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World Journal of Gastroenterology 2024年第6期30卷 527-541页

作者： Xin Li Li-Jiang Ji Kai-Di Feng Hua Huang Mei-Rou Liang shi-jin cheng Xiu-Dong Meng School of Basic Medicine Guizhou University of Traditional Chinese MedicineGuiyang 550025Guizhou ProvinceChina Department of Anorectal Surgery Changshu Hospital Affiliated to Nanjing University of Chinese MedicineChangshu 215500Jiangsu ProvinceChina College of Traditional Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China

Ulcerative colitis(UC)is a chronic recurrent inflammatory bowel *** ongoing advances in our understanding of UC,its pathogenesis is yet unelu-cidated,underscoring the urgent need for novel treatment strategies for patients with *** are nanoscale membrane particles that mediate intercellular communication by carrying various bioactive molecules,such as proteins,RNAs,DNA,and *** NOD-like receptor family pyrin domain containing 3(NLRP3)inflammasome is a cytosolic tripartite protein complex whose activation induces the maturation and secretion of proinflammatory cytokines interleukin-1β(IL-1β)and IL-18,triggering the inflammatory response to a pathogenic agent or *** evidence suggests that exosomes are new modulators of the NLRP3 inflammasome,with vital roles in the pathological process of ***,recent evidence is reviewed on the role of exosomes and NLRP3 inflammasome in ***,the dual role of exosomes on NLRP3 inflammasome and the effect of NLRP3 inflammasome on exosome secretion are ***,an outlook on the directions of exosome-NLRP3 inflammasome crosstalk research in the context of UC is proposed and areas of further research on this topic are high-lighted.

关键词： Ulcerative colitis Exosomes Inflammasome Evidence Therapeutics

Meta-analysis of the comparison between reduning injection and ribavirin injection for acute upper respiratory tract infection in children

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Infectious Diseases Research 2022年第4期3卷 1-9页

作者： Chen Yang Lin-Hui Li shi-Pian Li shi-jin cheng Tian-Yu Zhu Wei Zhai Tianjin University of Traditional Chinese Medicine Tianjin 301617China

Objective:To systematically evaluate the effectiveness and safety of reduning injection in acute upper respiratory tract infection of ***:Use computer to search PubMed,the Cochrane Library,EMBASE,Web of Science,China National Knowledge Infrastructure(CNKI),Wanfang Database,Weipu database(VIP)and China Biomedical studies Service System(CBM)for randomized controlled trials(RCT)of acute upper respiratory tract infection in children,and the retrieval time is from their establishment to May,*** two researchers independently screened the studies,extracted data and evaluated the risk bias of studies,RevMan5.3 software was used to perform ***:10 studies in total were included,involving 1466 *** of the meta-analysis:total effective rate[RR=1.12,95%CI(1.07,1.16),P<0.00001],cure time[MD=-1.51,95%CI(-1.71,-1.32),P<0.00001],antipyretic time[MD=-1.32,95%CI(-1.72,-0.92),P<0.00001],disappearing time of nasal obstruction and nose running[MD=-1.04,95%CI(-1.45,-0.62),P<0.00001],disappearing time of cough[MD=-1.35,95%CI(-1.58,-1.13),P<0.00001],disappearing time of throat congestion[MD=-1.36,95%CI(-1.68,-1.03),P<0.00001],disappearing time of sore throat[MD=-1.55,95%CI(-1.74,-1.35),P<0.00001],the incidence of adverse reactions[RR=0.34,95%CI(0.20,0.57),P<0.0001].The differences between two groups in total effective rate,cure time,antipyretic time,disappearing time of nasal obstruction and nose running,disappearing time of cough,disappearing time of throat congestion,disappearing time of sore throat and the incidence of adverse reactions are all statistically significant(P<0.05).The sensitivity analysis demonstrates that three outcomes(total effective rate,cure time and disappearing time of sore throat)have unstable results,while others having stable ***:Reduning injection is more effective than ribavirin injection in clinical,and it is better than ribavirin injection at relieving fever,nasal obstruction and nose running,cou

关键词： acute upper respiratory tract infection reduning injection ribavirin injection meta-analysis

Proper beverages may reduce the risk of Alzheimer’s disease

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Aging Communications 2023年第4期5卷 3-6页

作者： Lian-Yi Hu shi-jin cheng Jia-Rong shi Yu-Hui Wang Xin-Ju Li College of Traditional Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China College of Integrated Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China

