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胆管混合性神经内分泌-非神经内分泌肿瘤1例并文献复习

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诊断病理学杂志 2024年第1期31卷 52-54页

作者：石玉香王芳姜瑞瑞李长天甘肃中医药大学第一临床医学院兰州730000 兰州大学第一医院兰州730000

混合性神经内分泌-非神经内分泌肿瘤(mixed neuroendocrine non-neuroendocrine neoplasm,MiNEN)是指神经内分泌成分和非神经内分泌成分并存的复合肿瘤,其成分各占病变的30%以上,属于神经内分泌肿瘤(neuroendocrine neoplasm,NEN),通常... 详细信息

关键词：胆管混合性神经内分泌-非神经内分泌肿瘤神经内分泌肿瘤免疫组化

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色氨酸代谢与肝纤维化

世界华人消化杂志 2024年第3期32卷 192-198页

作者：吴辉星龙昌锐张振华陈宇莲王炎玉乡世健周本杰中山大学附属第七医院药学部广东省深圳市518107 深圳市中药活性物质筛选与转化重点实验室广东省深圳市518107

肝纤维化是一种肝脏组织在长期炎症状态下持续损伤和自我修复形成纤维化瘢痕的过程,以细胞外基质过度沉积为特征的病理综合征.目前肝纤维化常见的病因包括酒精性脂肪肝炎、非酒精性肝炎、胆汁淤积性肝病、化学性肝损伤、病毒性肝炎等.... 详细信息

肝纤维化是一种肝脏组织在长期炎症状态下持续损伤和自我修复形成纤维化瘢痕的过程,以细胞外基质过度沉积为特征的病理综合征.目前肝纤维化常见的病因包括酒精性脂肪肝炎、非酒精性肝炎、胆汁淤积性肝病、化学性肝损伤、病毒性肝炎等.肝纤维化是肝硬化和肝功能衰竭的主要前期阶段,在持续炎症刺激下,若不加以控制,可能会进一步发展成肝硬化,乃至肝癌,对患者的治疗负担和生存质量产生重要影响.近年来,研究表明色氨酸及其代谢产物在肝纤维化的发生和进展中起着重要的调控作用,本文将综述色氨酸代谢与肝纤维化的相关研究进展,以期深入了解其潜在的治疗价值.

关键词：色氨酸代谢肝纤维化发病机制

Selection of internal fixation method for femoral intertrochanteric fractures using a finite element method

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World Journal of Clinical Cases 2021年第22期9卷 6343-6356页

作者： Jia-Xuan Mu shi-Yang xiang Qing-Yu Ma Hai-Lun Gu Department of Orthopedics Shengjing HospitalChina Medical UniversityShenyang 117004Liaoning ProvinceChina

BACKGROUND Failure to fix unstable intertrochanteric fractures impairs return to daily *** To simulate five different internal fixation methods for unstable proximal femoral *** A three-dimensional model of the femur was established from sectional computed tomography images,and an internal fixation model was *** element analysis of the femur model was established,and three intertrochanteric fracture models,medial defect,lateral defect,and medial-lateral defects,were *** and stress distribution after fixation with a proximal femoral anti-rotation intramedullary nail(PFNA),integrated dual-screw fixation(ITN),PFNA+wire,PFNA+plate,and PFNA+wire+plate were compared during daily *** The maximum displacement and stress of PFNA and ITN were 3.51 mm/473 MPa and 2.80 mm/588 MPa for medial defects;2.55 mm/288 MPa and 2.10 mm/307 MPa for lateral defects;and 3.84 mm/653 MPa and 3.44 mm/641 MPa for mediallateral defects,*** medial-lateral defects,reconstructing the medial side alone changed the maximum displacement and stress to 2.79 mm/515 MPa;reconstructing the lateral side changed them to 3.72 mm/608 MPa,when both sides were reconstructed,they changed to 2.42 mm/309 *** For medial defects,intramedullary fixation would allow early low-intensity rehabilitation exercise,and ITN rather than PFNA reduces the risk of varus and cut-out;for lateral wall defects or weakness,intram-edullary fixation allows higher-intensity rehabilitation exercise,and ITN reduces the risk of *** both medial and lateral defects,intramedullary fixation alone will not allow early functional exercise,but locating lateral or medial reconstruction *** defects in both the inner and outer sides,if reconstruction cannot be completed,ITN is more stable.

