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Journal of Pharmaceutical Analysis 2013年第6期3卷 440-446页

作者： shi-Ying Dai shi-ting qiu Wei Wu Chun-Mei Fu Key Laboratory of Drug Targeting and Drug Delivery System Ministry of EducationWest China School of Pharmacy Sichuan University

AnRP-HPLC method for the simultaneous determination ofRamipril （RP） andAmlodipine （AL） in tablets was developed and validated by Chinese Pharmacopoeia 2010. The linearity of the proposed method was investigated in the range of 0.01-0.25 mg/mL （r^2=0.9998） for RP and 0.014-0.36 mg/mL （r^2=0.9997） for AL. The limits of detection （LOD） were 0.06 lag/mL and 0.02 μg/mL for RP and AL, and the limits of quantitation （LOQ） were 0.2 Dg/mL and 0.07 μg/mL, respectively. Some major impurities and degradation products did not disturb the detection of RP and AL and the assay can thus be considered stability-indicating.

关键词： Ramipril Amlodipine RP-HPLC Stability-indicating

An investigation on the wind profiles and gravity wave dynamics in MLT region based on the meteor radars from the Meridian Project

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Earth and Planetary Physics 2025年第1期9卷 29-38页

作者： Tai Liu Zhe Wang MengXi shi Willie Soon shiCan qiu Department of Geophysics College of the Geology Engineering and GeomaticsChang’an UniversityXi’an 710054China Center for Environmental Research and Earth Sciences(CERES) SalemMA 01970USA Institute of Earth Physics and Space Science(ELKH EPSS) 9400SopronHungary

The meteor radar can detect the zenith angle,azimuth,radial velocity,and altitude of meteor trails so that one can invert the wind profiles in the mesosphere and low thermosphere(MLT)region,based on the Interferometric and Doppler *** this paper,the horizontal wind field,gravity wave(GW)disturbance variance,and GW fluxes are analyzed through the meteor radar observation from 2012−2022,at Mohe(53.5°N,122.4°E)and Zuoling(30.5°N,114.6°E)stations of the(Chinese)Meridian *** Lomb−Scargle periodogram method has been utilized to analyze the periodic variations for time series with observational data *** results show that the zonal winds at both stations are eastward dominated,while the meridional winds are southward *** variance of GW disturbances in the zonal and meridional directions increases gradually with height,and there is a strong pattern of annual *** zonal momentum flux of GW changes little with height,showing weak annual *** meridional GW flux varies gradually from northward to southward with height,and the annual periodicity is *** both stations,the maximum values of zonal and meridional wind occur close to the peak heights of GW flux,with opposite *** observational evidence is consistent with the filtering *** horizontal wind velocity,GW flux,and disturbance variance of the GW at Mohe are overall smaller than those at Zuoling,indicating weaker activities in the MLT at *** power spectral density(PSD)calculated by the Lomb−Scargle periodogram shows that there are 12-month period and 6-month period in horizontal wind field,GW disturbance variance and GW flux at both stations,and especially there is also a 4-month cycle in the disturbance *** PSD of the 12-month and 6-month cycles exhibits maximum values below 88 km and above 94 km.

关键词： meteor radar wind field gravity wave Lomb−Scargle method

河北省香河县农村心血管疾病及危险因素的流行病学调查

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中华心血管病杂志 2013年第10期41卷 882-885页

作者：陈丽竹丁荣晶石秋婷胡大一重庆医科大学附属第一医院心内科 400016 北京大学人民医院心脏中心河北省香河县哮喘病医院心内科

目的调查河北省香河县农村居民心血管疾病及危险因素的流行情况,分析该人群未来10年缺血性心血管病（ICVD）的发病风险.方法入选在河北省香河县哮喘病医院内科门诊就医的≥35岁本地农村人口2532例.对受检者进行问卷调查、体格及生化检... 详细信息

目的调查河北省香河县农村居民心血管疾病及危险因素的流行情况,分析该人群未来10年缺血性心血管病（ICVD）的发病风险.方法入选在河北省香河县哮喘病医院内科门诊就医的≥35岁本地农村人口2532例.对受检者进行问卷调查、体格及生化检查,对其中35 ～59岁人群采用“国人ICVD 10年发病危险度评估表”评估10年ICVD发病风险.结果河北省香河县农村居民卒中和冠心病的患病率分别为2.2％（56/2532）和6.9％（176/2532）,标化患病率分别为1.3％和5.9％；高血压、糖尿病、血脂异常、超重、肥胖和中心性肥胖的患病率分别为59.9％（1516/2532）、26.9％（682/2532）、68.5％（1735/2532）、40.9％（1038/2532）、14.8％（374/2532）和49.5％（1254/2532）,标化患病率分别为43.8％、19.9％、56.5％、35.1％、15.6％和41.9％.35 ～ 59岁人群10年ICVD发病风险≥10％的检出率为14.1％（188/1336）.结论河北省香河县农村居民心血管病及危险因素患病率高,35 ～59岁人群10年ICVD发病风险较大,应加强对危险因素的干预.

