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Selective recognition in molecularly imprinted polymer and its chromatographic characterization for cinchonine

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Journal of Central South University of Technology 2005年第Z1期12卷 102-107页

作者： ZHONG shi-an huang ke-long LEI Qi-fu XIANG Hai-yan School of Chemistry and Chemical Engineering Central South University Changsha 410083 China School of Chemistry and Chemical Engineering Central South University Changsha 410083 China School of Chemistry and Chemical Engineering Central South University Changsha 410083 China School of Chemistry and Chemical Engineering Central South University Changsha 410083 China

A molecularly imprinting polymer (MIP) was synthesized via bulk polymerization under different conditions using anti-ague drug cinchonine (CN) as template. Infrared spectra (IR) results show that the template CNand functional monomer α-methyl acrylic acid (MAA) formed complexes before polymerization and the structure of complexes was simulated by Hyperchem. The results indicate that there are hydrogen bond or ionic bond between functional monomer and template molecule in acetonitrile solution. The MIP made in cold-initiated photo-polymerization has higher separation performance than that in the therm-initiated polymerization. The separation of the isomers CN and cinchonidine (CD) can be successfully obtained when its separate factor α reaches 1.82. Scatchard analysis suggests that the MIP recognizing CN with two classes of binding sites. The partition coefficient Kd, 1 and apparent maximum number nmax, 1 of binding sites with high affinity are 131.43 μmol/L and 58. 90 μmol/g, respectively,while Kd, 2 and nmax, 2 of binding sites with low affinity are 2.32 mmol/L and 169.08 mmol/g, respectively.

关键词： molecular imprinting cinchonine chiral separation HPLC

Bayesian Filtering for High-Dimensional State-Space Models With State Partition and Error Compensation

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IEEE/CAA Journal of Automatica Sinica 2024年第5期11卷 1239-1249页

作者： ke Li Shunyi Zhao Biao huang Fei Liu key Laboratory of Advanced Process Control for Light Industry(Ministry of Education) Institute of AutomationJiangnan UniversityWuxi 214122China Department of Chemical and Materials Engineering University of AlbertaEdmonton AB T6G 2G6Canada

In the era of exponential growth of data availability,the architecture of systems has a trend toward high dimensionality,and directly exploiting holistic information for state inference is not always computationally *** paper proposes a novel Bayesian filtering algorithm that considers algorithmic computational cost and estimation accuracy for high-dimensional linear *** high-dimensional state vector is divided into several blocks to save computation resources by avoiding the calculation of error covariance with immense *** that,two sequential states are estimated simultaneously by introducing an auxiliary variable in the new probability space,mitigating the performance degradation caused by state ***,the computational cost and error covariance of the proposed algorithm are analyzed analytically to show its distinct features compared with several existing *** results illustrate that the proposed Bayesian filtering can maintain a higher estimation accuracy with reasonable computational cost when applied to high-dimensional linear systems.

关键词： filtering estimation error

Effect of quenching cooling rate on residual stress and microstructure evolution of 6061 aluminum alloy

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Journal of Central South University 2024年第7期31卷 2167-2180页

作者： huang ke YI You-ping huang shi-quan HE Hai-lin LIU Jie HUA Hong-en TANG Yun-jian Research Institute of Light Alloy Central South UniversityChangsha 410083China State key Laboratory of Precision Manufacturing for Extreme Service Performance Changsha 410083China School of Mechanical and Electrical Engineering Central South UniversityChangsha 410083China

In this study,the cooling rate was manipulated by quenching with water of different temperatures(30,60 and 100℃).Surface and internal residual stresses in the quenched 6061 aluminum alloy samples were measured using hole-drilling and crack compliance methods,***,the processability of the quenched samples was evaluated at cryogenic *** mechanical properties of the as-aged samples were assessed,and microstructure evolution was *** surface residual stresses of samples W30℃,W60℃and W100℃is−178.7,−161.7 and−117.2 MPa,respectively along x-direction,respectively;and−191.2,−172.1 and−126.2 MPa,respectively along *** sample quenched in boiling water displaying the lowest residual stress(~34%and~60%reduction in the surface and core).The generation and distribution of quenching residual stress could be attributed to the lattice distortion *** plasticity was also exhibited in the samples with relatively low quenching cooling rates at cryogenic *** strengthes of the as-aged samples are 291.2 to 270.1 MPa as the quenching water temperature increase from 30℃to 100℃.Fine and homogeneous β"phases were observed in the as-aged sample quenched with boiling water due to the clusters and Guinier-Preston zones(GP zones)premature precipitated during quenching process.