关键词： Hip fractures Fracture fixation,Intramedullary Finite element analysis

Highly lipophilic coumarin fluorophore with excimer-monomer transition property for lipid droplet imaging

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Chinese Chemical Letters 2023年第3期34卷 367-371页

作者： xiang shi Ge Gao Xiaoyang Liu Lingling Xu Yu Deng Rui Wang Gaolin Liang State Key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China

Lipid droplet(LD) fluorescent imaging plays an important role in the detection of lipid-related *** to their poor photostability and low hydrophobicity of currently available LD imaging fluorophores,LD imaging is limited by its short imaging period and low imaging contrast. Herein, we reasonably designed a highly lipophilic compound Cou-Flu with excellent photostability and excimer-monomer transition property. It exhibited weak excimer emission in cytoplasm, but strong monomer emission in LDs,enabling high contrast LD imaging and LD movement tracing in cells. Zebrafish imaging study demonstrated that Cou-Flu was also suitable for in vivo LD detection with excellent sensitivity. We anticipate that Cou-Flu could be widely applied to understand LD-related intracellular activities and even LD-related diseases in the future.

关键词： Excimer-monomer transition Fluorescent probe Hydrophobicity Lipid droplets Monomer emission

Mass Human Migration and the Urban Heat Island during the Chinese New Year Holiday: A Case Study in Harbin City, Northeast China

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Atmospheric and Oceanic Science Letters 2015年第2期8卷 63-66页

作者： WU Ling-Yun ZHANG Jing-Yong shi Chun-xiang State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics (LASG) Institute of Atmospheric Physics Chinese Academy of Sciences Center for Monsoon System Research Institute of Atmospheric Physics Chinese Academy of Sciences National Meteorological Information Center China Meteorological Administration

Many Chinese people leave big cities for family reunions during the Chinese New Year （CNY）, which is the most important public holiday in China. However, how modem mass human migration during the CNY holiday affects the urban heat island （UHI） is still un- known. Here, the authors investigate the role of modem human migration for the UHI effects during the CNY holiday for the period of 1992-2006 in Harbin City, Northeast China. The results show that during the CNY week, the UHI effects expressed as daily mean, maxi- mum, and minimum temperature differences between urban and rural stations averaged over the period of 1992-2006 are 0.65℃ （43%）, 0.31℃ （48%）, and 1.14℃ （71%） lower than during the background period （four weeks before and four weeks after the CNY week）, re- spectively. Our findings identify previously unknown impacts of modem mass human migration on the UHI effects based on a case study in Harbin City.

关键词： urban heat island Chinese New Year holiday mass human migration surface air temperature Harbin City

某高压长距离变径铁精矿矿浆管道清管除垢实践

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包钢科技 2024年第1期50卷 10-14页

作者：唐林匙胜利卫强周春林李扬曾辉宋士祥中油管道检测技术有限责任公司河北廊坊065000

文章以某长距离高压变径铁精矿矿浆管道清管除垢为例,系统介绍了矿浆管道的杂质分布特征以及不同类型清管器的清管效果。通过实际清管发现,采用软质泡沫清管器和不同邵氏硬度皮碗的机械清管器可初步探测出管道的可通过性。另外,泡沫清... 详细信息

文章以某长距离高压变径铁精矿矿浆管道清管除垢为例,系统介绍了矿浆管道的杂质分布特征以及不同类型清管器的清管效果。通过实际清管发现,采用软质泡沫清管器和不同邵氏硬度皮碗的机械清管器可初步探测出管道的可通过性。另外,泡沫清管器对矿浆管道的结垢物清理效果较差,应优先采用清管能力更强的机械清管器,这对今后类似矿浆管道的清管具有重要的指导意义。

关键词：矿浆管道高压管道变径管道清管除垢

Phase diagram and transport properties of Sb-doped Ca0.88La0.12Fe2As2 single crystals

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Frontiers of physics 2017年第4期12卷 167-172页