关键词：心血管疾病危险因素流行病学

CD8^(+)T细胞相关的免疫逃逸机制的研究进展

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解剖科学进展 2024年第3期30卷 325-328页

作者：丁雪晴史秋婷中国医科大学附属第一医院肿瘤内科辽宁沈阳110001

临床上有效的CD8^(+)T细胞反应主要来自肿瘤中积累的特异性突变的抗原,也称为新抗原。肿瘤抗原通过I类人白细胞抗原(Class I human leukocyte antigen,HLA-I)显示在细胞表面。为了引起有效的抗肿瘤反应,抗原呈递必须在两个不同的事件中... 详细信息

临床上有效的CD8^(+)T细胞反应主要来自肿瘤中积累的特异性突变的抗原,也称为新抗原。肿瘤抗原通过I类人白细胞抗原(Class I human leukocyte antigen,HLA-I)显示在细胞表面。为了引起有效的抗肿瘤反应,抗原呈递必须在两个不同的事件中取得成功:首先,肿瘤抗原必须被树突状细胞(dendritic cell,DC)吸收并交叉呈递用于CD8^(+)T细胞启动。其次,抗原必须由肿瘤直接呈递,以便被引物CD8^(+)T细胞识别和杀伤。肿瘤利用多种逃逸机制来逃避这两个步骤的免疫识别,表现出促进其存活的免疫逃逸特性。这些特性包括调节Ag呈递,免疫抑制因子的分泌,抗细胞凋亡和诱导免疫偏差。本文针对近几年报道的一些与CD8^(+)T细胞相关的免疫逃逸机制进行综述。

关键词：免疫逃逸机制人白细胞抗原肿瘤抗原免疫识别免疫抑制因子树突状细胞 T细胞抗原呈递

基于生物信息学分析B3GNT6作为胃癌早期诊断及预后生物标志物的研究

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解剖科学进展 2023年第4期29卷 378-382页

作者：史秋婷孙铭泽中国医科大学附属第一医院肿瘤内科辽宁沈阳110001

目的通过生物信息学分析筛选出可以早期诊断及判断胃癌预后的生物标志物。方法从GEO数据库获得GSE数据集,使用GEO2R在线工具筛选出差异表达基因(DEGs),应用基因本体论(GO)及京都基因和基因组数据库(KEGG)进行功能及通路富集分析,利用STR... 详细信息

目的通过生物信息学分析筛选出可以早期诊断及判断胃癌预后的生物标志物。方法从GEO数据库获得GSE数据集,使用GEO2R在线工具筛选出差异表达基因(DEGs),应用基因本体论(GO)及京都基因和基因组数据库(KEGG)进行功能及通路富集分析,利用STRING、Cytoscape和cBioPortal分析出蛋白相互作用(PPI)网络、共表达基因及枢纽(Hub)基因。基于Kaplan-Meier分析预后生存曲线,使用HPA、Onco mine、UALCAN分析Hub基因在胃癌组织中的表达情况。结果本研究共得到26个Hub基因,它们主要富集在O-聚糖(O-glycan)生物过程。Hub基因中生存分析显示B3GNT6和GATA6的GC患者总生存期较差。在TCGA中,B3GNT6在胃癌组织中表达明显下调,而GATA6表达无显著性差异。结论B3GNT6可能作为潜在的胃癌早期诊断及判断预后的生物标志物。

关键词：胃癌生物信息学 B3GNT6 O-Glycan

Electrocatalytic cleavage of a lignin β-O-4 model compound and coupling with nitrogen-containing aromatics using Prussian blue analogue-derived nickel–cobalt spinel

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Journal of Energy Chemistry 2025年第1期100卷 628-636页

