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"Five steps four quadrants" modularized en bloc dissection technique for accessing hepatic hilum lymph nodes in laparoscopic pancreaticoduodenectomy

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 503-510页

作者： Xiao-Si Hu Yong Wang Hong-Tao Pan Chao Zhu shi-lei chen Hui-Chun Liu Qing Pang Hao Jin Department of Hepatopancreatobiliary Surgery Anhui No.2 Provincial People’s HospitalHefei 230041Anhui ProvinceChina

BACKGROUND Although en bloc dissection of hepatic hilum lymph nodes has many advantages in radical tumor treatment,the feasibility and safety of this approach for laparo-scopic pancreaticoduodenectomy(LPD)require further clinical evaluation and *** To explore the application value of the"five steps four quadrants"modularized en bloc dissection technique for accessing hepatic hilum lymph nodes in LPD *** A total of 52 patients who underwent LPD via the"five steps four quadrants"modularized en bloc dissection technique for hepatic hilum lymph nodes from April 2021 to July 2023 in our department were analyzed *** patients'body mass index(BMI),preoperative laboratory indices,intraoperative variables and postoperative complications were *** relationships between preoperative data and intraoperative lymph node dissection time and blood loss were also *** Among the 52 patients,36 were males and 16 were females,and the average age was 62.2±11.0 *** were 26 patients with pancreatic head cancer,16 patients with periampullary cancer,and 10 patients with distal bile duct *** BMI was 22.3±3.3 kg/m²,and the median total bilirubin(TBIL)concentration was 57.7(16.0-155.7)µmol/*** patients successfully underwent the"five steps four quadrants"modularized en bloc dissection technique without lymph node clearance-related complications such as postoperative bleeding or lymphatic *** analysis revealed significant associations between preoperative BMI(r=0.3581,P=0.0091),TBIL level(r=0.2988,P=0.0341),prothrombin time(r=0.3018,P=0.0297)and lymph node dissection ***,dissection time was significantly correlated with intraoperative blood loss(r=0.7744,P<0.0001).Further stratified analysis demonstrated that patients with a preoperative BMI≥21.9 kg/m²and a TIBL concentration≥57.7μmol/L had significantly longer lymph node dissection times(both P<0.05).CONCLUSION The"five steps four quadrants

关键词： Five steps four quadrants Hepatic hilum lymph node Modularized en bloc clearance Laparoscopic pancreaticoduodenectomy

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“Hepatic hilum area priority,liver posterior first”:An optimized strategy in laparoscopic resection for type Ⅲ-Ⅳ hilar cholangiocarcinoma

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2167-2174页

作者： Xiao-Si Hu Yong Wang Hong-Tao Pan Chao Zhu shi-lei chen Shuai Zhou Hui-Chun Liu Qing Pang Hao Jin Department of Hepatopancreatobiliary Surgery Anhui No.2 Provincial People's HospitalHefei 230041Anhui ProvinceChina

BACKGROUND In recent years,pure laparoscopic radical surgery for Bismuth-Corlette type Ⅲ and Ⅳ hilar cholangiocarcinoma(HCCA)has been preliminarily explored and applied,but the surgical strategy and safety are still worthy of further improvement and *** To summarize and share the application experience of the emerging strategy of“hepatic hilum area dissection priority,liver posterior separation first”in pure laparoscopic radical resection for patients with HCCA of Bismuth-Corlette types Ⅲ and *** The clinical data and surgical videos of 6 patients with HCCA of Bismuth-Corlette types Ⅲ and Ⅳ who underwent pure laparoscopic radical resection in our department from December 2021 to December 2023 were retrospectively *** Among the 6 patients,4 were males and 2 were *** average age was 62.2±11.0 years,and the median body mass index was 20.7(19.2-24.1)kg/m^(2).The preoperative median total bilirubin was 57.7(16.0-155.7)μmol/*** patient had Bismuth-Corlette type Ⅲa,4 patients had Bismuth-Corlette type Ⅲb,and 1 patient had Bismuth-Corlette type Ⅳ.All patients successfully underwent pure laparoscopic radical resection following the strategy of“hepatic hilum area dissection priority,liver posterior separation first”.The operation time was 358.3±85.0 minutes,and the intraoperative blood loss volume was 195.0±108.4 *** of the patients received blood transfusions during the perioperative *** median length of stay was 8.3(7.0-10.0)*** bile leakage occurred in 2 patients,and all patients were discharged without serious surgery-related *** The emerging strategy of“hepatic hilum area dissection priority,liver posterior separation first”is safe and feasible in pure laparoscopic radical surgery for patients with HCCA of Bismuth-Corlette types Ⅲ and Ⅳ.This strategy is helpful for promoting the modularization and process of pure laparoscopic radical surgery for complicated HCCA,shortens the learning curve,and