Alzheimer’s disease (AD) is one of the most common neurodegenerative disorders, characterized by a progressive decline in cognitive ability. Around 50 million people worldwide are reportedly affected, with annual losses estimated at about $1 trillion [1]. Nevertheless, there remains unknown about the exact pathological mechanisms of AD and currently available treatments have a lack of efficacy. Thus, experts have reached a consensus that interventions in the preclinical stage of AD should be prioritized [2], especially when the amount of patients is set to reach 78 million by the end of this decade [3]. Recently, the proposition “integrating food and nutrition into healthcare” has been promoted [4]. Prevention from dietary eating and drinking may be an effective and age-friendly method. Nowadays, many beverages have been proven to offer great preventative benefits to AD like coffee, soy milk, tea, and wine. Coffee, consumed by tens of thousands of people every day, has been proven in several epidemiological studies to have a protective effect against AD [5-7]. A study including 411 individuals shows that significant negative correlation between stratified lifetime coffee intake and β-amyloid positivity [8]. In other words, higher coffee intake (≥ 2 cups/day) is associated with lower risk of AD. However, a Mendelian randomization (MR) analysis came to the opposite conclusion, with an additional 1 cup of coffee per day being associated with a 1.16-fold increased risk of developing AD [9]. In meta-analyses of cohort studies, it was proposed that there was a non-linear “U-shaped” link between coffee consumption and AD, with 3-4 cups per day being optimal [10]. In addition to the possibility that different conclusions are due to inconsistent estimations of coffee intake and populations in these studies, research recently proposed a hypothesis that the cytochrome P450 1A2 played an essential role in the metabolism of coffee in the human body [11]. Rs762551 is its most rep

关键词： metabolism protective integrating

Discovery of and Preliminary studies on a Rapid-Leafing Rice Genotype at the Vegetative Growth Stage

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Rice science 2008年第1期15卷 29-35页

作者： MAO Hai-yan PAN Cun-hong CHEN Zong-xiang ZHANG Ya-fang Zuo shi-min cheng jin-rong PAN Xue-biao Key Laboratory of Crop Genetics and Physiology of Jiangsu Province~Key Laboratory of Plant Functional Genomics of Ministry ofEducation of China Yangzhou University Yangzhou 225009 China

The leafing rates of fourteen rice varieties were measured in a sowing-time experiment, and a rapid leafing genotype at the vegetative growth stage was discovered in an indica variety Yanhui 559. The leaf number on the main culm of Yanhui 559 was always 4-5 leaves more than that of Lemont, and the leafing rate of Yanhui 559 was significantly higher than that of Lemont based on similar growth durations from sowing to heading. Furthermore, the difference of the leafing rate was significant at the vegetative growth stage, but not distinctive at the panicle initiation stage. Genetic analysis of the leafing rates in the two backcross populations of Yanhui 559 and Lemont showed that major and quantitative genes controlled the expression of rapid leafing character. Based on results of investigation for some plants with similar growth durations in the backcrossing populations, the rapid leafing genotypes exhibited earlier tillering and more tiller numbers per plant, and its yield components including the number of panicles per plant and number of grains per panicle were superior to those of the slow leafing genotypes. Further research and application feasibility of the rapid leafing genotype in breeding were discussed.

关键词： rapid leafing vegetative growth stage leaf number on the main culm number of panicles per plant rice

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一类双曲方程解的空间渐近性态

高校应用数学学报（A辑） 2022年第3期37卷 268-276页

作者：石金诚广州华商学院数据科学学院广东广州511300

研究了一类双曲方程的解的空间性态,利用能量方法与微分不等式的技巧得到了解的类似于Phragmen-Lindelof二择一定理的结果:沿空间变量z趋于无穷大时解或者爆破,或者衰减.接着在解衰减的基础上得到解的衰减为指数衰减,最后得到解的点点... 详细信息

研究了一类双曲方程的解的空间性态,利用能量方法与微分不等式的技巧得到了解的类似于Phragmen-Lindelof二择一定理的结果:沿空间变量z趋于无穷大时解或者爆破,或者衰减.接着在解衰减的基础上得到解的衰减为指数衰减,最后得到解的点点指数衰减估计.该文的结果可看成Saint-Venant原则在双曲方程上的应用.

关键词：空间性态双曲方程 Phragmen-Lindelof二择一爆破

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基于二部图的概念聚类研究

计算机工程与应用 2010年第13期46卷 132-134页

作者：史金成胡学钢铜陵学院数学与计算机科学系安徽铜陵244000 合肥工业大学计算机与信息学院合肥230009

传统概念聚类算法中簇的更新和存储不仅依赖于对象数目和属性数目,而且依赖于属性值的数目,这种局限性使其不适用于大型数据集。提出一种新的基于二部图的概念聚类算法(BGBCC),该算法通过获得二部图的近似极大ε二元组集,有效地进行数... 详细信息

传统概念聚类算法中簇的更新和存储不仅依赖于对象数目和属性数目,而且依赖于属性值的数目,这种局限性使其不适用于大型数据集。提出一种新的基于二部图的概念聚类算法(BGBCC),该算法通过获得二部图的近似极大ε二元组集,有效地进行数据与属性的关联聚类。实验表明,该算法能得到较好的聚类结果,且能在较短的时间内进行大型数据集的概念聚类。

