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Development of a Mengla virus minigenome and comparison of its polymerase complexes with those of other filoviruses

Virologica Sinica 2024年第3期39卷 459-468页

作者： shi-zhe xie Ke Yao Bei Li Cheng Peng Xing-Lou Yang zheng-Li shi State Laboratory of Virology Wuhan Institute of VirologyChinese Academy of SciencesWuhan430071China University of Chinese Academy of Sciences Beijing100049China Yunnan Key Laboratory of Biodiversity Information Kunming Institute of ZoologyChinese Academy of SciencesKunming650201China Hubei Jiangxia Laboratory Wuhan430200China

Ebola virus(EBOV)and Marburg virus(MARV),members of the Filoviridae family,are highly pathogenic and can cause hemorrhagic fevers,significantly impacting human *** are considered reservoirs of these viruses because related filoviruses have been discovered in ***,due to the requirement for maximum containment laboratories when studying infectious viruses,the characterization of bat filoviruses often relies on pseudoviruses and minigenome *** this study,we used RACE technology to sequence the 30-leader and 50-trailer of Mengla virus(MLAV)and constructed a *** to MARV,the transcription activities of the MLAV minigenome are independent of *** further assessed the effects of polymorphisms at the 50 end on MLAV minigenome activity and identified certain mutations that decrease minigenome reporter efficiency,probably due to alterations in the RNA secondary *** reporter activity upon recombination of the 30-leaders and 50-trailers of MLAV,MARV,and EBOV with those of the homologous or heterologous minigenomes was compared and it was found that the polymerase complex and leader and trailer sequences exhibit intrinsic ***,we investigated whether the polymerase complex proteins from EBOV and MARV support MLAV minigenome RNA synthesis and found that the homologous system is more efficient than the heterologous *** efficiently inhibited MLAV as well as EBOV *** summary,this study provides new information on bat filoviruses and the minigenome will be a useful tool for high-throughput antiviral drug screening.

关键词： Bat filovirus Mengla virus(MLAV) Minigenome Replication Antiviral drug screening

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Ecological study of cave nectar bats reveals low risk of direct transmission of bat viruses to humans

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Zoological Research 2022年第4期43卷 514-522页

作者： Kai Zhao Wei Zhang Bei Li shi-zhe xie Fan Yi Ren-Di Jiang Yun Luo Xiang-Yang He Yun-Zhi Zhang zheng-Li shi Li-Biao Zhang Xing-Lou Yang CAS Key Laboratory of Special Pathogens and Biosafety Wuhan Institute of VirologyChinese Academy of SciencesWuhanHubei 430071China University of Chinese Academy of Sciences Beijing 100049China Guangdong Key Laboratory of Animal Conservation and Resource Utilization Guangdong Public Laboratory of Wild Animal Conservation and UtilizationInstitute of ZoologyGuangdong Academy of SciencesGuangzhouGuangdong 510260China School of Public Health Dali UniversityDaliYunnan 671003China

Bats are reservoirs of various *** widely distributed cave nectar bat(Eonycteris spelaea)is known to carry both filoviruses and ***,the potential transmission of theses bat viruses to humans is not fully *** this study,we tracked 16 *** bats in Mengla County,Yunnan Province,China,using miniaturized GPS devices to investigate their movements and potential contact with ***,to determine the prevalence of coronavirus and filovirus infections,we screened for the nucleic acids of the Měnglàvirus(MLAV)and two coronaviruses(GCCDC1-CoV and HKU9-CoV)in anal swab samples taken from bats and for antibodies against these viruses in human serum *** of the serum samples were found to contain antibodies against the bat *** GPS tracking results showed that the bats did not fly during the daytime and rarely flew to residential *** foraging range of individual bats also varied,with a mean cumulative nightly flight distance of 25.50 km and flight speed of up to 57.4 km/*** together,these results suggest that the risk of direct transmission of GCCDC1-CoV,HKU9-CoV,and MLAV from *** bats to humans is very low under natural conditions.

关键词： Bats Eonycteris spelaea GPS tracking GCCDC1-CoV HKU9-CoV Měnglàvirus

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QoE oriented intelligent online learning evaluation technology in B5G scenario

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Digital Communications and Networks 2024年第1期10卷 7-15页

作者： Mingzi Chen Xin Wei Peizhong xie zhe Zhang School of Communications and Information Engineering Nanjing University of Posts and TelecommunicationsNanjing210003China Key Lab of Broadband Wireless Communication and Sensor Network Technology(Nanjing University of Posts and Telecommunications) Ministry of EducationNanjing210003China Institute of Higher Education Nanjing University of Posts and TelecommunicationsNanjing210003China

Students'demand for online learning has exploded during the post-COvID-19 pandemic ***,due to their poor learning experience,students'dropout rate and learning performance of online learning are not always *** technical advantages of Beyond Fifth Generation(B5G)can guarantee a good multimedia Quality of Experience(QoE).As a special case of multimedia services,online learning takes into account both the usability of the service and the cognitive development of the *** that affect the Quality of Online Learning Experience(OL-QoE)become more *** get over this dilemma,we propose a systematic scheme by integrating big data,Machine Learning(ML)technologies,and educational psychology ***,we first formulate a general definition of OL-QoE by data analysis and experimental *** formula considers both the subjective and objective factors(i.e.,video watching ratio and test scores)that most affect ***,we induce an extended layer to the classic Broad Learning System(BLS)to construct an Extended Broad Learning System(EBLS)for the students'OL-QoE *** the extended layer can increase the width of the BLS model and reduce the redundant nodes of BLS,the proposed EBLS can achieve a trade-off between the prediction accuracy and computation ***,we provide a series of early intervention suggestions for different types of students according to their predicted OL-QoE *** timely interventions,their OL-QoE and learning performance can be *** results verify the effectiveness oftheproposed scheme.