关键词： Hilar cholangiocarcinoma Bismuth-Corlette typesⅢandⅣ Laparoscopy Radical resection Strategy

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示踪用盐酸米托蒽醌在甲状腺乳头状癌术中应用研究

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中国实用外科杂志 2024年第6期44卷 685-691页

作者：陶星儒石臣磊石铁锋吴罡刘英明董加宇哈尔滨医科大学附属第二临床医院普外四科黑龙江哈尔滨150086

目的探讨盐酸米托蒽醌与纳米碳注射液在甲状腺乳头状癌术中对甲状旁腺保护及淋巴结示踪效果的差异性,并研究盐酸米托蒽醌注射的最佳时间。方法前瞻性分析2023年1月至2023年7月哈尔滨医科大学附属第二医院甲状腺外科行单侧甲状腺癌根... 详细信息

目的探讨盐酸米托蒽醌与纳米碳注射液在甲状腺乳头状癌术中对甲状旁腺保护及淋巴结示踪效果的差异性,并研究盐酸米托蒽醌注射的最佳时间。方法前瞻性分析2023年1月至2023年7月哈尔滨医科大学附属第二医院甲状腺外科行单侧甲状腺癌根治术病人的临床资料,观察示踪剂腺体注射后和不同注射时间点注射后的染色满意度、淋巴结示踪效果、甲状旁腺辨识情况、原位保留情况、意外切除情况、自体移植情况、喉返神经损伤情况、手术时长及术后甲状旁腺激素(PTH)和血钙情况。结果试验一:盐酸米托蒽醌组染色满意度评分较纳米碳组差异无统计学意义(P=0.341),米托蒽醌组的被膜染色例数显著少于纳米碳组(5例vs.13例,P<0.05),且米托蒽醌组的气管食管沟染色例数(4例)较纳米碳组(10例)有减少趋势(P=0.067)。米托蒽醌组术中甲状旁腺检出量及原位保留量分别为(1.80±0.41)枚、(1.66±0.48)枚,纳米碳组为(1.73±0.45)枚、(1.57±0.50)枚,显著高于对照组(1.37±0.49)枚、(1.20±0.41)枚,差异有统计学意义(P<0.05)。试验二:米托蒽醌术前2 h和术中注射组的甲状旁腺检出量和原位保留量分别为(1.70±0.47)枚、(1.57±0.50)枚,(1.73±0.45)枚、(1.60±0.50)枚,显著高于术前24 h注射组(1.37±0.49)枚、(1.20±0.41)枚,差异有统计学意义(P<0.05)。术中注射组的手术时间为(46.77±9.71)min,与术前2 h组的(42.10±11.03)min和术前24 h组(41.73±10.42)min相比增加(P=0.064、P=0.086)。结论盐酸米托蒽醌与纳米碳相比具有更好的术区清晰度,有更好的显露并保护喉返神经的潜力,且术前2 h为示踪用盐酸米托蒽醌注射的最佳时间。

关键词：甲状腺乳头状癌示踪用盐酸米托蒽醌注射液纳米碳注射液甲状旁腺

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课程思政背景下后现代教育理论对高校创新创业教育效果影响的研究

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黑龙江教育（高教研究与评估） 2024年第8期 55-58页

作者：石臣磊李盛泽张思佳哈尔滨医科大学黑龙江哈尔滨150086

创新创业教育课程的核心是培养大学生的创新思维,促进学生了解创新方法,帮助学生增强自我认知并产生创新创业想法,激励学生组建双创团队,学会运用双创思维、运用双创实现创新创业价值。本文以课程思政理念为导向,在“创新创业基础”课... 详细信息

创新创业教育课程的核心是培养大学生的创新思维,促进学生了解创新方法,帮助学生增强自我认知并产生创新创业想法,激励学生组建双创团队,学会运用双创思维、运用双创实现创新创业价值。本文以课程思政理念为导向,在“创新创业基础”课程中融入思政案例,采取“后现代教育理论”进行教学,融入思政案例实现具有“过程性”体验的教学场景,培养双创精神,构建双创团队,激励大学生踏上创新创业理想征程,开展创新创业实践。

关键词：课程思政创新创业后现代主义课程建设

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Revolution in thermoelectric cooling using PbSe thermoelectrics by grid plainification

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Science China Materials 2024年第5期67卷 1672-1673页