关键词：机器学习概念聚类关联聚类二部图二元组

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基于数据流的概念聚类

计算机工程 2010年第9期36卷 62-64页

作者：史金成胡学钢铜陵学院数学与计算机科学系铜陵244000 合肥工业大学计算机与信息学院合肥230009

分析二部图的二元组和概念聚类问题之间的关系,在此基础上结合数据流的特点,提出一种适用于对象属性为布尔型的数据流概念聚类算法。将数据流分段,对每一批到来的数据流,生成局部的近似极大ε二元组集合,对全局的近似极大ε二元组集合... 详细信息

分析二部图的二元组和概念聚类问题之间的关系,在此基础上结合数据流的特点,提出一种适用于对象属性为布尔型的数据流概念聚类算法。将数据流分段,对每一批到来的数据流,生成局部的近似极大ε二元组集合,对全局的近似极大ε二元组集合进行更新,从而有效地对整个数据流进行聚类。实验结果表明,该算法具有良好的时间效率和空间效率。

关键词：数据流概念聚类近似极大ε二元组

Continuous Dependence for a Brinkman-Forchheimer Type Model with Temperature-Dependent Solubility

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Chinese Quarterly Journal of Mathematics 2021年第3期36卷 308-319页

作者： shi jin-cheng XIAO Sheng-zhong School of Date Science Guangzhou Huashang CollegeGuangzhou 511300China Foundation Department Guangdong AIB UniversityGuangzhou 510507China

The structural stability for the Brinkman-Forchheimer equations with temperature-dependent solubility in a bounded region in R3 was *** reaction boundary conditions for the temperature T and the salt concentration were *** the aid of some useful a priori bounds,we were able to demonstrate the continuous dependence result for the Forchheimer coefficient λ.

关键词： Structural stability Brinkman-Forchheimer equations Temperature-dependent solubility Continuous dependence Robin boundary

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会聚视角下关键核心技术研发特征与突破路径

科学学研究 2024年第3期42卷 571-582,672页

作者：施锦诚朱凌王迎春上海人工智能实验室治理研究中心上海200232 浙江大学中国科教战略研究院浙江杭州310058

会聚科学引发新一波科技创新浪潮,对关键核心技术实现从“落后追赶”到“领先超越”的突破具有重要作用,然而对关键核心技术的研发特征及其突破路径的研究仍存在缺口。本文面向传统制造业和新兴产业领域,选取工业机器人轴承和脑机接口... 详细信息

会聚科学引发新一波科技创新浪潮,对关键核心技术实现从“落后追赶”到“领先超越”的突破具有重要作用,然而对关键核心技术的研发特征及其突破路径的研究仍存在缺口。本文面向传统制造业和新兴产业领域,选取工业机器人轴承和脑机接口两个典型技术,运用德温特专利网络分析方法,探索关键核心技术研发特征及突破路径。研究发现:技术会聚视角下关键核心技术研发特征存在显著差异,工业机器人轴承为代表的基础性技术,以相近学科交叉、技术内部类别交叉为主,强调技术网络融通;脑机接口为代表的前沿性技术,以大范围学科交叉、跨技术部类交叉为主,强调技术集群多样性;在关键核心技术研发特征分析基础上,研究得出“场景需求牵引+技术内部类别融合+领军企业带动产业链”“技术创新驱动+跨技术部类间融合+产学研创新联合体”两条突破路径。本文进一步完善与发展了关键核心技术突破的理论研究,对实现我国高水平科技自立自强具有一定的借鉴意义。

关键词：关键核心技术技术网络技术会聚研发特征突破路径

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人工智能多元研发模式研究

科学学研究 2024年第9期42卷 1897-1906,1927页

作者：施锦诚王迎春上海人工智能实验室治理研究中心上海200232

人工智能科技突破亟须探究研发模式系统布局。本文从研发组织方式和战略导向两个维度构建人工智能研发模式理论分析框架,运用多案例比较法,研究发现:人工智能研发组织聚焦创新链不同环节,在理论原创、关键核心技术攻关、开放生态建设、... 详细信息

人工智能科技突破亟须探究研发模式系统布局。本文从研发组织方式和战略导向两个维度构建人工智能研发模式理论分析框架,运用多案例比较法,研究发现:人工智能研发组织聚焦创新链不同环节,在理论原创、关键核心技术攻关、开放生态建设、行业前沿探索上各有侧重,形成“创新探索者”“攻关主导者”“生态赋能者”“行业引领者”四类研发角色。通过对研发角色的画像分析,发现研发主体间存在角色差异性。研究结论对我国从国家创新体系层面推进人工智能研发系统布局、提升人工智能科技创新体系协同效能具有参考意义。

关键词：人工智能研发组织研发模式国家创新体系