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Impacts of angiotensin II on retinal artery changes in apolipoprotein E deficient mice

International Journal of Ophthalmology(English edition) 2024年第1期17卷 16-24页

作者： Li-Hui Meng shi-yu cheng He Chen yue-Lin Wang Wen-Fei Zhang Huan Chen Xin-yu Zhao You-Xin Chen Department of Ophthalmology Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100730China Key Lab of Ocular Fundus Diseases Chinese Academy of Medical SciencesBeijing 100730China

AIM:To investigate the impacts of angiotensin II(Ang II)on retinal artery changes in apolipoprotein E deficient(apoE^(-/-))***:ApoE^(-/-)male mice were infused by minipumps with Ang II at 1000 ng/kg·min(Ang II group)or saline(control group)for *** were underwent ophthalmic fundus examination on day 0,14,and 28 of *** examination,ribonucleic acid(RNA)sequencing and local Ang II measurement of retinas were ***:Ophthalmic fundus examination showed Ang II infusion promoted the formation of retinal arterial aneurysm-like lesions on day *** coherence tomography revealed the ganglion cell and inner plexiform layer(GCIPL)thickness in the control group was significantly thinner than that in Ang II group(P<0.001).Hematoxylin-eosin staining demonstrated diffused swelling of GCIPL layer and its disordered structure in Ang II *** electron microscopy showed Ang II infusion caused aggravation of atherosclerotic lesions,including increased swelling,roughness,disorganization of the retinal vasculature,and vacuoles ***-sequencing and gene ontology enrichment analysis demonstrated that the structure and function of cellular membrane might be disturbed and visual function might be compromised by Ang *** local level of Ang II was higher in Ang II infusion group but did not show significant differences compared to the control group(P=0.086).CONCLUSION:Ang II infusion promotes the formation of retinal arterial aneurysm-like lesions in apoE^(-/-)mice,causing aggravation of atherosclerotic lesions,more severe disorganization of the retinal vasculature and disturbance of the cellular membrane.

关键词： angiotensin II retinal artery aneurysm apoE^(-/-)mice

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特应性皮炎伴双眼视网膜脱离及视网膜血管炎1例

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Chinese Medical Sciences Journal 2024年第1期39卷 74-78,I0008页

作者：程世瑜王造文戴荣平中国医学科学院北京协和医学院北京协和医院眼科北京100730 中国医学科学院北京协和医学院眼底病重点实验室北京100730

特应性皮炎可伴有多种眼部并发症,如结膜炎、角膜炎、白内障和视网膜脱离等。我们报道了1例因双眼视网膜脱离及白内障就诊于眼科的21岁中国男性患者。该患者8年前诊断为特应性皮炎,并接受氯雷他定和吡美莫司治疗。我们为该患者进行了双... 详细信息

特应性皮炎可伴有多种眼部并发症,如结膜炎、角膜炎、白内障和视网膜脱离等。我们报道了1例因双眼视网膜脱离及白内障就诊于眼科的21岁中国男性患者。该患者8年前诊断为特应性皮炎,并接受氯雷他定和吡美莫司治疗。我们为该患者进行了双眼白内障摘除术、右眼巩膜外加压术,以及左眼玻璃体切除及硅油填充术。术后随访期间,患者的特应性皮炎加重,眼底荧光素血管造影结果显示双眼视网膜血管广泛渗漏和左眼黄斑水肿。随后患者至皮肤科接受4个月规律的度普利尤单抗治疗,左眼黄斑水肿好转,术后3年眼部情况一直保持稳定。

关键词：特应性皮炎视网膜脱离视网膜血管炎

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血清CA19-9、MUC5AC、Exo-EphA2在胰腺癌与肿块型胰腺炎中的临床意义

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承德医学院学报 2024年第3期41卷 203-206页

作者：施玉成张旭营周口市中心医院检验科河南周口466000

目的分析血清CA19-9、黏蛋白5AC(MUC5AC)、外泌EphrinA型受体2(Exo-EphA2)对胰腺癌与肿块型胰腺炎的鉴别诊断价值及与影像学病理特征的相关性。方法选取2022年1月~2023年6月于周口市中心医院就诊的82例胰腺癌患者作为观察组,选择同期41... 详细信息

