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Reduced mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor contributes to neurodegeneration in a model of spinal and bulbar muscular atrophy pathology

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Neural Regeneration Research 2025年第9期20卷 2655-2666页

作者： Yiyang Qin Wenzhen Zhu Tingting guo Yiran Zhang Tingting Xing Peng Yin shihua Li Xiao-Jiang Li Su Yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong–HongKong–Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina

Spinal and bulbar muscular atrophy is a neurodegenerative disease caused by extended CAG trinucleotide repeats in the androgen receptor gene,which encodes a ligand-dependent transcription facto *** mutant androgen receptor protein,characterized by polyglutamine expansion,is prone to misfolding and forms aggregates in both the nucleus and cytoplasm in the brain in spinal and bulbar muscular atrophy *** aggregates alter protein-protein interactions and compromise transcriptional *** this study,we reported that in both cultured N2a cells and mouse brain,mutant androgen receptor with polyglutamine expansion causes reduced expression of mesencephalic astrocyte-de rived neurotrophic *** n of mesencephalic astrocyte-derived neurotrophic factor amelio rated the neurotoxicity of mutant androgen receptor through the inhibition of mutant androgen receptor *** down endogenous mesencephalic astrocyte-derived neurotrophic factor in the mouse brain exacerbated neuronal damage and mutant androgen receptor *** findings suggest that inhibition of mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor is a potential mechanism underlying neurodegeneration in spinal and bulbar muscular atrophy.

关键词： androgen receptor mesencephalic astrocyte-derived neurotrophic factor mouse model neurodegeneration neuronal loss neurotrophic factor polyglutamine disease protein misfolding spinal and bulbar muscular atrophy transcription factor

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Identification of a microRNA switch in spinal commissural axon guidance

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Neural Regeneration Research 2019年第7期14卷 1208-1209页

作者： guo-fa Liu Tao Yang Department of Biological Sciences University of Toledo

The formation of neural circuits is governed by multiple classes of highly conserved extracellular guidance signals such as guidance cues,growth factors,and cell adhesion molecules(Kolodkin and Tessier-Lavigne,2011;Stoeckli et al.,2018).During embryonic development,vertebrate commissural neurons project axons toward the floor plate and cross the midline of the spinal cord,a process relying upon the coordination of attractive and repulsive guidance cues(Kolodkin and Tessier-Lavigne,2011;Stoeckli et al.,2018).

关键词： formation Identification commissural axon guidance

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Measurement-device-independent quantum dialogue

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Chinese Physics B 2021年第10期30卷 132-137页

作者： guo-fang shi School of Science Xi’an University of Posts and TelecommunicationsXi’an 710061China

Recently,measurement-device-independent quantum secure direct communication schemes were proposed by Niu et al.[***.631345(2018)]and Zhou et al.[***.63230362(2020)].Inspired by their ideas,in this paper,a measurement-device-independent quantum dialogue protocol based on entanglement is designed and proven to be *** advantage of this scheme is that it can not only allow two communicators to transmit secret messages between each other,making the application scenarios more extensive,but can also eliminate all the security loopholes related to the measurement device and information *** terms of experimental implementation,the scheme mainly involves the preparation of entangled states,the preparation of single photons,quantum storage,Bell measurement and other technologies,all of which are mature at present,therefore,the scheme is feasible by using current technologies.

关键词： quantum dialogue entanglement state Bell measurement

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Emission characteristics and combustion instabilities in an oxy-fuel swirl-stabilized combustor

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第11期9卷 1582-1589页

作者： guo-neng LI Hao ZHOU Ke-fa CEN State Key Laboratory of Clean Energy Utilization Zhejiang University Hangzhou 310027 China

