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Caffeine and its main targets of colorectal cancer

World Journal of Gastrointestinal Oncology 2020年第2期12卷 149-172页

作者： Wen-qi Cui shi-Tong Wang Dan pan Bing Chang Li-Xuan Sang Department of Neurology Shengjing HospitalAffiliated Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina China Medical University 101K class 87 Shenyang 110001Liaoning ProvinceChina Department of Cardiovascular Ultrasound First Affiliated Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Department of Geriatrics First Affiliated Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Department of Gastroenterology First Affiliated Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina

Caffeine is a purine alkaloid and is widely consumed in coffee,soda,tea,chocolate and energy *** date,a growing number of studies have indicated that caffeine is associated with many diseases including colorectal *** exerts its biological activity through binding to adenosine receptors,inhibiting phosphodiesterases,sensitizing calcium channels,antagonizing gamma-aminobutyric acid receptors and stimulating adrenal *** studies have indicated that caffeine can interact with signaling pathways such as transforming growth factorβ,phosphoinositide-3-kinase/AKT/mammalian target of rapamycin and mitogen-activated protein kinase pathways through which caffeine can play an important role in colorectal cancer pathogenesis,metastasis and ***,caffeine can act as a general antioxidant that protects cells from oxidative stress and also as a regulatory factor of the cell cycle that modulates the DNA repair ***,as for intestinal homeostasis,through the interaction with receptors and cytokines,caffeine can modulate the immune system mediating its effects on T lymphocytes,B lymphocytes,natural killer cells and ***,caffeine can not only directly inhibit species in the gut microbiome,such as Escherichia coli and Candida albicans but also can indirectly exert inhibition by increasing the effects of other antimicrobial *** review summarizes the association between colorectal cancer and caffeine that is being currently studied.

关键词： Caffeine Colorectal cancer Epidemiology Signaling pathway Immune response Cell cycle

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Bounds on the overall properties of composites with ellipsoidal inclusions

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Acta Mechanica Sinica 2012年第5期28卷 1340-1355页

作者： Lin-Zhi Wu shi-Dong pan Center for Composite Materials Harbin Institute of Technology

A new model is put forward to bound the effective elastic moduli of composites with ellipsoidal inclusions. In the present paper, transition layer for each ellipsoidal inclusion is introduced to make the trial displacement field for the upper bound and the trial stress field for the lower bound satisfy the continuous interface conditions which are absolutely necessary for the application of variational principles. According to the principles of minimum potential energy and minimum complementary energy, the upper and lower bounds on the effective elastic moduli of composites with ellipsoidal inclusions are rigorously derived. The effects of the distribution and geometric parameters of ellipsoidal in- clusions on the bounds of the effective elastic moduli are an- alyzed in details. The present upper and lower bounds are still finite when the bulk and shear moduli of ellipsoidal inclusions tend to infinity and zero, respectively. It should be mentioned that the present method is simple and needs not calculate the complex integrals of multi-point correlation functions. Meanwhile, the present paper provides an entirely different way to bound the effective elastic moduli of composites with ellipsoidal inclusions, which can be developed to obtain a series of bounds by taking different trial displacement and stress fields.

关键词： Composites Ellipsoidal inclusions Effectiveelastic moduli Upper and lower bounds Transition layer

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Effect of algal flocculation on dissolved organic matters using cationic starch modified soils

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Journal of Environmental Sciences 2016年第7期28卷 177-184页

作者： Wenqing shi Lei Bi Gang pan Research Center for Eco-Environmental Sciences Chinese Academy of Sciences School of Animal Rural and Environmental Sciences Nottingham Trent University

Modified soils（MSs） are being increasingly used as geo-engineering materials for the sedimentation removal of cyanobacterial blooms. Cationic starch（CS） has been tested as an effective soil modifier, but little is known about its potential impacts on the treated *** study investigated dissolved organic matters in the bloom water after algal removal using cationic starch modified soils（CS-MSs）. Results showed that the dissolved organic carbon（DOC） could be decreased by CS-MS flocculation and the use of higher charge density CS yielded a greater DOC reduction. When CS with the charge density of 0.052, 0.102 and0.293 meq/g were used, DOC was decreased from 3.4 to 3.0, 2.3 and 1.7 mg/L, *** excitation–emission matrix fluorescence spectroscopy and UV254 analysis indicated that CS-MS exhibits an ability to remove some soluble organics, which contributed to the DOC reduction. However, the use of low charge density CS posed a potential risk of DOC increase due to the high CS loading for effective algal removal. When CS with the charge density of 0.044 meq/g was used, DOC was increased from 3.4 to 3.9 mg/L. This study suggested, when CS-MS is used for cyanobacterial bloom removal, the content of dissolved organic matters in the treated water can be controlled by optimizing the charge density of CS. For the settled organic matters, other measures（e.g., capping treatments using oxygen loaded materials） should be jointly applied after algal flocculation.