关键词： B5G Online learning Quality of experience

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Fish ACE2 is not susceptible to SARS-CoV-2

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Virologica Sinica 2022年第1期37卷 142-144页

作者： shi-zhe xie Mei-Qin Liu Ren-Di Jiang Hao-Feng Lin Wei Zhang Bei Li Jia Su Fei Ke Qi-Ya Zhang zheng-Li shi Xing-Lou Yang CAS Key Laboratory of Special Pathogens Wuhan Institute of VirologyChinese Academy of SciencesWuhan430071China University of Chinese Academy of Sciences Beijing100049China State Key Laboratory of Freshwater Ecology and Biotechnology Institute of HydrobiologyChinese Academy of SciencesWuhan430072China

Dear Editor,The ongoing pandemic of coronavirus disease 2019(COVID-19)has reshaped our daily life and caused>4 million deaths worldwide(https://***/).Although lockdown and vaccination have improved the situation in many countries,imported cases and sporadic outbreaks pose a constant stress to the prevention and control of COVID-19.

关键词： ACE2 prevention vaccination

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Influence characteristics of water penetration on fibre-reinforced polymer/rigid polyurethane foam interface of the composite cross-arm considering natural ageing

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High Voltage 2024年第1期9卷 81-93页

作者： Jun xie zhe Zhou Ziqian Liu Haonan Tian Sigang Zhang Qing xie Hebei Provincial Key Laboratory of Power Transmission Equipment Security Defense North China Electric Power UniversityBaodingChina State Grid Gansu Electric Power Company LanzhouChina

Fibre-reinforced polymer(FRP)/rigid polyurethane foam(RPUF)interface is susceptible to moisture intrusion in addition to natural ageing during *** study investigated the influence of moisture intrusion on the FRP/RPUF interface under natural ageing using experiments and molecular dynamics(MD)*** absorption,shear strength,and leakage current tests were used to clarify the changes in the interface *** degradation mechanism of moisture intrusion at the interface under natural ageing was revealed by MD simulation and *** results show that the natural ageing of interfacial materials will slightly reduce the quality of the interface but will reduce the water resistance of the material and promote the process of water intrusion into the *** addition,water mainly invades the interface through *** water penetration,the interfacial bonding strength and insulation performance significantly *** and hydrolysis of interfacial materials are the main reasons for decreased interfacial *** can cause irreversible damage to the interface,increasing interface defects and water *** vicious cycle of material hydrolysis is the ultimate cause of interfacial *** polar molecules produced by this process and the water absorbed by the interface caused the degradation of the interface insulation performance.

关键词： interface polyurethane interfacial

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Waking Up Brain with Electrical Stimulation to Boost Memory in Sleep:A Neuroscience Exploration

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Neuroscience Bulletin 2024年第6期40卷 852-854页

作者： zhe Zhong Fuling Yan Chunming xie Department of Neurology School of MedicineAffiliated Zhongda HospitalSoutheast UniversityNanjing210009China Institute of Neuropsychiatry Affiliated Zhongda HospitalSoutheast UniversityNanjing210009China The Key Laboratory of Developmental Genes and Human Disease Southeast UniversityNanjing210009China

Imagine that,in the future,you could enhance your memory by applying a mild electric current to your brain during *** might sound like science fiction,but it is based on cutting-edge neuroscience *** is widely recognized as a crucial factor for long-term memory consolidation,but the exact mechanisms by which the brain coordinates neural activity across different regions during sleep to reorganize and integrate memories are unknown[1,2].

关键词： Sleep integrate applying

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Robust AUC maximization for classification with pairwise confidence comparisons

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Frontiers of Computer Science 2024年第4期18卷 73-83页

作者： Haochen shi Mingkun xie Shengjun HUANG College of Computer Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 211106China College of Electronic and Information Engineering Nanjing University of Aeronautics and AstronauticsNanjing 211106China MIIT Key Laboratory of Pattern Analysis and Machine Intelligence Nanjing 211106China

Supervised learning often requires a large number of labeled examples,which has become a critical bottleneck in the case that manual annotating the class labels is *** mitigate this issue,a new framework called pairwise comparison(Pcomp)classification is proposed to allow training examples only weakly annotated with pairwise comparison,i.e.,which one of two examples is more likely to be *** previous study solves Pcomp problems by minimizing the classification error,which may lead to less robust model due to its sensitivity to class *** this paper,we propose a robust learning framework for Pcomp data along with a pairwise surrogate loss called *** provides an unbiased estimator to equivalently maximize AUC without accessing the precise class ***,we prove the consistency with respect to AUC and further provide the estimation error bound for the proposed *** studies on multiple datasets validate the effectiveness of the proposed method.

