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Prognostic Nutritional Index Associates with the Severity of Silicosis:A Study from a Tertiary Class A Prevention and Treatment Institute for Occupational Diseases in China

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Biomedical and Environmental Sciences 2024年第1期37卷 122-126页

作者： HE La Gu LIANG Yun Lai yang Lu Qi YUAN Hua Min Medical laboratory Department Hunan Prevention and Treatment Institute for Occupational DiseasesChangsha 410000HunanChina Laboratory Medicine Department Xiangya HospitalCentral South UniversityChangsha 410013HunanChina

Pneumoconiosis is a group of heterogeneous fibrotic lung diseases caused by inorganic mineral dust and includes coal workers’pneumoconiosis and *** involves diffuse or nodular interstitial pulmonary fibrosis caused by exposure to asbestos or silica *** is thought to have the highest number of silicosis cases,with 6,000 new cases reported annually^([1]).Currently,the clinical diagnosis and monitoring of silicosis relies mainly on a history of occupational exposure and radiological abnormalities^([2]).Therefore,determining further indicators is crucial to reflect the severity of silicosis.

关键词： diagnosis lung diseases

Microstructural evolution and mechanical properties of duplex-phase Ti6242 alloy treated by laser shock peening

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Transactions of Nonferrous Metals Society of China 2024年第8期34卷 2521-2532页

作者： Pu-ying shi Xiang-hong LIU Yong REN Zeng TIAN Feng-shou ZHANG Wei-feng HE Institute of Aeronautics Engine School of Mechanical EngineeringXi’an Jiaotong UniversityXi’an 710049China Western Superconducting Technologies Co. Ltd.Xi’an 710018China School of Aeronautical Engineering Air Force Engineering UniversityXi’an 710038China

The effects of laser shock peening(LSP)on the microstructural evolution and mechanical properties of the Ti6242 alloy,including the residual stress,surface roughness,Vickers microhardness,tensile mechanical response,and high-cycle fatigue properties,were *** results showed that the LSP induced residual compressive stresses on the surface and near surface of the *** maximum surface residual compressive stress was−661 MPa,and the compressive-stress-affected depth was greater than 1000μ*** roughness and Vickers micro-hardness increased with the number of shocks,and the maximum hardness-affected depth was about 700μm after three LSP *** enhanced the fraction of low-angle grain boundaries,changed the grain preferred orientations,and notably increased the pole density ofαphase on the near surface from 2.41 to *** surface hardness values of the LSP samples increased with the increase of the number of shocks due to work hardening,while the LSP had a limited effect on the tensile *** high-cycle fatigue life of the LSP-treated sample was significantly enhanced by more than 20%compared with that of the untreated sample,which was caused by the suppression of the initiation and propagation of fatigue cracks.

关键词： duplex-phase Ti6242 alloy surface modification laser shock peening gradient microstructure high-cycle fatigue properties

3D interlocked all-textile structured triboelectric pressure sensor for accurately measuring epidermal pulse waves in amphibious environments

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Nano Research 2024年第3期17卷 1923-1932页

作者： Shaobo Si Chenchen Sun Yufen Wu Jingjing Li Han Wang Yinggang Lin Jin yang Zhong Lin Wang Department of Optoelectronic Engineering Key Laboratory of Optoelectronic Technology and Systems Ministry of EducationChongqing UniversityChongqing 400044China College of Physics and Electronic Engineering Chongqing Normal UniversityChongqing 401331China Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of SciencesBeijing 100083China School of Materials Science and Engineering Georgia Institute of TechnologyAtlantaGA 30332USA