关键词： 6061 aluminum alloy residual stress cooling rate cryogenic cooling mechanical properties microstructure evolution

In situ direct reprogramming of astrocytes to neurons via polypyrimidine tract-binding protein 1 knockdown in a mouse model of ischemic stroke

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Neural Regeneration Research 2024年第10期19卷 2240-2248页

作者： Meng Yuan Yao Tang Tianwen huang Lining ke En huang key Laboratory of Brain Aging and Neurodegenerative Diseases of Fujian Province Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Human Anatomy School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Scientific Research Center School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurology Fujian Medical University Union HospitalFuzhouFujian ProvinceChina Fujian key Laboratory of Vascular Aging Fujian Medical UniversityFuzhouFujian ProvinceChina

In situ direct reprogramming technology can directly convert endogenous glial cells into functional neurons in vivo for central nervous system repair. Polypyrimidine tract-binding protein 1(PTB) knockdown has been shown to reprogram astrocytes to functional neurons in situ. In this study, we used AAV-PHP.e B-GFAP-sh PTB to knockdown PTB in a mouse model of ischemic stroke induced by endothelin-1, and investigated the effects of GFAP-sh PTB-mediated direct reprogramming to neurons. Our results showed that in the mouse model of ischemic stroke, PTB knockdown effectively reprogrammed GFAP-positive cells to neurons in ischemic foci, restored neural tissue structure, reduced inflammatory response, and improved behavioral function. These findings validate the effectiveness of in situ transdifferentiation of astrocytes, and suggest that the approach may be a promising strategy for stroke treatment.

关键词： astrocyte in situ direct reprogramming ischemic stroke miR-30 based shRNA neuron polypyrimidine tract-binding protein 1 transdifferentiation

Robust AUC maximization for classification with pairwise confidence comparisons

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Frontiers of Computer Science 2024年第4期18卷 73-83页

作者： Haochen shi Mingkun XIE Shengjun huang College of Computer Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 211106China College of Electronic and Information Engineering Nanjing University of Aeronautics and AstronauticsNanjing 211106China MIIT key Laboratory of Pattern Analysis and Machine Intelligence Nanjing 211106China

Supervised learning often requires a large number of labeled examples,which has become a critical bottleneck in the case that manual annotating the class labels is *** mitigate this issue,a new framework called pairwise comparison(Pcomp)classification is proposed to allow training examples only weakly annotated with pairwise comparison,i.e.,which one of two examples is more likely to be *** previous study solves Pcomp problems by minimizing the classification error,which may lead to less robust model due to its sensitivity to class *** this paper,we propose a robust learning framework for Pcomp data along with a pairwise surrogate loss called *** provides an unbiased estimator to equivalently maximize AUC without accessing the precise class ***,we prove the consistency with respect to AUC and further provide the estimation error bound for the proposed *** studies on multiple datasets validate the effectiveness of the proposed method.

关键词： method. pairwise weakly

Physiological and pathological functions of circular RNAs in the nervous system

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Neural Regeneration Research 2024年第2期19卷 342-349页

作者： Min Zhou shi Li Chuan huang School of Life Sciences Chongqing UniversityChongqingChina

Circular RNAs(circRNAs)are a class of covalently closed single-stranded RNAs that are expressed during the development of specific cells and *** play crucial roles in physiological and pathological processes by sponging microRNAs,modulating gene transcription,controlling the activity of certain RNA-binding proteins,and producing functional peptides.A key focus of research at present is the functionality of circRNAs in the nervous system and several advances have emerged over the last 2 ***,the precise role of circRNAs in the nervous system has yet to be comprehensively *** this review,we first summarize the recently described roles of circRNAs in brain development,maturity,and ***,we focus on the involvement of circRNAs in various diseases of the central nervous system,such as brain cancer,chronic neurodegenerative diseases,acute injuries of the nervous system,and neuropathic pain.A better understanding of the functionality of circRNAs will help us to develop potential diagnostic,prognostic,and therapeutic strategies to treat diseases of the nervous system.

关键词： Alzheimer’s disease amyotrophic lateral sclerosis brain development circRNAs neuropathic pain Parkinson’s disease

An ecological perspective on Joseph Rock’s(1884-1962)plant collection activities in China

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Journal of Plant Ecology 2024年第4期17卷 100-113页

作者： Jifan Luo Ruozhi huang Hai Yan Renwu Wu Shuai Liao Zhoubing Xiang Yongxi Zou Liangchen shi ke Wang Zhiyi Bao College of Landscape Architecture Zhejiang Agriculture and Forestry UniversityHangzhou 311300China Zhejiang Agriculture and Forestry University Landscape Architecture Institute Hangzhou 311300China South China Botanical Garden Chinese Academy of SciencesGuangzhou 510650China

In the early 20th century,numerous western botanists,often referred to as‘plant hunters’,embarked on ambitious expeditions to China,playing a crucial role in the study of botany and botanical *** their contributions,comprehensive assessments of their explorations are *** bridge this gap,this article focuses on the work of Joseph Charles Francis Rock,a notable figure in that *** work revisits Rock’s botanical expeditions within the broader context of botanical diversity *** outlines his historical experiences in collecting plants in China and enumerates the species composition and phenotypic traits of the plants he ***,it also analyzes the spatial distribution of the species,the completeness of his collection and the α-and β-diversity of the plants he *** findings reveal that Rock led four major botanical expeditions in China between 1922 and 1933,amassing a total of 28184 sheets and 16608 numbers across 204 families,1081 genera and 4231 *** focus was predominantly on ornamental species,which exhibit a variety of flower colors and *** collection work spanned 5 provinces,35 cities and 72 counties,with a notable concentration in the Hengduan Mountains,a current biodiversity *** study not only reconstructs Rock’s botanical legacy but also offers valuable historical data and fresh analytical insights for understanding contemporary plant *** contributes to the ongoing discourse on the importance of preserving plant diversity as a cornerstone of environmental sustainability.

