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Effectiveness of Histopathological Examination of Ultrasound-guided Puncture Biopsy Samples for Diagnosis of Extrapulmonary Tuberculosis

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Biomedical and Environmental Sciences 2024年第2期37卷 170-177页

作者： GU Wen Fei shi Xia MA Xin yu Jun Lei XU Jin Chuan QIAN cheng cheng HU Zhi Dong ZHANG Hui Shanghai Public Health Clinical Center Fudan UniversityShanghai 201508China School of Laboratory Medicine and Life Science Wenzhou Medical UniversityWenzhou 325000ZhejiangChina Department of Laboratory Medicine Zhejiang Putuo HospitalZhoushan 316100ZhejiangChina Zhongshan Hospital Fudan UniversityShanghai 200032China

Objective To evaluate the diagnostic value of histopathological examination of ultrasound-guided puncture biopsy samples in extrapulmonary tuberculosis(EPTB).Methods This study was conducted at the Shanghai Public Health Clinical Center.A total of 115patients underwent ultrasound-guided puncture biopsy,followed by MGIT 960 culture(culture),smear,Gene Xpert MTB/RIF(Xpert),and histopathological *** assays were performed to evaluate their effectiveness in diagnosing EPTB in comparison to two different diagnostic criteria:liquid culture and composite reference standard(CRS).Results When CRS was used as the reference standard,the sensitivity and specificity of culture,smear,Xpert,and histopathological examination were(44.83%,89.29%),(51.72%,89.29%),(70.11%,96.43%),and(85.06%,82.14%),*** on liquid culture tests,the sensitivity and specificity of smear,Xpert,and pathological examination were(66.67%,72.60%),(83.33%,63.01%),and(92.86%,45.21%),*** examination showed the highest sensitivity but lowest ***,we found that the combination of Xpert and histopathological examination showed a sensitivity of 90.80%and a specificity of 89.29%.Conclusion Ultrasound-guided puncture sampling is safe and effective for the diagnosis of *** with culture,smear,and Xpert,histopathological examination showed higher sensitivity but lower *** combination of histopathology with Xpert showed the best performance characteristics.

关键词： Extrapulmonary tuberculosis Diagnosis Biopsy Histopathological examination Puncture samples

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Quantifying structural distortion manipulation for desired perovskite phase:PartⅠ.Paradigm demonstration in tungsten oxides

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Journal of Materiomics 2024年第2期10卷 293-303页

作者： cheng Fang Hong Wang Siqi shi State Key Laboratory of Green Building Materials China Building Materials AcademyBeijing100024China Beijing Key Laboratory of Solar Energy and Building Energy-saving Glass Materials Processing Technology China Building Materials AcademyBeijing100024China Materials Genome Initiative Center Shanghai Jiao Tong UniversityShanghai200240China School of Materials Science and Engineering Shanghai Jiao Tong UniversityShanghai200240China School of Materials Science and Engineering Shanghai UniversityShanghai200444China Materials Genome Institute Shanghai UniversityShanghai200444China

Slight distortions can cause dramatic changes in the properties of crystalline perovskite materials and their *** to the numerous types of distortions and unclarified distortion-structure relations,a quantitative distortion manipulation for the desired crystalline phase of perovskite materials suitable for various application remains ***,by establishing parameter sets to systematically describe the types,magnitudes and positional relations involved in distortions,we are able to interpret the structural regulations and manipulation strategies in 7 reported crystal *** the con-struction of distortion-phase-property functional curves,we further propose a paradigm to quantify the structural distortion manipulation for desired perovskite *** the example of perovskite-like tungsten oxides,we successfully quantify their volume shrinkage and symmetry increase during *** work verifies that the complicated research and development of perovskite materials can be simplified into a mathematical problem solving process,which will inspire researchers with different backgrounds to participate,especially mathematicians and computer scientists.