作者： xiang-Zhuo Xing Wei Zhou Chun-Qiang Xu Nan Zhou Fei-Fei Yuan Yu-Feng Zhang Xiao-Feng Xu Zhi-xiang shi Department of Physics and Key Laboratory of MEMS of the Ministry of Education Southeast University Nanjing 211189 China Department of Physics and Hangzhou Key Laboratory of Quantum Matters Hangzhou Normal University Hangzhou 310036 China

The effects of isovalent Sb substitution on the superconducting properties of the Ca0.88La0.12Fe2（As1-ySby）2 system have been studied through electrical resistivity measure- ments. It is seen that the antiferromagnetic or structural transition is suppressed with Sb content, and a high-To superconducting phase, accompanied by a low-Tc phase, emerges at 0.02 ≤y ≤ 0.06. In this intermediate-doping regime, normal-state transport shows non-Fermi-liquid-like behaviors with nearly T-linear resistivity above the high-Tc phase. With further Sb doping, this high-Tc phase abruptly vanishes for y 〉 0.06 and the conventional Fermi liquid is restored, while the low-T,, phase remains robust against Sb inlpurities. The coincidence of the high-Tc phase and non-Fermi liquid transport behaviors in the intermediate Sb-doping regime suggests that AFM fluctuations play an important role in the observed non-Fermi liquid behaviors, which may be intimately related to the unusual nonbulk high-Tc phase in this system.

关键词： Sb doped Ca0.88La0.12Fe2As2 superconductors electrical resistivity measurement phase diagram

Discriminating 1D new physics solutions in b→slldecays

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Chinese Physics C 2022年第6期46卷 114-123页

作者： Shuang-Yi Li Rui-xiang shi Li-Sheng Geng School of Physics Beihang UniversityBeijing 102206China School of Space and Environment Beihang UniversityBeijing 102206China School of Physics&Beijing Key Laboratory of Advanced Nuclear Materials and Physics Beihang UniversityBeijing 102206China School of Physics and Microelectronics Zhengzhou UniversityZhengzhou 450001China

The recent measurements of RK^(+),R_(K_(S)^(O)),RK^(*+),Bs→μ+μ-,a set of CP-averaged angular observables for the B^(0)→K^(*0)μ^(+)μ^(-)decay and its isospin partner B^(+)→K^(*+)μ^(+)μ^(-)by the LHCb Collaboration consistently hint at lepton universality violation in the b→sll *** this work,we first perform global fits to the b→sll data and show that five one-dimensional scenarios,i.e,δC_(9)^(μ),δC_(10)^(μ),δC_(L)^(μ),δC_(9)^(μ)=C_(10)^(μ’),andδC_(9)^(μ)=-C_(9)^(μ’)can best explain the so-called B ***,we explore how these scenarios can be distinguished from each *** this purpose,we first study the combinations of four angular asymmetries Ai(i=3,4,5,9)and find that they cannot distinguish the five new physics *** then show that a newly constructed ratio RS can uniquely discriminate the five new physics scenarios in proper intervals of q^(2) if it can be measured with percent-level precision.

关键词： lepton universality violation rare B meson decays beyond SM physics

基于ANSYS对软基预应力管桩在建筑施工中的应用

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建筑技术开发 2024年第7期51卷 132-134页

作者：李彬彬李宁生杰任世祥曹安中国建筑第二工程局有限公司华东分公司上海200135

预应力管桩具有承载能力强、便于运输和吊装、接桩速度快等优势。在软弱地基工程的基础设计与建设中,预应力管桩对承载能力有较好的适应能力。在工程实践中,采用的方法有2种,一种是静力压桩,另一种是锤击桩。通过结合某软土地区房建小... 详细信息

预应力管桩具有承载能力强、便于运输和吊装、接桩速度快等优势。在软弱地基工程的基础设计与建设中,预应力管桩对承载能力有较好的适应能力。在工程实践中,采用的方法有2种,一种是静力压桩,另一种是锤击桩。通过结合某软土地区房建小区建设中预应力管桩的工程实例,并依托ANSYS平台,对预应力管桩在软基房建施工中的应用效果进行了研究,并对其在实践中遇到的问题和解决办法进行了分析,同时介绍了需要注意的问题,其可为相似工程的建设提供借鉴。

关键词：预应力管桩 ANSYS 软土地基数值分析