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Discovery of Three Large HII Regions in the Galactic Plane

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Chinese Journal of Astronomy and Astrophysics 2008年第5期8卷 575-579页

作者： Wei-Bin shi Xiao-Hui Sun Jin-Lin Han Xu-yang Gao Li Xiao National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China Department of Space Science and Applied Physics Shandong University at Weihai Weihai 264209 China

We discovered three large HⅡ regions： G148.8＋2.3, G149.5＋0.0 and G169.9＋2.0 in the Sino-German A6 cm polarization survey of the Galactic plane. They have been identified based on the flat spectral indexes and the... 详细信息

关键词： radio continuum general - methods observational - HⅡ regions

Ultrasensitive and Signal-on Electrochemiluminescence Aptasensor Using the Multi-tris(bipyridine)ruthenium(Ⅱ)- β-cyclodextrin Complexes

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Chinese Journal of Chemistry 2014年第11期32卷 1161-1168页

作者： Yingying Zhao Hong Chen Qiong Chen Yantao Qi Fan yang jie Tang Pingang He Fan Zhang Department of Chemistry East China Normal UniversityShanghai 200241China

An ultrasensitive and signal-on electrochemiluminescence(ECL)aptasensor to detect target protein(thrombin or lysozyme)was developed using the host-guest recognition between a metallocyclodextrin complex and single-stranded DNA(ss-DNA).The aptasensor uses both the photoactive properties of the metallocyclodextrins named multi-tris(bipyridine)ruthenium(Ⅱ)-β-cyclodextrin complexes and their specific recognition with ss-DNA,which amplified the ECL signal without luminophore *** investigating the ECL performance of different multi-tris(bipyridine)ruthenium(Ⅱ)-β-cyclodextrin(multi-Ru-β-CD)complexes,tris-tris(bipyridine)-ruthenium(Ⅱ)-β-cyclodextrin(tris(bpyRu)-β-CD)was selected as a suitable host molecule to construct an ***,double-stranded DNA(ds-DNA)formed by hybridization of the aptamer and its target DNA was attached to a glassy carbon electrode via coupling interaction,which showed low ECL intensity with 2-(dibutylamino)ethanol(DBAE)as coreactant,because of the weak recognition between ds-DNA and tris(bpyRu)-β-*** addition of the corresponding protein,the ECL intensity increased when target ss-DNA was released because of the higher stability of the aptamer-protein complex than the aptamer-DNA one.A linear relationship was observed in the range of 0.01 pmol/L to 100 pmol/L between ECL intensity and the logarithm of thrombin concentrations with a limited detection of 8.5 fmol/L(S/N=3).Meanwhile,the measured concentration of lysozyme was from 0.05 pmol/L to 500 pmol/L and the detection limit was 33 fmol/L(S/N=3).The investigations of proteins in human serum samples were also performed to demonstrate the validity of detection in real clinical *** simplicity,high sensitivity and specificity of this aptasensor show great promise for practical applications in protein monitoring and disease diagnosis.

关键词： aptasensor host-guest recognition electrochemiluminescence metallocyclodextrin

Multi-Scale Image Segmentation Model for Fine-Grained Recognition of Zanthoxylum Rust

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Computers, Materials & Continua 2022年第5期71卷 2963-2980页

作者： Fan yang jie Xu Haoliang Wei Meng Ye Mingzhu Xu Qiuru Fu Lingfei Ren Zhengwen Huang School of Information and Communication Engineering University of Electronic Science and Technology of ChinaChengdu611731China College of Forestry Sichuan Agricultural UniversityChengdu611130China Sichuan Zizhou Agricultural Science and Technology Co.Ltd. Mianyang621100China Department of Electronic and Computer Engineering Brunel UniversityUxbridgeMiddlesexUB83PHUnited Kingdom