The performance degradation and even damage of the e-textiles caused by sweat,water,or submersion during all-weather health monitoring are the main reasons that e-textiles have not been commercialized and routinized so ***,we developed an amphibious,high-performance,air-permeable,and comfortable all-textile triboelectric sensor for continuous and precise measurement of epidermal pulse waves during full-day *** on the principle of preparing gas by acid-base neutralization reaction,a one-piece preparation process of amphibious conductive yarn(ACY)with densely porous structures is *** innovative three-dimensional(3D)interlocking fabric knitted from ACYs(0.6 mm in diameter)and polytetrafluoroethylene yarns exhibit high sensitivity(0.433 V·kPa^(-1)),wide bandwidth(up to 10 Hz),and stability(>30,000 cycles).With these benefits,98.8%agreement was achieved between wrist pulse waves acquired by the sensor and a high-precision laser ***,the polytetrafluoroethylene yarn with good compression resilience provides sufficient mechanical support for the contact separation of the ***,the unique skeletonized design of the 3D interlocking structure can effectively relieve the water pressure on the sensor surface to obtain stable and accurate pulse waves(underwater depth of 5 cm).This achievement represents an important step in improving the practicality of e-textiles and early diagnosis of cardiovascular diseases.

关键词： triboelectric pressure sensor amphibious fabric interlocking fabric pulse wave measurement one-piece preparation method

Trogocytosis of CAR molecule regulates CAR-T cell dysfunction and tumor antigen escape

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Signal Transduction and Targeted Therapy 2024年第1期9卷 326-337页

作者： You Zhai Yicong Du Guanzhang Li Mingchen Yu Huimin Hu Changqing Pan Di Wang Zhongfang shi Xu Yan Xuesong Li Tao Jiang Wei Zhang Department of Molecular Neuropathology Beijing Neurosurgical InstituteCapital Medical UniversityBeijingPR China Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijingPR China Department of Urology Peking University First HospitalInstitute of UrologyPeking UniversityNational Urological Cancer CenterBeijingPR China Department of Pathophysiology Beijing Neurosurgical InstituteCapital Medical UniversityBeijingPR China China National Clinical Research Center for Neurological Diseases BeijingPR China Center of Brain Tumor Beijing Institute for Brain DisordersBeijingPR China Research Unit of Accurate Diagnosis Treatmentand Translational Medicine of Brain TumorsChinese Academy of Medical SciencesBeijingPR China Chinese Glioma Genome Atlas Network(CGGA)and Asian Glioma Genome Atlas Network(AGGA) BeijingPR China

Chimeric antigen receptor(CAR)T-cell therapy has demonstrated clinical response in treating both hematologic malignancies and solid *** instances of rapid tumor remissions have been observed in animal models and clinical trials,tumor relapses occur with multiple therapeutic resistance ***,while the mechanisms underlying the long-term therapeutic resistance are well-known,short-term adaptation remains less ***,more views shed light on short-term adaptation and hold that it provides an opportunity window for long-term *** this study,we explore a previously unreported mechanism in which tumor cells employ trogocytosis to acquire CAR molecules from CAR-T cells,a reversal of previously documented *** mechanism results in the depletion of CAR molecules and subsequent CAR-T cell dysfunction,also leading to short-term antigen loss and antigen *** type of intercellular communication is independent of CAR downstream signaling,CAR-T cell condition,target antigen,and tumor cell ***,it is mainly dependent on antigen density and CAR sensitivity,and is associated with tumor cell cholesterol *** mitigation of this trogocytosis-induced CAR molecule transfer can be achieved by adaptively administering CAR-T cells with antigen density-individualized CAR ***,our study reveals a dynamic process of CAR molecule transfer and refining the framework of clinical CAR-T therapy for solid tumors.

关键词： Together instance depletion

Development and identification of two novel wheat-rye 6R derivative lines with adult-plant resistance to powdery mildew and high-yielding potential

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The Crop Journal 2024年第1期12卷 308-313页

作者： Guohao Han Jing Wang Hanwen Yan Tiantian Gu Lijun Cao shiyu Liu Xiuquan Li Yilin Zhou Jieru Fan Zhipeng shi Hong Liu Lihui Li Diaoguo An Center for Agricultural Resources Research Institute of Genetics and Developmental BiologyChinese Academy of SciencesShijiazhuang 050021HebeiChina The National Key Facility for Crop Gene Resources and Genetic Improvement Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China The State Key Laboratory for Biology of Plant Disease and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193China

