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Dual mechanisms of Bcl-2 regulation in IP_(3)-receptor-mediated Ca^(2+)release:A computational study

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Chinese Physics B 2021年第10期30卷 689-697页

作者： Hong Qi Zhi-Qiang shi Zhi-Chao Li Chang-Jun Sun shi-miao wang Xiang Li Jian-Wei Shuai Complex Systems Research Center Shanxi UniversityTaiyuan 030006China Shanxi Key Laboratory of Mathematical Techniques and Big Data Analysis on Disease Control and Prevention Shanxi UniversityTaiyuan 030006China School of Mathematical Sciences Shanxi UniversityTaiyuan 030006China Department of Physics and Fujian Provincial Key Laboratory for Soft Functional Materials Research Xiamen UniversityXiamen 361005China State Key Laboratory of Cellular Stress Biology Innovation Center for Cell Signaling Networkand National Institute for Data Science in Health and MedicineXiamen UniversityXiamen 361005China

Inositol 1,4,5-trisphosphate receptors(IP_(3)R)-mediated calcium ion(Ca^(2+))release plays a central role in the regulation of cell survival and ***-2 limits the Ca^(2+)release function of the IP3R through a direct or indirect ***,the two mechanisms are overwhelmingly complex and not completely ***,we convert the mechanisms into a set of ordinary differential *** firstly simulate the time evolution of Ca^(2+)concentration under two different levels of Bcl-2 for the direct and indirect mechanism models and compare them with experimental results available in the ***,we employ one-and two-parameter bifurcation analysis to demonstrate that Bcl-2 can suppress Ca^(2+)signal from a global point of view both in the direct and indirect mechanism *** then use mathematical analysis to clarify that the indirect mechanism is more efficient than the direct mechanism in repressing Ca^(2+)***,we predict that the two mechanisms restrict Ca^(2+)signal ***,our study provides theoretical insights into Bcl-2 regulation in IP_(3)R-mediated Ca^(2+)release,which may be instrumental for the successful development of therapies to target Bcl-2 for cancer treatment.

关键词： Ca^(2+) Bcl-2 bifurcation analysis oscillations

Comparing Mn-based oxides filters started by KMnO_(4)versus K_(2)FeO_(4)for ammonium and manganese removal:Formation mechanism of active species

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Journal of Environmental Sciences 2024年第11期145卷 180-192页

作者： Ya Cheng Fengkai shi Tinglin Huang Anqi miao Gang Wen Chunwei wang Key Laboratory of Northwest Resource Environment and EcologyMOEXi’an University of Architecture and TechnologyXi’an 710055China Shaanxi Key Laboratory of Environmental Engineering Xi’an University of Architecture and TechnologyXi’an 710055China Collaborative Innovation Center of Water Pollution Control and Water Quality Security Assurance of Shaanxi Province Xi’an University of Architecture and TechnologyXi’an 710055China

A pilot-scale filtration system was adopted to prepare filter media with catalytic activity to remove manganese(Mn^(2+))and ammonium(NH_(4)^(+)-N).Three different combinations of oxidants(KMnO_(4)and K_(2)FeO_(4))and reductants(MnSO_(4)and FeCl_(2))were used during the start-up *** R3 started up by KMnO_(4)and FeCl_(2)(Mn^(7+)→MnO_(x))exhibited excellent catalytic property,and the NH_(4)^(+)-N and Mn^(2+)removal efficiency reached over 80%on the 10th and 35th days,*** R1 started up by K_(2)FeO_(4)and MnSO_(4)(MnO_(x)←Mn^(2+))exhibited the worst catalytic *** R2 started up by KMnO_(4)and MnSO_(4)(Mn^(7+)→MnO_(x)←Mn^(2+))were in *** to Zeta potential results,the Mn-based oxides(MnO_(x))formed by Mn^(7+)→MnO_(x)performed the highest pHIEP and *** higher the pHIEP and pHPZC,the more unfavorable the cation ***,it was inconsistent with its excellent Mn^(2+)and NH_(4)^(+)-N removal abilities,implying that catalytic oxidation played a key *** with XRD and XPS analysis,the results showed that the MnO_(x)produced by the reduction of KMnO_(4)showed early formation of buserite crystals,high degree of amorphous,high content of Mn3+and lattice oxygen with the higher activity to form *** above results showed that MnO_(x)produced by the reduction of KMnO_(4)was more conducive to the formation of active species for catalytic oxidation of NH_(4)^(+)-N and Mn^(2+)*** study provides new insights on the formation mechanisms of the active MnO_(x)that could catalytic oxidation of NH_(4)^(+)-N and Mn^(2+).