This paper presents an experimental study on the emission characteristics and combustion instabilities of oxy-fuel combustions in a swirl-stabilized combustor. Different oxygen concentrations (Xoxy=25%～45%, where Xoxy is oxygen concentra- tion by volume), equivalence ratios (φ=0.75～1.15) and combustion powers (CP=1.08～2.02 kW) were investigated in the oxy-fuel (CH4/CO2/O2) combustions, and reference cases (Xoxy=25%～35%, CH4/N2/O2 flames) were covered. The results show that the oxygen concentration in the oxidant stream significantly affects the combustion delay in the oxy-fuel flames, and the equivalence ratio has a slight effect, whereas the combustion power shows no impact. The temperature levels of the oxy-fuel flames inside the combustion chamber are much higher (up to 38.7%) than those of the reference cases. Carbon monoxide was vastly produced when Xoxy>35% or φ>0.95 in the oxy-fuel flames, while no nitric oxide was found in the exhaust gases because no N2 participates in the combustion process. The combustion instability of the oxy-fuel combustion is very different from those of the reference cases with similar oxygen content. Oxy-fuel combustions excite strong oscillations in all cases studied Xoxy=25%～45%. However, no pressure fluctuations were detected in the reference cases when Xoxy>28.6% accomplished by heavily sooting flames which were not found in the oxy-fuel combustions. Spectrum analysis shows that the frequency of dynamic pressure oscillations exhibits randomness in the range of 50～250 Hz, therefore resulting in a very small resultant amplitude. Temporal oscillations are very strong with amplitudes larger than 200 Pa, even short time fast Fourier transform (FFT) analysis (0.08 s) shows that the pressure amplitude can be larger than 40 Pa.

关键词： Swirl Oxy-fuel Combustion instability Pollutant emissions

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Influence of N/C ratio on microstructure and properties of new highstrength weathering steels

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Journal of Iron and Steel Research International 2019年第1期26卷 84-90页

作者： Jian Cheng Yue-hua guo Hou-fa Shen The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina Key Laboratory for Advanced Materials Processing Technology School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China Pangang Group Research Institute Co. Ltd.State Key Laboratory of Vanadium and Titanium Comprehensive UtilizationPanzhihua 617000SichuanChina

Influence of the N/C ratio on the microstructure and properties of new-generation high-strength weathering steels was investigated using calculation of phase diagram(CALPHAD)and *** microstructures of weathering steels containing different N/C ratios were predicted by a CALPHAD approach,and only three phases were predicted in these steels within the rolling temperature range of 850-1050℃.The precipitation fraction of VN/V(C,N)in creases with increasing N/C *** of the four tested steels were all experimentally determined to contain bainite,ferrite,and VN precipitates after air cooling to room *** bainite fraction increases with in creasing N/C ratio,and it is 85%in the steel containing 0.038% N and 0.032% C,The results of the tensile tests and impact tests demonstrated that the yield strength and tensile strength of the steel containing 0.038%N and 0.032%C are greater than 550 and 650 MPa,respectively,and the elongation is greater than 24%,which satisfies the design objectives for mechanical *** impact toughness values of the four steels at 0,-20,and-40℃ are all greater than 24 *** increasing N/C ratio,the bainite fraction and the precipitation fraction of VN/V(C,N)increase,resulting in increasing yield strength and tensile strength.

关键词： CALPHAD Weathering steel Tensile test-Impact test Microstructure

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A Note on Homoclinic or Heteroclinic Orbits for the Generalized Hénon Map

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Acta Mathematicae Applicatae Sinica 2016年第2期32卷 283-288页

作者： Yong-guo shi College of Mathematics and Information Science Xinyang Normal UniversityXinyang 464000China Key Laboratory of Numerical Simulation of Sichuan Province College of Mathematics and Information ScienceNeijiang Normal UniversityNeijiang 641112China

An important problem in a given dynamical system is to determine the existence of a homoclinic orbit. We improve the results of Qin and Xiao [Nonlinearity, 20 （2007）, 2305-2317], who present some sufficient conditions for the existence of a homoclinic/heteroclinic orbit for the generalized H@non map. Moreover, an algorithm is presented to locate these homoclinic orbits.