作者： Xiao-lei shi Qingfeng Liu Zhi-Gang chen School of Chemistry and Physics ARC Research Hub in Zero-emission Power Generation for Carbon Neutralityand Centre for Materials ScienceQueensland University of TechnologyBrisbaneQueensland4000Australia State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical EngineeringNanjing Tech UniversityNanjing211816China

Thermoelectric materials and devices enable direct conversion between heat and electricity,holding potential applications in thermoelectric power generation,localized cooling,and electronic thermal management[1].Howev... 详细信息

关键词： enable thermoelectric constrained

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Distribution, bioaccumulation, trophic transfer and risk assessment of trace elements in fish from a typical shallow outflow lake basin, China

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Frontiers of Environmental Science & Engineering 2024年第7期18卷 141-156页

作者： Miao He Guijian Liu Xiaodan shi lei Wu Qiang chen CAS Key Laboratory of Crust-Mantle Materials and Environment School of Earth and Space SciencesUniversity of Science and Technology of ChinaHefei 230026China Anhui Academy of Environmental Sciences Hefei 230022China School of Resources and Environmental Engineering Hefei University of TechnologyHefei 230009China

Fish are important food sources for humans,and the availability of appropriate amount of trace elements(TEs)plays a crucial role in fish ***,due to large volumes of sewage discharge,high levels of certain elements are present in aquatic environments,and these elements accumulate in fish and potentially affect human *** this study,the distribution and bioaccumulation capacity of trace elements in six dominant fish species from Chaohu Lake(China)were *** results showed that the bioaccumulation capacity of fish for Zn was greater than other *** the source of the TEs in the fish were explored along with the concentration of the TEs in the aquatic environment,which indicated that TEs in fish were mainly obtained through ingestion and indirectly affected by the industrial activities in the ***,stable carbon and nitrogen isotopes were used to classify the trophic levels and explore the biological magnification of TEs of the *** was found that Sb and Sr showed biomagnification with the increase of trophic level of *** on the above analyses,the environmental biogeochemical cycle model of TEs in the lake was distinguished and established,which can offer valuable insights for sustainable fishery management in the downstream Yangtze River Delta ecosystem.

关键词： Trophic level Bioaccumulation Risk assessment Trace elements

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Utilizing quantum coherence in Cs Rydberg atoms for high-sensitivity room-temperature terahertz detection: a theoretical exploration

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Photonics Research 2024年第7期12卷 1583-1592页

作者： lei HOU JUNNAN WANG QIHUI HE SUGUO chen lei YANG SUNCHAO HUANG WEI shi Department of Physics Xi’an University of TechnologyXi’an 710048China School of Electrical Engineering Xi’an University of TechnologyXi’an 710048China School of Electrical and Electronic Engineering Nanyang Technological UniversitySingapore 610101Singapore

In recent years,terahertz (THz) technology has made significant progress in numerous applications;however,the highly sensitive,room-temperature THz detectors are still rare,which is one of the bottlenecks in THz *** this paper,we proposed a room-temperature electrometry method for THz detection by laser spectroscopy of cesium(^(133)Cs) Rydberg atoms,and conducted a comprehensive investigation of the five-level system involving electromagnetically induced transparency (EIT),electromagnetically induced absorption (EIA),and Autler–Townes (AT) splitting in^(133)Cs *** solving the Lindblad master equation,we found that the influence of the THz electric field,probe laser,dressing laser,and Rydberg laser on the ground state atomic population as well as the coherence between the ground state and the Rydberg state,plays a crucial role in the transformation and amplitude of the EIT and EIA *** and the atomic vapor cell’s dimensions affect the number of^(133)Cs atoms involved in the detection,and ultimately determine the *** predicted the proposed quantum coherence THz detection method has a remarkable sensitivity of as low as 10^(-9)V m^(-1)Hz^(-1/2).This research offers a valuable theoretical basis for implementing and optimizing quantum coherence effects based on Rydberg atoms for THz wave detection with high sensitivity and room-temperature operation.