Powdery mildew,caused by Blumeria graminis ***(Bgt),is a devastating disease that seriously threatens wheat yield and *** control this disease,host resistance is the most effective *** with the resistance genes from common wheat,alien resistance genes can better withstand infection of this highly variable *** of elite alien germplasm resources with powdery mildew resistance and other key breeding traits is an attractive strategy in wheat *** this study,three wheat-rye germplasm lines YT4-1,YT4-2,and YT4-3 were developed through hybridization between octoploid triticale and common wheat,out of which the lines YT4-1 and YT4-2 conferred adult-plant resistance(APR)to powdery mildew while the line YT4-3 was susceptible to powdery mildew during all of its growth *** genomic in situ hybridization,multi-color fluorescence in situ hybridization,multi-color GISH,and molecular marker analysis,YT4-1,YT4-2,and YT4-3 were shown to be cytogenetically stable wheat-rye 6R addition and T1RS.1BL translocation line,6RL ditelosomic addition and T1RS.1BL translocation line,and T1RS.1BL translocation line,*** with previously reported wheat-rye derivative lines carrying chromosome 6R,YT4-1 and YT4-2 showed stable APR without undesirable pleiotropic effects on agronomic ***,these novel wheat-rye 6R derivative lines are expected to be promising bridge resources in wheat disease breeding.

关键词： Powdery mildew Secale cereale Triticum aestivum Wheat-rye 6R derivatives Agronomic performance

Construction of 2D/2D Ti_(3)C_(2)T_(x)MXene/CdS heterojunction with photothermal effect for efficient photocatalytic hydrogen production

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Journal of Materials Science & Technology 2024年第4期171卷 1-9页

作者： T.Y.Huang Z.yang S.Y.yang Z.H.Dai Y.J.Liu J.H.Liao G.Y.Zhong Z.J.Xie Y.P.Fang S.S.Zhang Key Laboratory for Biobased Materials and Energy of Ministry of Education Guangdong Laboratory for Lingnan Modern AgricultureCollege of Materials and EnergySouth China Agricultural UniversityGuangzhou 510643China School of Physics and Optoelectronics South China University of TechnologyGuangzhou 510640China School of Chemical Engineering and Energy Technology Guangdong Provincial Key Laboratory of Distributed Energy SystemsDongguan University of TechnologyDongguan 523808China

The insensitivity of semiconductors to visible and infrared light is a key constraint on the utilization of light energy in photocatalytic *** photocatalysts with full-spectrum absorption through surface engineering is an effective approach to fully harnessing light energy in semiconductor ***,a novel stable Ti_(3)C_(2)T_(x)MXene/CdS heterojunction catalyst is obtained by in-situ epitaxial growth of two-dimensional(2D)CdS nanosheets on 2D MXene interface via a solvothermal *** exceptional light absorption properties of MXene confer outstanding full-spectrum driven photocat-alytic hydrogen evolution capability upon the heterogeneous *** unique 2D/2D structure effectively mitigated the recombination of photogenerated carriers,enhancing the photocatalytic performance of the ***,the composite catalyst exhibits a significantly higher surface temperature of 80.4℃under visible light irradiation at an intensity of 0.1 W/cm^(2),which is 1.84 times higher than that of *** irradiation of visible and near infrared light,the composite catalyst with photothermal ef-fect demonstrates a remarkable hydrogen evolution rate of 65.4 mmol g^(-1)h^(-1),which is 7.2 times higher than that of CdS *** study introduces a novel approach for constructing full-spectrum absorption catalysts and expands the application of the photothermal effect in photocatalytic hydrogen evolution research.

关键词： Two-dimensional structure Heterostructure Photothermal effect Photocatalyst Hydrogen evolution

中国式现代化理论视域中的“发展和安全的动态平衡”

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马克思主义哲学 2024年第3期 30-36页

作者：杨海曹鏸华北电力大学马克思主义学院

当今世界正经历百年未有之大变局,我国正处于实现中华民族伟大复兴关键时期。站在“两个一百年”奋斗目标的历史交汇点上,推进中国式现代化就必须坚持以发展和安全的动态平衡防范化解重大风险。其中,高质量发展中的供给与需求的动态平衡... 详细信息