关键词： reversible planar map homoclinic orbit heteroclinic orbit generalized Henon map

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MoS2 synaptic transistor with one-step manufacture

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Science China(Information Sciences) 2025年第1期68卷 357-365页

作者： Yihao guo Yang WANG Wenjie DENG Yi WU Jingtao LI Kexin LI Yuehui ZHAO Songlin YU Xiaoting WANG Yongzhe ZHANG Hui YAN Key Laboratory of Optoelectronics Technology of Education Ministry of China Faculty of Information TechnologyBeijing University of Technology Key Laboratory of Advanced Functional Materials Ministry of Education Faculty of Materials and ManufacturingBeijing University of Technology The 11th Research Institute of Electronics Technology Group Corporation

The synaptic transistor,which is a neuromorphic device with brain-like functions,has garnered significant attention due to characteristics such as low energy consumption,high integration,multiple functions,and high computational ***,the current synaptic transistor possesses a complicated structure and involves complex manufacturing steps,which is not conducive to low-cost,large-scale bionic ***,we introduce a simple MoS2synaptic transistor exhibiting robust synaptic *** transistor utilizes magnetron sputtering manufacture to combine the process of device metal electrode deposition and the introduction of defect states,which helps streamline the manufacturing process into a single *** long-term potentiation and long-term depression in photoelectric coordination are initially ***,biological functions,such as double pulse facilitation and the transformation behavior of short-term memory to long-term memory,are thoroughly evaluated,along with learning-forgetting-relearning ***,the device exhibits robust synaptic plasticity until incident light angles down to 30° to imitate the multi-to-one axon-cellular ***,a classical simulation of Pavlov's dog conditioned reflex is demonstrated along with the multiview extraction *** experimental results demonstrate a promising synaptic transistor with a simple structure,manufacturing technique,and excellent *** further indicates the potential for large-scale integration of bionic neuromorphic systems.

关键词： process optimization artificial synaptic device one-stepmanufacture synaptic plasticity bionic simulation

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High-performance poly(aromatic pyridine) copolymers with crown ether moieties for high temperature polymer electrolyte membrane fuel cells

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Science China Chemistry 2025年

作者： Qian Wang Songhao Zhao Yunpeng guo Wei Wei Lele Wang Jingshuai Yang Department of Chemistry College of Sciences Northeastern University Institute of Metal Research Chinese Academy of Sciences

This study concentrates on the development of high temperature polymer electrolyte membranes（HT-PEMs）, which are essential components for HT-PEM fuel cells（HT-PEMFCs）. Although the phosphoric acid（PA）-doped polybenzimidazole（PBI） has been regarded as the successful HT-PEM, this system still suffers from several challenges, including the use of carcinogenic monomers, complex synthesis procedures, and poor solubility in organic solvents. To develop more cost-effective, readily synthesized and high-performance alternatives, this study employs a simply superacid-catalyzed Friedel-Crafts reaction to synthesize a series of poly（triphenyl-co-dibenzo-18-crown-6 pyridine） copolymers, denoted as P(TPx%-co-CEy%), using ptriphenyl, dibenzo-18-crown-6 and 4-acetylpyridine as monomers. The copolymerized hydrophilic and bulky crown ether unites introduce large free volumes and multiple interaction sites with PA molecules, as elucidated by theoretical *** microphase separation structures are formed as confirmed by atomic force microscope（AFM）, transmission electron microscopy（TEM） and small-angle X-ray scattering（SAXS）. Thus P(TPx%-co-CEy%) membranes exhibit excellent PA absorption and proton conduction abilities. For example, after immersing in 85 wt% PA at 30 °C, the P(TP91%-co-CE9%) membrane achieves a PA doping content of 205% and a high conductivity of 0.138 S cm-1at 180 °C, while maintaining a tensile strength of 7.5 MPa at room temperature. Without humidification and backpressure, the peak power density of an H2-O2cell equipped with P(TP91%-co-CE9%)/205%PA reaches nearly 1200 mW cm-2, representing one of the highest performances reported for PA-doped HT-PEMs to date. This work demonstrates the enormous potential of poly（triphenyl-co-crown ether pyridine） membranes in the HT-PEMFC applications.

