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Effect of perioperative chemotherapy on resection of isolated pulmonary metastases from colorectal cancer:A single center experience

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3457-3470页

作者： Zhao Gao Xuan Jin Ying-Chao wu shi-Jie Zhang shi-Kai wu Xin Wang Department of Medical Oncology Peking University First HospitalBeijing 10000China Department of General Surgery Peking University First HospitalBeijing 10000China Department of Thoracic Surgery Peking University First HospitalBeijing 10000China

BACKGROUND Numerous studies have assessed surgical resection as a standard treatment option for patients with colorectal cancer(CRC)and resectable pulmonary metastases(PM).However,the role of perioperative chemotherapy after complete resection of isolated PM from patients with CRC patients remains *** hypothesize that perioperative chemotherapy does not provide significant survival benefits for patients undergoing resection of PM from *** To determine whether perioperative chemotherapy affects survival after radical resection of isolated PM from *** We retrospectively collected demographic,clinical,and pathologic data on patients who underwent radical surgery for isolated PM from *** survival(CSS)and disease-free survival were calculated using Kaplan-Meier ***-group differences were compared using the log-rank *** multivariate analysis,Cox regression was utilized when *** This study included 120 patients with a median age of 61.6 *** 5-year CSS rate was 78.2%,with 36.7% experiencing *** resection for isolated PM resulted in a 5-year CSS rate of 50.0% for second *** chemotherapy(P=0.079)did not enhance survival *** associated with improved survival included fewer metastatic lesions[hazard ratio(HR):2.51,P=0.045],longer disease-free intervals(HR:0.35,P=0.016),and wedge lung resections(HR:0.42,P=0.035).Multiple PM predicted higher recurrence risk(HR:2.22,P=0.022).The log-rank test showed no significant difference in CSS between single and repeated metastasectomy(P=0.92).CONCLUSION Perioperative chemotherapy shows no survival benefit post-PM resection in ***-free intervals and fewer metastatic lesions predict better *** metastasectomy is warranted for eligible patients.

关键词： Pulmonary metastasis Colorectal cancer Perioperative chemotherapy Survival Repeated pulmonary metastasectomy

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Blockade of the deubiquitinating enzyme USP48 degrades oncogenic HMGA2 and inhibits colorectal cancer invasion and metastasis

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Acta Pharmaceutica Sinica B 2024年第4期14卷 1624-1643页

作者： Can Cheng Hanhui Yao Heng Li Jingwen Liu Zhengyi Liu Yang wu liang Zhu Hejie Hu Zhengdong Fang liang wu Department of General Surgery the First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Anhui Province Key Laboratory of Hepatopancreatobiliary Surgery the First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Department of Comprehensive Surgery Anhui Provincial Cancer HospitalWest District of the First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Anhui Provincial Hospital Health Management Center the First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Department of Breast Surgery Henan Provincial People's HospitalPeople's Hospital of Zhengzhou UniversityPeople's Hospital of Henan UniversityZhengzhou 450003China

HMGA2,a pivotal transcription factor,functions as a versatile regulator implicated in the progression of diverse aggressive *** this study,mass spectrometry was employed to identify ubiquitin-specific proteases that potentially interact with HMGA2,and USP48 was identified as a deubiquitinating enzyme of *** enforced expression of USP48 significantly increased HMGA2 protein levels by inhibiting its degradation,while the deprivation of USP48 promoted HMGA2 degradation,thereby suppressing tumor invasion and *** discovered that USP48 undergoes SUMOylation at lysine 258,which enhances its binding affinity to *** subsequent phenotypic screening of small molecules,we identified DUB-IN-2 as a remarkably potent pharmacological inhibitor of ***,the small-molecule inhibitor targeting USP48 induces destabilization of ***,upregulation of USP48 or HMGA2 in cancerous tissues is indicative of poor prognosis for patients with colorectal cancer(CRC).Collectively,our study not only elucidates the regulatory mechanism of DUBs involved in HMGA2 stability and validates USP48 as a potential therapeutic target for CRC,but also identifies DUB-IN-2 as a potent inhibitor of USP48 and a promising candidate for CRC treatment.