当今世界正经历百年未有之大变局,我国正处于实现中华民族伟大复兴关键时期。站在“两个一百年”奋斗目标的历史交汇点上,推进中国式现代化就必须坚持以发展和安全的动态平衡防范化解重大风险。其中,高质量发展中的供给与需求的动态平衡,加快完善社会主义市场经济体制中的“放”与“管”的动态平衡,全面深化改革中的公平与效率的动态平衡,全面依法治国中的维权与维稳的动态平衡,全面从严治党中的容错纠错与执纪问责的动态平衡,人类命运共同体建构中的多边主义与全球共治的动态平衡等是中国式现代化征程中必须把握和聚焦的“六个方面的动态平衡”。开展这一研究是进一步深化中国式现代化这一理论研究的新思路,为以发展和安全的动态平衡推进中国式现代化提供学理支撑。

关键词：中国式现代化发展和安全的动态平衡深度融合

新质生产力论断探赜:科学内涵、生成逻辑与实践路径

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山西青年职业学院学报 2024年第1期37卷 25-29页

作者：杨蕾李海阳湖南师范大学马克思主义学院湖南长沙410000

新质生产力是习近平总书记立足我国高质量发展和中国式现代化提出的发展先进生产力的全新论断。其理论根源于马克思主义经典作家的生产力思想,近代中国的磨难史和党解放发展生产力的百年奋斗史为其提供了历史经验,新征程上推动高质量发... 详细信息

新质生产力是习近平总书记立足我国高质量发展和中国式现代化提出的发展先进生产力的全新论断。其理论根源于马克思主义经典作家的生产力思想,近代中国的磨难史和党解放发展生产力的百年奋斗史为其提供了历史经验,新征程上推动高质量发展的必然要求成为其发展动力。具备科技创新本领的新质劳动人才、与科学技术相结合的新质劳动资料、以绿色环保为底色的新质劳动对象构成了新质生产力的三个基本要素。推动新质生产力的形成和发展需要加强人力资源建设,培育新质劳动人才;加快科技创新攻关,研发新质劳动工具;践行绿色发展理念,优化新质劳动对象。

关键词：新质生产力科学内涵生成逻辑实践路径

The optimal atropine concentration for myopia control in Chinese children: a systematic review and network Metaanalysis

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International Journal of Ophthalmology(English edition) 2024年第6期17卷 1128-1137页

作者： Xiao-Yan Wang Hong-Wei Deng Jian yang Xue-Mei Zhu Feng-Ling Xiang Jing Tu Ming-Xue Huang Yun Wang Jin-Hua Gan Wei-Hua yang School of Nursing Southwest Medical UniversityLuzhou 646600Sichuan ProvinceChina Shenzhen Eye Institute Shenzhen Eye HospitalJinan UniversityShenzhen 518040Guangdong ProvinceChina Luzhou Traditional Chinese Medicine Hospital Luzhou 646000Sichuan ProvinceChina The Affiliated Hospital of Southwest Medical University Luzhou 646099Sichuan ProvinceChina

AIM:To figure out whether various atropine dosages may slow the progression of myopia in Chinese kids and teenagers and to determine the optimal atropine concentration for effectively slowing the progression of ***:A systematic search was conducted across the Cochrane Library,PubMed,Web of Science,EMBASE,CNKI,CBM,VIP,and Wanfang database,encompassing literature on slowing progression of myopia with varying atropine concentrations from database inception to January 17,*** extraction and quality assessment were performed,and a network Meta-analysis was executed using Stata version 14.0 *** were visually represented through ***:Fourteen papers comprising 2475 cases were included;five different concentrations of atropine solution were *** network Meta-analysis,along with the surface under the cumulative ranking curve(SUCRA),showed that 1%atropine(100%)>0.05%atropine(74.9%)>0.025%atropine(51.6%)>0.02%atropine(47.9%)>0.01%atropine(25.6%)>control in refraction change and 1%atropine(98.7%)>0.05%atropine(70.4%)>0.02%atropine(61.4%)>0.025%atropine(42%)>0.01%atropine(27.4%)>control in axial length(AL)***:In Chinese children and teenagers,the five various concentrations of atropine can reduce the progression of *** the network Meta-analysis showed that 1%atropine is the best one for controlling refraction and AL change,there is a high incidence of adverse effects with the use of 1%***,we suggest that 0.05%atropine is optimal for Chinese children to slow myopia progression.

关键词： atropine China children and adolescents myopia network Meta-analysis