关键词： Cyanobacterial bloom Cationic starch Modified soil Charge density Dissolved organic carbon

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Synthesis and characterization of (Ni,Sb)-co-doped rutile ceramic pigment via mechanical activation-assisted solid-state reaction

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Particuology 2018年第6期16卷 20-29页

作者： shi Zhang Zhidong pan Yanmin Wang School of Materials Science and Engineering South China University of TechnologyGuangzhou 510640China

(Ni,Sb)-co-doped rutile yellow ceramic pigments were synthesized via a mechanical activation-assisted solid-state reaction in a stirred bead *** effects of mechanical grinding of the raw materials on the synthesis of (Ni,Sb)-co-doped rutile pigment were *** results show that mechanical activation effectively decreased the crystallinity of the mixed precursors,thus enhancing their reactivity and the migration rate of *** effects lowered the temperature required for formation of the rutile *** with results from a mixture of separately ground precursors,the mixture of raw materials ground together was more effective for accelerating nickel/antimony ions doping into the TiO2structure and improved the color performance of the *** pigment from the mixed raw materials ground for 2.0h and heat-treated at 1100℃ could be used as an environmentally-friendly ceramic yellow pigment owing to its low-toxicity,bright yellow hue,good chemical/thermal durability, and high cost-effectiveness.

关键词： Mechanical activation Solid-state synthesis (Ni,Sb)-co-doped rutile Ceramic pigment

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Variable-model SMA-driven spherical robot

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Science China(Technological Sciences) 2019年第8期62卷 1401-1411页

作者： pan Jie shi ZhenYun WANG TianMiao Robotic Laboratory Beihang University

In this paper, we introduce a bionic spherical robot. This research has been inspired by the muscular organs and modularity of organisms such as starfish and octopuses. The robot that we fabricated uses five soft feet to crawl like a starfish, and the robotic feet are driven by the shape memory alloy springs. The robotic spherical structure and the soft feet were fabricated by 3 D printing. The robotic feet were made of silicone gel;these feet could bend upward and downward to help the robot to crawl on the ground and roll down a slope. The shell separation module installed inside the robot could divide the robot into two identical modules, and this smart structure could enhance the robotic flexibility in a small space. We performed force analysis and robotic simulation, and the results verified the feasibility of the model. The robot can switch between rigidity and softness by using human control. Three types of gaits have been proposed for controlling robotic movement and improving robotic flexibility in movement;these include rolling, crawling, and avoiding obstacles. The results of this study indicate that the variable-model design of the robot is an effective way to enhance the flexibility of soft robots.

关键词： bionic robot soft animals shape memory alloy smart structure variable model

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Thermally Stable Guest-Host Polyetherketone Poled Polymer for Electro-Optical Applications

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Chinese Physics Letters 2002年第8期19卷 1125-1127页

作者： pan qi-Wei, Fang Chang-Shui State Key Laboratory of Crystal Materials Shandong University Ji\'nan 250100 State Key Laboratory on Integrated Optoelectronics of Semiconductor Chinese Academy of Sciences Beijing 100083

The high glass transition temperature polymer polyetherketone doped with disperse red 13 (DR13/PEK-c) has been prepared by the spin-coating method. Through in situ second-harmonic generation, the corona poling temperature was optimized by measuring the temperature dependence of the in situ second-harmonic generation signal intensity under the poling electric field. The linear electro-optic coefficients of the poled polymer films have been determined at 632.8 nm by using a simple interferometric technique. The polymer system was measured after 13 000 h, and found that it remained at 80% of its initial value.

关键词： Harmonic generation

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A Novel Process for High-efficient Synthesis of One-dimensional Carbon Nanomaterials from Flames

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Journal of Materials Science & Technology 2008年第4期24卷 603-607页

作者： XianG qi Jun ZHANG Chunxu pan Department of Physics and Key Laboratory of Acoustic and Photonic Materials and Devices of Ministry of Education Wuhan University Wuhan 430072 China Center for Electron Microscopy Wuhan University Wuhan 430072 China

The substrate pre-treatment plays a key role in obtaining hollow-cored carbon nanotubes （CNTs） and solid-cored carbon nanofibers （CNFs） from flames. This paper introduces a simply and high-efficient process by coating a NiSO4 or FeSO4 layer on the substrate as catalyst precursors. Comparing with the regular pre-treatment methods, the present experiments showed that the coating pre-treatment provided the following advantages： 1） greatly shortening the synthesis time; 2） available variant substrates and carbon sources; 3） narrowing the diameters distribution. The sulfate is considered to be a crucial factor at the growth of CNTs and CNFs, because it increases the surface energy of catalyst particles and the surface specificity of sulfurs action in metallic grains. This novel process provides a possibility for high quality and mass production of CNTs and CNFs from flames.