目的分析血清CA19-9、黏蛋白5AC(MUC5AC)、外泌EphrinA型受体2(Exo-EphA2)对胰腺癌与肿块型胰腺炎的鉴别诊断价值及与影像学病理特征的相关性。方法选取2022年1月~2023年6月于周口市中心医院就诊的82例胰腺癌患者作为观察组,选择同期41例肿块性胰腺炎患者作为对照组,比较2组及不同病理参数血清CA19-9、MUC5AC、Exo-EphA2水平,对其诊断价值进行分析,并进一步分析相关性。结果研究组血清CA19-9、MUC5AC、Exo-EphA2水平较对照组明显增加(P<0.05);不同病理学参数胰腺癌患者血清CA19-9、MUC5AC、Exo-EphA2水平比较:低分化高于中高分化,Ⅰ~Ⅱ期低于Ⅲ~Ⅳ期,有远处转移高于无远处转移(P<0.05);CA19-9、MUC5AC、Exo-EphA2水平与远处转移、TNM分期呈正相关,与分化程度呈负相关(P<0.05);血清CA19-9、MUC5AC、Exo-EphA2水平联合诊断胰腺癌的AUC为0.802,均高于各指标单独诊断。结论血清CA19-9、MUC5AC、Exo-EphA2水平与胰腺癌病理学参数存在一定关系,联合检测可显著提升在胰腺癌、肿块型胰腺癌中的鉴别诊断价值。

关键词： CA19-9 黏蛋白5AC 外泌EphrinA型受体2 胰腺癌

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断点回归方法及应用实现

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环境卫生学杂志 2024年第1期14卷 1-7页

作者：屈水令张悦王琦琦金承刚于石成中国疾病预防控制中心北京102206 辽宁金融职业学院北京师范大学社会发展与公共政策学院

目的完整、系统介绍断点回归设计(RDD)原理及统计方法,为其在公共卫生领域应用提供参考。方法在介绍断点回归设计原理基础上,用室内甲醛干预的实例演示了利用Stata软件实现断点回归统计方法的过程,介绍和比较属于参数法的多项式回归和... 详细信息

目的完整、系统介绍断点回归设计(RDD)原理及统计方法,为其在公共卫生领域应用提供参考。方法在介绍断点回归设计原理基础上,用室内甲醛干预的实例演示了利用Stata软件实现断点回归统计方法的过程,介绍和比较属于参数法的多项式回归和属于非参数法的局部线性回归的分析方法和结果。结果RDD是一种准实验设计,对研究对象没有随机分组,而是选择一个与干预措施有关的变量,根据该变量的取值选择切点划分干预组和对照组。RDD在内部有效性方面优于其他准实验设计,但外部有效性受到一定限制。基于观察性资料的RDD不仅可控制可观测的混杂因素,还可控制无法观测的混杂因素,也更符合伦理道德。在本文实例中,多项式回归和局部线性回归两种分析方法的结果基本一致。结论RDD在公共卫生领域的真实世界研究中有广阔的应用前景,为科学评估干预政策和提供高质量决策依据提供新的思路和方法。

关键词：准实验设计断点回归设计多项式回归局部线性回归效果评估

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Influence of Built Environment in Hygienic City in China on Self-rated Health of Residents

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Biomedical and Environmental Sciences 2022年第12期35卷 1126-1132页

作者： ZHENG Wen Jing QI Xiao YAO Hong Yan LIU Jian Jun yu shi cheng ZHANG Tao Office of Epidemiology Chinese Center for Disease Control and PreventionBeijing 102206China Chinese Center for Disease Control and Prevention Beijing 102206China Aerospace Center Hospital Beijing 100049Chin