关键词： Distortion manipulation Distortion-phase-property function Coordination polyhedron Tungsten oxide Perovskite

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Pressure transient characteristics of non-uniform conductivity fractured wells in viscoelasticity polymer flooding based on oil-water two-phase flow

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Petroleum Science 2024年第1期21卷 343-351页

作者： Yang Wang Jia Zhang shi-Long Yang Ze-Xuan Xu shi-Qing cheng National Key Laboratory of Petroleum Resources and Engineering China University of Petroleum(Beijing)Beijing102249China

Polymer flooding in fractured wells has been extensively applied in oilfields to enhance oil *** contrast to water,polymer solution exhibits non-Newtonian and nonlinear behavior such as effects of shear thinning and shear thickening,polymer convection,diffusion,adsorption retention,inaccessible pore volume and reduced effective ***,the flux density and fracture conductivity along the hydraulic fracture are generally non-uniform due to the effects of pressure distribution,formation damage,and proppant *** this paper,we present an oil-water two-phase flow model that captures these complex non-Newtonian and nonlinear behavior,and non-uniform fracture characteristics in fractured polymer *** hydraulic fracture is firstly divided into two parts:high-conductivity fracture near the wellbore and low-conductivity fracture in the far-wellbore section.A hybrid grid system,including perpendicular bisection(PEBI)and Cartesian grid,is applied to discrete the partial differential flow equations,and the local grid refinement method is applied in the near-wellbore region to accurately calculate the pressure distribution and shear rate of polymer *** combination of polymer behavior characterizations and numerical flow simulations are applied,resulting in the calculation for the distribution of water saturation,polymer concentration and reservoir *** with the polymer flooding well with uniform fracture conductivity,this non-uniform fracture conductivity model exhibits the larger pressure difference,and the shorter bilinear flow period due to the decrease of fracture flow ability in the far-wellbore *** field case of the fall-off test demonstrates that the proposed method characterizes fracture characteristics more accurately,and yields fracture half-lengths that better match engineering reality,enabling a quantitative segmented characterization of the near-wellbore section with high fracture conductivity and th

关键词： Polymer flooding Non-Newtonian fluid Non-uniform fracture conductivity Two-phase flow Pressure transient analysis

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Microstructure recognition of steels by machine learning based on visual attention mechanism

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Journal of Iron and Steel Research International 2024年第4期31卷 909-923页

作者： Xing-yu Chen Lin cheng cheng-yang Hu yu-peng Zhang Kai-ming Wu The State Key Laboratory of Refractories and Metallurgy Hubei Province Key Laboratory of Systems Science on Metallurgical ProcessingInternational Research Institute for Steel TechnologyCollaborative Center on Advanced SteelsWuhan University of Science and TechnologyWuhan 430081HubeiChina Metals Valley and Band(Foshan)Metallic Composite Materials Co. Ltd.Foshan 528000GuangdongChina

U-Net has achieved good performance with the small-scale datasets through skip connections to merge the features of the low-level layers and high-level layers and has been widely utilized in biomedical image segmentation as well as recent microstructure image segregation of the *** representative visual attention mechanism modules,named as squeeze-and-excitation networks,convolutional block attention module,and extended calibration algorithm,were intro-duced into the traditional U-Net architecture to further improve the prediction *** is found that compared with the original U-Net architecture,the evaluation index of the improved U-Net architecture has been significantly improved for the microstructure segmentation of the steels with the ferrite/martensite composite microstructure and pearlite/ferrite composite microstructure and the complex martensite/austenite island/bainite microstructure,which demonstrates the advantages of the utilization of the visual attention mechanism in the microstructure *** reasons for the accuracy improvement were discussed based on the feature maps analysis.

关键词： Microstructure recognition-Steel Machine learning Visual attention mechanism Visualization

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Science Letters:Proteomic analysis of differentially expressed proteins in mice with concanavalin A-induced hepatitis

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第3期11卷 221-226页

作者： Xu-fei TAN Feng CHEN Shan-shan WU yu shi Dong-cheng LIU Zhi CHEN State Key Laboratory for Diagnosis and Treatment of lnfectious Diseases the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China

Objective： To find new protein biomarkers for the detection and evaluation of liver injury and to analyze the relationship between such proteins and disease progression in concanavalin A （Con A）-induced hepatitis. Methods： Twenty-five mice were randomly divided into five groups： an untreated group, a control group injected with phosphate buffered saline （PBS）, and groups with Con A-induced hepatitis evaluated at 1, 3 and 6 h. Two-dimensional gel electrophoresis （2-DE） and mass spectrometry （MS） were used to identify differences in protein expression among groups. Quantitative real-time polymerase chain reaction （qRT-PCR） was performed to verify the results. Results： In mice with Con A-induced hepatitis, expression levels of four proteins were increased： RIKEN, fructose bisphosphatase 1 （fbp1）, ketohexokinase （khk）, and Chain A of class pi glutathione S-transferase. Changes in fbpl and khk were confirmed by qRT-PCR. Conclusion： Levels of two proteins, fbp1 and khk, are clearly up-regulated in mice with Con A-induced hepatitis.