Zanthoxylum bungeanum Maxim,generally called prickly ash,is widely grown in *** rust is the main disease affecting the growth and quality of *** method for recognizing the degree of infection of Zanthoxylum rust mainly rely on manual *** to the complex colors and shapes of rust areas,the accuracy of manual recognition is low and difficult to be *** recent years,the application of artificial intelligence technology in the agricultural field has gradually *** this paper,based on the DeepLabV2 model,we proposed a Zanthoxylum rust image segmentation model based on the FASPP module and enhanced features of rust *** paper constructed a fine-grained Zanthoxylum rust image *** this dataset,the Zanthoxylum rust image was segmented and labeled according to leaves,spore piles,and brown *** experimental results showed that the Zanthoxylum rust image segmentation method proposed in this paper was *** segmentation accuracy rates of leaves,spore piles and brown lesions reached 99.66%,85.16%and 82.47%*** reached 91.80%,and MIoU reached 84.99%.At the same time,the proposed image segmentation model also had good efficiency,which can process 22 images per *** article provides an intelligent method for efficiently and accurately recognizing the degree of infection of Zanthoxylum rust.

关键词： Zanthoxylum rust image segmentation deep learning

Conditional gene manipulation:Cre-ating a new biological era

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第7期13卷 511-524页

作者： Jian ZHANG Jing ZHAO Wen-jie JIANG Xi-wei SHAN Xiao-mei yang Jian-gang GAO School of Life Science Shandong University Jinan 250100China

To solve the problem of embryonic lethality in conventional gene knockouts, site-specific recombinase （SSR） systems （Cre-loxP, FIp-FRT, and φC31） have been used for tissue-specific gene knockout. With the combination of an SSR system and inducible gene expression systems （tetracycline and tamoxifen）, stage-specific knockout and transgenic expression can be achieved. The application of this ＂SSR＋inducible＂ conditional tool to genomic manipulation can be extended in various ways. Alternatives to conditional gene targeting, such as conditional gene trapping, multipurpose conditional alleles, and conditional gene silencing, have been developed. SSR systems can also be used to construct precise disease models with point mutations and chromosomal abnormalities. With these exciting achievements, we are moving towards a new era in which the whole genome can be manipulated as we wish.

关键词： Site-specific recombinase Gene targeting Gene trapping Inducible systems φC31 system

Mesoporous PtPd nanoparticles for ligand-mediated and imaging-guided chemo-photothermal therapy of breast cancer

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Nano Research 2020年第6期13卷 1739-1748页

作者： Yanpeng Jia yang Song Ying Qu Jinrong Peng Kun shi Dan Du He Li Yuehe Lin Zhiyong Qian State Key Laboratory of Biotherapy and Cancer Center West China HospitalSichuan Universityand Collaborative Innovation CenterChengdu610041China College of Optoelectronics Technology Chengdu University of Information TechnologyChengdu610225China School of Mechanical and Material Engineering Washington State UniversityPullmanWA99163USA

The synergistic therapy of chemotherapy and photothermal therapy(PTT)has been reported as a promising antitumor *** achieve effective combination therapy,developing more suitable candidate nanomaterials with optimal photothermal property and high chemical drug loading capacity is very ***,a bimetallic PtPd nanoparticle was synthesized with the merits of excellent photothermal effect and mesoporous structure for doxorubicin(DOX)*** further designed PtPd-ethylene glycol(PEG)-folic acid(FA)-doxorubicin(DOX)nanoparticle for chemo-photothermal therapy of MCF-7 tumor with folic acid engineering to achieve active ***,excellent photoacoustic(PA)imaging of PtPd-PEG-FA-DOX nanoparticles facilitated the precise in vivo tracking and further evaluation of nanoparticles’targeting *** in vitro and in vivo results both demonstrated PtPd-PEG-FA-DOX nanoparticles serve as a safe and promising system for effective treatment of MCF-7 tumor.