关键词： Colorectal cancer Invasion and metastasis Post-translational modification Ubiquitination SUMOylation USP48 HMGA2 Specific inhibitors

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Epitaxial growth of borophene on graphene surface towards efficient and broadband photodetector

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Nano Research 2024年第4期17卷 3053-3060页

作者： Zenghui wu Chen shifan Zitong wu Yi Liu Wei Shao Xinchao liang Chuang Hou Guoan Tai The State Key Laboratory of Mechanics and Control of Mechanical Structures and Laboratory of Intelligent Nano Materials and Devices of Ministry of Education College of Aerospace EngineeringNanjing University of Aeronautics and AstronauticsNanjing 210016China

In-situ integration of multiple materials with well-defined interfaces as heterostructures is of great interest due to their unique properties and potential for new device *** of its polymorphism and diverse bonding geometries,borophene is a promising candidate for two-dimensional heterostructures,but suitable synthesis conditions have limited its potential *** this end,we demonstrate the vertical borophene and graphene heterostructures which form by epitaxial growth of borophene onto multilayer graphene on Cu substrates via chemical vapor deposition,where hydrogen and NaBH_(4) are respectively used as the carrier gas and the boron *** lattice structure of the as-synthesized borophene well coincides with the predictedα′-boron *** borophene-based photodetector shows an excellent broadband photoresponse from the ultraviolet(255 nm)to the infrared(940 nm)wavelengths,with enhanced responsivity compared to pristine borophene or graphene *** work informs emerging efforts to integrate borophene into nanoelectronic applications for both fundamental investigations and technological applications.

关键词： borophene graphene heterostructure photodetector two-dimensional materials

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A Deep Learning-Enabled Skin-Inspired Pressure Sensor for Complicated Recognition Tasks with Ultralong Life

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Research 2024年第1期2023卷 443-454页

作者： Yingxi Xie Xiaohua wu Xiangbao Huang Qinghua liang shiping Deng Zeji wu Yunpeng Yao Longsheng Lu School of Mechanical&Automotive Engineering South China University of TechnologyGuangzhouChina

Flexible full-textile pressure sensor is able to integrate with clothing directly,which has drawn extensive attention from scholars *** the realization of flexible full-textile pressure sensor with high sensitivity,wide detection range,and long working life remains *** recognition tasks necessitate intricate sensor arrays that require extensive data processing and are susceptible to *** human skin is capable of interpreting tactile signals,such as sliding,by encoding pressure changes and performing complex perceptual *** by the skin,we have developed a simple dip-and-dry approach to fabricate a full-textile pressure sensor with signal transmission layers,protective layers,and sensing *** sensor achieves high sensitivity(2.16 kPa^(−1)),ultrawide detection range(0 to 155.485 kPa),impressive mechanical stability of 1 million loading/unloading cycles without fatigue,and low material *** signal transmission layers that collect local signals enable real-world complicated task recognition through one single *** developed an artificial Internet of Things system utilizing a single sensor,which successfully achieved high accuracy in 4 tasks,including handwriting digit recognition and human activity *** results demonstrate that skin-inspired full-textile sensor paves a promising route toward the development of electronic textiles with important potential in real-world applications,including human–machine interaction and human activity detection.

关键词： Deep Skin utilizing

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Modification of the CuO electronic structure for enhanced selective electrochemical CO_(2) reduction to ethylene

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Nano Research 2024年第8期17卷 7194-7202页

作者： Xin wu Zhuang Tong Yunliang Liu Yaxi Li Yuanyuan Cheng Jingwen Yu Peng Cao Chunqiang Zhuang Qiuzhong shi Naiyun Liu Xiang Liu Hongyu liang Haitao Li Institute for Energy Research School of Energy and Power EngineeringJiangsu UniversityZhenjiang 212013China Faculty of Materials and Manufacturing Beijing University of TechnologyBeijing 100124China Institute of Medicine&Chemical Engineering Zhenjiang CollegeZhenjiang 212013China Institute of Advanced Manufacturing and Modern Equipment Technology School of Mechanical EngineeringJiangsu UniversityZhenjiang 212013China

Electrochemical carbon dioxide reduction reaction(CO_(2)RR)can produce value-added hydrocarbons from renewable electricity,providing a sustainable and promising approach to meet dual-carbon targets and alleviate the energy ***,it is still challenging to improve the selectivity and stability of the products,especially the C^(2+) *** we propose to modulate the electronic structure of copper oxide(CuO)through lattice strain construction by zinc(Zn)doping to improve the selectivity of the catalyst to *** performance and in situ characterization analyses show that the compressive strain generated within the CuO lattice and the electronic structure modulation by Zn doping enhances the adsorption of the key intermediate*CO,thereby increasing the intrinsic activity of CO_(2)RR and inhibiting the hydrogen precipitation *** the best catalysts had significantly improved ethylene selectivity of 60.5%and partial current density of 500 mA·cm^(–2),and the highest C^(2+) Faraday efficiency of 71.47%.This paper provides a simple idea to study the modulation of CO_(2)RR properties by heteroatom doped and lattice strain.