关键词： Joseph Charles Francis Rock plant specimen collection history plant diversity plant collector

Taxonomic studies of some often over-looked Diaporthomycetidae and Sordariomycetidae

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Fungal Diversity 2021年第6期111卷 443-572页

作者： shi-ke huang kevin D.Hyde Ausana Mapook Sajeewa S.N.Maharachchikumbura Jayarama D.Bhat Eric H.C.Mckenzie Rajesh Jeewon Ting-Chi Wen State key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering Key Laboratory of Green Pesticide and Agricultural BioengineeringMinistry of EducationGuizhou UniversityGuiyang 550025China The Engineering Research Center of Southwest Bio-Pharmaceutical Resources Ministry of EducationGuizhou UniversityGuiyang 550025Guizhou ProvinceChina Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand The Mushroom Research Centre Guizhou UniversityGuiyang 550025China Institute of Plant Health Zhongkai University of Agriculture and EngineeringHaizhu DistrictGuangzhou 510225China School of Life Science and Technology University of Electronic Science and Technology of ChinaChengdu 611731China Department of Botany Goa UniversityGoaIndia Present Address:Goa Velha India Manaaki Whenua-Landcare Research Private Mail Bag 92170AucklandNew Zealand Department of Health Sciences Faculty of Medicine and Health SciencesUniversity of MauritiusReduitMauritius

Sordariomycetes is an earlier-introduced and one of the widely distributed class of *** class was initially clas-sified based on morphology in having inoperculate and unitunicate *** the development of DNA based phylogenetic analysis,several undetermined or polyphyletic members of Sordariomycetes were ***,not all species belonging to this class have been sequenced and *** are a number of species,especially those old and poorly studied ones which have never been sequenced before and not even recollected again for further taxonomic *** of the main objective in this study is to revise and update the taxonomy of several well-known early and poorly studied spe-cies whose classification are still ***,we re-examined the type materials and/or authentic specimens together to explore 74 relatively poorly-studied genera,which mainly belong to Boliniales,Calosphaeriales,Chaetosphaeriales,Jobellisiales,and Sordariales classified under Diaporthomycetidae and *** provide descriptions,notes,figures and/or drawings and discussed their phylogenetic *** a result,the monotypic Jobellisiales is transferred from Hypocreomycetidae to *** on phylogenetic analysis,the polyphyletic Lasiosphaeriaceae is divided into five families,Bombardiaceae(Apodospora,Bombardia,Bombardioidea,Fimetariella and Ramophialophora),Lasiosphaeriaceae(Anopodium,Bellojisia,Corylomyces,Lasiosphaeria,Mammaria and Zopfiella),Lasiosphaeridaceae(Lasiosphaeris),Strattoniaceae(Strattonia)and Zygospermellaceae(Episternus and Zygospermella).In addition,a new family Neoschizotheciaceae is established based on *** of the type species of Boothiella,Stel-latospora,Sulcatistroma and Tengiomyces placed them in Sordariaceae,Chaetomiaceae,Hypocreales and Coronophorales,*** classify the genera lacking molecular data based on their morphology and expect them to be recollected;that is

关键词： 43 new taxa Boliniales Calosphaeriales Helminthosphaeriaceae Jobellisiales Sordariales Sordariomycetes

Base-controlled NHC-Ru-catalyzed transfer hydrogenation andα-methylation/transfer hydrogenation of ketones using methanol

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Chinese Chemical Letters 2024年第7期35卷 276-280页

作者： Ming huang Xiuju Cai Yan Liu Zhuofeng ke School of pharmacy School of clinical pharmacyGuangdong Pharmaceutical UniversityGuangzhou 510006China School of Materials Science&Engineering PCFM LabSchool of ChemistrySun Yat-sen UniversityGuangzhou 510275China School of Chemical Engineering and Light Industry Guangdong University of TechnologyGuangzhou 510006China

Herein,we report the NHC-Ru catalyst system that realizes the chemo-selective transformation of ketones with *** simply changing the base,a broad range of structurally diverse ketones,could be selectively and efficiently converted to the correspondingβ-methylated secondary alcohols or secondary ***,this catalytic system was very effective for the synthesis of bio-related molecules and deuterated alcohols,as well as the three-component coupling between methyl ketones,primary alcohols,and *** reaction mechanism was further revealed by experiment and DFT mechanistic investigations.

关键词： Ru complexes Methanol ketones β-Methylated secondary alcohols Transfer hydrogenation