关键词： Concanavalin A (Con A) Liver injury Protein Two-dimensional electrophoresis (2-DE)

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A semi-analytical pressure and rate transient analysis model for inner boundary and propped fractures exhibiting dynamic behavior under long-term production conditions

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Petroleum Science 2024年第4期21卷 2520-2535页

作者： Lin-Song cheng Chong Cao Quan-yu Pan Pin Jia Ren-Yi Cao Zhi-Kai Wang Jun-Jie shi College of Petroleum Engineering China University of Petroleum (Beijing) Sinopec Petroleum Exploration and Production Research Institute CNOOC Research Institute State Key Laboratory of Water Resources Protection and Utilization in Coal Mining

The loss of hydrocarbon production caused by the dynamic behavior of the inner boundary and propped fractures under long-term production conditions has been widely reported in recent studies. However,the quantitative relationships for the variations of the inner boundary and propped fractures have not been determined and incorporated in the semi-analytical models for the pressure and rate transient analysis. This work focuses on describing the variations of the inner boundary and propped fractures and capturing the typical characteristics from the pressure transient curves.A generalized semi-analytical model was developed to characterize the dynamic behavior of the inner boundary and propped fractures under long-term production conditions. The pressure-dependent length shrinkage coefficients, which quantify the length changes of the inner zone and propped fractures, are modified and incorporated into this multi-zone semi-analytical model. With simultaneous numerical iterations and numerical inversions in Laplace and real-time space, the transient solutions to pressure and rate behavior are determined in just a few seconds. The dynamic behavior of the inner boundary and propped fractures on transient pressure curves is divided into five periods: fracture bilinear flow(FR1),dynamic PFs flow(FR2), inner-area linear flow(FR3), dynamic inner boundary flow(FR4), and outer-area dominated linear flow(FR5). The early hump during FR2 period and a positive upward shift during FR4period are captured on the log-log pressure transient curves, reflecting the dynamic behavior of the inner boundary and propped fractures during the long-term production *** transient pressure behavior will exhibit greater positive upward trend and the flow rate will be lower with the shrinkage of the inner boundary. The pressure derivative curve will be upward earlier as the inner boundary shrinks more rapidly. The lower permeability caused by the closure of un-propped fractures in the inner zo

关键词： Semi-analytical model Length shrinkage Dynamic behavior Boundary changes Transient behavior

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Contrasting strategies of optimizing carrier concentration in bulk InSe for enhanced thermoelectric performance

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Rare Metals 2024年第9期43卷 4425-4432页

作者： Hao-Nan shi Shu-Lin Bai yu-Ping Wang Li-Zhong Su Qian Cao cheng Chang Li-Dong Zhao School of Materials Science and Engineering Beihang UniversityBeijing 100191China School of Materials Science and Engineering Taiyuan University of Science and TechnologyTaiyuan 030024China Huabei Cooling Device Co.Ltd. Hebei 065400China

Indium selenide(InSe),as a wide-bandgap semiconductor,has received extensive attention in the flexible electronics field in recent years due to its exceptional plasticity and promising thermoelectric ***,the low carrier concentration severely limits its thermoelectric performance *** this work,we conducted contrasting strategies that can be employed to increase the carrier concentration of InSe,including bandgap narrowing and heterovalent ***,the carrier concentration initially increases as a result of the reduced bandgap upon Te alloying and then slightly decreases due to the weak electronegativity of *** Br doping realizes high carrier concentration by pushing the Fermi level into the conduction bands and activating the multiple *** the other hand,both Te and Br obviously suppress the thermal conductivity due to the point defect *** contrast,Br doping realizes a higher thermoelectric performance with a maximum ZT of~0.13 at 773 K benefiting from the better optimization of carrier *** work elucidates the strategies for enhancing carrier concentration at anion sites and demonstrates the high efficiency of halogen doping in ***,the carrier concentration of InSe is promising to be further optimized,and future work should focus on employing approaches such as cation doping or secondphase compositing.