关键词： CO_(2) reduction heteroatom-doped lattice strain ethylene selectivity

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Global-local combined features to detect pain intensity from facial expression images with attention mechanism

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Journal of Electronic Science and Technology 2024年第3期22卷 80-93页

作者： Jiang wu Yi shi Shun Yan Hong-Mei Yan Yangtze Delta Region Institute(Huzhou) University of Electronic Science and Technology of ChinaHuzhou313001China MOE Key Laboratory for Neuroinformation School of Life Science and TechnologyUniversity of Electronic Science and Technology of ChinaChengdu611731China College of Engineering University of California at Santa BarbaraSanta Barbara93106USA

The estimation of pain intensity is critical for medical diagnosis and treatment of *** the development of image monitoring technology and artificial intelligence,automatic pain assessment based on facial expression and behavioral analysis shows a potential value in clinical *** paper reports a framework of convolutional neural network with global and local attention mechanism(GLA-CNN)for the effective detection of pain intensity at four-level thresholds using facial expression ***-CNN includes two modules,namely global attention network(GANet)and local attention network(LANet).LANet is responsible for extracting representative local patch features of faces,while GANet extracts whole facial features to compensate for the ignored correlative features between *** the end,the global correlational and local subtle features are fused for the final estimation of pain *** under the UNBC-McMaster Shoulder Pain database demonstrate that GLA-CNN outperforms other state-of-the-art ***,a visualization analysis is conducted to present the feature map of GLA-CNN,intuitively showing that it can extract not only local pain features but also global correlative facial *** study demonstrates that pain assessment based on facial expression is a non-invasive and feasible method,and can be employed as an auxiliary pain assessment tool in clinical practice.

关键词： Attention Convolutional neural network Facial expression Pain intensity

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Integrated optical frequency transfer and optical physical layer key distribution with enhanced link reciprocity detection

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Science China(Information Sciences) 2024年第7期67卷 335-336页

作者： Kunfeng XIE liang HU Jianping CHEN Guiling wu State Key Laboratory of Advanced Optical Communication System and Networks Department of Electronic EngineeringShanghai Jiao Tong University

Optical fiber transmission has been widely used in communications and metrology, wherein optical frequency transfer (OFT) and optical physical layer secure key distribution (OKD) have become research hotspots [1, 2]. Moreover,OFT can perform a comparison between state-of-the-art optical atomic clocks and implement coherent optical phase transfer over long distances to support geodesy [1, 3].

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Microstructure,Corrosion and Mechanical Properties of Medium-Thick 6061-T6 Alloy/T2 Pure Cu Dissimilar Joints Produced by Double Side Friction Stir Z Shape Lap-Butt Welding

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Chinese Journal of Mechanical Engineering 2024年第2期37卷 385-400页

作者： Jiuxing Tang Guoxin Dai Lei shi Chuansong wu Sergey Mironov Surendra Kumar Patel Song Gao Mingxiao wu MOE Key Lab for Liquid-Solid Structure Evolution and Materials Processing Shandong UniversityJinan 250061China Laboratory of Mechanical Properties of Nanoscale Materials and Superalloys Belgorod State UniversityBelgorod 308015Russia School of Mechanical Engineering Qilu University of Technology(Shandong Academy of Sciences)Jinan 250353China State Grid Henan Electric Power Research Institute Zhengzhou 450052China

A novel double side friction stir Z shape lap-butt welding(DS-FSZW)process was proposed to achieve excellent mechanical properties of Al/Cu medium-thick dissimilar *** influence of welding parameters on weld microstructure and properties of DS-FSZW joint were systematically *** indicated that defect-free medium-thick Al/Cu DS-FSZW joint could be achieved under an optimal welding ***-FSZW joint was prone to form void defects in the bottom of the second-pass *** recrystallization mechanisms at the top and middle of the weld nugget zone(WNZ)were continuous dynamic recrystallization(CDRX)and geometric dynamic recrystallization(GDRX).While the major recrystallization mechanism at the bottom of the WNZ was ***-FSZW joint of the optimal welding condition with 850 r/min-400 mm/min was produced with a continuous thin and crack-free IMCs layer at the Al/Cu interface,and the maximum tensile strength of this joint is 160.57 MPa,which is equivalent to 65.54%of pure Cu base ***,the corrosion resistance of Al/Cu DS-FSZW joints also achieved its maximum value at the optimal welding parameter of 850 r/min-400 mm/*** demonstrates that the DS-FSZW process can simultaneously produce medium-thick Al/Cu joints with excellent mechanical performance and corrosion resistance.