作者： Yi Qi Xueying Chen Bowen Liu Xuliang Lin Xueqing qiu Yanlin Qin Guangdong Provincial Key Laboratory of Plant Resources Biorefinery School of Chemical Engineering and Light Industry Guangdong University of Technology Guangdong Provincial Laboratory of Chemistry and Fine Chemical Engineering Jieyang Center Guangdong Basic Research Center of Excellence for Ecological Security and Green Development Guangdong University of Technology

Electrochemical conversion of lignin for the production of high-value heterocyclic aromatic compounds has great *** demonstrate the targeted synthesis and cation modulation of NiCo2O4spinel nanoboxes,synthesized via cation exchange and calcination *** catalysts exhibit excellent efficacy in the electrocatalytic conversion of lignin model compounds,specifically 2-phenoxy-1-phenylethanol,into nitrogen-containing aromatics,achieving high conversion rates and *** catalysts were synthesized via a cation exchange and calcination oxidation process,using Prussian blue nanocubes as *** porous architecture and polymetallic composition of the NiCo2O4spinel demonstrated superior performance in electrocatalytic oxidative coupling,achieving a 99.2 wt%conversion rate of the 2-phenoxy-1-phenylethanol with selectivities of 37.5 wt%for quinoline derivatives and 31.5 wt%for *** innovations include the development of a sustainable one-pot synthesis method for quinoline derivatives,the elucidation of a multistage reaction pathway involving CAO bond cleavage,hydroxyaldol condensation,and CAN bond formation,and a deeper mechanistic understanding derived from DFT *** work establishes a new strategy for lignin valorization,offering a sustainable route to produce high-value nitrogen-containing aromatics from renewable biomass under mild conditions,without the need for additional reagents.

关键词： Spinel Biomass valorization Electrocatalysis Lignin oxidation Coupling

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基于改进的粒子滤波的视觉跟踪算法

宁波工程学院学报 2013年第4期25卷 58-62页

作者：江妙永王泽慧施秋婷邱雪娜宁波工程学院浙江宁波315211

通过对基于粒子滤波算法的运动目标跟踪技术进行研究,并针对粒子滤波算法的退化现象做出了两方面的调整。第一,对粒子滤波的重采样阶段做出了改进,在粒子上添加一个微小的高斯干扰,使得重采样的粒子分布发生变化,同时使采样枯竭得到了抑... 详细信息

通过对基于粒子滤波算法的运动目标跟踪技术进行研究,并针对粒子滤波算法的退化现象做出了两方面的调整。第一,对粒子滤波的重采样阶段做出了改进,在粒子上添加一个微小的高斯干扰,使得重采样的粒子分布发生变化,同时使采样枯竭得到了抑制;第二,经过一段时间的跟踪后,将跟踪目标重新初始化,继续跟踪,使得跟踪结果更加完善。通过自适应调整跟踪目标的窗口,使其大小改变,背景中的颜色尽量没有与跟踪目标相同的颜色。实验结果表明,这种改进过的粒子滤波算法能够在复杂的情况下进行跟踪,并且跟踪性能优于Meanshift方法。

关键词：运动目标跟踪粒子滤波退化现象

Potassium and calcium channels in different nerve cells act as therapeutic targets in neurological disorders

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Neural Regeneration Research 2025年第5期20卷 1258-1276页

作者： Qing qiu Mengting Yang Danfeng Gong Haiying Liang tingting Chen Department of Pharmacology School of PharmacyNantong UniversityNantongJiangsu ProvinceChina Jiangsu Province Key Laboratory of Inflammation and Molecular Drug Target NantongJiangsu ProvinceChina Department of Pharmacy Longyan First Affiliated Hospital of Fujian Medical UniversityLongyanFujian ProvinceChina

The central nervous system, information integration center of the body, is mainly composed of neurons and glial cells. The neuron is one of the most basic and important structural and functional units of the central nervous system, with sensory stimulation and excitation conduction functions. Astrocytes and microglia belong to the glial cell family, which is the main source of cytokines and represents the main defense system of the central nervous system. Nerve cells undergo neurotransmission or gliotransmission, which regulates neuronal activity via the ion channels, receptors, or transporters expressed on nerve cell membranes. Ion channels, composed of large transmembrane proteins, play crucial roles in maintaining nerve cell homeostasis. These channels are also important for control of the membrane potential and in the secretion of neurotransmitters. A variety of cellular functions and life activities, including functional regulation of the central nervous system, the generation and conduction of nerve excitation, the occurrence of receptor potential, heart pulsation, smooth muscle peristalsis, skeletal muscle contraction, and hormone secretion, are closely related to ion channels associated with passive transmembrane transport. Two types of ion channels in the central nervous system, potassium channels and calcium channels, are closely related to various neurological disorders, including Alzheimer's disease, Parkinson's disease, and epilepsy. Accordingly, various drugs that can affect these ion channels have been explored deeply to provide new directions for the treatment of these neurological disorders. In this review, we focus on the functions of potassium and calcium ion channels in different nerve cells and their involvement in neurological disorders such as Parkinson's disease, Alzheimer's disease, depression, epilepsy, autism, and rare disorders. We also describe several clinical drugs that target potassium or calcium channels in nerve cells and could be u