关键词： Thermoelectric InSe Carrier concentration Bandgap Heterovalent doping

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分位数回归模型在公共卫生领域中的应用及SAS实现

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环境卫生学杂志 2024年第1期14卷 8-12,35页

作者：张紫琦王爱玲屈水令王潇滟于石成潘晓平中国疾病预防控制中心妇幼保健中心北京100081 中国疾病预防控制中心

目的探讨分位数回归模型在公共卫生领域中应用及SAS实现,为该方法推广使用提供参考。方法在介绍分位数回归模型基本概念基础上,介绍了分位数回归模型应用情景与优势,并以血清克拉拉细胞蛋白水平和第一秒用力呼气容积/用力肺活量(FEV1/F... 详细信息

目的探讨分位数回归模型在公共卫生领域中应用及SAS实现,为该方法推广使用提供参考。方法在介绍分位数回归模型基本概念基础上,介绍了分位数回归模型应用情景与优势,并以血清克拉拉细胞蛋白水平和第一秒用力呼气容积/用力肺活量(FEV1/FVC)变化数据为例,与简单线性回归模型相比,探讨分位数回归模型应用及SAS实现过程。结果分位数回归模型不仅可以分析血清克拉拉细胞蛋白水平对FEV1/FVC均值的影响,还可以分析血清克拉拉细胞蛋白水平对FEV1/FVC不同分位数的影响,得到更全面的信息,且通过统计软件SAS可方便实现。结论分位数回归模型可弥补简单线性回归模型仅关注应变量均值特征而不能分析其完整分布特征的不足,SAS软件提供了相对成熟的分析语句,值得推广。

关键词：分位数回归分布特征公共卫生 SAS

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Photocatalytic vinyl radical-mediated multicomponent 1,4-/1,8-carboimination across alkynes and olefins/(hetero)arenes

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Science China Chemistry 2024年第2期67卷 558-567页

作者： Shan-Shan Li yu-shi Jiang Xue-Ling Luo Xuming Ran yuqiang Li Dong Wu cheng-Xue Pan Peng-Ju Xia School of Chemistry and Pharmaceutical Sciences Guangxi Normal UniversityGuilin541004China Shanghai Artificial Intelligence Laboratory Shanghai200433China The Institute for Advanced Studies Wuhan UniversityWuhan430064China

We developed a highly selective and efficient multicomponent transformation by utilizing alkynes and olefins/(hetero)arenes through photoinduced energy-transfer *** reaction involves the formation of three distinct chemical bonds,namely C(sp~3)–C(sp~2),C(sp~2)–C(sp~3),and C(sp~3)–N,in a single coordinated *** strategy used a vinyl radical-mediated radical relay approach under mild conditions,exhibiting a broad substrate scope(>70 examples),excellent functional-group tolerance,and remarkable regio-and *** the utilization of a combination of experimental techniques and density functional theory(DFT),we delved deeper into the mechanistic intricacies of this distinctive *** revealed that the selective radical addition to electron-deficient alkynes,rather than olefins,was governed by the inherent reactivity of alkyl *** discovery presented a highly effective approach for the synthesis of stereodefined multisubstituted alkenes.

关键词： alkyne-olefin coupling DFT studies regio-and anti-stereoselectivity multisubstituted alkenes

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Preclinical evaluation on ^(125)I-BMIPP

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Nuclear Science and Techniques 2003年第4期14卷 257-260页

作者： LU Chun-Xiong, WU Chun-Ying, JI Shu-Ren, DING shi-yu, cheng Zheng-Ping (State Key Laboratory of Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063) Jiangsu Institute of Nuclear Medicine State Key Laboratory of Nuclear Medicine Wuxi 214063

The biodistribution of 125I-BMIPP and the variation of myocardial uptake of 125I-BMIPP using themetabolic intervention drug were reported. Myocardial uptake of the 125I-BMIPP in rats showed a peak of 5.70ID%/gat 2 min. The ratios of myocardium to blood, to liver and to lung at 30 min were 3.40, 2.64 and 2.88 respectively. Theinitial elimination half time of 4.0 min in rabbits was in accordance with the half elimination time of free fatty acidfrom blood. Myocardial uptake of 125I-BMIPP in the group of glucose-insulin was significantly increased (p＜0.05)than those of the normal control. In vivo and in vitro binding test for 125I-BMIPP to HSA showed a rather constantlevel of activation up to 2 h. Partition coefficients (lgP) were 1.93 and 1.68, respectively.

关键词：碘脂肪酸葡萄糖心肌新陈代谢作用

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