关键词： inorganic nanoparticles photoacoustic imaging porous structure photothermal therapy chemotherapy

A novel synthesis of nitroform by the nitrolysis of cucurbituril

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Chinese Chemical Letters 2015年第3期26卷 365-368页

作者： Hong-Yan Lu Jia-Rong Li De-Li yang Qi Zhang Da-Xin shi Chemical Engineering and Environment Beijing Institute of Technology

Cucurbituril has a high symmetry and rigid *** cucurbit[6]uril（CB[6]） was nitrolyzed with the mixed solution of acetic anhydride in fuming nitric acid,nitroform（NF） was *** also can be obtained by the nitration of both CB[5,7,8].This nitration procedure provides a lower risk,inexpensive,new preparation of nitroform,and the reaction condition of this new method is very mild.

关键词： anhydride inexpensive acetic symmetry rigid oligomer supramolecular hexane condensation solubility

Hawking Radiation from Horizons of Reissner-Nordstrm de Sitter Black Hole with a Global Monopole via Anomalies

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Communications in Theoretical Physics 2008年第8期50卷 537-540页

作者： CHEN shi-Wu LIU Xiong-Wei LIN Kai ZENG Xiao-Xiong yang Shu-Zheng Institute of Theoretical Physics China West Normal University Nanchong 637002 China

Hawking radiation from cosmological horizon and event horizon of the Reissner-Nordstrom de Sitter black hole with a global monopole is studied via a new method that was propounded by Robinson and Wilzek and elaborated by Banerjee and Kulkarni. The results show that the gauge current and energy-momentum tensor fluxes, which required keeping gauge covariance and general coordinate invariance at the quantum level in the effective field theory, are exactly equivalent to those of Hawking radiation from the event horizon and the cosmological horizon, respectively.

关键词： covariant anomaly Hawking radiation Reissner-Nordstrom de sitter black hole global monopole

An Expedient Method for Regioselective Methylation of Catechol Coumarins

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Chemical Research in Chinese Universities 2016年第5期32卷 786-791页

作者： LU Junxia WANG Ping HOU jie ZOU Liwei CUI Pan yang Ling GE Guangbo GONG Xiaojie College of Environmental and Chemical Engineering Dalian University Dalian 116622 P. R. China College of Medical Dalian University Dalian 116622 P. R. China Laboratory of Pharmaceutical Resource Discovery Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian 116023 P. R. China College of Basic Medical Sciences Dalian Medical University Dalian 116044 P. R. China

An expedient and efficient method for selective methylation of catechol coumarins by working with different alkalis under appropriate reaction conditions was reported. Esculetins were selectively methylated at position 6 and position 7 in good yields using CH3I in the presence of Nail and Na2CO3, respectively. However, daphnetins showed less regioselectivity under the same reaction conditions. Furthermore, the site preference for the methylation reaction was interpreted by the density functional theory at B3LYP/6-31 ＋G（d） level.

关键词： Catechol coumarin Regioselective methylation Density functional theory

Kinematics and Dynamics Model of GH4169 Alloy for Thermal Deformation

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Journal of Iron and Steel Research International 2010年第7期17卷 75-78页

作者： WANG Zhong-tang ZHANG shi-hong CHENG Ming LI De-fu yang Xiao-hong School of Materials Science and Engineering Shenyang Ligong University Shenyang 110159 Liaoning China Institute of Metal Research Chinese Academy of Sciences Shenyang 110016 Liaoning China General Research Institute for Nonferrous Metals Beijing 100088 China

The stress-strain curves and microstructure properties of superalloy GH4169 was tested by thermal simulation experiment with different parameters,which were deformation temperature and strain rate and strain and original grain *** influence of technology parameters on crystal grain size of dynamic recrystallization（DRC）was *** kinematics model of superalloy GH4169 was established,in which the relation between grain size of dynamic recrystallization and function Z（Zener-Hollomon）and parameters was *** dynamics model of superalloy GH4169 was put forward,which described the relation between the quantity of dynamic recrystallization and function Z and *** research results showed that the grain size of dynamic recrystallization increased with increasing the temperature and decreasing the strain *** the grain size of DRC bore no relationship to original grain *** the quantity of dynamic recrystallization decreased with increasing the original grain size.

关键词： GH4169 superalloy kinematics model dynamics model thermal deformation