关键词： method. pairwise weakly

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Observation of transition from superfluorescence to polariton condensation in CsPbBr3 quantum dots film

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Light(Science & Applications) 2024年第2期13卷 316-324页

作者： Danqun Mao Linqi Chen zheng Sun Min Zhang zhe-Yu shi Yongsheng Hu Long Zhang Jian Wu Hongxing Dong Wei xie Hongxing Xu State Key Laboratory of Precision Spectroscopy East China Normal UniversityShanghai 200241China Key Laboratory of Materials for High-Power Laser Shanghai Institute of Optics and Fine MechanicsChinese Academy of Sciences201800 ShanghaiChina Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuanShanxi 030006China Chongqing Key Laboratory of Precision Optics Chongqing Institute of East China Normal UniversityChongqing 401121China CAS Center for Excellence in Ultraintense Laser Science Shanghai 201800China School of Physics and Technology Center for Nanoscience and NanotechnologyWuhan UniversityWuhan 430072China

The superfluorescence effect has received extensive attention due to the many-body physics of quantum correlation in dipole gas and the optical applications of ultrafast bright radiation field based on the cooperative quantum ***,we demonstrate not only to observe the superfluorescence effect but also to control the cooperative state of the excitons ensemble by externally applying a regulatory dimension of coupling light fields.A new quasi-particle called cooperative exciton-polariton is revealed in a light-matter hybrid structure of a perovskite quantum dot thin film spin-coated on a Distributed Bragg *** the nonlinear threshold,polaritonic condensation occurs at a nonzero momentum state on the lower polariton branch owning to the vital role of the synchronized *** phase transition from superfluorescence to polariton condensation exhibits typical signatures of a decrease of the linewidth,an increase of the macroscopic coherence as well as an accelerated radiation decay *** findings are promising for opening new potential applications for super-brightness and unconventional coherent light sources and could enable the exploitation of cooperative effects for quantum optics.

关键词： quantum condensation polar

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Optimal Coordination of Transportable Power Sources and Repair Crews for Service Restoration of Distribution Networks Considering Uncertainty of Traffic Congestion

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Journal of Modern Power Systems and Clean Energy 2024年第1期12卷 189-201页

作者： Zhao shi Yan Xu Dunjian xie shiwei xie Amer M.Y.M.Ghias Nanyang Technological University Singapore the School of Electrical Engineering and Automation Fuzhou UniversityFuzhou 350108China

This paper proposes a new method for service restoration of distribution network with the support of transportable power sources(TPSs)and repair crews(RCs).Firstly,a coupling model of distribution networks and vehicle routing of TPSs and RCs is proposed,where the TPSs serve as emergency power supply sources,and the RCs are used to repair the faulted *** the uncertainty of traffic congestion,the probability distribution of the travel time spent on each road is derived based on the Nesterov user equilibrium model,and a two-stage stochastic program is formulated to determine the optimal routings of TPSs and *** efficiently solve the proposed stochastic mixed-integer linear program(MILP),a two-phase scenario reduction method is then developed to scale down the problem size,and an adaptive progressive hedging algorithm is used for an efficient *** effectiveness of the proposed methods and algorithms has been illustrated in a modified IEEE 33-bus system.

关键词： Service restoration distribution network traffic uncertainty transportable power source repair crew stochastic program

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Experimental and numerical study on protective effect of RC blast wall against air shock wave

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Defence Technology（防务技术） 2024年第1期31卷 567-579页

作者： Xin-zhe Nian Quan-min xie Xin-li Kong Ying-kang Yao Kui Huang State Key Laboratory of Precision Blasting Jianghan UniversityWuhan430056China Hubei Key Laboratory of Blasting Engineering Jianghan UniversityWuhan430056China Hubei(Wuhan)Institute of Explosion and Blasting Technology Jianghan UniversityWuhan430056China College of Defense Engineering Army Engineering University of PLANanjing210007China Institute of Defense Engineering AMSPLALuoyang471023China

Prototype experiments were carried out on the explosion-proof performance of the RC blast *** mass of TNT detonated in the experiments is 5 kg and 20 kg *** shock wave overpressure was tested in different *** above experiments were numerically simulated,and the simulated shock wave overpressure waveforms were compared with that tested and given by CONWEP *** results show that the numerically simulated waveform is slightly different from the test waveform,but similar to CONWEP *** dimensional analysis and numerical simulation under different working conditions,the equation for the attenuation rate of the diffraction overpressure behind the blast wall was *** to the corresponding standards,the degree of casualties and the damage degree of the brick concrete building at a certain distance behind the wall can be determined when parameters are *** above results can provide a reference for the design and construction of the reinforced concrete blast wall.

关键词： Blast wall Shock wave Diffraction Overpressure Protection

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