关键词： Carbon nanotubes Carbon nanofibers Flames Sulfate

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Late-Time Evolution of the Phantom Scalar Perturbation in the Background of a Spherically Symmetric Static Black Hole

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Chinese Physics Letters 2010年第6期27卷 9-12页

作者： pan qi-Yuan JING Ji-Liang Institute of Physics and Department of Physics Hunan Normal University Changsha 410081

The late-time evolution of the phantom scalar perturbation is investigated in the spacetime of a four-dimensionai spherically symmetric static black hole. It is revealed that the asymptotic tail of the phantom scalar field is dominated by the growth behavior t-（l＋3/2）eμt, which depends on the multipole moment l and the field moss but is independent of the mass M and charge Q of the black hole. This growth behavior is in strong contrast to the decaying tall of the usual massive scalar perturbation and shows that the external phantom scalar perturbation is unstable in the spherically symmetric static black hole spacetime.

关键词： PHANTOMS (Radiology) SCALAR field theory PERTURBATION (Quantum dynamics) COSMIC background radiation SYMMETRY (Physics) SUPERMASSIVE black holes

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Ordered Bicontinuous Network Structures Regulated by Orientational Interactions in a Rod-Coil Block Copolymer

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Chinese Journal of Polymer Science 2024年第5期42卷 636-642,I0008页

作者： Xiao-Lin Lyu shi-Chu Yang An-qi Xiao Ping-Ping Hou Wei Zhang Hong-Bing pan Zhi-Hao Shen Xing-He Fan qi-Feng Zhou Beijing National Laboratory for Molecular Sciences Key Laboratory of Polymer Chemistry and Physics of Ministry of EducationCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing100871China Key Laboratory of Advanced Materials Technologies International(HongKong Macao and Taiwan)Joint Laboratory on Advanced Materials TechnologiesCollege of Materials Science and EngineeringFuzhou UniversityFuzhou350108China

The rich phase behavior of block copolymers(BCPs)has drawn great attention in recent ***,the double diamond(DD)phase is rarely obtained because of the competition between the minimization of interfacial energy and packing ***,a rod-coil BCP containing mesogen-jacketed liquid crystalline polymer is designed to acquire ordered bicontinuous network *** reduction of internal energy originating from the orientational interaction among the rod blocks can compensate for the free energy penalty of packing frustration to stabilize the DD *** resulting BCP can also experience lamellae-to-DD and double gyroid-to-lamellae transitions by changing the annealing *** results make the rod-coil BCP an excellent candidate for the self-assembly of ordered network structures,demonstrating great potential in nanopatterning and metamaterials.

关键词： Block copolymer Rod-coil Ordered bicontinuous phase Double diamond Double gyroid

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Effective utilization of dolomitic lead-zinc waste rock by replacing dolomite as flux in iron ore sintering process

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Journal of Iron and Steel Research International 2024年第8期31卷 1861-1872页

作者： Xin Wang Cong-cong Yang Jian pan De-qing Zhu Zheng-qi Guo Guang-hui Xia shi-juan Qu School of Minerals Processing and Bioengineering Central South UniversityChangsha 410083HunanChina Low-Carbon and Hydrogen Metallurgy Research Center Central South UniversityChangsha 410083HunanChina

With increasingly stringent environmental protection policies,cost-effective and value-added treatment of massive lead-zinc waste rock(LZWR)generated from the preconcentration process has attracted substantial attention.A type of dolomitic LZWR with 18 wt.%MgO,27 wt.%CaO,0.29 wt.%Zn and 1.43 wt.%S was used as a replacement flux in the iron ore sintering *** sinter pot tests were carried out based on an industrial ore *** results show that replacing 0%-60%of dolomite with LZWR does not adversely affect the sintering productivity,fuel consumption rate,and the quality of the sinter products,while the Zn and S elements contained in LZWR can be effectively removed with the residual Zn and S contents of the resultant sinter products being less than 0.02 and 0.055 wt.%,***,substituting LZWR for dolomite as a flux inevitably increases the SO_(2) concentration in the sintering flue gas due to its high sulfur *** the processing capacity of the sintering flue gas desulfurization system,the replacement ratio of dolomite can reach 40%,equal to LZWR consumption of 24.3 kg per ton of *** SO_(2) in sintering flue gas can be recovered to produce(NH_(4))_(2)SO_(4) or HSO_(4),while the volatilized Zn collected into the zinc-containing dust can be subsequently recycled by the rotary hearth furnace ***,it is technologically and economically feasible to use the LZWR as a replacement flux in the iron ore sintering process,providing a new way for the safe,large-scale and low-cost treatment of LZWR.

关键词： Lead Zinc waste rock Dolomite Sintering Flue gas Sinter product

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