Objective To assess the subjective perception of residents on the built environment in hygienic cities and its relation to the self-rated health(SRH)status of residents,providing a basis for a better promotion on construction of health-supportive *** The online survey was adopted with the respondents recruited from residents living in Chaoyang District of Beijing in January *** SRH level as the dependent variable,two-category logistic regression analysis was conducted to analyze the impact of the built environment in hygienic cities on the SRH status of *** A total of 1,357 respondents were enrolled in this *** controlling confounding factors,four aspects in the built environment in hygienic cities were detected remarkable influences on the SRH level of residents,including enough green space in the living area[odds ratio(OR)=1.395,95%confidence interval(95%CI):1.055–1.845],clean and hygienic living environment(OR=1.472,95%CI:1.107–1.956),residents’confidence in drinking water safety in the living area(OR=1.856,95%CI:1.354–2.544)and residents’confidence in food safety in the living area(OR=1.405,95%CI:1.027–1.921).Conclusion Regarding city construction,the government should focus more on the subjective perception of residents on built environments to build a supportive environment benefiting the health of residents.

关键词： Hygienic city Built environment Self-rated health

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Effect of FeSi additive in dual-chamber sample cup on thermal analysis characteristic values and vermiculating rate of compacted graphite iron

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China Foundry 2024年第1期21卷 91-100页

作者： De-quan shi Ze-yu Liu Gui-li Gao Yi-cheng Feng School of Materials and Chemistry University of Shanghai for Science and TechnologyShanghai 200093China School of Materials Science and Chemical Engineering Harbin University of Science&TechnologyHarbin 150040China School of Mechanical and Energy Engineering Shanghai Technical Institute of Electronics and InformationShanghai 201411China

Thermal analysis plays a key role in the online inspection of molten iron *** solidification process of molten iron can be reflected by thermal analysis curves,and silicon is one of important elements affecting the solidification of molten *** this study,FeSi75 was added in one chamber of the dual-chamber sample cup,and the influences of FeSi75 additive on the characteristic values of thermal analysis curves and vermiculating rate were *** results show that with the increase of FeSi75,the start temperature of austenite formation TALfirstly decreases and then increases,but the start temperature of eutectic growth TSEF,the lowest eutectic temperature TEU,temperature at maximum eutectic reaction rate TEM,and highest eutectic temperature TERkeep always an *** temperature at final solidification point TEShas little *** FeSi75 additive has different influences on the vermiculating rate of molten iron with different vermiculation,and the vermiculating rate increases for lower vermiculation molten iron while decreases for higher *** to the thermal analysis curves obtained by a dual-chamber sample cup with 0.30wt.%FeSi75 additive in one chamber,the vermiculating rate of molten iron can be evaluated by comparing the characteristic values of these *** time differenceΔtERcorresponding to the highest eutectic temperature TERhas a closer relationship with the vermiculating rate,and a parabolic regression curve between the time differenceΔtERand vermiculating rateηhas been obtained within the range of 65%to 95%,which is suitable for the qualified melt.

关键词： FeSi75 additive characteristic value vermiculating rate thermal analysis compacted graphite iron

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Changes in Notified Incidence of Pulmonary Tuberculosis in China,2005–2020

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Biomedical and Environmental Sciences 2023年第2期36卷 117-126页

作者： DONG Zhe YAO Hong Yan yu shi cheng HUANG Fei LIU Jian Jun ZHAO Yan Lin WANG Qi Qi Epidemiology Office Chinese Center for Disease Control and PreventionBeijing 102206China