关键词： DS-FSZW Al/Cu dissimilar joint Corrosion behaviour Intermetallic compounds Microstructure Mechanical properties

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Counteracting effects on ENSO induced by ocean chlorophyll interannual variability and tropical instability wave-scale perturbations in the tropical Pacific

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Science China Earth Sciences 2024年第2期67卷 387-404页

作者： Rong-Hua ZHANG Feng TIAN Qidong shi Xiujun WANG Tongwen wu School of Marine Sciences Nanjing University of Information Science and TechnologyNanjing210044China Laoshan Laboratory Qingdao266237China Key Laboratory of Ocean Circulation and Waves Institute of OceanologyChinese Academy of SciencesQingdao266071China University of Chinese Academy of Sciences Beijing101408China Faculty of Geographical Sciences Beijing Normal UniversityBeijing100875China Earth System Modeling and Prediction Centre China Meteorological AdministrationBeijing100081China

Large perturbations in chlorophyll(Chl)are observed to coexist at interannual and tropical instability wave(TIW)scales in the tropical Pacific;at present,their combined effects on El Ni?o-Southern Oscillation(ENSO)through ocean biologyinduced heating(OBH)feedbacks are not understood ***,a hybrid coupled model(HCM)for the atmosphere and ocean physics-biogeochemistry(AOPB)in the tropical Pacific is adopted to quantify how ENSO can be modulated by Chl perturbations at interannual and TIW scales,individually or collectively,*** HCM-based sensitivity experiments demonstrate a counteracting effect on ENSO:the bio-climate feedback due to large-scale Chl interannual variability acts to damp ENSO through its impact on upper-ocean stratification and vertical mixing,whereas that due to TIW-scale Chl perturbations tends to amplify *** ENSO simulations are sensitively dependent on the ways Chl effects are represented at these different scales,it is necessary to adequately take into account these related differential Chl effects in climate modeling.A bias source for ENSO simulations is illustrated that is related with the Chl effects in the tropical Pacific,adding in a new insight into interactions between the climate system and ocean ecosystem on different scales in the *** results reveal a level of complexity of ENSO modulations resulting from Chl effects at interannual and TIW scales,which are associated with ocean biogeochemical processes and their interactions with physical processes in the tropical Pacific.

关键词： Ocean chlorophyll Bio-climate feedbacks Interannual variability Tropical instability waves Counteracting effects A hybrid coupled model

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Distribution, bioaccumulation, trophic transfer and risk assessment of trace elements in fish from a typical shallow outflow lake basin, China

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Frontiers of Environmental Science & Engineering 2024年第7期18卷 141-156页

作者： Miao He Guijian Liu Xiaodan shi Lei wu Qiang Chen CAS Key Laboratory of Crust-Mantle Materials and Environment School of Earth and Space SciencesUniversity of Science and Technology of ChinaHefei 230026China Anhui Academy of Environmental Sciences Hefei 230022China School of Resources and Environmental Engineering Hefei University of TechnologyHefei 230009China

Fish are important food sources for humans,and the availability of appropriate amount of trace elements(TEs)plays a crucial role in fish ***,due to large volumes of sewage discharge,high levels of certain elements are present in aquatic environments,and these elements accumulate in fish and potentially affect human *** this study,the distribution and bioaccumulation capacity of trace elements in six dominant fish species from Chaohu Lake(China)were *** results showed that the bioaccumulation capacity of fish for Zn was greater than other *** the source of the TEs in the fish were explored along with the concentration of the TEs in the aquatic environment,which indicated that TEs in fish were mainly obtained through ingestion and indirectly affected by the industrial activities in the ***,stable carbon and nitrogen isotopes were used to classify the trophic levels and explore the biological magnification of TEs of the *** was found that Sb and Sr showed biomagnification with the increase of trophic level of *** on the above analyses,the environmental biogeochemical cycle model of TEs in the lake was distinguished and established,which can offer valuable insights for sustainable fishery management in the downstream Yangtze River Delta ecosystem.

关键词： Trophic level Bioaccumulation Risk assessment Trace elements

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