关键词： Ammonium Manganese Mn-based oxide Filter Start-up Active species

Nanofluidic memristor based on the elastic deformation of nanopores with nanoparticle adsorption

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National Science Review 2024年第04期11卷 46-54页

作者： Xi Zhou Yuanyuan Zong Yongchang wang miao Sun Deli shi Wei wang Guanghua Du Yanbo Xie Department of Chemistry and Chemical Engineering Northwestern Polytechnical University School of Physical Science and Technology Northwestern Polytechnical University School of Aeronautics and Institute of Extreme Mechanics Northwestern Polytechnical University Institute of Modern Physics Chinese Academy of Sciences

The memristor is the building block of neuromorphic computing. We report a new type of nanofluidic memristor based on the principle of elastic strain on polymer nanopores. With nanoparticles absorbed at the wall of a single conical polymer nanopore, we find a pinched hysteresis of the current within a scanning frequency range of 0.01–0.1 Hz, switching to a diode below 0.01 Hz and a resistor above 0.1 Hz. We attribute the current hysteresis to the elastic strain at the tip side of the nanopore, caused by electrical force on the particles adsorbed at the inner wall surface. Our simulation and analytical equations match well with experimental results, with a phase diagram for predicting the system transitions. We demonstrate the plasticity of our nanofluidic memristor to be similar to a biological synapse. Our findings pave a new way for ionic neuromorphic computing using nanofluidic memristors.

关键词： nanofluidics memristor neurocomputing elastic deformation

How can technology and efficiency alleviate the dilemma of economic growth and carbon emissions in China's industrial economy? A metafrontier decoupling decomposition analysis

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Petroleum Science 2024年第2期21卷 1415-1428页

作者： miao wang Chao Feng School of Business Zhengzhou UniversityZhengzhou450001HenanChina School of Economics and Business Administration Chongqing UniversityChongqing400030China

This paper attempts to explore the decoupling relationship and its drivers between industrial economic increase and energy-related CO_(2) emissions(ICE). Firstly, the decoupling relationship was evaluated by Tapio index. Then, based on the DEA meta-frontier theory framework which taking into account the regional and industrial heterogeneity and index decomposition method, the driving factors of decoupling process were explored mainly from the view of technology and efficiency. The results show that during2000-2019, weak decoupling was the primary state. Investment scale expansion was the largest reason hindering decoupling process of industrial increase from ICE. Both energy saving and production technology achieved significant progress, which facilitated the decoupling process. Simultaneously, the energy technology gap and production technology gap among regions have been narrowed, and played a role in promoting decoupling process. On the contrary, both scale economy efficiency and pure technical efficiency have inhibiting effects on decoupling process. The former indicates that the scale economy of China's industry was not conducive to improve energy efficiency and production efficiency, while the latter indicates that resource misallocation problem may exist in both energy market and product market.

