SU_q(2)群表示,证明对任意q值,BA态是量子SU_q(2)的最高权态,由此生成量子群的不可约表示,对q=e^(ir)为单位根,证明Bethe Ansatz方程存在新的解组,利用极限方法,导出... 详细信息

本文利用Bethe Ansatz方法讨论具有特定的边界条件的H_(xxz)模型与量子SU_q(2)群表示,证明对任意q值,BA态是量子SU_q(2)的最高权态,由此生成量子群的不可约表示,对q=e^(ir)为单位根,证明Bethe Ansatz方程存在新的解组,利用极限方法,导出|b~′> ,构造了量子SU_q(2)群的不完全可约表示(Ⅰ型)和不可约表示(Ⅱ型)。

关键词：量子群对称性自旋链权态矢量

Superfluidity of Paired Bosons from Correlated Tunneling

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Communications in Theoretical Physics 2009年第10期52卷 611-614页

作者： yang shi-jie Department of Physics Beijing Normal University Beijing 100875 China

We study superfluidity of paired Bosonic atoms in optical lattices. The atoms have strong repulsive on-slte energy. Single atom tunneling is severely suppressed while the atom-pair may co-tunnel by the second order quantum transition, which induces paired superfluidity as repulsive nearest-neighbor interactions are included. The mean-field phase diagram and low energy excitations are explored for a square lattice system.

关键词： superfluidity correlated tunneling pairing