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Transition metaldoping effect and high catalytic activity of CeO_(2)-TiO_(2) for chlorinated VOCs degradation

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Journal of Rare Earths 2022年第5期40卷 745-752,I0003页

作者： Yijun shi Xiaolin guo Zhinan shi Renxian Zhou Institute of Catalysis Zhejiang UniversityHangzhou 310028China College of Materials and Chemistry China Jiliang University Hangzhou 310018China

A series of transition metals(Fe,Co,Ni,Cu,Cr and Mn)-doped CeO_(2)-TiO_(2) catalysts were prepared by the sol-gel method and applied for the catalytic removal of 1,2-dichloroethane(DCE) as a model for chlorinated VOCs(CVOCs).The various characterization methods including X-ray diffraction(XRD),N_(2) adsorption-desorption,UV-Raman,NH_(3) temperature-programmed desorption(NH_(3)-TPD) and H_(2) temperature-programmed reduction(H_(2)-TPR) were utilized to investigate the physicochemical properties of the *** results show that doping Fe,Co,Ni or Mn can obviously promote the activity of CeO_(2)-TiO_(2) mixed oxides for DCE degradation,which is related to their improved texture properties,acid sites(especially for strong acidity) and low-temperature ***,CeTi-Fe doped with moderate Fe exhibits excellent activity for 1,2-dichloroethane(DCE) degradation,giving a T_(90%) value as low as 250℃.More importantly,only trace chlorinated byproducts were produced during the low-temperature degradation of various CVOCs(dichloromethane(DCM),trichloroethylene(TCE) and chlorobenzene(CB)) over CeTi-Fe1/9 catalyst with high durability.

关键词： Transition metals doping CeO_(2)-TiO_(2)mixed oxides CVOCs degradation High activity Excellent durability Rare earths

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Modeling tactile perceived intensity for vibration from a coin eccentric rotating mass motor

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Science China Technological Sciences 2025年

作者： Yun faNG Jingchen HUANG Yujun WU Jiaqi DONG Weichao guo Xinjun SHENG State Key Laboratory of Mechanical System and Vibration School of Mechanical Engineering Shanghai Jiao Tong University Meta Robotics Institute Shanghai Jiao Tong University

Establishing the relationship between vibrotactile parameters and perceived intensity（PI） is of great significance in the regulation of desired sensations, which contribute to haptic interfaces in practical applications. Coin eccentric rotating mass（ERM） motors are routinely utilized due to their lightweight design and efficient ability to evoke strong tactile sensations. By adjusting input voltages, ERMs can yield different stimuli, but the effects of their physical properties on PI remain ***, we developed the physical model of the ERM-skin system and optimized the parameters affecting PI. Moreover, the relationship between stimulus and perception was derived based on Fechner?s law. Three experiments were conducted on fifteen subjects（ten males and five females, aged 24.40 ± 2.87 years） to identify the vibration parameters and corresponding PI to verify the proposed PI model. ERMs in this study were attached to phantom skin/forearm with slim adhesive tape to minimize the interference. Experiment 1 performed vibration calibration with ERM attached to the skin phantom to simulate the actual configuration. Then, the relative and absolute PI of subjects on specific stimuli were acquired in Experiments 2 and *** fitting reliability of the proposed PI model was evaluated on fifteen subjects with R2of 0.73 ± 0.07 and root mean squared error（RMSE） of 1.35 ± 0.28. Overall, the proposed PI model established the quantitative relationship between stimulus parameters（vibration parameters and physical parameters） and subjective PI, which provided theoretical support for ERM optimization and vibrotactile modulation.

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