关键词： China's industrial sector Decoupling process Meta-frontier DEA Index decomposition method Driving factors

Intelligent UAV Based Energy Supply for 6G Wireless Powered IoT Networks

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China Communications 2024年第9期21卷 321-337页

作者： miao Jiansong Chen Haoqiang wang Pengjie Li Hairui Zhao Yan Mu Junsheng Yan shi School of Information and Communication Engineering Beijing University of Posts and TelecommunicationsBeijing 100876China Beijing Key Laboratory of Network System Architecture and Convergence Beijing University of Posts and TelecommunicationsBeijing 100876China

In this paper,we develop a 6G wireless powered Internet of Things(IoT)system assisted by unmanned aerial vehicles(UAVs)to intelligently supply energy and collect data at the same *** our dual-UAV scheme,UAV-E,with a constant power supply,transmits energy to charge the IoT devices on the ground,whereas UAV-B serves the IoT devices by data collection as a base *** this framework,the system's energy efficiency is maximized,which we define as a ratio of the sum rate of IoT devices to the energy consumption of two UAVs during a fixed working *** the constraints of duration,transmit power,energy,and mobility,a difficult non-convex issue is presented by optimizing the trajectory,time duration allocation,and uplink transmit power of *** tackle the non-convex fractional optimization issue,we deconstruct it into three subproblems and we solve each of them iteratively using the descent method in conjunction with sequential convex approximation(SCA)approaches and the Dinkelbach *** simulation findings indicate that the suggested cooperative design has the potential to greatly increase the energy efficiency of the 6G intelligent UAV-assisted wireless powered IoT system when compared to previous benchmark systems.

关键词： 6G wireless powered network energy efficiency IoT intelligent network UAV communication

An attention graph stacked autoencoder for anomaly detection of electro-mechanical actuator using spatio-temporal multivariate signals

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Chinese Journal of Aeronautics 2024年第9期37卷 506-520页

作者： Jianyu wang Heng ZHANG Qiang miao College of Electrical Engineering Sichuan UniversityChengdu 610065China

Health monitoring of electro-mechanical actuator(EMA)is critical to ensure the security of *** is difficult or even impossible to collect enough labeled failure or degradation data from actual *** autoencoder based on reconstruction loss is a popular model that can carry out anomaly detection with only consideration of normal training data,while it fails to capture spatio-temporal information from multivariate time series signals of multiple monitoring *** mine the spatio-temporal information from multivariate time series signals,this paper proposes an attention graph stacked autoencoder for EMA anomaly ***,attention graph con-volution is introduced into autoencoder to convolve temporal information from neighbor features to current features based on different weight ***,stacked autoencoder is applied to mine spatial information from those new aggregated temporal ***,based on the bench-mark reconstruction loss of normal training data,different health thresholds calculated by several statistic indicators can carry out anomaly detection for new testing *** comparison with tra-ditional stacked autoencoder,the proposed model could obtain higher fault detection rate and lower false alarm rate in EMA anomaly detection experiment.

关键词： Anomaly detection Spatio-temporal informa-tion Multivariate time series signals Attention graph convolution Stacked autoencoder

A new method for evaluating the firing precision of multiple launch rocket system based on Bayesian theory

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Defence Technology（防务技术） 2024年第2期32卷 232-241页

作者： Yunfei miao Guoping wang Wei Tian College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and AstronauticsNanjingJiangsuChina Institute of Launch Dynamics Nanjing University of Science and TechnologyNanjingJiangsuChina

How to effectively evaluate the firing precision of weapon equipment at low cost is one of the core contents of improving the test level of weapon system.A new method to evaluate the firing precision of the MLRS considering the credibility of simulation system based on Bayesian theory is proposed in this *** of all,a comprehensive index system for the credibility of the simulation system of the firing precision of the MLRS is constructed combined with the group analytic hierarchy process.A modified method for determining the comprehensive weight of the index is established to improve the rationality of the index weight *** Bayesian posterior estimation formula of firing precision considering prior information is derived in the form of mixed prior distribution,and the rationality of prior information used in estimation model is discussed *** the simulation tests,the different evaluation methods are compared to validate the effectiveness of the proposed ***,the experimental results show that the effectiveness of estimation method for firing precision is improved by more than 25%.