关键词： astrocytes calcium channels central nervous system extracellular ion concentration microglia neurological disorders neurons potassium channels

Multi-View Auxiliary Diagnosis Algorithm for Lung Nodules

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Computers, Materials & Continua 2022年第9期72卷 4897-4910页

作者： shi qiu Bin Li Tao Zhou Feng Li ting Liang Key Laboratory of Spectral Imaging Technology CAS Xi’an Institute of Optics and Precision MechanicsChinese Academy of SciencesXi’an710119P.R.China School of Information Science and Technology Northwest UniversityXi’an710127P.R.China School of Computer Science and Engineering North Minzu UniversityYinchuan750021P.R.China Institute of Education University College LondonLondonThe United Kingdom Department of Radiology The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an10061P.R.China

Lung is an important organ of human *** and more people are suffering from lung diseases due to air *** diseases are usually highly *** as lung tuberculosis,novel coronavirus COVID-19,*** nodule is a kind of high-density globular lesion in the *** need to spend a lot of time and energy to observe the computed tomography image sequences to make a diagnosis,which is *** this reason,the use of computer-assisted diagnosis of lung nodules has become the current main *** the process of computer-aided diagnosis,how to reduce the false positive rate while ensuring a low missed detection rate is a difficulty and focus of current *** solve this problem,we propose a three-dimensional optimization model to achieve the extraction of suspected regions,improve the traditional deep belief network,and to modify the dispersion matrix between *** construct a multi-view model,fuse local three-dimensional information into two-dimensional images,and thereby to reduce the complexity of the *** alleviate the problem of unbalanced training caused by only a small number of positive *** show that the false positive rate of the algorithm proposed in this paper is as low as 12%,which is in line with clinical application standards.

关键词： Lung nodules deep belief network computer-aided diagnosis multi-view

Colorectal Cancer Segmentation Algorithm Based on Deep Features from Enhanced CT Images

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Computers, Materials & Continua 2024年第8期80卷 2495-2510页

作者： shi qiu Hongbing Lu Jun Shu ting Liang Tao Zhou School of Biomedical Engineering Fourth Military Medical UniversityXi’an710119China Department of Radiology Xijing HospitalFourth Military Medical UniversityXi’an710032China Department of Radiology The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an710061China School of Computer Science and Engineering North Minzu UniversityYinchuan750030China

Colorectal cancer,a malignant lesion of the intestines,significantly affects human health and life,emphasizing the necessity of early detection and *** segmentation of colorectal cancer regions directly impacts subsequent staging,treatment methods,and prognostic *** colonoscopy is an effective method for detecting colorectal cancer,its data collection approach can cause patient *** address this,current research utilizes Computed Tomography(CT)imaging;however,conventional CT images only capture transient states,lacking sufficient representational capability to precisely locate colorectal *** study utilizes enhanced CT images,constructing a deep feature network from the arterial,portal venous,and delay phases to simulate the physician’s diagnostic process and achieve accurate cancer *** innovations include:1)Utilizing portal venous phase CT images to introduce a context-aware multi-scale aggregation module for preliminary shape extraction of colorectal cancer.2)Building an image sequence based on arterial and delay phases,transforming the cancer segmentation issue into an anomaly detection problem,establishing a pixel-pairing strategy,and proposing a colorectal cancer segmentation algorithm using a Siamese *** with 84 clinical cases of colorectal cancer enhanced CT data demonstrated an Area Overlap Measure of 0.90,significantly better than Fully Convolutional Networks(FCNs)at *** research will explore the relationship between conventional and enhanced CT to further reduce segmentation time and improve accuracy.

关键词： Colorectal cancer enhanced CT multi-scale siamese network segmentation