Objective To evaluate the trend of notified incidence of pulmonary tuberculosis(PTB)in China at different periods by population and region and to explore the effect of TB prevention and control in recent *** Using pooled data on TB cases reported by the TB Information Management Reporting System(TBIMS)from 2005 to 2020,we calculated the annual percentage change(APC)using the Joinpoint regression *** From 2005 to 2020,a total of 16.2 million cases of PTB were reported in China,with an average notified incidence of 75.5 per 100,000 *** age standardization rate(ASR)continued to decline from 116.9(/100,000)in 2005 to 47.6(/100,000)in 2020,with an average annual decrease of5.6%[APC=-5.6,95%confidence interval(CI):-7.0 to-4.2].The smallest decline occurred in2011–2018(APC=-3.4,95%CI:-4.6 to-2.3)and the largest decrease in 2018–2020(APC=-9.2,95%CI:-16.4 to-1.3).From 2005 to 2020,the ASR in males(159.8 per 100,000 in 2005,72.0 per 100,000 in2020)was higher than that in females(62.2 per 100,000 in 2005,32.3 per 100,000 in 2020),with an average annual decline of 6.0%for male and 4.9%for *** average notified incidence was the highest among older adults(65 years and over)(182.3/100,000),with an average annual decline of6.4%;children(0–14 years)were the lowest(4.8/100,000),with an average annual decline of 7.3%,but a significant increase of 3.3%between 2014 and 2020(APC=3.3,95%CI:1.4 to 5.2);middle-aged(35–64years)decreased by 5.8%;and youth(15–34 years)decreased by an average annual rate of 4.2%.The average ASR in rural areas(81.3/100,000)is higher than that in urban areas(76.1/100,000).The average annual decline in rural areas was 4.5%and 6.3%in urban *** China had the highest average ASR(103.2/100,000),with an average annual decline of 5.9%,while North China had the lowest(56.5/100,000),with an average annual decline of 5.9%.The average ASR in the southwest was 95.3(/100,000),with the smallest annual decline(APC=-4.5,95%CI:-5.5 to

关键词： Tuberculosis Notified incidence Joinpoint regression model Trends China

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Joint Association of Metabolic Health and Obesity with Ten-Year Risk of Cardiovascular Disease among Chinese Adults

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Biomedical and Environmental Sciences 2022年第1期35卷 13-21页

作者： LIU Jun Ting YAO Hong Yan yu shi cheng LIU Jian Jun ZHU Guang Jin HAN Shao Mei XU Tao Chinese Center for Disease Control and Prevention Beijing 102206China Capital Institute of Pediatrics Beijing 100020China Department of Physiopathology Institute of Basic Medical SciencesChinese Academy of Medical Sciences&School of Basic Medicine Peking Union Medical CollegeBeijing 100006China Department of Epidemiology and Statistics Institute of Basic Medical SciencesChinese Academy of Medical Sciences&School of Basic Medicine Peking Union Medical CollegeBeijing 100005China

Objective This study aims to investigate the association of metabolic phenotypes that are jointly determined by body mass index(BMI)or fat mass percentage and metabolic health status with the tenyear risk of cardiovascular disease(CVD)among Chinese *** Data were obtained from a cross-sectional *** and body fat mass percentage(FMP)combined with the metabolic status were used to define metabolic *** linear regression and logistic regression were used to examine the effects of metabolic phenotypes on CVD *** A total of 13,239 adults aged 34-75 years were included in this *** with the metabolically healthy non-obese(MHNO)phenotype,the metabolically unhealthy non-obese(MUNO)and metabolically unhealthy obese(MUO)phenotypes defined by BMI showed a higher CVD risk[odds ratio,OR(95% confidence interval,CI):2.34(1.89-2.89),3.45(2.50-4.75),respectively],after adjusting for the *** MUNO and MUO phenotypes defined by FMP showed a higher CVD risk[OR(95%CI):2.31(1.85-2.88),2.63(1.98-3.48),respectively]than the MHNO *** metabolically healthy obese phenotype,regardless of being defined by BMI or FMP,showed no CVD risk compared with the MHNO *** General obesity without central obesity does not increase CVD risk in metabolically healthy *** might be a more meaningful factor for the evaluation of the association of obesity with CVD *** and metabolic status have a synergistic effect on CVD risk.

关键词： Body mass index Fat mass Obesity Metabolic health Metabolic phenotype Cardiovascular risk

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Age-period-cohort analysis of pulmonary tuberculosis reported incidence, China, 2006-2020

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Infectious Diseases of Poverty 2022年第4期11卷 62-71页

作者： Zhe Dong Qi-Qi Wang shi-cheng yu Fei Huang Jian-Jun Liu Hong-Yan Yao Yan-Lin Zhao Chinese Center for Disease Control and Prevention BejingChina