关键词： quantum Rydberg dimensions

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Effect of Reclamation on the Groundwater-Lake Water Interaction in chen Lake

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Journal of Earth Science 2024年第3期35卷 1083-1086页

作者： Kun lei Teng Ma Liuzhu chen Zhenxing Li Yu chen School of Environmental Studies State Key Laboratory of Biogeology and Environmental GeologyChina University of GeosciencesWuhan 430078China

0 INTRODUCTION To relieve the short supply of suitable land for residing,cultivating,and commerce,it is accepted to reclaim land from lakes,river estuaries,and coastal regions in many countries(Mancini et al.,2020).The large-scale reclamation activities have an irreversible effect on the mico-geomorphology and hydrodynamic system of seasonally flooded areas(Zhang et al.,2019;Yu et al.,2018).For example,coastal regions reclaimed extended the groundwater flow paths,as well as created groundwater level rise,resulting in water-logging in the reclaimed area(Hu et al.,2008).Similar changes in groundwater flow systems may alter groundwater-lake water interactions,and it can ultimately affect the water cycle in the lake ***,such detailed studies are presently *** addition,natural exchanges between the lake and groundwater systems can be strongly affected by physical hydrological processes(Javadzadeh et al.,2020),chemical properties(Kamtchueng et al.,2015),and bioto behavior(Hancock et al.,2005).

关键词： groundwater coastal logging

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Rapid surface texturing to achieve robust superhydrophobicity,controllable droplet impact,and anti-frosting performances

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Friction 2024年第2期12卷 291-304页

作者： Qingwen DAI lei chen Jiabao PAN Liping shi Dameng LIU Wei HUANG Xiaolei WANG College of Mechanical and Electrical Engineering Nanjing University of Aeronautics&AstronauticsNanjing 210016China State Key Laboratory of Tribology in Advanced Equipment Department of Mechanical EngineeringTsinghua UniversityBeijing 100084China School of Mechanical Engineering Anhui Polytechnic UniversityWuhu 241000China School of Mechanical Engineering Anhui University of TechnologyMa’anshan 243032China

Robust superhydrophobic surfaces with excellent capacities of repelling water and anti-frosting are of importance for many mechanical *** this work,wear-resistant superhydrophobic surfaces were fabricated by curing a mixture of polyurethane acrylate(PUA)coating and 1H,1H,2H,2H-Perfluorodecyltrichlorosilane(HFTCS)on titanium alloy(TC4)surfaces decorated with micropillars pattern,thus,composite functional surfaces with PUA coating in the valleys around the micropillars pattern of TC4 were *** contact angle on fabricated surfaces could reach 167°.Influences of the geometric parameters of micropillars pattern on the apparent contact angle were investigated,and the corresponding wear-resistant property was *** impact and anti-frosting performances on the prepared surfaces were *** optimized design of surface texture with robust superhydrophobicity,controllable droplet impact,and anti-frosting performances was *** design principle is of promising prospects for fabricating superhydrophobic surfaces in traditional mechanical systems.

关键词： surface texture robust superhydrophobic wear-resistant droplet impact anti-frosting

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DAPK2 promotes autophagy to accelerate the progression of ossification of the posterior longitudinal ligament through the mTORC1 complex

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BIOCELL 2024年第9期48卷 1389-1400页

作者： lei shi JIANshi YIN YU chen JIANGANG shi JINHAO MIAO Department of Spine Surgery Shanghai Changzheng HospitalShanghai200003China Department of Orthopedics The 967th Hospital of Chinese People’s Liberation ArmyDalian116000China

Background:Ossification of the posterior longitudinal ligament(OPLL)is a prevalent condition in *** death-associated protein kinase 2(DAPK2)is known to play roles in cellular apoptosis and autophagy,its specific contributions to the advancement of OPLL are not well ***:Ligament fibroblasts were harvested from patients diagnosed with *** such as real-time reverse transcriptasepolymerase chain reaction(RT-qPCR)and Western blot analysis were employed to assess DAPK2 levels in both ligament tissues and cultured *** extent of osteogenic differentiation in these cells was evaluated using an alizarin red S(ARS)***,the expression of ossification markers and autophagy markers was *** autophagic activity was further analyzed through LC3 immunofluorescence and transmission electron microscopy(TEM).An in vivo heterotopic bone formation assay was conducted in mice to assess the role of DAPK2 in ***:Elevated DAPK2 expression was confirmed in both OPLL patient tissues and derived fibroblasts,in contrast to non-OPLL *** of DAPK2 significantly curtailed osteogenic differentiation and autophagy in these fibroblasts,evidenced by decreased levels of LC3,and Beclin1,and reduced autophagosome ***,DAPK2 was found to inhibit the mechanistic target of the rapamycin complex 1(mTORC1)complex’s *** vivo studies demonstrated that DAPK2 facilitates ossification,and this effect could be counteracted by the mTORC1 inhibitor ***:DAPK2 enhances autophagy and osteogenic processes in OPLL through modulation of the mTORC1 pathway.

关键词： Ossification of the posterior longitudinal ligament DAPK2 Autophagy mTORC1

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