关键词： Multiple launch rocket system Bayesian theory Simulation credibility Mixed prior distribution Firing precision

Crystal engineering regulation achieving inverse temperature symmetry breaking ferroelasticity in a cationic displacement type hybrid perovskite system

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Chinese Chemical Letters 2024年第5期35卷 477-481页

作者： Na wang wang Luo Huaiyi Shen Huakai Li Zejiang Xu Zhiyuan Yue Chao shi Hengyun Ye Leping miao Chaotic Matter Science Research Center Department of MaterialsMetallurgy and ChemistryJiangxi University of Science and TechnologyGanzhou 341000China

Ferroelastic hybrid perovskite materials have been revealed the significance in the applications of switches,sensors,actuators,***,it remains a challenge to design high-temperature ferroelastic to meet the requirements for the practical ***,we reported an one-dimensional organicinorganic hybrid perovskites(OIHP)(3-methylpyrazolium)CdCl_(3)(3-MBCC),which possesses a mmmF2/m ferroelastic phase transition at 263 ***,utilizing crystal engineering,we replace-CH_(3) with-NH_(2) and-H,which increases the intermolecular force between organic cations and inorganic *** phase transition temperature of(3-aminopyrazolium)CdCl_(3)(3-ABCC),and(pyrazolium)CdCl_(3)(BCC)increased by 73 K and 10 K,***,BCC undergoes an unconventional inverse temperature symmetry breaking(ISTB)ferroelastic phase transition around 273 ***,it transforms from a high symmetry low-temperature paraelastic phase(point group 2/m)to a low symmetry high-temperature ferroelastic phase(point group ī)originating from the rare mechanism of displacement of organic cations phase *** means that crystal BCC retains in ferroelastic phase above 273 K until melting point(446 K).Furthermore,characteristic ferroelastic domain patterns on crystal BCC are confirmed with polarized optical *** study enriches the molecular mechanism of ferroelastics in the family of organic-inorganic hybrids and opens up a new avenue for exploring high-temperature ferroic materials.

关键词： Organic-inorganic hybrid perovskite Crystal engineering Inverse temperature symmetry breaking Displacement type phase transition Ferroelasticity

Optimized Mask-RCNN model for particle chain segmentation based on improved online ferrograph sensor

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Friction 2024年第6期12卷 1194-1213页

作者： Shuo wang miao WAN Tonghai WU Zichen BAI Kunpeng wang Key Laboratory of Education Ministry for Modern Design and Rotor-Bearing System Xi’an Jiaotong UniversityXi’an 710049China

Ferrograph-based wear debris analysis(WDA)provides significant information for wear fault analysis of mechanical *** decades of offline application,this conventional technology is being driven by the online ferrograph sensor for real-time wear state ***,online ferrography has been greatly limited by the low imaging quality and segmentation accuracy of particle chains when analyzing degraded lubricant oils in practical *** address this issue,an integrated optimization method is developed that focuses on two aspects:the structural re-design of the online ferrograph sensor and the intelligent segmentation of particle *** enhancing the imaging quality of wear particles,the magnetic pole of the online ferrograph sensor is optimized to enable the imaging system directly observe wear particles without penetrating ***,a light source simulation model is established based on the light intensity distribution theory,and the LED installation parameters are determined for particle illumination uniformity in the online ferrograph *** this basis,a Mask-RCNN-based segmentation model of particle chains is constructed by specifically establishing the region of interest(ROI)generation layer and the ROI align layer for the irregular particle *** these measures,a new online ferrograph sensor is designed to enhance the image acquisition and information extraction of wear *** verification,the developed sensor is tested to collect particle images from different degraded oils,and the images are further handled with the Mask-RCNN-based model for particle feature *** results reveal that the optimized online ferrography can capture clear particle images even in highly-degraded lubricant oils,and the illumination uniformity reaches 90%in its imaging *** importantly,the statistical accuracy of wear particles has been improved from 67.2%to 94.1%.

关键词： wear particle analysis online ferrography particle image acquisition particle chain segmentation