Background:Tuberculosis(TB)poses a severe public health challenge in China and *** study evaluated the effects of age,period,and birth cohort on reported incidence trends of TB based on population and refined the characteristics of high-risk ***:Aggregate data that reported pulmonary tuberculosis(PTB)cases from China Tuberculosis Management Information System(TBIMS)from 2006 to 2020 were used to analyze effect coefficients through the age-period-cohort(APC)model based on intrinsic estimator(IE)method,and converted them into relative risk(RR)to estimate ***:A total of 14.82 million cases of PTB were reported in China from 2006 to 2020,showing a continuous downward *** reporting rate increased with age by age group,with 70-74 years old being 2-3 times higher than that in 20-24 years *** analysis model showed that age effects were bimodal in 20-24 years old[RR=2.29,95%confidence interval(CI):1.73-3.03]and 70-74 years old(RR=1.95,95%CI:1.67-2.27),and lower than the overall average in the groups under 15 years *** results showed that the risk was higher for women under age 40 than men and higher for men over *** risk was higher in urban than in rural areas under 30 years old and slightly higher in rural than in urban between 30 and 64 years *** risk for 15-34 years old was significantly higher in the east than in other *** period effects showed a decreasing trend,and the risk was higher in rural in recent *** for cohorts born in 1961-1965 and 2001-2005,where theRR increased,the later the cohort was born,the lower the *** cohort 1926-1930 in eastern had the highest risk(RR=3.49,95%CI:2.44-4.98).Conclusions:The reported incidence of PTB continued to decline in China from 2006 to *** young(20-24 years old)and the elderly(70-74 years old)were equally at high *** were differences in the age,period and cohort effects on PTB incidence among gender,urban-rural and *** findings

关键词： Pulmonary tuberculosis Reported incidence Age-period-cohort model China

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未成熟粒细胞百分比在预测儿童急性阑尾炎严重程度中的临床价值

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中国现代普通外科进展 2024年第7期27卷 533-537页

作者：张新丽李凯江赵蒲宇赵亮梁冰卢东方施玉成周口市中心医院检验科河南周口466000 周口市中心医院普通外科河南周口466000

目的:探讨未成熟粒细胞百分比(IG%)及其他炎症指标联合检测在评估儿童急性阑尾炎(AA)严重程度中的临床价值。方法:纳入2022年6月—2023年8月行手术治疗的AA患儿201例,其中单纯性阑尾炎105例(ASA组),复杂性阑尾炎96例(ACA组)。比较两组... 详细信息

目的:探讨未成熟粒细胞百分比(IG%)及其他炎症指标联合检测在评估儿童急性阑尾炎(AA)严重程度中的临床价值。方法:纳入2022年6月—2023年8月行手术治疗的AA患儿201例,其中单纯性阑尾炎105例(ASA组),复杂性阑尾炎96例(ACA组)。比较两组白细胞(WBC)、中性粒细胞计数(ANC)、淋巴细胞计数(ALC)、中性粒细胞与淋巴细胞比值(NLR)、IG%、降钙素原(PCT)、C反应蛋白(CRP)、血小板与淋巴细胞比值(PLR)等指标的差异,Logistic回归分析构建回归模型,并利用受试者工作特征(ROC)曲线评估各指标及回归模型对ACA的诊断价值。另外,纳入2023年9月—2024年2月的AA患儿156例为验证队列,对Logistic模型进行验证,并用ROC曲线分析该模型对于ACA的诊断价值。结果:ACA组IG%、WBC、ANC、NLR、PCT、CRP和PLR水平均高于ASA组(P均<0.05),ALC水平低于ASA组(P=0.003)。Logistic回归分析显示,IG%、NLR和CRP是诊断儿童ACA的影响因素(P均<0.05),以此建立模型,以模型判断ACA的预测概率和单个炎症指标绘制ROC曲线,该模型预测概率和IG%、NLR、CRP的AUC分别为0.868和0.821、0.691和0.790,差异有统计学意义(P均<0.001)。通过独立队列验证Logistic模型,AUC为0.872,模型拟合较好,敏感度为90.0%,特异度为75.6%。结论:IG%可作为早期鉴别儿童ASA和ACA的重要指标,包括IG%、NLR、CRP这3项炎症标志物的Logistic回归模型对儿童ACA有良好的临床诊断价值。

关键词：未成熟粒细胞百分比急性阑尾炎炎症标志物

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